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Article

Plk3 Interacts with and Specifically Phosphorylates VRK1 in Ser342, a Downstream Target in a Pathway That Induces Golgi Fragmentation

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Pages 1189-1201 | Received 22 Aug 2008, Accepted 10 Dec 2008, Published online: 21 Mar 2023

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Jing Liu, Yuchan Wang, Song He, Xiaohong Xu, Yuejiao Huang, Jie Tang, Yaxun Wu, Xiaobing Miao, Yunhua He, Qiru Wang, Li Liang & Chun Cheng. (2016) Expression of vaccinia-related kinase 1 (VRK1) accelerates cell proliferation but overcomes cell adhesion mediated drug resistance (CAM-DR) in multiple myeloma. Hematology 21:10, pages 603-612.
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Lucian Mocan, Cristian Matea, Flaviu A Tabaran, Ofelia Mosteanu, Teodora Pop, Teodora Mocan & Cornel Iancu. (2015) Photothermal treatment of liver cancer with albumin-conjugated gold nanoparticles initiates Golgi Apparatus–ER dysfunction and caspase-3 apoptotic pathway activation by selective targeting of Gp60 receptor. International Journal of Nanomedicine 10, pages 5435-5445.
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Guillermo de Cárcer, Beatriz Escobar, Alonso M. Higuero, Laura García, Alejandra Ansón, Gema Pérez, Manuela Mollejo, Gerard Manning, Bárbara Meléndez, José Abad-Rodríguez & Marcos Malumbres. (2011) Plk5, a Polo Box Domain-Only Protein with Specific Roles in Neuron Differentiation and Glioblastoma Suppression . Molecular and Cellular Biology 31:6, pages 1225-1239.
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Articles from other publishers (44)

Eva Monte-Serrano & Pedro A. Lazo. (2023) VRK1 Kinase Activity Modulating Histone H4K16 Acetylation Inhibited by SIRT2 and VRK-IN-1. International Journal of Molecular Sciences 24:5, pages 4912.
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Inbal Wortzel, Galia Maik-Rachline, Suresh Singh Yadav, Tamar Hanoch & Rony Seger. (2021) Mitotic HOOK3 phosphorylation by ERK1c drives microtubule-dependent Golgi destabilization and fragmentation. iScience 24:6, pages 102670.
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Rebeca Carrión-Marchante, Valerio Frezza, Ana Salgado-Figueroa, M. Isabel Pérez-Morgado, M. Elena Martín & Víctor M. González. (2021) DNA Aptamers against Vaccinia-Related Kinase (VRK) 1 Block Proliferation in MCF7 Breast Cancer Cells. Pharmaceuticals 14:5, pages 473.
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Ignacio Campillo-Marcos, Raúl García-González, Elena Navarro-Carrasco & Pedro A. Lazo. (2021) The human VRK1 chromatin kinase in cancer biology. Cancer Letters 503, pages 117-128.
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Christopher A. Raab, Monika Raab, Sven Becker & Klaus Strebhardt. (2021) Non-mitotic functions of polo-like kinases in cancer cells. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1875:1, pages 188467.
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Raúl García-González, Patricia Morejón-García, Ignacio Campillo-Marcos, Marcella Salzano & Pedro A. Lazo. (2020) VRK1 Phosphorylates Tip60/KAT5 and Is Required for H4K16 Acetylation in Response to DNA Damage. Cancers 12:10, pages 2986.
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Jan Škubník, Michal Jurášek, Tomáš Ruml & Silvie Rimpelová. (2020) Mitotic Poisons in Research and Medicine. Molecules 25:20, pages 4632.
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Inmaculada Ayala, Fabiola Mascanzoni & Antonino Colanzi. (2020) The Golgi ribbon: mechanisms of maintenance and disassembly during the cell cycle. Biochemical Society Transactions 48:1, pages 245-256.
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Mahamat Babagana, Julia V. Kichina, Hannah Slabodkin, Sydney Johnson, Alexei Maslov, Lorin Brown, Kristopher Attwood, Mikhail A. Nikiforov & Eugene S. Kandel. (2019) The role of polo‐like kinase 3 in the response of BRAF‐mutant cells to targeted anticancer therapies. Molecular Carcinogenesis 59:1, pages 5-14.
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Elena Martín-Doncel, Ana M. Rojas, Lara Cantarero & Pedro A. Lazo. (2019) VRK1 functional insufficiency due to alterations in protein stability or kinase activity of human VRK1 pathogenic variants implicated in neuromotor syndromes. Scientific Reports 9:1.
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David S. Moura, Ignacio Campillo-Marcos, Marta Vázquez-Cedeira & Pedro A. Lazo. (2018) VRK1 and AURKB form a complex that cross inhibit their kinase activity and the phosphorylation of histone H3 in the progression of mitosis. Cellular and Molecular Life Sciences 75:14, pages 2591-2611.
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Lara Cantarero, David S. Moura, Marcella Salzano, Diana M. Monsalve, Ignacio Campillo-Marcos, Elena Martín-Doncel & Pedro A. Lazo. 2018. Encyclopedia of Signaling Molecules. Encyclopedia of Signaling Molecules 5955 5965 .
Inmaculada Ayala & Antonino Colanzi. (2017) Mitotic inheritance of the Golgi complex and its role in cell division. Biology of the Cell 109:10, pages 364-374.
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Annabel T. Olson, Amber B. Rico, Zhigang Wang, Gustavo Delhon & Matthew S. Wiebe. (2017) Deletion of the Vaccinia Virus B1 Kinase Reveals Essential Functions of This Enzyme Complemented Partly by the Homologous Cellular Kinase VRK2. Journal of Virology 91:15.
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Lara Cantarero, David S. Moura, Marcella Salzano, Diana M. Monsalve, Ignacio Campillo-Marcos, Elena Martín-Doncel & Pedro A. Lazo. 2017. Encyclopedia of Signaling Molecules. Encyclopedia of Signaling Molecules 1 11 .
David S. Moura, Isabel F. Fernández, Gema Marín-Royo, Inmaculada López-Sánchez, Elena Martín-Doncel, Francisco M. Vega & Pedro A. Lazo. (2016) Oncogenic Sox2 regulates and cooperates with VRK1 in cell cycle progression and differentiation. Scientific Reports 6:1.
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Diana M. Monsalve, Ignacio Campillo-Marcos, Marcella Salzano, Marta Sanz-García, Lara Cantarero & Pedro A. Lazo. (2016) VRK1 phosphorylates and protects NBS1 from ubiquitination and proteasomal degradation in response to DNA damage. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1863:4, pages 760-769.
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C Helmke, S Becker & K Strebhardt. (2015) The role of Plk3 in oncogenesis. Oncogene 35:2, pages 135-147.
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Lara Cantarero, David S. Moura, Marcella Salzano, Diana M. Monsalve, Ignacio Campillo-Marcos, Elena Martín-Doncel & Pedro A. Lazo. 2016. Encyclopedia of Signaling Molecules. Encyclopedia of Signaling Molecules 1 11 .
Carmen Valente & Antonino Colanzi. (2015) Mechanisms and Regulation of the Mitotic Inheritance of the Golgi Complex. Frontiers in Cell and Developmental Biology 3.
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YA-JUN ZHU, CHAO WANG, GUANGYAO SONG, SHA-SHA ZANG, YI-XUAN LIU & LING LI. (2015) Toll-like receptor-2 and -4 are associated with hyperlipidemia. Molecular Medicine Reports 12:6, pages 8241-8246.
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Lara Cantarero, Marta Sanz-García, Hadar Vinograd-Byk, Paul Renbaum, Ephrat Levy-Lahad & Pedro A. Lazo. (2015) VRK1 regulates Cajal body dynamics and protects coilin from proteasomal degradation in cell cycle. Scientific Reports 5:1.
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Hui Wang, Chan Tian, Xue-Yu Fan, Li-Na Chen, Yan Lv, Jing Sun, Yang-Jing Zhao, Lu-bin Zhang, Jing Wang, Qi Shi, Chen Gao, Cao Chen, Qi-Xiang Shao & Xiao-Ping Dong. (2015) Polo-like kinase 3 (PLK3) mediates the clearance of the accumulated PrP mutants transiently expressed in cultured cells and pathogenic PrPSc in prion infected cell line via protein interaction. The International Journal of Biochemistry & Cell Biology 62, pages 24-35.
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Hadar Vinograd-Byk, Tamar Sapir, Lara Cantarero, Pedro A. Lazo, Sharon Zeligson, Dorit Lev, Tally Lerman-Sagie, Paul Renbaum, Orly Reiner & Ephrat Levy-Lahad. (2015) The Spinal Muscular Atrophy with Pontocerebellar Hypoplasia Gene VRK1 Regulates Neuronal Migration through an Amyloid-β Precursor Protein-Dependent Mechanism . The Journal of Neuroscience 35:3, pages 936-942.
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Ye Seul Kim, Seong-Hoon Kim, Joon Shin, Amaravadhi Harikishore, Jong-Kwan Lim, Youngseob Jung, Ha-Na Lyu, Nam-In Baek, Kwan Yong Choi, Ho Sup Yoon & Kyong-Tai Kim. (2014) Luteolin Suppresses Cancer Cell Proliferation by Targeting Vaccinia-Related Kinase 1. PLoS ONE 9:10, pages e109655.
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Su-Yeon Lee, Chuljoon Jang & Kyung-Ah Lee. (2014) Polo-Like Kinases (Plks), a Key Regulator of Cell Cycle and New Potential Target for Cancer Therapy. Development & Reproduciton 18:1, pages 65-71.
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