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Molecular and Cellular Biology Volume 28, 2008 - Issue 2
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Article

Caffeine Regulates Alternative Splicing in a Subset of Cancer-Associated Genes: a Role for SC35

Jia ShiCancer Institute of New Jersey, Department of Pharmacology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey08901
,
Zhen HuCancer Institute of New Jersey, Department of Pharmacology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey08901
,
Kirk PabonCancer Institute of New Jersey, Department of Pharmacology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey08901
&
Kathleen W. ScottoCancer Institute of New Jersey, Department of Pharmacology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey08901Correspondence[email protected]
Pages 883-895 | Received 26 Jul 2007, Accepted 02 Nov 2007, Published online: 27 Mar 2023

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Asaf Shilo, Zahava Siegfried & Rotem Karni. (2015) The role of splicing factors in deregulation of alternative splicing during oncogenesis and tumor progression. Molecular & Cellular Oncology 2:1.
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Articles from other publishers (31)

Dianyang Li, Wenying Yu & Maode Lai. (2023) Towards understandings of serine/arginine-rich splicing factors. Acta Pharmaceutica Sinica B 13:8, pages 3181-3207.
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Kundan Kumar, Shubham Kumar Sinha, Upasana Maity, Pulugurtha Bharadwaja Kirti & Koppolu Raja Rajesh Kumar. (2022) Insights into established and emerging roles of SR protein family in plants and animals . WIREs RNA 14:3.
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Sean R. Kundinger, Eric B. Dammer, Luming Yin, Cheyenne Hurst, Sarah Shapley, Lingyan Ping, Sohail Khoshnevis, Homa Ghalei, Duc M. Duong & Nicholas T. Seyfried. (2021) Phosphorylation regulates arginine-rich RNA-binding protein solubility and oligomerization. Journal of Biological Chemistry 297:5, pages 101306.
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Antje Banning & Ritva Tikkanen. (2021) Towards Splicing Therapy for Lysosomal Storage Disorders: Methylxanthines and Luteolin Ameliorate Splicing Defects in Aspartylglucosaminuria and Classic Late Infantile Neuronal Ceroid Lipofuscinosis. Cells 10:11, pages 2813.
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Laura Lentini, Raffaella Melfi, Patrizia Cancemi, Ivana Pibiri & Aldo Di Leonardo. (2019) Caffeine boosts Ataluren's readthrough activity. Heliyon 5:6, pages e01963.
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Andreas Neueder, Anaelle A. Dumas, Agnesska C. Benjamin & Gillian P. Bates. (2018) Regulatory mechanisms of incomplete huntingtin mRNA splicing. Nature Communications 9:1.
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Jung-Chun Lin. (2017) Therapeutic Applications of Targeted Alternative Splicing to Cancer Treatment. International Journal of Molecular Sciences 19:1, pages 75.
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Yung-Lung Chang, Yu-Juei Hsu, Ying Chen, Yi-Wen Wang & Shih-Ming Huang. (2017) Theophylline exhibits anti-cancer activity via suppressing SRSF3 in cervical and breast cancer cell lines . Oncotarget 8:60, pages 101461-101474.
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Hyerim Park, Na Yeon Kim, Sangkyu Lee, Nury Kim, Jihoon Kim & Won Do Heo. (2017) Optogenetic protein clustering through fluorescent protein tagging and extension of CRY2. Nature Communications 8:1.
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Efraín E. Rivera-Serrano, Ethan J. Fritch, Elizabeth H. Scholl & Barbara Sherry. (2017) A Cytoplasmic RNA Virus Alters the Function of the Cell Splicing Protein SRSF2. Journal of Virology 91:7.
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David O. Bates, Jonathan C. Morris, Sebastian Oltean & Lucy F. Donaldson. (2017) Pharmacology of Modulators of Alternative Splicing. Pharmacological Reviews 69:1, pages 63-79.
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Jing Tian, Yaping Liu, Beibei Zhu, Yao Tian, Rong Zhong, Wei Chen, Xinghua Lu, Li Zou, Na Shen, Jiaming Qian, Hui Li, Xiaoping Miao & Li Wang. (2015) SF3A1 and pancreatic cancer: new evidence for the association of the spliceosome and cancer. Oncotarget 6:35, pages 37750-37757.
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Marco Silipo, Hannah Gautrey & Alison Tyson-Capper. (2015) Deregulation of splicing factors and breast cancer development. Journal of Molecular Cell Biology 7:5, pages 388-401.
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Jia Shi, Kirk Pabon & Kathleen W. Scotto. (2015) Methylxanthines Increase Expression of the Splicing Factor SRSF2 by Regulating Multiple Post-transcriptional Mechanisms. Journal of Biological Chemistry 290:24, pages 14986-15003.
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Guan-Yu Lu, Shih-Ming Huang, Shu-Ting Liu, Pei-Yao Liu, Wei-Yuan Chou & Wei-Shiang Lin. (2014) Caffeine induces tumor cytotoxicity via the regulation of alternative splicing in subsets of cancer-associated genes. The International Journal of Biochemistry & Cell Biology 47, pages 83-92.
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Justin J.-L. Wong, William Ritchie, Olivia A. Ebner, Matthias Selbach, Jason W.H. Wong, Yizhou Huang, Dadi Gao, Natalia Pinello, Maria Gonzalez, Kinsha Baidya, Annora Thoeng, Teh-Liane Khoo, Charles G. Bailey, Jeff Holst & John E.J. Rasko. (2013) Orchestrated Intron Retention Regulates Normal Granulocyte Differentiation. Cell 154:3, pages 583-595.
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Julie K Johnson, Nic Waddell & Georgia Chenevix-Trench. (2012) The application of nonsense-mediated mRNA decay inhibition to the identification of breast cancer susceptibility genes. BMC Cancer 12:1.
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XiaoMei Liu, Alejandro Gomez-Pinillos, Charisse Loder, Enrique Carrillo-de Santa Pau, Ruifang Qiao, Pamela D. Unger, Ralf Kurek, Carole Oddoux, Jonathan Melamed, Robert E. Gallagher, John Mandeli & Anna C. Ferrari. (2012) KLF6 Loss of Function in Human Prostate Cancer Progression Is Implicated in Resistance to Androgen Deprivation. The American Journal of Pathology 181:3, pages 1007-1016.
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Rui Ding, Jia Shi, Kirk Pabon & Kathleen W. Scotto. (2012) Xanthines Down-Regulate the Drug Transporter ABCG2 and Reverse Multidrug Resistance. Molecular Pharmacology 81:3, pages 328-337.
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M. Andrea Markus, Francine Z. Marques & Brian J. Morris. (2011) Resveratrol, by Modulating RNA Processing Factor Levels, Can Influence the Alternative Splicing of Pre-mRNAs. PLoS ONE 6:12, pages e28926.
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Sanjai Sharma, Wei Liao, Xiaofeng Zhou, David T.W. Wong & Alan Lichtenstein. (2011) Exon 11 Skipping of E-Cadherin RNA Downregulates Its Expression in Head and Neck Cancer Cells. Molecular Cancer Therapeutics 10:9, pages 1751-1759.
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Lulzim Shkreta, Laetitia Michelle, Johanne Toutant, Michel L. Tremblay & Benoit Chabot. (2011) The DNA Damage Response Pathway Regulates the Alternative Splicing of the Apoptotic Mediator Bcl-x. Journal of Biological Chemistry 286:1, pages 331-340.
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Jason T Huff, Alex M Plocik, Christine Guthrie & Keith R Yamamoto. (2010) Reciprocal intronic and exonic histone modification regions in humans. Nature Structural & Molecular Biology 17:12, pages 1495-1499.
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Andrei Anghel, Diana Narita, Edward Seclaman, Emilian Popovici, Mariana Anghel & Liviu Tamas. (2010) Estrogen Receptor Alpha Polymorphisms and the Risk of Malignancies. Pathology & Oncology Research 16:4, pages 485-496.
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Panagiotis Chandris, Christina C. Giannouli, George Panayotou & Dimitris Kletsas. (2010) Compromise in mRNA processing machinery in senescent human fibroblasts: implications for a novel potential role of Phospho-ATR (ser428). Biogerontology 11:4, pages 421-436.
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Natacha Dreumont, Sara Hardy, Isabelle Behm-Ansmant, Liliane Kister, Christiane Branlant, James Stévenin & Cyril F. Bourgeois. (2010) Antagonistic factors control the unproductive splicing of SC35 terminal intron. Nucleic Acids Research 38:4, pages 1353-1366.
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Amjad P. Khan, Laila M. Poisson, Vadiraja B. Bhat, Damian Fermin, Rong Zhao, Shanker Kalyana-Sundaram, George Michailidis, Alexey I. Nesvizhskii, Gilbert S. Omenn, Arul M. Chinnaiyan & Arun Sreekumar. (2010) Quantitative Proteomic Profiling of Prostate Cancer Reveals a Role for miR-128 in Prostate Cancer. Molecular & Cellular Proteomics 9:2, pages 298-312.
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Sanjai Sharma & Alan Lichtenstein. (2009) Aberrant splicing of the E-cadherin transcript is a novel mechanism of gene silencing in chronic lymphocytic leukemia cells. Blood 114:19, pages 4179-4185.
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Ravi K. Singh, Aixa Tapia-Santos, Thomas W. Bebee & Dawn S. Chandler. (2009) Conserved sequences in the final intron of MDM2 are essential for the regulation of alternative splicing of MDM2 in response to stress. Experimental Cell Research 315:19, pages 3419-3432.
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Katarína Bíliková, Ekaterina Mirgorodskaya, Gabriela Bukovská, Johan Gobom, Hans Lehrach & Jozef Šimúth. (2009) Towards functional proteomics of minority component of honeybee royal jelly: The effect of post-translational modifications on the antimicrobial activity of apalbumin2. PROTEOMICS 9:8, pages 2131-2138.
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Jennifer C. LongJavier F. Caceres. (2008) The SR protein family of splicing factors: master regulators of gene expression. Biochemical Journal 417:1, pages 15-27.
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