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Molecular and Cellular Biology Volume 28, 2008 - Issue 7
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Article

CtBP Is an Essential Corepressor for BCL6 Autoregulation

Lourdes M. Mendez1 Department of Cell Biology
,
Jose M. Polo2 Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York10461
,
J. Jessica Yu1 Department of Cell Biology
,
Melissa Krupski1 Department of Cell Biology
,
B. Belinda Ding1 Department of Cell Biology
,
Ari Melnick2 Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York10461
&
B. Hilda Ye1 Department of Cell BiologyCorrespondence[email protected]
 show all
Pages 2175-2186 | Received 03 Aug 2007, Accepted 01 Jan 2008, Published online: 27 Mar 2023

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Sarah R. Walker, Erik A. Nelson, Jennifer E. Yeh, Luca Pinello, Guo-Cheng Yuan & David A. Frank. (2013) STAT5 Outcompetes STAT3 To Regulate the Expression of the Oncogenic Transcriptional Modulator BCL6. Molecular and Cellular Biology 33:15, pages 2879-2890.
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Capucine Van Rechem, Gaylor Boulay, Sébastien Pinte, Nicolas Stankovic-Valentin, Cateline Guérardel & Dominique Leprince. (2010) Differential Regulation of HIC1 Target Genes by CtBP and NuRD, via an Acetylation/SUMOylation Switch, in Quiescent versus Proliferating Cells. Molecular and Cellular Biology 30:16, pages 4045-4059.
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Markus M. Xie, Tohti Amet, Hong Liu, Qigui Yu & Alexander L. Dent. (2017) AMP kinase promotes Bcl6 expression in both mouse and human T cells. Molecular Immunology 81, pages 67-75.
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Igor F. Tsigelny, Valentina L. Kouznetsova, Nathan Lian & Santosh Kesari. (2016) Molecular mechanisms of OLIG2 transcription factor in brain cancer. Oncotarget 7:33, pages 53074-53101.
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Xiaoming Hu, Yuanfei Zhou, Yang Yang, Jie Peng, Tongxing Song, Tao Xu, Hongkui Wei, Siwen Jiang & Jian Peng. (2016) Identification of zinc finger protein Bcl6 as a novel regulator of early adipose commitment. Open Biology 6:6, pages 160065.
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ChuanXin Huang & Ari Melnick. (2015) Mechanisms of action of BCL6 during germinal center B cell development. Science China Life Sciences 58:12, pages 1226-1232.
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Jin-Mei Yu, Wei Sun, Fang Hua, Jing Xie, Heng Lin, Dan-Dan Zhou & Zhuo-Wei Hu. (2015) BCL6 induces EMT by promoting the ZEB1-mediated transcription repression of E-cadherin in breast cancer cells. Cancer Letters 365:2, pages 190-200.
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S R Walker, S Liu, M Xiang, M Nicolais, K Hatzi, E Giannopoulou, O Elemento, L Cerchietti, A Melnick & D A Frank. (2014) The transcriptional modulator BCL6 as a molecular target for breast cancer therapy. Oncogene 34:9, pages 1073-1082.
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Grace Lin, Christopher R. LaPensee, Zhaohui S. Qin & Jessica Schwartz. (2014) Reciprocal occupancy of BCL6 and STAT5 on Growth Hormone target genes: contrasting transcriptional outcomes and promoter-specific roles of p300 and HDAC3. Molecular and Cellular Endocrinology 395:1-2, pages 19-31.
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Christopher R. LaPensee, Grace Lin, Alexander L. Dent & Jessica Schwartz. (2014) Deficiency of the Transcriptional Repressor B Cell Lymphoma 6 (Bcl6) Is Accompanied by Dysregulated Lipid Metabolism. PLoS ONE 9:6, pages e97090.
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Katerina Hatzi & Ari Melnick. (2014) Breaking bad in the germinal center: how deregulation of BCL6 contributes to lymphomagenesis. Trends in Molecular Medicine 20:6, pages 343-352.
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Srividya Swaminathan, Cihangir Duy & Markus Müschen. (2014) BACH2–BCL6 balance regulates selection at the pre-B cell receptor checkpoint. Trends in Immunology 35:3, pages 131-137.
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Katerina Hatzi, Yanwen Jiang, Chuanxin Huang, Francine Garrett-Bakelman, Micah D. Gearhart, Eugenia G. Giannopoulou, Paul Zumbo, Kevin Kirouac, Srividya Bhaskara, Jose M. Polo, Matthias Kormaksson, Alexander D. MacKerellJr.Jr., Fengtian Xue, Christopher E. Mason, Scott W. Hiebert, Gilbert G. Prive, Leandro Cerchietti, Vivian J. Bardwell, Olivier Elemento & Ari Melnick. (2013) A Hybrid Mechanism of Action for BCL6 in B Cells Defined by Formation of Functionally Distinct Complexes at Enhancers and Promoters. Cell Reports 4:3, pages 578-588.
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Chuanxin Huang, Katerina Hatzi & Ari Melnick. (2013) Lineage-specific functions of Bcl-6 in immunity and inflammation are mediated by distinct biochemical mechanisms. Nature Immunology 14:4, pages 380-388.
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B. Belinda Ding, Enguang Bi, Hongshan Chen, J. Jessica Yu & B. Hilda Ye. (2013) IL-21 and CD40L Synergistically Promote Plasma Cell Differentiation through Upregulation of Blimp-1 in Human B Cells. The Journal of Immunology 190:4, pages 1827-1836.
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Jung S. Byun & Kevin Gardner. (2013) C-Terminal Binding Protein: A Molecular Link between Metabolic Imbalance and Epigenetic Regulation in Breast Cancer. International Journal of Cell Biology 2013, pages 1-14.
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Melanie Issigonis & Erika Matunis. (2012) The Drosophila BCL6 homolog ken and barbie promotes somatic stem cell self-renewal in the testis niche. Developmental Biology 368:2, pages 181-192.
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Shane Crotty. (2012) The 1-1-1 fallacy. Immunological Reviews 247:1, pages 133-142.
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Katia Basso & Riccardo Dalla-Favera. (2012) Roles of BCL6 in normal and transformed germinal center B cells. Immunological Reviews 247:1, pages 172-183.
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Raffaela Pero, Dario Palmieri, Tiziana Angrisano, Teresa Valentino, Antonella Federico, Renato Franco, Francesca Lembo, Andres J. Klein-Szanto, Luigi Del Vecchio, Donatella Montanaro, Simona Keller, Claudio Arra, Vasiliki Papadopoulou, Simon D. Wagner, Carlo M. Croce, Alfredo Fusco, Lorenzo Chiariotti & Monica Fedele. (2012) POZ-, AT-hook-, and Zinc Finger-containing Protein (PATZ) Interacts with Human Oncogene B Cell Lymphoma 6 (BCL6) and Is Required for Its Negative Autoregulation. Journal of Biological Chemistry 287:22, pages 18308-18319.
Crossref
Arthur L. ShafferIIIIIIRyan M. YoungLouis M. Staudt. (2012) Pathogenesis of Human B Cell Lymphomas. Annual Review of Immunology 30:1, pages 565-610.
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Christian Hurtz, Katerina Hatzi, Leandro Cerchietti, Melanie Braig, Eugene Park, Yong-mi Kim, Sebastian Herzog, Parham Ramezani-Rad, Hassan Jumaa, Martin C. Müller, Wolf-Karsten Hofmann, Andreas Hochhaus, B. Hilda Ye, Anupriya Agarwal, Brian J. Druker, Neil P. Shah, Ari M. Melnick & Markus Müschen. (2011) BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia. Journal of Experimental Medicine 208:11, pages 2163-2174.
Crossref
Shane Crotty. (2011) Follicular Helper CD4 T Cells (T FH ) . Annual Review of Immunology 29:1, pages 621-663.
Crossref
Grant D. Barish, Ruth T. Yu, Malith Karunasiri, Corinne B. Ocampo, Jesse Dixon, Chris Benner, Alexander L. Dent, Rajendra K. Tangirala & Ronald M. Evans. (2010) Bcl-6 and NF-κB cistromes mediate opposing regulation of the innate immune response. Genes & Development 24:24, pages 2760-2765.
Crossref
Himabindu RamachandrareddyAlyssa BouskaYulei ShenMing Ji, Angie Rizzino, Wing C. ChanTimothy W. McKeithan. (2010) BCL6 promoter interacts with far upstream sequences with greatly enhanced activating histone modifications in germinal center B cells . Proceedings of the National Academy of Sciences 107:26, pages 11930-11935.
Crossref
Jonathan U Peled, J Jessica Yu, Jeganathan Venkatesh, Enguang Bi, B Belinda Ding, Melissa Krupski-Downs, Rita Shaknovich, Piotr Sicinski, Betty Diamond, Matthew D Scharff & B Hilda Ye. (2010) Requirement for cyclin D3 in germinal center formation and function. Cell Research 20:6, pages 631-646.
Crossref
Vasiliki PapadopoulouAntonio Postigo, Ester Sánchez-Tilló, Andrew C. G. PorterSimon D. Wagner. (2010) ZEB1 and CtBP form a repressive complex at a distal promoter element of the BCL6 locus. Biochemical Journal 427:3, pages 541-550.
Crossref
Leandro C. Cerchietti, Alexandru F. Ghetu, Xiao Zhu, Gustavo F. Da Silva, Shijun Zhong, Marilyn Matthews, Karen L. Bunting, Jose M. Polo, Christophe Farès, Cheryl H. Arrowsmith, Shao Ning Yang, Monica Garcia, Andrew Coop, Alexander D. MacKerellJr.Jr., Gilbert G. Privé & Ari Melnick. (2010) A Small-Molecule Inhibitor of BCL6 Kills DLBCL Cells In Vitro and In Vivo. Cancer Cell 17:4, pages 400-411.
Crossref
Shane Crotty, Robert J Johnston & Stephen P Schoenberger. (2010) Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation. Nature Immunology 11:2, pages 114-120.
Crossref
Katia Basso & Riccardo Dalla-Favera. 2010. 193 210 .
Yili Chen, Grace Lin, Jeffrey S. Huo, Deborah Barney, Zhenni Wang, Tamara Livshiz, David J. States, Zhaohui S. Qin & Jessica Schwartz. (2009) Computational and Functional Analysis of Growth Hormone (GH)-Regulated Genes Identifies the Transcriptional Repressor B-Cell Lymphoma 6 (Bc16) as a Participant in GH-Regulated Transcription. Endocrinology 150:8, pages 3645-3654.
Crossref
Weimin CiJose M. Polo, Leandro CerchiettiRita ShaknovichLing WangShao Ning YangKenny YePedro Farinha, Douglas E. Horsman, Randy D. Gascoyne, Olivier Elemento & Ari Melnick. (2009) The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL. Blood 113:22, pages 5536-5548.
Crossref
Leandro C. Cerchietti, Shao Ning Yang, Rita ShaknovichKaterina Hatzi, Jose M. Polo, Amy ChadburnSteven F. Dowdy & Ari Melnick. (2009) A peptomimetic inhibitor of BCL6 with potent antilymphoma effects in vitro and in vivo. Blood 113:15, pages 3397-3405.
Crossref
Weimin Ci, Jose M Polo & Ari Melnick. (2008) B-cell lymphoma 6 and the molecular pathogenesis of diffuse large B-cell lymphoma. Current Opinion in Hematology 15:4, pages 381-390.
Crossref

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