CtBP Is an Essential Corepressor for BCL6 Autoregulation

REFERENCES

• Ahmad, K. F., A. Melnick, S. Lax, D. Bouchard, J. Liu, C. L. Kiang, S. Mayer, S. Takahashi, J. D. Licht, and G. G. Prive. 2003. Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain. Mol. Cell 12:1551–1564.
   PubMed Web of Science ®Google Scholar
• Arguni, E., M. Arima, N. Tsuruoka, A. Sakamoto, M. Hatano, and T. Tokuhisa. 2006. JunD/AP-1 and STAT3 are the major enhancer molecules for high BCL6 expression in germinal center B cells. Int. Immunol. 18:1079–1089.
   PubMed Web of Science ®Google Scholar
• Baron, B. W., J. Anastasi, A. Montag, D. Huo, R. M. Baron, T. Karrison, M. J. Thirman, S. K. Subudhi, R. K. Chin, D. W. Felsher, Y. X. Fu, T. W. McKeithan, and J. M. Baron. 2004. The human BCL6 transgene promotes the development of lymphomas in the mouse. Proc. Natl. Acad. Sci. USA 101:14198–14203.
   PubMed Web of Science ®Google Scholar
• Bereshchenko, O. R., W. Gu, and R. Dalla-Favera. 2002. Acetylation inactivates the transcriptional repressor BCL6. Nat. Genet. 32:606–613.
   PubMed Web of Science ®Google Scholar
• Bergman, L. M., and J. P. Blaydes. 2006. C-terminal binding proteins: emerging roles in cell survival and tumorigenesis. Apoptosis 11:879–888.
   PubMed Web of Science ®Google Scholar
• Cattoretti, G., L. Pasqualucci, G. Ballon, W. Tam, S. V. Nandula, Q. Shen, T. Mo, V. V. Murty, and R. Dalla-Favera. 2005. Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B cell lymphomas in mice. Cancer Cell 7:445–455.
   PubMed Web of Science ®Google Scholar
• Chang, C. C., B. H. Ye, R. S. Chaganti, and R. Dalla-Favera. 1996. BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor. Proc. Natl. Acad. Sci. USA 93:6947–6952.
   PubMed Web of Science ®Google Scholar
• Chevallier, N., C. M. Corcoran, C. Lennon, E. Hyjek, A. Chadburn, V. J. Bardwell, J. D. Licht, and A. Melnick. 2004. ETO protein of t(8;21) AML is a corepressor for Bcl-6 B-cell lymphoma oncoprotein. Blood 103:1454–1463.
   PubMed Web of Science ®Google Scholar
• Chinnadurai, G. 2002. CtBP, an unconventional transcriptional corepressor in development and oncogenesis. Mol. Cell 9:213–224.
   PubMed Web of Science ®Google Scholar
• Dallery, E., S. Galiegue-Zouitina, M. Collyn-d'Hooghe, S. Quief, C. Denis, M. P. Hildebrand, D. Lantoine, C. Deweindt, H. Tilly, C. Bastard, et al. 1995. TTF, a gene encoding a novel small G protein, fuses to the lymphoma-associated LAZ3 gene by t(3;4) chromosomal translocation. Oncogene 10:2171–2178.
   PubMed Web of Science ®Google Scholar
• Deltour, S., S. Pinte, C. Guerardel, B. Wasylyk, and D. Leprince. 2002. The human candidate tumor suppressor gene HIC1 recruits CtBP through a degenerate GLDLSKK motif. Mol. Cell. Biol. 22:4890–4901.
   PubMedGoogle Scholar
• Dent., A. L., A. L. Shaffer, X. Yu, D. Allman, and L. M. Staudt. 1997. Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science 276:589–592.
   PubMed Web of Science ®Google Scholar
• Dhordain, P., O. Albagli, R. J. Lin, S. Ansieau, S. Quief, A. Leutz, J. P. Kerckaert, R. M. Evans, and D. Leprince. 1997. Corepressor SMRT binds the BTB/POZ repressing domain of the LAZ3/BCL6 oncoprotein. Proc. Natl. Acad. Sci. USA 94:10762–10767.
   PubMed Web of Science ®Google Scholar
• Dhordain, P., R. J. Lin, S. Quief, D. Lantoine, J. P. Kerckaert, R. M. Evans, and O. Albagli. 1998. The LAZ3(BCL-6) oncoprotein recruits a SMRT/mSIN3A/histone deacetylase containing complex to mediate transcriptional repression. Nucleic Acids Res. 26:4645–4651.
   PubMed Web of Science ®Google Scholar
• Fujita, N., D. L. Jaye, C. Geigerman, A. Akyildiz, M. R. Mooney, J. M. Boss, and P. A. Wade. 2004. MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation. Cell 119:75–86.
   PubMedGoogle Scholar
• Gearhart, M. D., C. M. Corcoran, J. A. Wamstad, and V. J. Bardwell. 2006. Polycomb group and SCF ubiquitin ligases are found in a novel BCoR complex that is recruited to BCL6 targets. Mol. Cell. Biol. 26:6880–6889.
   PubMed Web of Science ®Google Scholar
• Han, S., B. Zheng, Y. Takahashi, and G. Kelsoe. 1997. Distinctive characteristics of germinal center B cells. Semin. Immunol. 9:255–260.
   PubMedGoogle Scholar
• Hildebrand, J. D., and P. Soriano. 2002. Overlapping and unique roles for C-terminal binding protein 1 (CtBP1) and CtBP2 during mouse development. Mol. Cell. Biol. 22:5296–5307.
   PubMed Web of Science ®Google Scholar
• Huynh, K. D., and V. J. Bardwell. 1998. The BCL-6 POZ domain and other POZ domains interact with the co-repressors N-CoR and SMRT. Oncogene 17:2473–2484.
   PubMed Web of Science ®Google Scholar
• Huynh, K. D., W. Fischle, E. Verdin, and V. J. Bardwell. 2000. BCoR, a novel corepressor involved in BCL-6 repression. Genes Dev. 14:1810–1823.
   PubMed Web of Science ®Google Scholar
• Klein, U., Y. Tu, G. A. Stolovitzky, J. L. Keller, J. Haddad, Jr., V. Miljkovic, G. Cattoretti, A. Califano, and R. Dalla-Favera. 2003. Transcriptional analysis of the B cell germinal center reaction. Proc. Natl. Acad. Sci. USA 100:2639–2644.
   PubMed Web of Science ®Google Scholar
• Kuppers, R., U. Klein, M. L. Hansmann, and K. Rajewsky. 1999. Cellular origin of human B-cell lymphomas. N. Engl. J. Med. 341:1520–1529.
   PubMed Web of Science ®Google Scholar
• Kuppuswamy, M., S. Vijayalingam, L. J. Zhao, Y. Zhou, T. Subramaninan, J. Ryerse, and G. Chinnadurai. 2008. Role of the PLDLS-binding cleft region of CtBP1 in recruitment of core and auxiliary components of the corepressor complex. Mol. Cell. Biol. 28:269–281.
   PubMed Web of Science ®Google Scholar
• Lemercier, C., M. P. Brocard, F. Puvion-Dutilleul, H. Y. Kao, O. Albagli, and S. Khochbin. 2002. Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor. J. Biol. Chem. 277:22045–22052.
   PubMed Web of Science ®Google Scholar
• Li, Z., X. Wang, R. Y. Yu, B. B. Ding, J. J. Yu, X. M. Dai, A. Naganuma, E. R. Stanley, and B. H. Ye. 2005. BCL-6 negatively regulates expression of the NF-κB1 p105/p50 subunit. J. Immunol. 174:205–214.
   PubMed Web of Science ®Google Scholar
• MacLennan, I. C. 1994. Somatic mutation. From the dark zone to the light. Curr. Biol. 4:70–72.
   PubMedGoogle Scholar
• Mascle, X., O. Albagli, and C. Lemercier. 2003. Point mutations in BCL6 DNA-binding domain reveal distinct roles for the six zinc fingers. Biochem. Biophys. Res. Commun. 300:391–396.
   PubMedGoogle Scholar
• Molloy, D. P., P. M. Barral, K. H. Bremner, P. H. Gallimore, and R. J. Grand. 2001. Structural determinants outside the PXDLS sequence affect the interaction of adenovirus E1A, C-terminal interacting protein and Drosophila repressors with C-terminal binding protein. Biochim. Biophys. Acta 1546:55–70.
   PubMedGoogle Scholar
• Niu, H., G. Cattoretti, and R. Dalla-Favera. 2003. BCL6 controls the expression of the B7-1/CD80 costimulatory receptor in germinal center B cells. J. Exp. Med. 198:211–221.
   PubMed Web of Science ®Google Scholar
• Niu, H., B. H. Ye, and R. Dalla-Favera. 1998. Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor. Genes Dev. 12:1953–1961.
   PubMed Web of Science ®Google Scholar
• Oberley, M. J., J. Tsao, P. Yau, and P. J. Farnham. 2004. High-throughput screening of chromatin immunoprecipitates using CpG-island microarrays. Methods Enzymol. 376:315–334.
   PubMedGoogle Scholar
• Parekh, S., J. M. Polo, R. Shaknovich, P. Juszczynski, P. Lev, S. M. Ranuncolo, Y. Yin, U. Klein, G. Cattoretti, R. Dalla Favera, M. A. Shipp, and A. Melnick. 2007. BCL6 programs lymphoma cells for survival and differentiation through distinct biochemical mechanisms. Blood 110:2067–2074.
   PubMed Web of Science ®Google Scholar
• Pasqualucci, L., A. Migliazza, K. Basso, J. Houldsworth, R. S. Chaganti, and R. Dalla-Favera. 2003. Mutations of the BCL6 proto-oncogene disrupt its negative autoregulation in diffuse large B-cell lymphoma. Blood 101:2914–2923.
   PubMed Web of Science ®Google Scholar
• Phan, R. T., and R. Dalla-Favera. 2004. The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells. Nature 432:635–639.
   PubMed Web of Science ®Google Scholar
• Polo, J. M., T. Dell'Oso, S. M. Ranuncolo, L. Cerchietti, D. Beck, G. F. Da Silva, G. G. Prive, J. D. Licht, and A. Melnick. 2004. Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells. Nat. Med. 10:1329–1335.
   PubMed Web of Science ®Google Scholar
• Quinlan, K. G., M. Nardini, A. Verger, P. Francescato, P. Yaswen, D. Corda, M. Bolognesi, and M. Crossley. 2006. Specific recognition of ZNF217 and other zinc-finger proteins at a surface groove of C-terminal binding proteins. Mol. Cell. Biol. 26:8159–8172.
   PubMed Web of Science ®Google Scholar
• Ranuncolo, S. M., J. M. Polo, J. Dierov, M. Singer, T. Kuo, J. Greally, R. Green, M. Carroll, and A. Melnick. 2007. Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR. Nat. Immunol. 8:705–714.
   PubMedGoogle Scholar
• Shaffer, A. L., A. Rosenwald, E. M. Hurt, J. M. Giltnane, L. T. Lam, O. K. Pickeral, and L. M. Staudt. 2001. Signatures of the immune response. Immunity 15:375–385.
   PubMed Web of Science ®Google Scholar
• Shi, Y., J. Sawada, G. Sui, B. Affar el, J. R. Whetstine, F. Lan, H. Ogawa, M. P. Luke, and Y. Nakatani. 2003. Coordinated histone modifications mediated by a CtBP co-repressor complex. Nature 422:735–738.
   PubMed Web of Science ®Google Scholar
• Tunyaplin, C., A. L. Shaffer, C. D. Angelin-Duclos, X. Yu, L. M. Staudt, and K. L. Calame. 2004. Direct repression of prdm1 by Bcl-6 inhibits plasmacytic differentiation. J. Immunol. 173:1158–1165.
   PubMed Web of Science ®Google Scholar
• Vasanwala, F. H., S. Kusam, L. M. Toney, and A. L. Dent. 2002. Repression of AP-1 function: a mechanism for the regulation of Blimp-1 expression and B lymphocyte differentiation by the B cell lymphoma-6 protooncogene. J. Immunol. 169:1922–1929.
   PubMed Web of Science ®Google Scholar
• Wang, X., Z. Li, A. Naganuma, and B. H. Ye. 2002. Negative autoregulation of BCL-6 is bypassed by genetic alterations in diffuse large B cell lymphomas. Proc. Natl. Acad. Sci. USA 99:15018–15023.
   PubMed Web of Science ®Google Scholar
• Wen, Y., D. Nguyen, Y. Li, and Z. C. Lai. 2000. The N-terminal BTB/POZ domain and C-terminal sequences are essential for Tramtrack69 to specify cell fate in the developing Drosophila eye. Genetics 156:195–203.
   PubMedGoogle Scholar
• Ye, B. H., G. Cattoretti, Q. Shen, J. Zhang, N. Hawe, R. de Waard, C. Leung, M. Nouri-Shirazi, A. Orazi, R. S. Chaganti, P. Rothman, A. M. Stall, P. P. Pandolfi, and R. Dalla-Favera. 1997. The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation. Nat. Genet. 16:161–170.
   PubMed Web of Science ®Google Scholar
• Ye, B. H., S. Chaganti, C. C. Chang, H. Niu, P. Corradini, R. S. Chaganti, and R. Dalla-Favera. 1995. Chromosomal translocations cause deregulated BCL6 expression by promoter substitution in B cell lymphoma. EMBO J. 14:6209–6217.
   PubMed Web of Science ®Google Scholar
• Ye, B. H., F. Lista, F. Lo Coco, D. M. Knowles, K. Offit, R. S. Chaganti, and R. Dalla-Favera. 1993. Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma. Science 262:747–750.
   PubMed Web of Science ®Google Scholar
• Ye, B. H., P. H. Rao, R. S. Chaganti, and R. Dalla-Favera. 1993. Cloning of BCL-6, the locus involved in chromosome translocations affecting band 3q27 in B-cell lymphoma. Cancer Res. 53:2732–2735.
   PubMed Web of Science ®Google Scholar
• Yu, R. Y., X. Wang, F. J. Pixley, J. J. Yu, A. L. Dent., H. E. Broxmeyer, E. R. Stanley, and B. H. Ye. 2005. BCL-6 negatively regulates macrophage proliferation by suppressing autocrine IL-6 production. Blood 105:1777–1784.
   PubMedGoogle Scholar
• Zhang, H., S. Okada, M. Hatano, S. Okabe, and T. Tokuhisa. 2001. A new functional domain of Bcl6 family that recruits histone deacetylases. Biochim. Biophys. Acta 1540:188–200.
   PubMedGoogle Scholar
• Zhang, Q., Y. Yoshimatsu, J. Hildebrand, S. M. Frisch, and R. H. Goodman. 2003. Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP. Cell 115:177–186.
   PubMed Web of Science ®Google Scholar