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Article

The Cyclin-Dependent Kinase Inhibitor p21 Is a Crucial Target for Histone Deacetylase 1 as a Regulator of Cellular Proliferation

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Pages 1171-1181 | Received 17 Nov 2009, Accepted 09 Dec 2009, Published online: 20 Mar 2023

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Carrie DraneyMatthew C. AustinAaron H. LeiferCourtney J. SmithKyle B. KenerTalon J. AitkenKavan H. HessAmanda C. HainesElle LettAngelina Hernandez-CarreteroPatrick T. FuegerMichelle ArlottoJeffery S. Tessem. (2018) HDAC1 overexpression enhances β-cell proliferation by down-regulating Cdkn1b/p27. Biochemical Journal 475:24, pages 3997-4010.
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Crossref
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Crossref
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Crossref
Mitsutake Yano, Masanori Yasuda, Mika Sakaki, Koji Nagata, Takashi Fujino, Eiichi Arai, Takahiro Hasebe, Masaki Miyazawa, Mariko Miyazawa, Naoki Ogane, Kosei Hasegawa & Hisashi Narahara. (2018) Association of histone deacetylase expression with histology and prognosis of ovarian cancer. Oncology Letters.
Crossref
Zan-Feng Xu, Xiao-Ke Sun, Gang Chen, Chao Han, Feng Wang & Yong-Dong Zhang. (2018) Oroxyloside inhibits human glioma progression by suppressing proliferation, metastasis and inducing apoptosis related pathways. Biomedicine & Pharmacotherapy 97, pages 1564-1574.
Crossref
Josef Večeřa, Eva Bártová, Jana Krejčí, Soňa Legartová, Denisa Komůrková, Jana Rudá‐Kučerová, Tibor Štark, Eva Dražanová, Tomáš Kašpárek, Alexandra Šulcová, Frank J. Dekker, Wiktor Szymanski, Christian Seiser, Georg Weitzer, Raphael Mechoulam, Vincenzo Micale & Stanislav Kozubek. (2017) HDAC1 and HDAC3 underlie dynamic H3K9 acetylation during embryonic neurogenesis and in schizophrenia‐like animals. Journal of Cellular Physiology 233:1, pages 530-548.
Crossref
Prathap Kumar S. Mahalingaiah, Logeswari Ponnusamy & Kamaleshwar P. Singh. (2016) Oxidative stress-induced epigenetic changes associated with malignant transformation of human kidney epithelial cells. Oncotarget 8:7, pages 11127-11143.
Crossref
Minoru YOSHIDA, Norio KUDO, Saori KOSONO & Akihiro ITO. (2017) Chemical and structural biology of protein lysine deacetylases. Proceedings of the Japan Academy, Series B 93:5, pages 297-321.
Crossref
Jana Krejčí, Soňa Legartová & Eva Bártová. (2017) Neural Differentiation in HDAC1-Depleted Cells Is Accompanied by Coilin Downregulation and the Accumulation of Cajal Bodies in Nucleoli. Stem Cells International 2017, pages 1-13.
Crossref
Jay Whelan, Yi Zhao, E-Chu Huang, Amber MacDonald & Dallas Donohoe. 2016. Complementary and Alternative Medicines in Prostate Cancer. Complementary and Alternative Medicines in Prostate Cancer 197 220 .
Kimino Fujimura, Takayuki Mitsuhashi, Shinsuke Shibata, Sachiko Shimozato & Takao Takahashi. (2016) In Utero Exposure to Valproic Acid Induces Neocortical Dysgenesis via Dysregulation of Neural Progenitor Cell Proliferation/Differentiation . The Journal of Neuroscience 36:42, pages 10908-10919.
Crossref
Yixuan Li & Edward Seto. (2016) HDACs and HDAC Inhibitors in Cancer Development and Therapy. Cold Spring Harbor Perspectives in Medicine 6:10, pages a026831.
Crossref
Guizhou Zhu, Tao Tao, Dongmei Zhang, Xiaojuan Liu, Huiyuan Qiu, LiJian Han, Zhiwei Xu, Ying Xiao, Chun Cheng & Aiguo Shen. (2016) O-GlcNAcylation of histone deacetylases 1 in hepatocellular carcinoma promotes cancer progression. Glycobiology 26:8, pages 820-833.
Crossref
Sara Loponte, Chiara V. Segré, Silvia Senese, Claudia Miccolo, Stefano Santaguida, Gianluca Deflorian, Simona Citro, Domenico Mattoscio, Federica Pisati, Mirjam A. Moser, Rosella Visintin, Christian Seiser & Susanna Chiocca. (2016) Dynamic phosphorylation of Histone Deacetylase 1 by Aurora kinases during mitosis regulates zebrafish embryos development. Scientific Reports 6:1.
Crossref
P Ma & R M Schultz. (2016) HDAC1 and HDAC2 in mouse oocytes and preimplantation embryos: Specificity versus compensation. Cell Death & Differentiation 23:7, pages 1119-1127.
Crossref
Neha R. Dhoke, Evangelene Kalabathula, Komal Kaushik, Ramasatyaveni Geesala, B. Sravani & Amitava Das. (2016) Histone deacetylases differentially regulate the proliferative phenotype of mouse bone marrow stromal and hematopoietic stem/progenitor cells. Stem Cell Research 17:1, pages 170-180.
Crossref
Mei-Yi Wu & Ray-Chang Wu. 2016. Histone Deacetylases. Histone Deacetylases 3 13 .
Alexis Gonneaud, Naomie Turgeon, François-Michel Boisvert, François Boudreau & Claude Asselin. (2015) Loss of histone deacetylase Hdac1 disrupts metabolic processes in intestinal epithelial cells. FEBS Letters 589:19PartB, pages 2776-2783.
Crossref
S Bianco, M Jangal, D Garneau & N Gévry. (2014) LRH-1 controls proliferation in breast tumor cells by regulating CDKN1A gene expression. Oncogene 34:34, pages 4509-4518.
Crossref
Kristy R. StengelScott W. Hiebert. (2015) Class I HDACs Affect DNA Replication, Repair, and Chromatin Structure: Implications for Cancer Therapy. Antioxidants & Redox Signaling 23:1, pages 51-65.
Crossref
Morgan P. Torchy, Ali Hamiche & Bruno P. Klaholz. (2015) Structure and function insights into the NuRD chromatin remodeling complex. Cellular and Molecular Life Sciences 72:13, pages 2491-2507.
Crossref
Christoph Burdelski, Oliver M. Ruge, Nathaniel Melling, Christina Koop, Ronald Simon, Stefan Steurer, Guido Sauter, Martina Kluth, Claudia Hube-Magg, Sarah Minner, Corinna Wittmer, Waldemar Wilczak, Andrea Hinsch, Patrick Lebok, Jakob R. Izbicki, Hans Heinzer, Markus Graefen, Hartwig Huland, Thorsten Schlomm & Till Krech. (2015) HDAC1 overexpression independently predicts biochemical recurrence and is associated with rapid tumor cell proliferation and genomic instability in prostate cancer. Experimental and Molecular Pathology 98:3, pages 419-426.
Crossref
H Yang, B Yan, D Liao, S Huang & Y Qiu. (2015) Acetylation of HDAC1 and degradation of SIRT1 form a positive feedback loop to regulate p53 acetylation during heat-shock stress. Cell Death & Disease 6:5, pages e1747-e1747.
Crossref
Yasushi Yamazoe, Takashi Yamada & Kunitoshi Mitsumori. (2015) Embryo- and Testicular-toxicities of Methoxyacetate and the Related: a Review on Possible Roles of One-carbon Transfer and Histone Modification. Food Safety 3:3, pages 92-107.
Crossref
E-Chu Huang, Yi Zhao, Guoxun Chen, Seung Joon Baek, Michael F McEntee, Steven Minkin, John P Biggerstaff & Jay Whelan. (2014) Zyflamend, a polyherbal mixture, down regulates class I and class II histone deacetylases and increases p21 levels in castrate-resistant prostate cancer cells. BMC Complementary and Alternative Medicine 14:1.
Crossref
Yingzi He, Chengfu Cai, Dongmei Tang, Shan Sun & Huawei Li. (2014) Effect of histone deacetylase inhibitors trichostatin A and valproic acid on hair cell regeneration in zebrafish lateral line neuromasts. Frontiers in Cellular Neuroscience 8.
Crossref
Mihaela E. Sardiu, Karen T. Smith, Brad D. Groppe, Joshua M. Gilmore, Anita Saraf, Rhonda Egidy, Allison Peak, Chris W. Seidel, Laurence Florens, Jerry L. Workman & Michael P. Washburn. (2014) Suberoylanilide Hydroxamic Acid (SAHA)-Induced Dynamics of a Human Histone Deacetylase Protein Interaction Network. Molecular & Cellular Proteomics 13:11, pages 3114-3125.
Crossref
Shereen Jamaladdin, Richard D. W. Kelly, Laura O’Regan, Oliver M. Dovey, Grace E. Hodson, Christopher J. Millard, Nicola Portolano, Andrew M. Fry, John W. R. Schwabe & Shaun M. Cowley. (2014) Histone deacetylase (HDAC) 1 and 2 are essential for accurate cell division and the pluripotency of embryonic stem cells. Proceedings of the National Academy of Sciences 111:27, pages 9840-9845.
Crossref
Lilian Varricchio, Carmela Dell’Aversana, Angela Nebbioso, Giovanni Migliaccio, Lucia Altucci, Antonello Mai, Giuliano Grazzini, James J. Bieker & Anna Rita Migliaccio. (2014) Identification of NuRSERY, a new functional HDAC complex composed by HDAC5, GATA1, EKLF and pERK present in human erythroid cells. The International Journal of Biochemistry & Cell Biology 50, pages 112-122.
Crossref
Mirjam Andrea Moser, Astrid Hagelkruys & Christian Seiser. (2013) Transcription and beyond: the role of mammalian class I lysine deacetylases. Chromosoma 123:1-2, pages 67-78.
Crossref
Sabnam ParbinSwayamsiddha KarArunima ShilpiDipta SenguptaMoonmoon DebSandip Kumar RathSamir Kumar Patra. (2013) Histone Deacetylases. Journal of Histochemistry & Cytochemistry 62:1, pages 11-33.
Crossref
Qinghong Ji, Huili Hu, Fan Yang, Jupeng Yuan, Yang Yang, Liangqian Jiang, Yanyan Qian, Baichun Jiang, Yongxin Zou, Yan Wang, Changshun Shao & Yaoqin Gong. (2014) CRL4B interacts and coordinates with SIN3A/HDAC complex to repress CDKN1A in driving cell cycle progression . Journal of Cell Science.
Crossref
Kimberly Mayes, Zhijun Qiu, Aiman Alhazmi & Joseph W. Landry. 2014. 183 233 .
Mircea Winter, Mirjam A Moser, Dominique Meunier, Carina Fischer, Georg Machat, Katharina Mattes, Beate M Lichtenberger, Reinhard Brunmeir, Simon Weissmann, Christina Murko, Christina Humer, Tina Meischel, Gerald Brosch, Patrick Matthias, Maria Sibilia & Christian Seiser. (2013) Divergent roles of HDAC1 and HDAC2 in the regulation of epidermal development and tumorigenesis. The EMBO Journal 32:24, pages 3176-3191.
Crossref
Jinhua Tang, Yanli Yan, Ting C. Zhao, George Bayliss, Haidong YanShougang Zhuang. (2013) Class I histone deacetylase activity is required for proliferation of renal epithelial cells. American Journal of Physiology-Renal Physiology 305:3, pages F244-F254.
Crossref
Elisabeth Simboeck, Arantxa Gutierrez, Luca Cozzuto, Malte Beringer, Livia Caizzi, William M Keyes & Luciano Di Croce. (2013) DPY30 regulates pathways in cellular senescence through ID protein expression. The EMBO Journal 32:16, pages 2217-2230.
Crossref
Richard D.W. KellyShaun M. Cowley. (2013) The physiological roles of histone deacetylase (HDAC) 1 and 2: complex co-stars with multiple leading parts. Biochemical Society Transactions 41:3, pages 741-749.
Crossref
Patrick Matthias. (2013) Too much or too little, how much HDAC activity is good for you?. Blood 121:11, pages 1930-1931.
Crossref
Oliver M. DoveyCharles T. FosterNathalie ConteSally A. EdwardsJennifer M. Edwards, Rajinder Singh, George VassiliouAllan BradleyShaun M. Cowley. (2013) Histone deacetylase 1 and 2 are essential for normal T-cell development and genomic stability in mice. Blood 121:8, pages 1335-1344.
Crossref
Inchul ChoiTimothy S. CareyCatherine A. WilsonJason G. Knott. (2012) Transcription factor AP-2γ is a core regulator of tight junction biogenesis and cavity formation during mouse early embryogenesis. Development 139:24, pages 4623-4632.
Crossref
Hsin‐Yi Huang, Demeral D. Liu, Hui‐Fen Chang, Wu‐Fu Chen, Hui‐Ru Hsu, Jon‐Son Kuo & Mei‐Jen Wang. (2012) Histone Deacetylase Inhibition Mediates Urocortin‐Induced Antiproliferation and Neuronal Differentiation in Neural Stem Cells. STEM CELLS 30:12, pages 2760-2773.
Crossref
Mitali Pandey, Parminder Kaur, Sanjeev Shukla, Ata Abbas, Pingfu Fu & Sanjay Gupta. (2012) Plant flavone apigenin inhibits HDAC and remodels chromatin to induce growth arrest and apoptosis in human prostate cancer cells: In vitro and in vivo study. Molecular Carcinogenesis 51:12, pages 952-962.
Crossref
Akram Ghantous, Melody Saikali, Tilman Rau, Hala Gali-Muhtasib, Regine Schneider-Stock & Nadine Darwiche. (2012) Inhibition of Tumor Promotion by Parthenolide: Epigenetic Modulation of p21 . Cancer Prevention Research 5:11, pages 1298-1309.
Crossref
Feng-Yao Tang, Man-Hui Pai & En-Pei Isabel Chiang. (2012) Consumption of high-fat diet induces tumor progression and epithelial–mesenchymal transition of colorectal cancer in a mouse xenograft model. The Journal of Nutritional Biochemistry 23:10, pages 1302-1313.
Crossref
Carola Parolin, Natalia Calonghi, Enrica Presta, Carla Boga, Paolo Caruana, Marina Naldi, Vincenza Andrisano, Lanfranco Masotti & Giorgio Sartor. (2012) Mechanism and stereoselectivity of HDAC I inhibition by (R)-9-hydroxystearic acid in colon cancer. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1821:10, pages 1334-1340.
Crossref
Yan-Ting Chen, Xue-Feng Zang, Jie Pan, Xiao-Lei Zhu, Fei Chen, Zhi-Bin Chen & Yun Xu. (2012) Expression patterns of histone deacetylases in experimental stroke and potential targets for neuroprotection. Clinical and Experimental Pharmacology and Physiology 39:9, pages 751-758.
Crossref
Lan ZhaoChien-Nien ChenNabil HajjiEduardo OliverEmanuele CotroneoJohn WhartonDaren WangMin LiTimothy A. McKinseyKurt R. StenmarkMartin R. Wilkins. (2012) Histone Deacetylation Inhibition in Pulmonary Hypertension. Circulation 126:4, pages 455-467.
Crossref
Nina Reichert, Mohamed-Amin Choukrallah & Patrick Matthias. (2012) Multiple roles of class I HDACs in proliferation, differentiation, and development. Cellular and Molecular Life Sciences 69:13, pages 2173-2187.
Crossref
S Spiegel, S Milstien & S Grant. (2011) Endogenous modulators and pharmacological inhibitors of histone deacetylases in cancer therapy. Oncogene 31:5, pages 537-551.
Crossref
Robert F Place, Ji Wang, Emily J Noonan, Rachel Meyers, Muthiah Manoharan, Klaus Charisse, Rick Duncan, Vera Huang, Xiaoling Wang & Long-Cheng Li. (2012) Formulation of Small Activating RNA Into Lipidoid Nanoparticles Inhibits Xenograft Prostate Tumor Growth by Inducing p21 Expression. Molecular Therapy - Nucleic Acids 1, pages e15.
Crossref
Christopher Chang. 2012. Epigenetics in Human Disease. Epigenetics in Human Disease 225 251 .
Praveen Rajendran, Emily Ho, David E Williams & Roderick H Dashwood. (2011) Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells. Clinical Epigenetics 3:1.
Crossref
Qiong Zhou, Clifton L Dalgard, Christopher Wynder & Martin L Doughty. (2011) Histone deacetylase inhibitors SAHA and sodium butyrate block G1-to-S cell cycle progression in neurosphere formation by adult subventricular cells. BMC Neuroscience 12:1.
Crossref
Z Wang, T Zhao, P Zhang, S Zhang, J Guan, X Ma, Y Yin, J Zhang, B Tang & Z Li. (2011) Histone Deacetylase 1 Down-Regulation on Developmental Capability and Histone Acetylation in Bovine Oocytes and Parthenogenetic Embryos. Reproduction in Domestic Animals 46:6, pages 1022-1028.
Crossref
Markus Kaller, Sven-Thorsten Liffers, Silke Oeljeklaus, Katja Kuhlmann, Simone Röh, Reinhard Hoffmann, Bettina Warscheid & Heiko Hermeking. (2011) Genome-wide Characterization of miR-34a Induced Changes in Protein and mRNA Expression by a Combined Pulsed SILAC and Microarray Analysis. Molecular & Cellular Proteomics 10:8, pages M111.010462.
Crossref
Yan Xiang, Yuanliang Wang, Yanfeng Luo, Bingbing Zhang, Juan Xin & Danfang Zheng. (2011) Molecular biocompatibility evaluation of poly(d,l-lactic acid)-modified biomaterials based on long serial analysis of gene expression. Colloids and Surfaces B: Biointerfaces 85:2, pages 248-261.
Crossref
Sergio Valente, Maria Tardugno, Mariarosaria Conte, Roberto Cirilli, Andrea Perrone, Rino Ragno, Silvia Simeoni, Anna Tramontano, Silvio Massa, Angela Nebbioso, Marco Miceli, Gianluigi Franci, Gerald Brosch, Lucia Altucci & Antonello Mai. (2011) Novel Cinnamyl Hydroxyamides and 2-Aminoanilides as Histone Deacetylase Inhibitors: Apoptotic Induction and Cytodifferentiation Activity. ChemMedChem 6:4, pages 698-712.
Crossref
Guoqiang Sun, Chelsea Fu, Caroline Shen & Yanhong Shi. (2011) Histone Deacetylases in Neural Stem Cells and Induced Pluripotent Stem Cells. Journal of Biomedicine and Biotechnology 2011, pages 1-6.
Crossref
Chiara V. Segré & Susanna Chiocca. (2011) Regulating the Regulators: The Post-Translational Code of Class I HDAC1 and HDAC2. Journal of Biomedicine and Biotechnology 2011, pages 1-15.
Crossref
Astrid Hagelkruys, Anna Sawicka, Magdalena Rennmayr & Christian Seiser. 2011. Histone Deacetylases: the Biology and Clinical Implication. Histone Deacetylases: the Biology and Clinical Implication 13 37 .
Elisabeth Simboeck & Luciano Di Croce. (2010) HDAC1, a novel marker for benign teratomas. The EMBO Journal 29:23, pages 3893-3895.
Crossref
Sabine Lagger, Dominique Meunier, Mario Mikula, Reinhard Brunmeir, Michaela Schlederer, Matthias Artaker, Oliver Pusch, Gerda Egger, Astrid Hagelkruys, Wolfgang Mikulits, Georg Weitzer, Ernst W Muellner, Martin Susani, Lukas Kenner & Christian Seiser. (2010) Crucial function of histone deacetylase 1 for differentiation of teratomas in mice and humans. The EMBO Journal 29:23, pages 3992-4007.
Crossref
Roel H Wilting, Eva Yanover, Marinus R Heideman, Heinz Jacobs, James Horner, Jaco van der Torre, Ronald A DePinho & Jan-Hermen Dannenberg. (2010) Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis. The EMBO Journal 29:15, pages 2586-2597.
Crossref
Teppei Yamaguchi, Fabien Cubizolles, Yu Zhang, Nina Reichert, Hubertus Kohler, Christian Seiser & Patrick Matthias. (2010) Histone deacetylases 1 and 2 act in concert to promote the G1-to-S progression. Genes & Development 24:5, pages 455-469.
Crossref

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