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Molecular and Cellular Biology Volume 27, 2007 - Issue 15
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Article

Wwp2-Mediated Ubiquitination of the RNA Polymerase II Large Subunit in Mouse Embryonic Pluripotent Stem Cells

Hui Li1 Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, 225 South Chongqing Road, Shanghai200025, China;2 Laboratory of Molecular Developmental Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, China;5 Graduate School of Chinese Academy of Sciences, Beijing, China
,
Zhihong Zhang1 Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, 225 South Chongqing Road, Shanghai200025, China
,
Beibei Wang1 Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, 225 South Chongqing Road, Shanghai200025, China
,
Junmei Zhang3 Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas75390
,
Yingming Zhao3 Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas75390
&
Ying Jin1 Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, 225 South Chongqing Road, Shanghai200025, China;2 Laboratory of Molecular Developmental Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, China;4 Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaCorrespondence[email protected]
Pages 5296-5305 | Received 06 Sep 2006, Accepted 13 May 2007, Published online: 27 Mar 2023

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Nathan M. Yurko & James L. Manley. (2018) The RNA polymerase II CTD “orphan” residues: Emerging insights into the functions of Tyr-1, Thr-4, and Ser-7. Transcription 9:1, pages 30-40.
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Noélia Custódio & Maria Carmo-Fonseca. (2016) Co-transcriptional splicing and the CTD code. Critical Reviews in Biochemistry and Molecular Biology 51:5, pages 395-411.
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Neelam Chaudhary & Subbareddy Maddika. (2014) WWP2-WWP1 Ubiquitin Ligase Complex Coordinated by PPM1G Maintains the Balance between Cellular p73 and ΔNp73 Levels. Molecular and Cellular Biology 34:19, pages 3754-3764.
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Martin Heidemann & Dirk Eick. (2012) Tyrosine-1 and threonine-4 phosphorylation marks complete the RNA polymerase II CTD phospho-code. RNA Biology 9:9, pages 1144-1146.
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Ryan P. Kempen, Preeti Dabas & Aseem Z. Ansari. (2023) The Phantom Mark: Enigmatic roles of phospho‐Threonine 4 modification of the C‐terminal domain of RNA polymerase II . WIREs RNA 14:4.
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Vaishna Vamadevan, Neelam Chaudhary & Subbareddy Maddika. (2022) Ubiquitin-assisted phase separation of dishevelled-2 promotes Wnt signalling. Journal of Cell Science 135:24.
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Yahong Wu & Weiwei Zhang. (2021) The Role of E3s in Regulating Pluripotency of Embryonic Stem Cells and Induced Pluripotent Stem Cells. International Journal of Molecular Sciences 22:3, pages 1168.
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Naijin Zhang, Ying Zhang, Hao Qian, Shaojun Wu, Liu Cao & Yingxian Sun. (2020) Selective targeting of ubiquitination and degradation of PARP1 by E3 ubiquitin ligase WWP2 regulates isoproterenol-induced cardiac remodeling. Cell Death & Differentiation 27:9, pages 2605-2619.
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Naijin Zhang, Ying Zhang, Boquan Wu, Shilong You & Yingxian Sun. (2020) Role of WW domain E3 ubiquitin protein ligase 2 in modulating ubiquitination and Degradation of Septin4 in oxidative stress endothelial injury. Redox Biology 30, pages 101419.
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Ke Wang, Jun Liu, Xinhui Zhao, Haitong Li, Guangwei Luo, Yanping Yu, Yuan Guo, Long Zhang, Jun Zhu, Shuai Wang, Wei Hua, Angang Yang, Rui Zhang & Jipeng Li. (2020) WWP2 regulates proliferation of gastric cancer cells in a PTEN-dependent manner. Biochemical and Biophysical Research Communications 521:3, pages 652-659.
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Xianlong Wang, Aleksandra Rusin, Christopher J. Walkey, Justin J. Lin & Deborah L. Johnson. (2019) The RNA polymerase III repressor MAF1 is regulated by ubiquitin-dependent proteasome degradation and modulates cancer drug resistance and apoptosis. Journal of Biological Chemistry 294:50, pages 19255-19268.
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Rui Zhang, Jianwu Zhang, Wei Luo, Zhuang Luo & Shaoqing Shi. (2018) WWP2 Is One Promising Novel Oncogene. Pathology & Oncology Research 25:2, pages 443-446.
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Gang Zou, Te Liu, Lihe Guo, Yongyi Huang, Ya Feng & Tao Duan. (2018) MicroRNA‑32 silences WWP2 expression to maintain the pluripotency of human amniotic epithelial stem cells and β islet‑like cell differentiation. International Journal of Molecular Medicine.
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Qing Tian, Chenchen Lu, Shuaishuai Wang, Qin Xiong, Haifeng Zhang, Yuanchao Wang & Xiaobo Zheng. (2016) Rapid diagnosis of soybean anthracnose caused by Colletotrichum truncatum using a loop-mediated isothermal amplification (LAMP) assay. European Journal of Plant Pathology 148:4, pages 785-793.
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Kevin M. Harlen & L. Stirling Churchman. (2017) The code and beyond: transcription regulation by the RNA polymerase II carboxy-terminal domain. Nature Reviews Molecular Cell Biology 18:4, pages 263-273.
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Rui Yang, Yao He, Shanshan Chen, Xinhua Lu, Chun Huang & Guojun Zhang. (2016) Elevated expression of WWP2 in human lung adenocarcinoma and its effect on migration and invasion. Biochemical and Biophysical Research Communications 479:2, pages 146-151.
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Justyna Zaborowska, Sylvain Egloff & Shona Murphy. (2016) The pol II CTD: new twists in the tail. Nature Structural & Molecular Biology 23:9, pages 771-777.
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Jun-Mei Yi, Xia-Juan Huan, Shan-Shan Song, Hu Zhou, Ying-Qing Wang & Ze-Hong Miao. (2016) Triptolide Induces Cell Killing in Multidrug-Resistant Tumor Cells via CDK7/RPB1 Rather than XPB or p44. Molecular Cancer Therapeutics 15:7, pages 1495-1503.
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Célia Jeronimo, Pierre Collin & François Robert. (2016) The RNA Polymerase II CTD: The Increasing Complexity of a Low-Complexity Protein Domain. Journal of Molecular Biology 428:12, pages 2607-2622.
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Rakesh Srivastava & Seong Hoon Ahn. (2015) Modifications of RNA polymerase II CTD: Connections to the histone code and cellular function. Biotechnology Advances 33:6, pages 856-872.
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Wei Gong, Xiaodan Zhang, Wen Zhang, Jie Li & Ze Li. (2015) Structure of the HECT domain of human WWP2. Acta Crystallographica Section F Structural Biology Communications 71:10, pages 1251-1257.
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Jiahong Jiang, Nan Wang, Yafei Jiang, Hongwei Tan, Jimin Zheng, Guangju Chen & Zongchao Jia. (2015) Characterization of substrate binding of the WW domains in human WWP2 protein. FEBS Letters 589:15, pages 1935-1942.
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Chonji Fukumoto, Dai Nakashima, Atsushi Kasamatsu, Motoharu Unozawa, Tomomi Shida-Sakazume, Morihiro Higo, Katsunori Ogawara, Hidetaka Yokoe, Masashi Shiiba, Hideki Tanzawa & Katsuhiro Uzawa. (2014) WWP2 is overexpressed in human oral cancer, determining tumor size and poor prognosis in patients: downregulation of WWP2 inhibits the AKT signaling and tumor growth in mice. Oncoscience 1:12, pages 807-820.
Crossref
Wei Chen, Xiaofei Jiang & Zhuang Luo. (2014) WWP2: A Multifunctional Ubiquitin Ligase Gene. Pathology & Oncology Research 20:4, pages 799-803.
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Zhe Wei, Ming Sun, Xinyi Liu, Jian Zhang & Ying Jin. (2014) Rufy3, a protein specifically expressed in neurons, interacts with actin-bundling protein Fascin to control the growth of axons. Journal of Neurochemistry 130:5, pages 678-692.
Crossref
Xinlong Luo, Beibei Wang, Fan Tang, Junmei Zhang, Yingming Zhao, Hui Li & Ying Jin. (2014) Wwp2 targets SRG3, a scaffold protein of the SWI/SNF-like BAF complex, for ubiquitination and degradation. Biochemical and Biophysical Research Communications 443:3, pages 1048-1053.
Crossref
Takako Hattori, Tetsuya Kishino, Shelley Stephen, Heidi Eberspaecher, Sayumi Maki, Masaharu Takigawa, Benoit de Crombrugghe & Hideyo Yasuda. (2013) E6-AP/UBE3A Protein Acts as a Ubiquitin Ligase toward SOX9 Protein. Journal of Biological Chemistry 288:49, pages 35138-35148.
Crossref
Célia Jeronimo, Alain R. Bataille & François Robert. (2013) The Writers, Readers, and Functions of the RNA Polymerase II C-Terminal Domain Code. Chemical Reviews 113:11, pages 8491-8522.
Crossref
Bing Liao, Xiaoming Zhong, Huiming Xu, Feng Xiao, Zhuoqing Fang, Junjie Gu, Yue Chen, Yingming Zhao & Ying Jin. (2013) Itch, an E3 ligase of Oct4, is required for embryonic stem cell self-renewal and pluripotency induction. Journal of Cellular Physiology 228:7, pages 1443-1451.
Crossref
Stephen M. Fuchs. (2012) Chemically Modified Tandem Repeats in Proteins: Natural Combinatorial Peptide Libraries. ACS Chemical Biology 8:2, pages 275-282.
Crossref
Martin Heidemann, Corinna Hintermair, Kirsten Voß & Dirk Eick. (2013) Dynamic phosphorylation patterns of RNA polymerase II CTD during transcription. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1829:1, pages 55-62.
Crossref
Olga Jasnovidova & Richard Stefl. (2013) The CTD code of RNA polymerase II: a structural view. Wiley Interdisciplinary Reviews: RNA 4:1, pages 1-16.
Crossref
Jing-Ping Hsin & James L. Manley. (2012) The RNA polymerase II CTD coordinates transcription and RNA processing. Genes & Development 26:19, pages 2119-2137.
Crossref
Marta Montes, Soraya Becerra, Miguel Sánchez-Álvarez & Carlos Suñé. (2012) Functional coupling of transcription and splicing. Gene 501:2, pages 104-117.
Crossref
Ian Hammond-Martel, Helen Yu & El Bachir Affar. (2012) Roles of ubiquitin signaling in transcription regulation. Cellular Signalling 24:2, pages 410-421.
Crossref
Roberto Marcucci, James Brindle, Simona Paro, Angela Casadio, Sophie Hempel, Nicholas Morrice, Andrea Bisso, Liam P Keegan, Giannino Del Sal & Mary A O'Connell. (2011) Pin1 and WWP2 regulate GluR2 Q/R site RNA editing by ADAR2 with opposing effects . The EMBO Journal 30:20, pages 4211-4222.
Crossref
Surinder M. Soond & Andrew Chantry. (2011) How ubiquitination regulates the TGF-β signalling pathway: New insights and new players. BioEssays 33:10, pages 749-758.
Crossref
Subbareddy Maddika, Sridhar Kavela, Neelam Rani, Vivek Reddy Palicharla, Jenny L. Pokorny, Jann N. Sarkaria & Junjie Chen. (2011) WWP2 is an E3 ubiquitin ligase for PTEN. Nature Cell Biology 13:6, pages 728-733.
Crossref
S M Soond & A Chantry. (2011) Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGFβ signalling and EMT. Oncogene 30:21, pages 2451-2462.
Crossref
Weiguo Zou, Xi Chen, Jae-Hyuck Shim, Zhiwei Huang, Nicholas Brady, Dorothy Hu, Rebecca Drapp, Kirsten Sigrist, Laurie H. Glimcher & Dallas Jones. (2010) The E3 ubiquitin ligase Wwp2 regulates craniofacial development through mono-ubiquitylation of Goosecoid. Nature Cell Biology 13:1, pages 59-65.
Crossref
Lisa Lukaesko & Robert Meller. 2011. Post-Translational Modifications in Health and Disease. Post-Translational Modifications in Health and Disease 281 315 .
Bing Liao & Ying Jin. (2009) Wwp2 mediates Oct4 ubiquitination and its own auto-ubiquitination in a dosage-dependent manner. Cell Research 20:3, pages 332-344.
Crossref
Christof Seidl, Matthias Port, Christos Apostolidis, Frank Bruchertseifer, Markus Schwaiger, Reingard Senekowitsch-Schmidtke & Michael Abend. (2009) Differential gene expression triggered by highly cytotoxic α-Emitter-immunoconjugates in gastric cancer cells. Investigational New Drugs 28:1, pages 49-60.
Crossref
Emily Brookes & Ana Pombo. (2009) Modifications of RNA polymerase II are pivotal in regulating gene expression states. EMBO reports 10:11, pages 1213-1219.
Crossref
Serena Carra, Jeanette F. Brunsting, Herman Lambert, Jacques Landry & Harm H. Kampinga. (2009) HspB8 Participates in Protein Quality Control by a Non-chaperone-like Mechanism That Requires eIF2α Phosphorylation. Journal of Biological Chemistry 284:9, pages 5523-5532.
Crossref
P. Aaron Kirkland, Malgorzata A. Gil, Ivanka M. Karadzic & Julie A. Maupin-Furlow. (2008) Genetic and Proteomic Analyses of a Proteasome-Activating Nucleotidase A Mutant of the Haloarchaeon Haloferax volcanii . Journal of Bacteriology 190:1, pages 193-205.
Crossref
Stephanie Pitts, Hester Liu, Adel Ibrahim, Amit Garg, Catarina Mendes Felgueira, Asma Begum, Wenjun Fan, Selina Teh, Jin-Yih Low, Brittany Ford, David A. Schneider, Ronald Hay & Marikki Laiho. (2022) Identification of an E3 Ligase Regulating the Catalytic Subunit of RNA Polymerase I. SSRN Electronic Journal.
Crossref

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