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Molecular and Cellular Biology Volume 28, 2008 - Issue 9
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Article

Evidence for an Overlapping Role of CLOCK and NPAS2 Transcription Factors in Liver Circadian Oscillators

Cristiano Bertolucci1 Dipartimento di Biologia ed Evoluzione, Università di Ferrara, I-44100Ferrara, Italy
,
Nicola Cavallari1 Dipartimento di Biologia ed Evoluzione, Università di Ferrara, I-44100Ferrara, Italy
,
Ilaria Colognesi1 Dipartimento di Biologia ed Evoluzione, Università di Ferrara, I-44100Ferrara, Italy
,
Jacopo Aguzzi2 Circadian Rhythms and Sleep Disorders Program, Neuroscience Institute, Morehouse School of Medicine, Atlanta, Georgia30310-1495
,
Zheng Chen3 Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas75390
,
Pierpaolo Caruso4 Dipartimento di Biochimica e Biologia Molecolare, Università di Ferrara, I-44100Ferrara, Italy
,
Augusto Foá1 Dipartimento di Biologia ed Evoluzione, Università di Ferrara, I-44100Ferrara, Italy
,
Gianluca Tosini2 Circadian Rhythms and Sleep Disorders Program, Neuroscience Institute, Morehouse School of Medicine, Atlanta, Georgia30310-1495
,
Francesco Bernardi4 Dipartimento di Biochimica e Biologia Molecolare, Università di Ferrara, I-44100Ferrara, Italy
&
Mirko Pinotti4 Dipartimento di Biochimica e Biologia Molecolare, Università di Ferrara, I-44100Ferrara, ItalyCorrespondence[email protected]
 show all
Pages 3070-3075 | Received 26 Oct 2007, Accepted 24 Feb 2008, Published online: 27 Mar 2023

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Inna Rabinovich-Nikitin, Mina Rasouli, Cristine J. Reitz, Illana Posen, Victoria Margulets, Rimpy Dhingra, Tarak N. Khatua, James A. Thliveris, Tami A. Martino & Lorrie A. Kirshenbaum. (2021) Mitochondrial autophagy and cell survival is regulated by the circadian Clock gene in cardiac myocytes during ischemic stress. Autophagy 17:11, pages 3794-3812.
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C. Chen, Z. Jiang, S. Cheng, Y. Zou, Y. Liu, Y. Wang, J. Xiao, H. Guo, S.J. Tebbutt & Z. Wang. (2012) Genetic variation in the circadian rhythm genes, clock and clif, and possible association with coronary artery disease in individuals of Chinese Han descent. Biological Rhythm Research 43:5, pages 563-575.
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Yiting He, Haobin Cen, Lianxia Guo, Tianpeng Zhang, Yi Yang, Dong Dong & Baojian Wu. (2022) Circadian oscillator NPAS2 regulates diurnal expression and activity of CYP1A2 in mouse liver. Biochemical Pharmacology 206, pages 115345.
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Darius D. Becker-Krail, William H. WalkerIIII & Randy J. Nelson. (2022) The Ventral Tegmental Area and Nucleus Accumbens as Circadian Oscillators: Implications for Drug Abuse and Substance Use Disorders. Frontiers in Physiology 13.
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Darius D. Becker‐Krail, Puja K. Parekh, Kyle D. Ketchesin, Shintaro Yamaguchi, Jun Yoshino, Mariah A. Hildebrand, Brandan Dunham, Madhavi K. Ganapathiraju, Ryan W. Logan & Colleen A. McClung. (2022) Circadian transcription factor NPAS2 and the NAD + ‐dependent deacetylase SIRT1 interact in the mouse nucleus accumbens and regulate reward . European Journal of Neuroscience 55:3, pages 675-693.
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Iveta Herichová, Barbora Tesáková, Lucia Kršková & Lucia Olexová. (2021) Food reward induction of rhythmic clock gene expression in the prefrontal cortex of rats is accompanied by changes in miR‐34a‐5p expression . European Journal of Neuroscience 54:10, pages 7476-7492.
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Kimberly H. Cox & Joseph S. Takahashi. 2021. Circadian Clock in Brain Health and Disease. Circadian Clock in Brain Health and Disease 3 20 .
Hodaka Sasaki, Akishige Hokugo, Lixin Wang, Kenzo Morinaga, John T. Ngo, Hiroko Okawa & Ichiro Nishimura. (2019) Neuronal PAS Domain 2 ( Npas2 )‐Deficient Fibroblasts Accelerate Skin Wound Healing and Dermal Collagen Reconstruction . The Anatomical Record 303:6, pages 1630-1641.
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Kelly Barko, Micah A. Shelton, Joseph A. Seggio & Ryan W. Logan. 2019. Neural Mechanisms of Addiction. Neural Mechanisms of Addiction 189 212 .
Saika Minegishi, Ikuko Sagami, Shigeru Negi, Koji Kano & Hiroaki Kitagishi. (2018) Circadian clock disruption by selective removal of endogenous carbon monoxide. Scientific Reports 8:1.
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Lindsay A. Holden & Kim H. Brown. (2018) Baseline mRNA expression differs widely between common laboratory strains of zebrafish. Scientific Reports 8:1.
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Zheng ChenSeung-Hee YooJoseph S. Takahashi. (2018) Development and Therapeutic Potential of Small-Molecule Modulators of Circadian Systems. Annual Review of Pharmacology and Toxicology 58:1, pages 231-252.
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Nathaniel Hassan, Kirstin McCarville, Kenzo Morinaga, Cristiane M. Mengatto, Peter Langfelder, Akishige Hokugo, Yu Tahara, Christopher S. Colwell & Ichiro Nishimura. (2017) Titanium biomaterials with complex surfaces induced aberrant peripheral circadian rhythms in bone marrow mesenchymal stromal cells. PLOS ONE 12:8, pages e0183359.
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Jonathan Aryeh Sobel, Irina Krier, Teemu Andersin, Sunil Raghav, Donatella Canella, Federica Gilardi, Alexandra Styliani Kalantzi, Guillaume Rey, Benjamin Weger, Frédéric Gachon, Matteo Dal Peraro, Nouria Hernandez, Ueli Schibler, Bart Deplancke & Felix Naef. (2017) Transcriptional regulatory logic of the diurnal cycle in the mouse liver. PLOS Biology 15:4, pages e2001069.
Crossref
I Dall'Ara, S Ghirotto, S Ingusci, G Bagarolo, C Bertolucci & G Barbujani. (2016) Demographic history and adaptation account for clock gene diversity in humans. Heredity 117:3, pages 165-172.
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Joseph C. Besharse & Douglas G. McMahon. (2016) The Retina and Other Light-sensitive Ocular Clocks. Journal of Biological Rhythms 31:3, pages 223-243.
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Dominic Landgraf, Lexie L. Wang, Tanja Diemer & David K. Welsh. (2016) NPAS2 Compensates for Loss of CLOCK in Peripheral Circadian Oscillators. PLOS Genetics 12:2, pages e1005882.
Crossref
Darius Becker-Krail & Colleen McClung. (2016) Implications of circadian rhythm and stress in addiction vulnerability. F1000Research 5, pages 59.
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L.-L. Lin, H.-C. Huang & H.-F. Juan. (2015) Circadian systems biology in Metazoa. Briefings in Bioinformatics 16:6, pages 1008-1024.
Crossref
Chih-Chung Liu, Li-Jen Su, Wei-Yuan Tsai, Hsiao-Lun Sun, Hoong-Chien Lee & Chih-Shung Wong. (2015) Hylan G-F 20 attenuates posttraumatic osteoarthritis progression: Association with upregulated expression of the circardian gene NPAS2. Life Sciences 141, pages 20-24.
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M. Baroni, G. Pavani, M. Pinotti, A. Branchini, F. Bernardi & R.M. Camire. (2015) Asymmetric processing of mutant factor X Arg386Cys reveals differences between intrinsic and extrinsic pathway activation. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1854:10, pages 1351-1356.
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Philipp Palombo, Maria Moreno-Villanueva & Aswin Mangerich. (2015) Day and night variations in the repair of ionizing-radiation-induced DNA damage in mouse splenocytes. DNA Repair 28, pages 37-47.
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Katsuhiro Yoshii, Fumihisa Tajima, Sumio Ishijima & Ikuko Sagami. (2015) Changes in pH and NADPH Regulate the DNA Binding Activity of Neuronal PAS Domain Protein 2, a Mammalian Circadian Transcription Factor. Biochemistry 54:2, pages 250-259.
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Sobia Rana, Adeela Shahid, Hafeez Ullah & Saqib Mahmood. (2014) Lack of Association of the NPAS2 Gene Ala394Thr Polymorphism (rs2305160:G>A) with Risk of Chronic Lymphocytic Leukemia. Asian Pacific Journal of Cancer Prevention 15:17, pages 7169-7174.
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Xiaofeng Xue, Fei Liu, Ye Han, Pu Li, Bin Yuan, Xu Wang, Yan Chen, Yuting Kuang, Qiaoming Zhi & Hong Zhao. (2014) Silencing NPAS2 promotes cell growth and invasion in DLD-1 cells and correlated with poor prognosis of colorectal cancer. Biochemical and Biophysical Research Communications 450:2, pages 1058-1062.
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D. Balestra, A. Faella, P. Margaritis, N. Cavallari, F. Pagani, F. Bernardi, V.R. Arruda & M. Pinotti. (2014) An engineered U1 small nuclear RNA rescues splicing‐defective coagulation F7 gene expression in mice. Journal of Thrombosis and Haemostasis 12:2, pages 177-185.
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Maria S. Robles, Jürgen Cox & Matthias Mann. (2014) In-Vivo Quantitative Proteomics Reveals a Key Contribution of Post-Transcriptional Mechanisms to the Circadian Regulation of Liver Metabolism. PLoS Genetics 10:1, pages e1004047.
Crossref
Fergal C. Kelleher, Aparna Rao & Anne Maguire. (2014) Circadian molecular clocks and cancer. Cancer Letters 342:1, pages 9-18.
Crossref
Ian B Hickie, Sharon L Naismith, Rébecca Robillard, Elizabeth M Scott & Daniel F Hermens. (2013) Manipulating the sleep-wake cycle and circadian rhythms to improve clinical management of major depression. BMC Medicine 11:1.
Crossref
Derek O'Neil, Hector Mendez-Figueroa, Toni-Ann Mistretta, Chunliu Su, Robert H. Lane & Kjersti M. Aagaard. (2013) Dysregulation of Npas2 leads to altered metabolic pathways in a murine knockout model. Molecular Genetics and Metabolism 110:3, pages 378-387.
Crossref
Xin Tong & Lei Yin. 2011. Comprehensive Physiology. Comprehensive Physiology 917 940 .
Katsutaka Oishi, Satoru Koyanagi & Naoki Ohkura. (2013) The molecular clock regulates circadian transcription of tissue factor gene. Biochemical and Biophysical Research Communications 431:2, pages 332-335.
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Loning Fu & Nicole M. Kettner. 2013. Chronobiology: Biological Timing in Health and Disease. Chronobiology: Biological Timing in Health and Disease 221 282 .
Rita Cortesi, Paola Bergamini, Laura Ravani, Markus Drechsler, Andrea Costenaro, Mirko Pinotti, Matteo Campioni, Lorenza Marvelli & Elisabetta Esposito. (2012) Long-chain cationic derivatives of PTA (1,3,5-triaza-7-phosphaadamantane) as new components of potential non-viral vectors. International Journal of Pharmaceutics 431:1-2, pages 176-182.
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Nicola Cavallari, Dario Balestra, Alessio Branchini, Iva Maestri, Ampaiwan Chuamsunrit, Werasak Sasanakul, Guglielmo Mariani, Franco Pagani, Francesco Bernardi & Mirko Pinotti. (2012) Activation of a cryptic splice site in a potentially lethal coagulation defect accounts for a functional protein variant. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1822:7, pages 1109-1113.
Crossref
Katsutaka Oishi, Satoru Koyanagi & Naoki Ohkura. (2011) Circadian mRNA expression of coagulation and fibrinolytic factors is organ-dependently disrupted in aged mice. Experimental Gerontology 46:12, pages 994-999.
Crossref
Shuting Cheng, Zhou Jiang, Yan Zou, Chen Chen, Yuhui Wang, Yanyou Liu, Jing Xiao, Huiling Guo & Zhengrong Wang. (2011) Downregulation of Clock in circulatory system leads to an enhancement of fibrinolysis in mice . Experimental Biology and Medicine 236:9, pages 1078-1084.
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Yukimasa Takeda, Hong Soon Kang, Martin Angers & Anton M. Jetten. (2011) Retinoic acid-related orphan receptor γ directly regulates neuronal PAS domain protein 2 transcription in vivo. Nucleic Acids Research 39:11, pages 4769-4782.
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Christine Crumbley & Thomas P. Burris. (2011) Direct Regulation of CLOCK Expression by REV-ERB. PLoS ONE 6:3, pages e17290.
Crossref
Frank A. J. L. Scheer, Kun Hu, Heather Evoniuk, Erin E. Kelly, Atul Malhotra, Michael F. Hilton & Steven A. Shea. (2010) Impact of the human circadian system, exercise, and their interaction on cardiovascular function. Proceedings of the National Academy of Sciences 107:47, pages 20541-20546.
Crossref
Christine Crumbley, Yongjun Wang, Douglas J. Kojetin & Thomas P. Burris. (2010) Characterization of the Core Mammalian Clock Component, NPAS2, as a REV-ERBα/RORα Target Gene. Journal of Biological Chemistry 285:46, pages 35386-35392.
Crossref
Pia Alhopuro, Mikael Björklund, Heli Sammalkorpi, Mikko Turunen, Sari Tuupanen, Mia Biström, Iina Niittymäki, Heli J. Lehtonen, Teemu Kivioja, Virpi Launonen, Juha Saharinen, Kari Nousiainen, Sampsa Hautaniemi, Kyösti Nuorva, Jukka-Pekka Mecklin, Heikki Järvinen, Torben Orntoft, Diego Arango, Rainer Lehtonen, Auli Karhu, Jussi Taipale & Lauri A. Aaltonen. (2010) Mutations in the Circadian Gene CLOCK in Colorectal Cancer . Molecular Cancer Research 8:7, pages 952-960.
Crossref
Ryosuke Doi, Katsutaka Oishi & Norio Ishida. (2010) CLOCK Regulates Circadian Rhythms of Hepatic Glycogen Synthesis through Transcriptional Activation of Gys2. Journal of Biological Chemistry 285:29, pages 22114-22121.
Crossref
Sudeep Bose & Fredric R. Boockfor. (2010) Episodes of Prolactin Gene Expression in GH3 Cells Are Dependent on Selective Promoter Binding of Multiple Circadian Elements. Endocrinology 151:5, pages 2287-2296.
Crossref
Rashidul Haque, Fatima G. Ali, Rebecca Biscoglia, Jane Abey, Joan Weller, David Klein & P. Michael Iuvone. (2010) CLOCK and NPAS2 have overlapping roles in the circadian oscillation of arylalkylamine N -acetyltransferase mRNA in chicken cone photoreceptors . Journal of Neurochemistry.
Crossref
Hideki Ukai & Hiroki R. Ueda. (2010) Systems Biology of Mammalian Circadian Clocks. Annual Review of Physiology 72:1, pages 579-603.
Crossref
Xiling Wu, Michael F. Wiater & Sue Ritter. (2010) NPAS2 deletion impairs responses to restricted feeding but not to metabolic challenges. Physiology & Behavior 99:4, pages 466-471.
Crossref
Zhaoyang Zhao & Cheng Chi Lee. 2010. The Circadian Clock. The Circadian Clock 139 155 .
Barbara Oesch-Bartlomowicz, Carsten Weiss, Cornelia Dietrich & Franz Oesch. (2009) Circadian rhythms and chemical carcinogenesis: Potential link. An overview. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 680:1-2, pages 83-86.
Crossref
Oluf Dimitri Røe, Endre Anderssen, Eli Helge, Caroline Hild Pettersen, Karina Standahl Olsen, Helmut Sandeck, Rune Haaverstad, Steinar Lundgren & Erik Larsson. (2009) Genome-Wide Profile of Pleural Mesothelioma versus Parietal and Visceral Pleura: The Emerging Gene Portrait of the Mesothelioma Phenotype. PLoS ONE 4:8, pages e6554.
Crossref
Kevin K. Lin, Vivek Kumar, Mikhail Geyfman, Darya Chudova, Alexander T. Ihler, Padhraic Smyth, Ralf Paus, Joseph S. Takahashi & Bogi Andersen. (2009) Circadian Clock Genes Contribute to the Regulation of Hair Follicle Cycling. PLoS Genetics 5:7, pages e1000573.
Crossref
Tomomi Kimiwada, Mikako Sakurai, Hiroki Ohashi, Shunsuke Aoki, Teiji Tominaga & Keiji Wada. (2009) Clock genes regulate neurogenic transcription factors, including NeuroD1, and the neuronal differentiation of adult neural stem/progenitor cells. Neurochemistry International 54:5-6, pages 277-285.
Crossref
Ann A. Kiessling, Ritsa Bletsa, Bryan Desmarais, Christina Mara, Kostas Kallianidis & Dimitris Loutradis. (2009) Evidence that human blastomere cleavage is under unique cell cycle control. Journal of Assisted Reproduction and Genetics 26:4, pages 187-195.
Crossref
Valerie W. Hu, Tewarit Sarachana, Kyung Soon Kim, AnhThu Nguyen, Shreya Kulkarni, Mara E. Steinberg, Truong Luu, Yinglei Lai & Norman H. Lee. (2009) Gene expression profiling differentiates autism case-controls and phenotypic variants of autism spectrum disorders: evidence for circadian rhythm dysfunction in severe autism. Autism Research 2:2, pages 78-97.
Crossref
Thomas Dickmeis. (2009) Glucocorticoids and the circadian clock. Journal of Endocrinology 200:1, pages 3-22.
Crossref

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