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Article

Selective Modulation of Hedgehog/GLI Target Gene Expression by Epidermal Growth Factor Signaling in Human Keratinocytes

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Pages 6283-6298 | Received 07 Mar 2006, Accepted 02 Jun 2006, Published online: 27 Mar 2023

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Hengxiang Cui, Wenjie Yu, Minhao Yu, Yang Luo, Mingming Yang, Ruochen Cong, Xin Chu, Ganglong Gao & Ming Zhong. (2021) GPR126 regulates colorectal cancer cell proliferation by mediating HDAC2 and GLI2 expression. Cancer Science 112:5, pages 1798-1810.
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Stephan J. Matissek & Sherine F. Elsawa. (2020) GLI3: a mediator of genetic diseases, development and cancer. Cell Communication and Signaling 18:1.
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
Priyanka Bhateja, Mathew Cherian, Sarmila Majumder & Bhuvaneswari Ramaswamy. (2019) The Hedgehog Signaling Pathway: A Viable Target in Breast Cancer?. Cancers 11:8, pages 1126.
Crossref
Nai‐Wen Fan, Tsung‐Chuan Ho, Cheng‐Wen Wu & Yeou‐Ping Tsao. (2019) Pigment epithelium‐derived factor peptide promotes limbal stem cell proliferation through hedgehog pathway. Journal of Cellular and Molecular Medicine 23:7, pages 4759-4769.
Crossref
Silvia Pietrobono, Sinforosa Gagliardi & Barbara Stecca. (2019) Non-canonical Hedgehog Signaling Pathway in Cancer: Activation of GLI Transcription Factors Beyond Smoothened. Frontiers in Genetics 10.
Crossref
Masaru Katoh. (2019) Genomic testing, tumor microenvironment and targeted therapy of Hedgehog-related human cancers. Clinical Science 133:8, pages 953-970.
Crossref
Elisabeth Peer, Suzana Tesanovic & Fritz Aberger. (2019) Next-Generation Hedgehog/GLI Pathway Inhibitors for Cancer Therapy. Cancers 11:4, pages 538.
Crossref
Ali Salaritabar, Ioana Berindan-Neagoe, Behrad Darvish, Farzaneh Hadjiakhoondi, Azadeh Manayi, Kasi Pandima Devi, Davide Barreca, Ilkay Erdogan Orhan, Ipek Süntar, Ammad Ahmad Farooqi, Diana Gulei, Seyed Fazel Nabavi, Antoni Sureda, Maria Daglia, Ahmad R. Dehpour, Seyed Mohammad Nabavi & Samira Shirooie. (2019) Targeting Hedgehog signaling pathway: Paving the road for cancer therapy. Pharmacological Research 141, pages 466-480.
Crossref
Junsheng Fu, Anju Shrivastava, Sushant Shrivastava, Rakesh Srivastava & Sharmila Shankar. (2019) Triacetyl resveratrol upregulates miRNA‑200 and suppresses the Shh pathway in pancreatic cancer: A potential therapeutic agent. International Journal of Oncology.
Crossref
Gabriela Basile Carballo, Jéssica Ribeiro Honorato, Giselle Pinto Farias de Lopes & Tania Cristina Leite de Sampaio e Spohr. (2018) A highlight on Sonic hedgehog pathway. Cell Communication and Signaling 16:1.
Crossref
Maria Fernanda Rodrigues, Lucyene Miguita, Nath�lia De Andrade, Daniele Heguedusch, Camila Rodini, Raquel Moyses, Tatiana Toporcov, Ricardo Gama, Eloiza Tajara & Fabio Nunes. (2018) GLI3 knockdown decreases stemness, cell proliferation and invasion in oral squamous cell carcinoma. International Journal of Oncology.
Crossref
Etienne Giroux-Leprieur, Adrien Costantini, Vivianne Ding & Biao He. (2018) Hedgehog Signaling in Lung Cancer: From Oncogenesis to Cancer Treatment Resistance. International Journal of Molecular Sciences 19:9, pages 2835.
Crossref
Maureen Spit, Bon-Kyoung Koo & Madelon M. Maurice. (2018) Tales from the crypt: intestinal niche signals in tissue renewal, plasticity and cancer. Open Biology 8:9.
Crossref
Haihua Zhang, Weixiao Nan, Shiyong Wang, Xingchao Song, Huazhe Si, Tong Li & Guangyu Li. (2018) Epigallocatechin-3-Gallate Promotes the Growth of Mink Hair Follicles Through Sonic Hedgehog and Protein Kinase B Signaling Pathways. Frontiers in Pharmacology 9.
Crossref
Kirti K. Chahal, Milind Parle & Ruben Abagyan. (2018) Hedgehog pathway and smoothened inhibitors in cancer therapies. Anti-Cancer Drugs 29:5, pages 387-401.
Crossref
Miroslava Didiasova, Liliana Schaefer & Malgorzata Wygrecka. (2018) Targeting GLI Transcription Factors in Cancer. Molecules 23:5, pages 1003.
Crossref
Philip M Iannaccone, Vasil Galat, Matthew I Bury, Yongchao C Ma & Arun K Sharma. (2017) The utility of stem cells in pediatric urinary bladder regeneration. Pediatric Research 83:1-2, pages 258-266.
Crossref
Cheng Bao, Pavel Kramata, Hong Jin Lee & Nanjoo Suh. (2018) Regulation of Hedgehog Signaling in Cancer by Natural and Dietary Compounds. Molecular Nutrition & Food Research 62:1, pages 1700621.
Crossref
Silja Wessler, Linda M. Krisch, Dominik P. Elmer & Fritz Aberger. (2017) From inflammation to gastric cancer – the importance of Hedgehog/GLI signaling in Helicobacter pylori-induced chronic inflammatory and neoplastic diseases. Cell Communication and Signaling 15:1.
Crossref
Fritz Aberger, Evelyn Hutterer, Christina Sternberg, Pedro J. del Burgo & Tanja N. Hartmann. (2017) Acute myeloid leukemia – strategies and challenges for targeting oncogenic Hedgehog/GLI signaling. Cell Communication and Signaling 15:1.
Crossref
Anshika Bakshi, Sandeep C. Chaudhary, Mehtab Rana, Craig A. Elmets & Mohammad Athar. (2017) Basal cell carcinoma pathogenesis and therapy involving hedgehog signaling and beyond. Molecular Carcinogenesis 56:12, pages 2543-2557.
Crossref
Xin Shen, Yu Peng & Hanmin Li. (2017) The Injury-Related Activation of Hedgehog Signaling Pathway Modulates the Repair-Associated Inflammation in Liver Fibrosis. Frontiers in Immunology 8.
Crossref
Fanping Wang, Wenjun Wang, Junpeng Li, Jingjing Zhang, Xia Wang & Mingyong Wang. (2017) Sulforaphane reverses gefitinib tolerance in human lung cancer cells via modulation of sonic hedgehog signaling. Oncology Letters.
Crossref
Xiulong Xu, Yurong Lu, Yi Li & Richard A. Prinz. (2017) Sonic Hedgehog Signaling in Thyroid Cancer. Frontiers in Endocrinology 8.
Crossref
Sahba Kasiri, Chunli Shao, Baozhi Chen, Alexandra N. Wilson, Paul Yenerall, Brenda C. Timmons, Luc Girard, Hui Tian, Carmen Behrens, Ignacio I. Wistuba, Adi F. Gazdar & James Kim. (2017) GLI1 Blockade Potentiates the Antitumor Activity of PI3K Antagonists in Lung Squamous Cell Carcinoma. Cancer Research 77:16, pages 4448-4459.
Crossref
Melchiorre Cervello, Giuseppa Augello, Antonella Cusimano, Maria Rita Emma, Daniele Balasus, Antonina Azzolina, James A. McCubrey & Giuseppe Montalto. (2017) Pivotal roles of glycogen synthase-3 in hepatocellular carcinoma. Advances in Biological Regulation 65, pages 59-76.
Crossref
Zixin Yang, Yingqian Lv, Long Wang, Yong Chen, Jinzhu Han, Shan Zhao & Wei Liu. (2017) Inhibition of hedgehog pathway reveals the regulatory role of SMO in gastric cancer cells. Tumor Biology 39:7, pages 101042831771554.
Crossref
Arpit Dheeraj, Cynthia M. Rigby, Cindy L. O'Bryant, Chapla Agarwal, Rana P. Singh, Gagan Deep & Rajesh Agarwal. (2017) Silibinin Treatment Inhibits the Growth of Hedgehog Inhibitor-Resistant Basal Cell Carcinoma Cells via Targeting EGFR-MAPK-Akt and Hedgehog Signaling. Photochemistry and Photobiology 93:4, pages 999-1007.
Crossref
Dae-Hee Lee, Suk-young Lee & Sang Cheul Oh. (2017) Hedgehog signaling pathway as a potential target in the treatment of advanced gastric cancer. Tumor Biology 39:6, pages 101042831769226.
Crossref
Carolina Constantin & Monica Neagu. 2017. Photomedicine - Advances in Clinical Practice. Photomedicine - Advances in Clinical Practice.
Ruowen Zhang, Jiahui Wu, Sylvain Ferrandon, Katie J. Glowacki & Janet A. Houghton. (2016) Targeting GLI by GANT61 involves mechanisms dependent on inhibition of both transcription and DNA licensing. Oncotarget 7:49, pages 80190-80207.
Crossref
Elisabeth Enzenhofer, Thomas Parzefall, Georg Haymerle, Sven Schneider, Lorenz Kadletz, Gregor Heiduschka, Johannes Pammer, Felicitas Oberndorfer, Fritz Wrba, Benjamin Loader, Matthäus Christoph Grasl, Christos Perisanidis & Boban M. Erovic. (2016) Impact of Sonic Hedgehog Pathway Expression on Outcome in HPV Negative Head and Neck Carcinoma Patients after Surgery and Adjuvant Radiotherapy. PLOS ONE 11:12, pages e0167665.
Crossref
Yan Wang, Jung-Mao Hsu, Ya'an Kang, Yongkun Wei, Pei-Chih Lee, Shing-Jyh Chang, Yi-Hsin Hsu, Jennifer L. Hsu, Hung-Ling Wang, Wei-Chao Chang, Chia-Wei Li, Hsin-Wei Liao, Shih-Shin Chang, Weiya Xia, How-Wen Ko, Chao-Kai Chou, Jason B. Fleming, Huamin Wang, Rosa F. Hwang, Yue Chen, Jun Qin & Mien-Chie Hung. (2016) Oncogenic Functions of Gli1 in Pancreatic Adenocarcinoma Are Supported by Its PRMT1-Mediated Methylation. Cancer Research 76:23, pages 7049-7058.
Crossref
Arianna L. Kim, Jung Ho Back, Yucui Zhu, Xiuwei Tang, Nathan P. Yardley, Katherine J. Kim, Mohammad Athar & David R. Bickers. (2016) AKT1 Activation is Obligatory for Spontaneous BCC Tumor Growth in a Murine Model that Mimics Some Features of Basal Cell Nevus Syndrome. Cancer Prevention Research 9:10, pages 794-802.
Crossref
Chao Shi, Dengliang Huang, Nonghua Lu, Dan Chen, Minhong Zhang, Yehong Yan, Libin Deng, Quqin Lu, Hua Lu & Shiwen Luo. (2016) Aberrantly activated Gli2-KIF20A axis is crucial for growth of hepatocellular carcinoma and predicts poor prognosis. Oncotarget 7:18, pages 26206-26219.
Crossref
Xiao-Yan Bai, Xu-Chao Zhang, Su-Qing Yang, She-Juan An, Zhi-Hong Chen, Jian Su, Zhi Xie, Lan-Ying Gou & Yi-Long Wu. (2016) Blockade of Hedgehog Signaling Synergistically Increases Sensitivity to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Non-Small-Cell Lung Cancer Cell Lines. PLOS ONE 11:3, pages e0149370.
Crossref
Randy Ringuette, Michael Atkins, Pamela S. Lagali, Erin A. Bassett, Charles Campbell, Chantal Mazerolle, Alan J. Mears, David J. Picketts & Valerie A. Wallace. (2016) A Notch-Gli2 axis sustains Hedgehog responsiveness of neural progenitors and Müller glia. Developmental Biology 411:1, pages 85-100.
Crossref
Elisabetta Rovida & Barbara Stecca. (2015) Mitogen-activated protein kinases and Hedgehog-GLI signaling in cancer: A crosstalk providing therapeutic opportunities?. Seminars in Cancer Biology 35, pages 154-167.
Crossref
Hongzhen Li, Wenli Liu, Weiping Chen, Jianqiong Zhu, Chu-Xia Deng & Griffin P. Rodgers. (2015) Olfactomedin 4 deficiency promotes prostate neoplastic progression and is associated with upregulation of the hedgehog-signaling pathway. Scientific Reports 5:1.
Crossref
D Kern, G Regl, S W Hofbauer, P Altenhofer, G Achatz, A Dlugosz, H Schnidar, R Greil, T N Hartmann & F Aberger. (2015) Hedgehog/GLI and PI3K signaling in the initiation and maintenance of chronic lymphocytic leukemia. Oncogene 34:42, pages 5341-5351.
Crossref
Shingo Inaguma, Hideaki Ito, Miho Riku, Hiroshi Ikeda & Kenji Kasai. (2015) Addiction of pancreatic cancer cells to zinc-finger transcription factor ZIC2. Oncotarget 6:29, pages 28257-28268.
Crossref
Ai-Chung Mar, Chun-Ho Chu, Hui-Ju Lee, Chia-Wen Chien, Jing-Jy Cheng, Shung-Haur Yang, Jeng-Kai Jiang & Te-Chang Lee. (2015) Interleukin-1 Receptor Type 2 Acts with c-Fos to Enhance the Expression of Interleukin-6 and Vascular Endothelial Growth Factor A in Colon Cancer Cells and Induce Angiogenesis. Journal of Biological Chemistry 290:36, pages 22212-22224.
Crossref
Dongsheng Gu & Jingwu Xie. (2015) Non-Canonical Hh Signaling in Cancer—Current Understanding and Future Directions. Cancers 7:3, pages 1684-1698.
Crossref
Shellese Cannonier & Julie Sterling. (2015) The Role of Hedgehog Signaling in Tumor Induced Bone Disease. Cancers 7:3, pages 1658-1683.
Crossref
Anna L. Furmanski, Alessandro Barbarulo, Anisha Solanki, Ching-In Lau, Hemant Sahni, Jose Ignacio Saldana, Fulvio D'Acquisto & Tessa Crompton. (2015) The transcriptional activator Gli2 modulates T-cell receptor signalling through attenuation of AP-1 and NFκB activity. Journal of Cell Science 128:11, pages 2085-2095.
Crossref
Wentao Deng, Daniel B. Vanderbilt, Chen-Chung Lin, Karen H. Martin, Kathleen M. Brundage & J. Michael Ruppert. (2015) SOX9 inhibits β-TrCP-mediated protein degradation to promote nuclear GLI1 expression and cancer stem cell properties. Journal of Cell Science.
Crossref
Silvia Pandolfi & Barbara Stecca. (2015) Cooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapy. Expert Reviews in Molecular Medicine 17.
Crossref
Doaa Al Ghamdi, Wafaey Gomaa, Abdulrhman Abulaban, Mahmoud Al-Ahwal, Abdelbaset Buhmeida, Mohammed Al-Qahtani & Jaudah Al-Maghrabi. (2015) The significance of sonic hedgehog immunohistochemical expression in colorectal carcinoma. Journal of Microscopy and Ultrastructure 3:4, pages 169.
Crossref
Yan Peng, Min Xuan, Victor Y.L. Leung & Biao Cheng. (2015) Stem cells and aberrant signaling of molecular systems in skin aging. Ageing Research Reviews 19, pages 8-21.
Crossref
Monica Mangoni, Mariangela Sottili, Mauro Loi, Chiara Gerini, Icro Meattini & Lorenzo Livi. 2015. Cancer Immunology. Cancer Immunology 151 176 .
Haiyan Liu, Qiang Jian, Ke Xue, Cuiling Ma, Fang Xie, Rui Wang, Wenjun Liao, Yufeng Liu, Sumin Chi & Chengxin Li. (2014) The MEK/ERK signalling cascade is required for sonic hedgehog signalling pathway-mediated enhancement of proliferation and inhibition of apoptosis in normal keratinocytes. Experimental Dermatology 23:12, pages 896-901.
Crossref
Xing LiuXiaofeng WangWenzhong DuLingchao Chen, Guangzhi WangYuqiong CuiYang LiuZhijin DouHongjun WangPing ZhangLiang ChangLiye YiJinquan CaiChuanlu Jiang. (2014) Suppressor of fused (Sufu) represses Gli1 transcription and nuclear accumulation, inhibits glioma cell proliferation, invasion and vasculogenic mimicry, improving glioma chemo-sensitivity and prognosis. Oncotarget 5:22, pages 11681-11694.
Crossref
Katherine B. Heiden, Ashley J. Williamson, Michelle E. Doscas, Jin Ye, Yimin Wang, Dingxie Liu, Mingzhao Xing, Richard A. Prinz & Xiulong Xu. (2014) The Sonic Hedgehog Signaling Pathway Maintains the Cancer Stem Cell Self-Renewal of Anaplastic Thyroid Cancer by Inducing Snail Expression. The Journal of Clinical Endocrinology & Metabolism 99:11, pages E2178-E2187.
Crossref
Changxin Xu, Xiufen Li, Matthew K. Topham & Scott K. Kuwada. (2014) Regulation of sonic hedgehog expression by integrin β1 and epidermal growth factor receptor in intestinal epithelium. IUBMB Life 66:10, pages 694-703.
Crossref
Fritz Aberger & Ariel Ruiz i Altaba. (2014) Context-dependent signal integration by the GLI code: The oncogenic load, pathways, modifiers and implications for cancer therapy. Seminars in Cell & Developmental Biology 33, pages 93-104.
Crossref
Began Gopalan, Karthikeyan Narayanan, Zhiyuan Ke, Ting Lu, Yugen Zhang & Lang Zhuo. (2014) Therapeutic effect of a multi-targeted imidazolium compound in hepatocellular carcinoma. Biomaterials 35:26, pages 7479-7487.
Crossref
Xuanfu Xu, Bin Su, Chuangao Xie, Shumei Wei, Yingqun Zhou, Hua Liu, Weiqi Dai, Ping Cheng, Fan Wang, Xiaorong Xu & Chuanyong Guo. (2014) Sonic Hedgehog-Gli1 Signaling Pathway Regulates the Epithelial Mesenchymal Transition (EMT) by Mediating a New Target Gene, S100A4, in Pancreatic Cancer Cells. PLoS ONE 9:7, pages e96441.
Crossref
Akwasi Agyeman, Babal K Jha, Tapati Mazumdar & Janet A Houghton. (2014) Mode and specificity of binding of the small molecule GANT61 to GLI determines inhibition of GLI-DNA binding. Oncotarget 5:12, pages 4492-4503.
Crossref
Masaru Katoh & Hitoshi Nakagama. (2014) FGF Receptors: Cancer Biology and Therapeutics. Medicinal Research Reviews 34:2, pages 280-300.
Crossref
Candice Alexandra Grzelak, Luciano Gastón Martelotto, Nicholas David Sigglekow, Bramilla Patkunanathan, Katerina Ajami, Sarah Ruth Calabro, Benjamin James Dwyer, Janina Elke Eleonore Tirnitz-Parker, D. Neil Watkins, Fiona Jane Warner, Nicholas Adam Shackel & Geoffrey William McCaughan. (2014) The intrahepatic signalling niche of hedgehog is defined by primary cilia positive cells during chronic liver injury. Journal of Hepatology 60:1, pages 143-151.
Crossref
Elspeth M. Beauchamp, Ruth Serrano & Leonidas C. Platanias. 2014. Nuclear Signaling Pathways and Targeting Transcription in Cancer. Nuclear Signaling Pathways and Targeting Transcription in Cancer 107 119 .
Andrea I. Ramos & Scott Barolo. (2013) Low-affinity transcription factor binding sites shape morphogen responses and enhancer evolution. Philosophical Transactions of the Royal Society B: Biological Sciences 368:1632, pages 20130018.
Crossref
Shingo Inaguma, Miho Riku, Mitsuyoshi Hashimoto, Hideki Murakami, Shinsuke Saga, Hiroshi Ikeda & Kenji Kasai. (2013) GLI1 Interferes with the DNA Mismatch Repair System in Pancreatic Cancer through BHLHE41-Mediated Suppression of MLH1. Cancer Research 73:24, pages 7313-7323.
Crossref
Leonardo Guasti, Dominic Cavlan, Kathryn Cogger, Zahida Banu, Amreen Shakur, Salima Latif & Peter J. King. (2013) Dlk1 Up-Regulates Gli1 Expression in Male Rat Adrenal Capsule Cells Through the Activation of β1 Integrin and ERK1/2. Endocrinology 154:12, pages 4675-4684.
Crossref
XIN ZHENG, WEN ZENG, XIAOHONG GAI, QIURAN XU, CHAO LI, ZHEYONG LIANG, HANG TUO & QINGGUANG LIU. (2013) Role of the Hedgehog pathway in hepatocellular carcinoma (Review). Oncology Reports 30:5, pages 2020-2026.
Crossref
S Pandolfi, V Montagnani, J Y Penachioni, M C Vinci, B Olivito, L Borgognoni & B Stecca. (2012) WIP1 phosphatase modulates the Hedgehog signaling by enhancing GLI1 function. Oncogene 32:40, pages 4737-4747.
Crossref
Sandra Laner-Plamberger, Florian Wolff, Alexandra Kaser-Eichberger, Stefan Swierczynski, Cornelia Hauser-Kronberger, Anna-Maria Frischauf & Thomas Eichberger. (2013) Hedgehog/GLI Signaling Activates Suppressor of Cytokine Signaling 1 (SOCS1) in Epidermal and Neural Tumor Cells. PLoS ONE 8:9, pages e75317.
Crossref
GUODONG ZHU, JIANCHENG ZHOU, WENBIN SONG, DAPENG WU, QIANG DANG, LINLIN ZHANG, LEI LI, XINYANG WANG & DALIN HE. (2013) Role of GLI-1 in epidermal growth factor-induced invasiveness of ARCaPE prostate cancer cells. Oncology Reports 30:2, pages 904-910.
Crossref
Viswanath Reddy Belum, Hiral Fontanilla Patel, Mario E Lacouture & Ulrich Rodeck. (2013) Skin toxicity of targeted cancer agents: mechanisms and intervention. Future Oncology 9:8, pages 1161-1170.
Crossref
Saikat Chowdhury, Rachana N. Pradhan & Ram Rup Sarkar. (2013) Structural and Logical Analysis of a Comprehensive Hedgehog Signaling Pathway to Identify Alternative Drug Targets for Glioma, Colon and Pancreatic Cancer. PLoS ONE 8:7, pages e69132.
Crossref
Stephen B. Keysar, Phuong N. Le, Ryan T. Anderson, J. Jason Morton, Daniel W. Bowles, Jeramiah J. Paylor, Brian W. Vogler, Jackie Thorburn, Pamela Fernandez, Magdalena J. Glogowska, Sarah M. Takimoto, Daniel B. Sehrt, Gregory N. Gan, Justin R. Eagles-Soukup, Hilary Serracino, Fred R. Hirsch, M. Scott Lucia, Andrew Thorburn, John I. Song, Xiao-Jing Wang & Antonio Jimeno. (2013) Hedgehog Signaling Alters Reliance on EGF Receptor Signaling and Mediates Anti-EGFR Therapeutic Resistance in Head and Neck Cancer. Cancer Research 73:11, pages 3381-3392.
Crossref
Amanda PsyrriTanguy Y. SeiwertAntonio Jimeno. (2013) Molecular Pathways in Head and Neck Cancer: EGFR, PI3K, and More. American Society of Clinical Oncology Educational Book:33, pages 246-255.
Crossref
Erika R. Geisbrecht, Ketki Sawant, Ying Su, Ze Cindy Liu, Debra L. Silver, Ashley Burtscher, Xuejiao Wang, Alan Jian Zhu & Jocelyn A. McDonald. (2013) Genetic Interaction Screens Identify a Role for Hedgehog Signaling in Drosophila Border Cell Migration . Developmental Dynamics 242:5, pages 414-431.
Crossref
Hyun Kook Cho, So Young Kim, Kook Hwan Kim, Hyeong Hoe Kim & JaeHun Cheong. (2013) Tumor suppressor protein VHL inhibits Hedgehog-Gli activation through suppression of Gli1 nuclear localization. FEBS Letters 587:7, pages 826-832.
Crossref
Hui Li, Natalie Lui, Tiffany Cheng, Hsin-Hui K. Tseng, Dongsheng Yue, Etienne Giroux-Leprieur, Hanh T. Do, Qing Sheng, Joy Q. Jin, Thomas W. Luh, David M. Jablons & Biao He. (2013) Gli as a Novel Therapeutic Target in Malignant Pleural Mesothelioma. PLoS ONE 8:3, pages e57346.
Crossref
Stefan Tholen, Martin L. Biniossek, Martina Gansz, Alejandro Gomez-Auli, Fee Bengsch, Agnes Noel, Jayachandran N. Kizhakkedathu, Melanie Boerries, Hauke Busch, Thomas Reinheckel & Oliver Schilling. (2013) Deletion of Cysteine Cathepsins B or L Yields Differential Impacts on Murine Skin Proteome and Degradome. Molecular & Cellular Proteomics 12:3, pages 611-625.
Crossref
William R. Swindell, Andrew Johnston, Xianying Xing, Andrew Little, Patrick Robichaud, John J. Voorhees, Gary Fisher & Johann E. Gudjonsson. (2013) Robust shifts in S100a9 expression with aging: A novel mechanism for chronic inflammation. Scientific Reports 3:1.
Crossref
Roberta Santini, Maria C. Vinci, Silvia Pandolfi, Junia Y. Penachioni, Valentina Montagnani, Biagio Olivito, Riccardo Gattai, Nicola Pimpinelli, Gianni Gerlini, Lorenzo Borgognoni & Barbara Stecca. (2012) HEDGEHOG-GLI Signaling Drives Self-Renewal and Tumorigenicity of Human Melanoma-Initiating Cells. Stem Cells 30:9, pages 1808-1818.
Crossref
Irena Pastar, Aly Azeem Khan, Olivera Stojadinovic, Elizabeth A. Lebrun, Mayrin Correa Medina, Harold Brem, Robert S. Kirsner, Joaquin J. Jimenez, Christina Leslie & Marjana Tomic-Canic. (2012) Induction of Specific MicroRNAs Inhibits Cutaneous Wound Healing. Journal of Biological Chemistry 287:35, pages 29324-29335.
Crossref
Hui-Fen Liao, Yu-Chieh Su, Zhi-Yu Zheng, Chang Jhih Cai, Ming-Hung Hou, K.S. Clifford Chao & Yu-Jen Chen. (2012) Sonic hedgehog signaling regulates Bcr-Abl expression in human chronic myeloid leukemia cells. Biomedicine & Pharmacotherapy 66:5, pages 378-383.
Crossref
Deng Pan, Yan Li, Zhe Li, Yazhu Wang, Pingping Wang & Ying Liang. (2012) Gli inhibitor GANT61 causes apoptosis in myeloid leukemia cells and acts in synergy with rapamycin. Leukemia Research 36:6, pages 742-748.
Crossref
Markus Eberl, Stefan Klingler, Doris Mangelberger, Andrea Loipetzberger, Helene Damhofer, Kerstin Zoidl, Harald Schnidar, Hendrik Hache, Hans‐Christian Bauer, Flavio Solca, Cornelia Hauser‐Kronberger, Alexandre N. Ermilov, Monique E. Verhaegen, Christopher K. Bichakjian, Andrzej A. Dlugosz, Wilfried Nietfeld, Maria Sibilia, Hans Lehrach, Christoph Wierling & Fritz Aberger. (2012) Hedgehog‐EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour‐initiating pancreatic cancer cells. EMBO Molecular Medicine 4:3, pages 218-233.
Crossref
Maria Kasper, Viljar Jaks, Daniel Hohl & Rune Toftgård. (2012) Basal cell carcinoma — molecular biology and potential new therapies. Journal of Clinical Investigation 122:2, pages 455-463.
Crossref
Michael A White, Davis S Parker, Scott Barolo & Barak A Cohen. (2012) A model of spatially restricted transcription in opposing gradients of activators and repressors. Molecular Systems Biology 8:1.
Crossref
Fritz Aberger, Daniela Kern, Richard Greil & Tanja Nicole Hartmann. 2012. Hedgehog Signaling. Hedgehog Signaling 25 54 .
Wenhui Mo, Xuanfu Xu, Ling Xu, Feng Wang, Aiwu Ke, Xingpeng Wang & Chuanyong Guo. (2011) Resveratrol Inhibits Proliferation and Induces Apoptosis through the Hedgehog Signaling Pathway in Pancreatic Cancer Cell. Pancreatology 11:6, pages 601-609.
Crossref
Ariel Ruiz i Altaba. (2011) Hedgehog Signaling and the Gli Code in Stem Cells, Cancer, and MetastasesA Presentation from the 1st International HEALING Meeting: Hh-Gli Signaling in Development, Regeneration, and Disease, Kolymbari, Crete, 23 to 25 June 2011.. Science Signaling 4:200.
Crossref
Tapati Mazumdar, Jennifer DeVecchio, Akwasi Agyeman, Ting Shi & Janet A. Houghton. (2011) Blocking Hedgehog Survival Signaling at the Level of the GLI Genes Induces DNA Damage and Extensive Cell Death in Human Colon Carcinoma Cells. Cancer Research 71:17, pages 5904-5914.
Crossref
Amy Sinor-Anderson & Laura Lillien. (2011) Akt1 interacts with epidermal growth factor receptors and hedgehog signaling to increase stem/transit amplifying cells in the embryonic mouse cortex. Developmental Neurobiology 71:9, pages 759-771.
Crossref
Ming Yan, Lijun Wang, Hui Zuo, Zhiyuan Zhang, Wantao Chen, Li Mao & Ping Zhang. (2011) HH/GLI signalling as a new therapeutic target for patients with oral squamous cell carcinoma. Oral Oncology 47:6, pages 504-509.
Crossref
Sandeep K. Nadendla, Allon Hazan, Matt Ward, Lisa J. Harper, Karwan Moutasim, Lucia S. Bianchi, Mahmoud Naase, Lucy Ghali, Gareth J. Thomas, David M. Prowse, Michael P. Philpott & Graham W. Neill. (2011) GLI1 Confers Profound Phenotypic Changes upon LNCaP Prostate Cancer Cells That Include the Acquisition of a Hormone Independent State. PLoS ONE 6:5, pages e20271.
Crossref
Christine H. ChungJames J. DignamM. Elizabeth HammondAlexander C. KlimowiczStephanie K. PetrilloAnthony MaglioccoRichard JordanAndy TrottiSharon SpencerJay S. CooperQuynh-Thu LeK. Kian Ang. (2011) Glioma-Associated Oncogene Family Zinc Finger 1 Expression and Metastasis in Patients With Head and Neck Squamous Cell Carcinoma Treated With Radiation Therapy (RTOG 9003). Journal of Clinical Oncology 29:10, pages 1326-1334.
Crossref
S Inaguma, K Kasai & H Ikeda. (2010) GLI1 facilitates the migration and invasion of pancreatic cancer cells through MUC5AC-mediated attenuation of E-cadherin. Oncogene 30:6, pages 714-723.
Crossref
Tapati Mazumdar, Jennifer DeVecchio, Ting Shi, Janay Jones, Akwasi Agyeman & Janet A. Houghton. (2011) Hedgehog Signaling Drives Cellular Survival in Human Colon Carcinoma Cells. Cancer Research 71:3, pages 1092-1102.
Crossref
. 2011. Growth Factors and Their Receptors in Cell Differentiation, Cancer and Cancer Therapy. Growth Factors and Their Receptors in Cell Differentiation, Cancer and Cancer Therapy 249 347 .
Martina Winklmayr, Carmen Schmid, Sandra Laner-Plamberger, Alexandra Kaser, Fritz Aberger, Thomas Eichberger & Anna-Maria Frischauf. (2010) Non-consensus GLI binding sites in Hedgehog target gene regulation. BMC Molecular Biology 11:1.
Crossref
Murielle Mimeault & Surinder K. Batra. (2010) Frequent Deregulations in the Hedgehog Signaling Network and Cross-Talks with the Epidermal Growth Factor Receptor Pathway Involved in Cancer Progression and Targeted Therapies. Pharmacological Reviews 62:3, pages 497-524.
Crossref
Thomas C. Whisenant, David T. Ho, Ryan W. Benz, Jeffrey S. Rogers, Robyn M. Kaake, Elizabeth A. Gordon, Lan Huang, Pierre Baldi & Lee Bardwell. (2010) Computational Prediction and Experimental Verification of New MAP Kinase Docking Sites and Substrates Including Gli Transcription Factors. PLoS Computational Biology 6:8, pages e1000908.
Crossref
Mayuko Yamaki, Kazumitsu Sugiura, Yoshinao Muro, Yoshie Shimoyama & Yasushi Tomita. (2010) Epidermal growth factor receptor tyrosine kinase inhibitors induce CCL2 and CCL5 via reduction in IL-1R2 in keratinocytes. Experimental Dermatology 19:8, pages 730-735.
Crossref
Akil A. Merchant & William Matsui. (2010) Targeting Hedgehog — a Cancer Stem Cell Pathway. Clinical Cancer Research 16:12, pages 3130-3140.
Crossref
B. Stecca & A. Ruiz i Altaba. (2010) Context-dependent Regulation of the GLI Code in Cancer by HEDGEHOG and Non-HEDGEHOG Signals. Journal of Molecular Cell Biology 2:2, pages 84-95.
Crossref
Hugo J. SnippertAndrea HaegebarthMaria KasperViljar JaksJohan H. van EsNick BarkerMarc van de WeteringMaaike van den BornHarry BegthelRobert G. VriesDaniel E. StangeRune ToftgårdHans Clevers. (2010) Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin . Science 327:5971, pages 1385-1389.
Crossref
L Yang, G Xie, Q Fan & J Xie. (2009) Activation of the hedgehog-signaling pathway in human cancer and the clinical implications. Oncogene 29:4, pages 469-481.
Crossref
Murielle Mimeault & Surinder K. Batra. (2010) Recent advances on skin-resident stem/progenitor cell functions in skin regeneration, aging and cancers and novel anti-aging and cancer therapies. Journal of Cellular and Molecular Medicine 14:1-2, pages 116-134.
Crossref
Laure Rittié, Stefan W. Stoll, Sewon Kang, John J. Voorhees & Gary J. Fisher. (2009) Hedgehog signaling maintains hair follicle stem cell phenotype in young and aged human skin. Aging Cell 8:6, pages 738-751.
Crossref
Liam Town, Edwina McGlinn, Salvatore Fiorenza, Vicki Metzis, Natalie C. Butterfield, Joy M. Richman & Carol Wicking. (2009) The metalloendopeptidase gene Pitrm1 is regulated by hedgehog signaling in the developing mouse limb and is expressed in muscle progenitors . Developmental Dynamics 238:12, pages 3175-3184.
Crossref
Sinclair M Gore, Maria Kasper, Tomos Williams, Gerhard Regl, Fritz Aberger, Reno Cerio, Graham W Neill & Michael P Philpott. (2009) Neuronal differentiation in basal cell carcinoma: possible relationship to Hedgehog pathway activation?. The Journal of Pathology 219:1, pages 61-68.
Crossref
Fritz Aberger. 2009. Cancer Stem Cells. Cancer Stem Cells 109 127 .
Simin Lim, Lee-Yee Choong, Chong Poh Kuan, Chen Yunhao & Yoon-Pin Lim. (2009) Regulation of Macrophage Inhibitory Factor (MIF) by Epidermal Growth Factor Receptor (EGFR) in the MCF10AT Model of Breast Cancer Progression. Journal of Proteome Research 8:8, pages 4062-4076.
Crossref
Motoko Seto, Miki Ohta, Yoshinari Asaoka, Tsuneo Ikenoue, Motohisa Tada, Koji Miyabayashi, Dai Mohri, Yasuo Tanaka, Hideaki Ijichi, Keisuke Tateishi, Fumihiko Kanai, Takao Kawabe & Masao Omata. (2009) Regulation of the hedgehog signaling by the mitogen-activated protein kinase cascade in gastric cancer. Molecular Carcinogenesis 48:8, pages 703-712.
Crossref
M. Kasper, V. Jaks, M. Fiaschi & R. Toftgard. (2009) Hedgehog signalling in breast cancer. Carcinogenesis 30:6, pages 903-911.
Crossref
S Laner-Plamberger, A Kaser, M Paulischta, C Hauser-Kronberger, T Eichberger & A M Frischauf. (2009) Cooperation between GLI and JUN enhances transcription of JUN and selected GLI target genes. Oncogene 28:13, pages 1639-1651.
Crossref
Barbara Stecca & Ariel Ruiz i Altaba. (2009) A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers. The EMBO Journal 28:6, pages 663-676.
Crossref
Peter J. Atkinson, Tammy Dellovade, David Albers, David Von Schack, Kathryn Saraf, Elie Needle, Peter H. Reinhart & Warren D. Hirst. (2009) Sonic Hedgehog signaling in astrocytes is dependent on p38 mitogen-activated protein kinase and G-protein receptor kinase 2. Journal of Neurochemistry 108:6, pages 1539-1549.
Crossref
Harald Schnidar, Markus Eberl, Stefan Klingler, Doris Mangelberger, Maria Kasper, Cornelia Hauser-Kronberger, Gerhard Regl, Renate Kroismayr, Richard Moriggl, Maria Sibilia & Fritz Aberger. (2009) Epidermal Growth Factor Receptor Signaling Synergizes with Hedgehog/GLI in Oncogenic Transformation via Activation of the MEK/ERK/JUN Pathway. Cancer Research 69:4, pages 1284-1292.
Crossref
Karl Quint, Sebastian Stintzing, Beate Alinger, Cornelia Hauser-Kronberger, Otto Dietze, Susanne Gahr, Eckhart G. Hahn, Matthias Ocker & Daniel Neureiter. (2009) The Expression Pattern of PDX-1, SHH, Patched and Gli-1 Is Associated with Pathological and Clinical Features in Human Pancreatic Cancer. Pancreatology 9:1-2, pages 116-126.
Crossref
Murielle Mimeault & Surinder K. Batra. 2009. Stem Cells and Cancer. Stem Cells and Cancer 287 308 .
Ulrich Rodeck. (2009) Skin toxicity caused by EGFR antagonists-An autoinflammatory condition triggered by deregulated IL-1 signaling?. Journal of Cellular Physiology 218:1, pages 32-34.
Crossref
Greg Shaw, Anna M. Price, Elena Ktori, Isabelle Bisson, Patricia E. Purkis, Siobhan McFaul, R. Tim D. Oliver & David M. Prowse. (2008) Hedgehog Signalling in Androgen Independent Prostate Cancer. European Urology 54:6, pages 1333-1343.
Crossref
Ervin H. Epstein. (2008) Basal cell carcinomas: attack of the hedgehog. Nature Reviews Cancer 8:10, pages 743-754.
Crossref
Pengfei Liang, Bimei Jiang, Xinghua Yang, Xianzhong Xiao, Xu Huang, Jianhong Long, Pihong Zhang, Minghua Zhang, Muzhang Xiao, Tinghong Xie & Xiaoyuan Huang. (2008) The role of peroxisome proliferator-activated receptor-β/δ in epidermal growth factor-induced HaCaT cell proliferation. Experimental Cell Research 314:17, pages 3142-3151.
Crossref
Pengfei Liang, Bimei Jiang, Xu Huang, Weimin Xiao, Pihong Zhang, Xinghua Yang, Jianhong Long, Xianzhong Xiao & Xiaoyuan Huang. (2008) Anti-apoptotic role of EGF in HaCaT keratinocytes via a PPARβ-dependent mechanism. Wound Repair and Regeneration 16:5, pages 691-698.
Crossref
Hong-Xiang Liu, Bradley S. Henson, Yanqiu Zhou, Nisha J. D'Silva & Charlotte M. Mistretta. (2008) Fungiform papilla pattern: EGF regulates inter-papilla lingual epithelium and decreases papilla number by means of PI3K/Akt, MEK/ERK, and p38 MAPK signaling. Developmental Dynamics 237:9, pages 2378-2393.
Crossref
Jingwu Xie. (2008) Implications of hedgehog signaling antagonists for cancer therapy. Acta Biochimica et Biophysica Sinica 40:7, pages 670-680.
Crossref
N Kostereva & M-C Hofmann. (2008) Regulation of the Spermatogonial Stem Cell Niche. Reproduction in Domestic Animals 43, pages 386-392.
Crossref
Takashi Shimokawa, Ulrica Tostar, Matthias Lauth, Ramesh Palaniswamy, Maria Kasper, Rune Toftgård & Peter G. Zaphiropoulos. (2008) Novel Human Glioma-associated Oncogene 1 (GLI1) Splice Variants Reveal Distinct Mechanisms in the Terminal Transduction of the Hedgehog Signal. Journal of Biological Chemistry 283:21, pages 14345-14354.
Crossref
Thomas Eichberger, Alexandra Kaser, Claudia Pixner, Carmen Schmid, Stefan Klingler, Martina Winklmayr, Cornelia Hauser-Kronberger, Fritz Aberger & Anna-Maria Frischauf. (2008) GLI2-specific Transcriptional Activation of the Bone Morphogenetic Protein/Activin Antagonist Follistatin in Human Epidermal Cells. Journal of Biological Chemistry 283:18, pages 12426-12437.
Crossref
Graham W. Neill, Wesley J. Harrison, Mohammed S. Ikram, Tomos D.L. Williams, Lucia S. Bianchi, Sandeep K. Nadendla, Judith L. Green, Lucy Ghali, Anna-Maria Frischauf, Edel A. O'Toole, Fritz Aberger & Michael P. Philpott. (2008) GLI1 repression of ERK activity correlates with colony formation and impaired migration in human epidermal keratinocytes. Carcinogenesis 29:4, pages 738-746.
Crossref
Jingwu Xie. (2008) Hedgehog signaling pathway: Development of antagonists for cancer therapy. Current Oncology Reports 10:2, pages 107-113.
Crossref
Jingwu Xie. 2008. Sunlight, Vitamin D and Skin Cancer. Sunlight, Vitamin D and Skin Cancer 241 251 .
Jung Sun Heo, Min Young Lee & Ho Jae Han. (2007) Sonic Hedgehog Stimulates Mouse Embryonic Stem Cell Proliferation by Cooperation of Ca2+/Protein Kinase C and Epidermal Growth Factor Receptor As Well as Gli1 Activation. Stem Cells 25:12, pages 3069-3080.
Crossref
M. Mimeault & S.K. Batra. (2007) Interplay of distinct growth factors during epithelial–mesenchymal transition of cancer progenitor cells and molecular targeting as novel cancer therapies. Annals of Oncology 18:10, pages 1605-1619.
Crossref
Ariel Ruiz i Altaba, Christophe Mas & Barbara Stecca. (2007) The Gli code: an information nexus regulating cell fate, stemness and cancer. Trends in Cell Biology 17:9, pages 438-447.
Crossref
M Lauth, Å Bergström & R Toftgård. (2007) Phorbol esters inhibit the Hedgehog signalling pathway downstream of Suppressor of Fused, but upstream of Gli. Oncogene 26:35, pages 5163-5168.
Crossref
Ping Dai, Takuo Nakagami, Hideo Tanaka, Toshiaki Hitomi & Tetsuro Takamatsu. (2007) Cx43 Mediates TGF-β Signaling through Competitive Smads Binding to Microtubules. Molecular Biology of the Cell 18:6, pages 2264-2273.
Crossref
Barbara SteccaChristophe MasVirginie ClementMarie ZbindenRafael Correa, Vincent Piguet, Friedrich Beermann & Ariel Ruiz i Altaba. (2007) Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways. Proceedings of the National Academy of Sciences 104:14, pages 5895-5900.
Crossref
Murielle Mimeault & Surinder K. Batra. (2007) Functions of tumorigenic and migrating cancer progenitor cells in cancer progression and metastasis and their therapeutic implications. Cancer and Metastasis Reviews 26:1, pages 203-214.
Crossref
Søren T. Christensen, Lotte B. Pedersen, Linda Schneider & Peter Satir. (2007) Sensory Cilia and Integration of Signal Transduction in Human Health and Disease. Traffic 8:2, pages 97-109.
Crossref
Jun Lu, Yumei Duan, Pinbo Liu, Xiang He, Yiping Yang, Ran Zhang & Liang Weng. (2022) Tumor-Infiltrating Myeloid Cell Subsets Correlate with Overall Survival in Lung Squamous Carcinoma. SSRN Electronic Journal.
Crossref

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