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Molecular and Cellular Biology Volume 31, 2011 - Issue 24
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Article

Regulation of MDM2 E3 Ligase Activity by Phosphorylation after DNA Damage

Qian ChengMolecular Oncology Department, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, Florida33612
,
Brittany CrossMolecular Oncology Department, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, Florida33612
,
Baozong LiMolecular Oncology Department, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, Florida33612
,
Lihong ChenMolecular Oncology Department, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, Florida33612
,
Zhenyu LiMolecular Oncology Department, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, Florida33612
&
Jiandong ChenMolecular Oncology Department, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, Florida33612Correspondence[email protected]
Pages 4951-4963 | Received 26 Apr 2011, Accepted 27 Sep 2011, Published online: 20 Mar 2023

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Leixiang Yang, Tanjing Song, Qian Cheng, Lihong Chen & Jiandong Chen. (2019) Mutant p53 Sequestration of the MDM2 Acidic Domain Inhibits E3 Ligase Activity. Molecular and Cellular Biology 39:4.
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Qian Cheng, Tanjing Song, Lihong Chen & Jiandong Chen. (2014) Autoactivation of the MDM2 E3 Ligase by Intramolecular Interaction. Molecular and Cellular Biology 34:15, pages 2800-2810.
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Shaofang Wu, Lihong Chen, Andreas Becker, Ernst Schonbrunn & Jiandong Chen. (2012) Casein Kinase 1α Regulates an MDMX Intramolecular Interaction To Stimulate p53 Binding. Molecular and Cellular Biology 32:23, pages 4821-4832.
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Siyao Deng, Tijana Vlatkovic, Moying Li, Tianzuo Zhan, Marlon R. Veldwijk & Carsten Herskind. (2022) Targeting the DNA Damage Response and DNA Repair Pathways to Enhance Radiosensitivity in Colorectal Cancer. Cancers 14:19, pages 4874.
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Heng Jiang, Jing Luo & Hetian Lei. (2022) The roles of mouse double minute 2 (MDM2) oncoprotein in ocular diseases: A review. Experimental Eye Research 217, pages 108910.
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Wen Li, Xinhao Peng, Jinyi Lang & Chuan Xu. (2020) Targeting Mouse Double Minute 2: Current Concepts in DNA Damage Repair and Therapeutic Approaches in Cancer. Frontiers in Pharmacology 11.
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Helge M. Magnussen, Syed F. Ahmed, Gary. J. Sibbet, Ventzislava A. Hristova, Koji Nomura, Andreas K. Hock, Lewis J. Archibald, Andrew G. Jamieson, David Fushman, Karen H. Vousden, Allan M. Weissman & Danny T. Huang. (2020) Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain. Nature Communications 11:1.
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Vishnu Balaji & Thorsten Hoppe. (2020) Regulation of E3 ubiquitin ligases by homotypic and heterotypic assembly. F1000Research 9, pages 88.
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Lauren E. Cowen, Hongwei Luo & Yi Tang. (2019) Characterization of SMG7 14-3-3-like domain reveals phosphoserine binding-independent regulation of p53 and UPF1. Scientific Reports 9:1.
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Fan HeWade Borcherds, Tanjing SongXi WeiMousumi DasLihong ChenGary W. Daughdrill & Jiandong Chen. (2019) Interaction between p53 N terminus and core domain regulates specific and nonspecific DNA binding. Proceedings of the National Academy of Sciences 116:18, pages 8859-8868.
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Robin Levy, Emily Gregory, Wade Borcherds & Gary Daughdrill. (2019) p53 Phosphomimetics Preserve Transient Secondary Structure but Reduce Binding to Mdm2 and MdmX. Biomolecules 9:3, pages 83.
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Mohamed Sham Shihabudeen Haider Ali, Xiao Cheng, Matthew Moran, Stefan Haemmig, Michael J Naldrett, Sophie Alvarez, Mark W Feinberg & Xinghui Sun. (2019) LncRNA Meg3 protects endothelial function by regulating the DNA damage response. Nucleic Acids Research 47:3, pages 1505-1522.
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Huili Li, Jing Zhang & Lee Niswander. (2018) Zinc deficiency causes neural tube defects through attenuation of p53 ubiquitylation. Development 145:24.
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David L. BrautiganShirish Shenolikar. (2018) Protein Serine/Threonine Phosphatases: Keys to Unlocking Regulators and Substrates. Annual Review of Biochemistry 87:1, pages 921-964.
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D F Comiskey Jr, A G Jacob, B L Sanford, M Montes, A K Goodwin, H Steiner, E Matsa, A S Tapia-Santos, T W Bebee, J Grieves, K La Perle, P Boyaka & D S Chandler. (2017) A novel mouse model of rhabdomyosarcoma underscores the dichotomy of MDM2-ALT1 function in vivo. Oncogene 37:1, pages 95-106.
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Scott Bang, Heeruk C. Bhatt, Yun Yue Chen & Manabu Kurokawa. 2018. Encyclopedia of Signaling Molecules. Encyclopedia of Signaling Molecules 3021 3028 .
Miran Rada, Mohammad Althubiti, Akang E. Ekpenyong-Akiba, Koon-Guan Lee, Kong Peng Lam, Olga Fedorova, Nickolai A. Barlev & Salvador Macip. (2017) BTK blocks the inhibitory effects of MDM2 on p53 activity. Oncotarget 8:63, pages 106639-106647.
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Paula M. Hauck, Eric R. Wolf, David J. OlivosIIIIII, Ciaran P. McAtarsney & Lindsey D. Mayo. (2017) The fate of murine double minute X (MdmX) is dictated by distinct signaling pathways through murine double minute 2 (Mdm2). Oncotarget 8:61, pages 104455-104466.
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Albert Lee, Stephanie L. Rayner, Alana De Luca, Serene S. L. Gwee, Marco Morsch, Vinod Sundaramoorthy, Hamideh Shahheydari, Audrey Ragagnin, Bingyang Shi, Shu Yang, Kelly L. Williams, Emily K. Don, Adam K. Walker, Katharine Y. Zhang, Justin J. Yerbury, Nicholas J. Cole, Julie D. Atkin, Ian P. Blair, Mark P. Molloy & Roger S. Chung. (2017) Casein kinase II phosphorylation of cyclin F at serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF (cyclin F) complex . Open Biology 7:10, pages 170058.
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Federica Bertoletti, Valentina Cea, Chih-Chao Liang, Taiba Lanati, Antonio Maffia, Mario D.M. Avarello, Lina Cipolla, Alan R. Lehmann, Martin A. Cohn & Simone Sabbioneda. (2017) Phosphorylation regulates human polη stability and damage bypass throughout the cell cycle. Nucleic Acids Research 45:16, pages 9441-9454.
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Koji Nomura, Marta Klejnot, Dominika Kowalczyk, Andreas K Hock, Gary J Sibbet, Karen H Vousden & Danny T Huang. (2017) Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity. Nature Structural & Molecular Biology 24:7, pages 578-587.
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Nicole R. Tackmann & Yanping Zhang. (2017) Mouse modelling of the MDM2/MDMX−p53 signalling axis. Journal of Molecular Cell Biology 9:1, pages 34-44.
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P L Leslie & Y Zhang. (2016) MDM2 oligomers: antagonizers of the guardian of the genome. Oncogene 35:48, pages 6157-6165.
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Michael I. Carr, Justine E. Roderick, Hugh S. Gannon, Michelle A. Kelliher & Stephen N. Jones. (2016) Mdm2 Phosphorylation Regulates Its Stability and Has Contrasting Effects on Oncogene and Radiation-Induced Tumorigenesis. Cell Reports 16:10, pages 2618-2629.
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Lionel Rougé, Travis W. Bainbridge, Michael Kwok, Raymond Tong, Paola Di Lello, Ingrid E. Wertz, Till Maurer, James A. Ernst & Jeremy Murray. (2016) Molecular Understanding of USP7 Substrate Recognition and C-Terminal Activation. Structure 24:8, pages 1335-1345.
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Hongwei Luo, Lauren Cowen, Guowu Yu, Wenguo Jiang & Yi Tang. (2016) SMG7 is a critical regulator of p53 stability and function in DNA damage stress response. Cell Discovery 2:1.
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Scott Bang, Heeruk C. Bhatt, Yun Yue Chen & Manabu Kurokawa. 2016. Encyclopedia of Signaling Molecules. Encyclopedia of Signaling Molecules 1 8 .
Digant Nayak & J. Sivaraman. (2015) Structural basis for the indispensable role of a unique zinc finger motif in LNX2 ubiquitination. Oncotarget 6:33, pages 34342-34357.
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Jiaqi Li & Manabu Kurokawa. (2015) Regulation of MDM2 Stability After DNA Damage. Journal of Cellular Physiology 230:10, pages 2318-2327.
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David W. Meek. (2015) Regulation of the p53 response and its relationship to cancer. Biochemical Journal 469:3, pages 325-346.
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Barzalobre-Gerónimo Raúl, Flores-López Luis Antonio, Baiza-Gutman Luis Arturo, Cruz Miguel, García-Macedo Rebeca, Ávalos-Rodríguez Alejandro, Contreras-Ramos Alejandra, Díaz-Flores Margarita & Ortega-Camarillo Clara. (2015) Hyperglycemia promotes p53-Mdm2 interaction but reduces p53 ubiquitination in RINm5F cells. Molecular and Cellular Biochemistry 405:1-2, pages 257-264.
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Patrick L. Leslie, Hengming Ke & Yanping Zhang. (2015) The MDM2 RING Domain and Central Acidic Domain Play Distinct Roles in MDM2 Protein Homodimerization and MDM2-MDMX Protein Heterodimerization. Journal of Biological Chemistry 290:20, pages 12941-12950.
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Irene Serrano, Yangnan Gu, Dong Qi, Ullrich Dubiella & Roger W. Innes. (2014) The Arabidopsis EDR1 Protein Kinase Negatively Regulates the ATL1 E3 Ubiquitin Ligase to Suppress Cell Death . The Plant Cell 26:11, pages 4532-4546.
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Vinod Pant & Guillermina Lozano. (2014) Limiting the power of p53 through the ubiquitin proteasome pathway. Genes & Development 28:16, pages 1739-1751.
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Andreas K. Hock & Karen H. Vousden. (2014) The role of ubiquitin modification in the regulation of p53. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1843:1, pages 137-149.
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Tongsen Zheng, Jiabei Wang, Yuhan Zhao, Cen Zhang, Meihua Lin, Xiaowen Wang, Haiyang Yu, Lianxin Liu, Zhaohui Feng & Wenwei Hu. (2013) Spliced MDM2 isoforms promote mutant p53 accumulation and gain-of-function in tumorigenesis. Nature Communications 4:1.
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Yong-Jun Shin, Kai-Yuan Chen, Ali H Sayed, Brandon Hencey & Xiling Shen. (2013) Post-translational regulation enables robust p53 regulation. BMC Systems Biology 7:1.
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Tatiana N. Moiseeva, Andrew Bottrill, Gerry Melino & Nickolai A. Barlev. (2013) DNA damage-induced ubiquitylation of proteasome controls its proteolytic activity. Oncotarget 4:9, pages 1338-1348.
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JUN CHE, YAN-WEI LU, KE-KANG SUN, CHAN FENG, AI-JING DONG & YANG JIAO. (2013) Overexpression of TOB1 confers radioprotection to bronchial epithelial cells through the MAPK/ERK pathway. Oncology Reports 30:2, pages 637-642.
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Gurpreet Kaur Dhami, Huadong Liu, Marek Galka, Courtney Voss, Ran Wei, Kimberly Muranko, Tomonori Kaneko, Sean P. Cregan, Lin Li & Shawn Shun-Cheng Li. (2013) Dynamic Methylation of Numb by Set8 Regulates Its Binding to p53 and Apoptosis. Molecular Cell 50:4, pages 565-576.
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Zengxin Lu, Guohui Wan, Huarong Guo, Xinna Zhang & Xiongbin Lu. (2013) Protein phosphatase 1 inhibits p53 signaling by dephosphorylating and stabilizing Mdmx. Cellular Signalling 25:4, pages 796-804.
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Yao-Cheng Li & Geoffrey M. Wahl. (2012) What a Difference a Phosphate Makes: Life or Death Decided by a Single Amino Acid in MDM2. Cancer Cell 21:5, pages 595-596.
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Hugh S. Gannon, Bruce A. Woda & Stephen N. Jones. (2012) ATM Phosphorylation of Mdm2 Ser394 Regulates the Amplitude and Duration of the DNA Damage Response in Mice. Cancer Cell 21:5, pages 668-679.
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