Advanced search
Publication Cover
Molecular and Cellular Biology Volume 32, 2012 - Issue 2
Submit an article Journal homepage
26
Views
18
CrossRef citations to date
0
Altmetric
Article

Hypergrowth mTORC1 Signals Translationally Activate the ARF Tumor Suppressor Checkpoint

Alexander P. MiceliBRIGHT Institute, Department of Internal Medicine, Division of Molecular Oncology, and Department of Cell Biology and Physiology, Siteman Cancer Center, Washington University School of Medicine, Saint Louis, Missouri, USA
,
Anthony J. SaporitaBRIGHT Institute, Department of Internal Medicine, Division of Molecular Oncology, and Department of Cell Biology and Physiology, Siteman Cancer Center, Washington University School of Medicine, Saint Louis, Missouri, USA
&
Jason D. WeberBRIGHT Institute, Department of Internal Medicine, Division of Molecular Oncology, and Department of Cell Biology and Physiology, Siteman Cancer Center, Washington University School of Medicine, Saint Louis, Missouri, USACorrespondence[email protected]
Pages 348-364 | Received 29 Jul 2011, Accepted 30 Oct 2011, Published online: 20 Mar 2023

Citations (18)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (4)

Tadashi Nakagawa, Takaaki Araki, Makiko Nakagawa, Atsushi Hirao, Michiaki Unno & Keiko Nakayama. (2015) S6 Kinase- and β-TrCP2-Dependent Degradation of p19Arf Is Required for Cell Proliferation. Molecular and Cellular Biology 35:20, pages 3517-3527.
Read now
Anna Budina-Kolomets, Robert D Hontz, Julia Pimkina & Maureen E Murphy. (2013) A conserved domain in exon 2 coding for the human and murine ARF tumor suppressor protein is required for autophagy induction. Autophagy 9:10, pages 1553-1565.
Read now
Hiroyuki Kawagishi, Michihiro Hashimoto, Hideaki Nakamura, Takayuki Tsugawa, Atsushi Watanabe, Dimitris L. Kontoyiannis & Masataka Sugimoto. (2013) HuR Maintains a Replicative Life Span by Repressing the ARF Tumor Suppressor. Molecular and Cellular Biology 33:10, pages 1886-1900.
Read now
Leonard B. Maggi$suffix/text()$suffix/text() & Jason D. Weber. (2013) Forget Transcription: Translation Is Where the Action Is. Molecular and Cellular Biology 33:10, pages 1884-1885.
Read now

Articles from other publishers (14)

Yanqing Liu & Wei Gu. (2022) The complexity of p53-mediated metabolic regulation in tumor suppression. Seminars in Cancer Biology 85, pages 4-32.
Crossref
Che-Pei Kung & Jason D. Weber. (2022) It’s Getting Complicated—A Fresh Look at p53-MDM2-ARF Triangle in Tumorigenesis and Cancer Therapy. Frontiers in Cell and Developmental Biology 10.
Crossref
Kyle A. Cottrell, Ryan C. Chiou & Jason D. Weber. (2020) Upregulation of 5′-terminal oligopyrimidine mRNA translation upon loss of the ARF tumor suppressor. Scientific Reports 10:1.
Crossref
Laura C Armstrong, Grant Westlake, John P Snow, Bryan Cawthon, Eric Armour, Aaron B Bowman & Kevin C Ess. (2017) Heterozygous loss of TSC2 alters p53 signaling and human stem cell reprogramming. Human Molecular Genetics 26:23, pages 4629-4641.
Crossref
Timothy J. Humpton & Karen H. Vousden. (2016) Regulation of Cellular Metabolism and Hypoxia by p53. Cold Spring Harbor Perspectives in Medicine 6:7, pages a026146.
Crossref
Aundrietta D. Duncan, Wen‐Wei Tsai & Michelle Craig Barton. 2015. Signaling Pathways in Liver Diseases. Signaling Pathways in Liver Diseases 364 373 .
Jose AramburuM. Carmen OrtellsSonia TejedorMaria BuxadéCristina López-Rodríguez. (2014) Transcriptional regulation of the stress response by mTOR. Science Signaling 7:332.
Crossref
Leonard B. MaggiJr.Jr., Crystal L. Winkeler, Alexander P. Miceli, Anthony J. Apicelli, Suzanne N. Brady, Michael J. Kuchenreuther & Jason D. Weber. (2014) ARF tumor suppression in the nucleolus. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1842:6, pages 831-839.
Crossref
Jason T. Forys, Catherine E. Kuzmicki, Anthony J. Saporita, Crystal L. Winkeler, Leonard B. MaggiJr.Jr. & Jason D. Weber. (2014) ARF and p53 Coordinate Tumor Suppression of an Oncogenic IFN-β-STAT1-ISG15 Signaling Axis. Cell Reports 7:2, pages 514-526.
Crossref
M J Kuchenreuther & J D Weber. (2013) The ARF tumor-suppressor controls Drosha translation to prevent Ras-driven transformation. Oncogene 33:3, pages 300-307.
Crossref
Jimin Shin, Jiwon Yang, Jang Choon Lee & Kwan-Hyuck Baek. (2013) Depletion of ERK2 but not ERK1 abrogates oncogenic Ras-induced senescence. Cellular Signalling 25:12, pages 2540-2547.
Crossref
Joyoti Dey, Adrian M. Dubuc, Kyle D. Pedro, Derek Thirstrup, Brig Mecham, Paul A. Northcott, Xiaochong Wu, David Shih, Stephen J. Tapscott, Michael LeBlanc, Michael D. Taylor & James M. Olson. (2013) MyoD Is a Tumor Suppressor Gene in Medulloblastoma. Cancer Research 73:22, pages 6828-6837.
Crossref
Celia R. Berkers, Oliver D.K. Maddocks, Eric C. Cheung, Inbal Mor & Karen H. Vousden. (2013) Metabolic Regulation by p53 Family Members. Cell Metabolism 18:5, pages 617-633.
Crossref
Chih-Hao Chang, Jonathan D. Curtis, Leonard B. MaggiJr.Jr., Brandon Faubert, Alejandro V. Villarino, David O’Sullivan, Stanley Ching-Cheng Huang, Gerritje J.W. van der Windt, Julianna Blagih, Jing Qiu, Jason D. Weber, Edward J. Pearce, Russell G. Jones & Erika L. Pearce. (2013) Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis. Cell 153:6, pages 1239-1251.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.