Advanced search
Publication Cover
Molecular and Cellular Biology Volume 32, 2012 - Issue 5
Submit an article Journal homepage
73
Views
55
CrossRef citations to date
0
Altmetric
Article

A Novel Feedback Loop Regulates the Response to Endoplasmic Reticulum Stress via the Cooperation of Cytoplasmic Splicing and mRNA Translation

Mithu Majumdera Departments of Nutrition, Case Western University School of Medicine, Cleveland, Ohio, USA
,
Charlie Huanga Departments of Nutrition, Case Western University School of Medicine, Cleveland, Ohio, USA
,
Martin D. Sniderb Biochemistry, Case Western University School of Medicine, Cleveland, Ohio, USA
,
Anton A. Komarc Center for Gene Regulation in Health and Disease, Department of Biological, Geological and Environmental Sciences, Cleveland State University, Cleveland, Ohio, USA
,
Junichi Tanakad Department of Science, Biology and Marine Science, University of the Ryukyus, Nishihara, Okinawa, Japan
,
Randal J. Kaufmane Center for Neuroscience, Aging, and Stem Cell Research, Sanford-Burnham Medical Research Institute, La Jolla, California, USA
,
Dawid Krokowskia Departments of Nutrition, Case Western University School of Medicine, Cleveland, Ohio, USA;f Department of Molecular Biology; Maria Curie-Skłodowska University, Lublin, Poland;g Center for RNA Molecular Biology, Case Western University School of Medicine, Cleveland, Ohio, USA
&
Maria Hatzogloua Departments of Nutrition, Case Western University School of Medicine, Cleveland, Ohio, USACorrespondence[email protected]
 show all
Pages 992-1003 | Received 05 Dec 2011, Accepted 22 Dec 2011, Published online: 20 Mar 2023

Citations (55)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (3)

Thao Thi Dang, Mi-Jeong Kim, Yoon Young Lee, Hien Thi Le, Kook Hwan Kim, Somi Nam, Seung Hwa Hyun, Hong Lim Kim, Su Wol Chung, Hun Taeg Chung, Eek-Hoon Jho, Hiderou Yoshida, Kyoungmi Kim, Chan Young Park, Myung-Shik Lee & Sung Hoon Back. (2023) Phosphorylation of EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha) is indispensable for nuclear translocation of TFEB and TFE3 during ER stress. Autophagy 19:7, pages 2111-2142.
Read now
Mridusmita Saikia, Raul Jobava, Marc Parisien, Andrea Putnam, Dawid Krokowski, Xing-Huang Gao, Bo-Jhih Guan, Yiyuan Yuan, Eckhard Jankowsky, Zhaoyang Feng, Guo-fu Hu, Marianne Pusztai-Carey, Madhavi Gorla, Naresh Babu V. Sepuri, Tao Pan & Maria Hatzoglou. (2014) Angiogenin-Cleaved tRNA Halves Interact with Cytochrome c, Protecting Cells from Apoptosis during Osmotic Stress. Molecular and Cellular Biology 34:13, pages 2450-2463.
Read now
Beth Overley-Adamson, Carol M Artlett, Connie Stephens, Sihem Sassi-Gaha, Ransome D Weis & James D Thacker. (2014) Targeting the unfolded protein response, XBP1, and the NLRP3 inflammasome in fibrosis and cancer. Cancer Biology & Therapy 15:4, pages 452-462.
Read now

Articles from other publishers (52)

Luning Sun, Boyu Yang, Zheng Peng, Tianle Yang, Bin Qin, Jieyu Ao, Yanqun Yang, Jingling Wang, Lan Zheng & Huaping Xie. (2023) Transcriptomics and Phenotypic Analysis of gpr56 Knockout in Zebrafish. International Journal of Molecular Sciences 24:9, pages 7740.
Crossref
Mohammed R. Alzahrani, Bo-Jhih Guan, Leah L. Zagore, Jing Wu, Chien-Wen Chen, Donny D. Licatalosi, Kristian E. Baker & Maria Hatzoglou. (2022) Newly synthesized mRNA escapes translational repression during the acute phase of the mammalian unfolded protein response. PLOS ONE 17:8, pages e0271695.
Crossref
Fátima Cairrão, Cristiana C. Santos, Adrien Le Thomas, Scot Marsters, Avi Ashkenazi & Pedro M. Domingos. (2022) Pumilio protects Xbp1 mRNA from regulated Ire1-dependent decay. Nature Communications 13:1.
Crossref
Tadhg O’Leary, Pauraic McCarron, Michael Devereux & Steve Meaney. (2022) Potential interactions between metal-based phenanthroline drugs and the unfolded protein response endoplasmic reticulum stress pathway. Experimental Results 3.
Crossref
Magdalena Gebert, Aleksandra Sobolewska, Sylwia Bartoszewska, Aleksandra Cabaj, David K. Crossman, Jarosław Króliczewski, Piotr Madanecki, Michał Dąbrowski, James F. Collawn & Rafal Bartoszewski. (2021) Genome-wide mRNA profiling identifies X-box-binding protein 1 (XBP1) as an IRE1 and PUMA repressor. Cellular and Molecular Life Sciences 78:21-22, pages 7061-7080.
Crossref
Daniela Ricci, Tali Gidalevitz & Yair Argon. (2021) The special unfolded protein response in plasma cells. Immunological Reviews 303:1, pages 35-51.
Crossref
Garrett Dalton Smedley, Keenan E. Walker & Shauna H. Yuan. (2021) The Role of PERK in Understanding Development of Neurodegenerative Diseases. International Journal of Molecular Sciences 22:15, pages 8146.
Crossref
Д.В. Ерёмин, Т.В. Ильчибаева & А.С. Цыбко. (2021) Дофаминовый нейротрофический фактор мозга (CDNF): структура, функции и терапевтический потенциал. Биохимия 86:7, pages 1027-1042.
Crossref
Dmitry V. Eremin, Tatiana V. Ilchibaeva & Anton S. Tsybko. (2021) Cerebral Dopamine Neurotrophic Factor (CDNF): Structure, Functions, and Therapeutic Potential. Biochemistry (Moscow) 86:7, pages 852-866.
Crossref
Rebeka Popovic, Ivana Celardo, Yizhou Yu, Ana C. Costa, Samantha H. Y. Loh & L. Miguel Martins. (2021) Combined Transcriptomic and Proteomic Analysis of Perk Toxicity Pathways. International Journal of Molecular Sciences 22:9, pages 4598.
Crossref
Heather Ballance & Bokai Zhu. (2021) Revealing the hidden reality of the mammalian 12-h ultradian rhythms. Cellular and Molecular Life Sciences 78:7, pages 3127-3140.
Crossref
Necola Guerrina, Noof Aloufi, Fangyi Shi, Kashmira Prasade, Caitlin Mehrotra, Hussein Traboulsi, Jason Matthews, David H. Eidelman, Qutayba Hamid & Carolyn J. Baglole. (2021) The aryl hydrocarbon receptor reduces LC3II expression and controls endoplasmic reticulum stress. American Journal of Physiology-Lung Cellular and Molecular Physiology 320:3, pages L339-L355.
Crossref
Irina Efimova, Inbar Steinberg, Isabel Zvibel, Anat Neumann, Dana Fernanda Mantelmacher, Daniel J. Drucker, Sigal Fishman & Chen Varol. (2021) GIPR Signaling in Immune Cells Maintains Metabolically Beneficial Type 2 Immune Responses in the White Fat From Obese Mice. Frontiers in Immunology 12.
Crossref
Samirul Bashir, Mariam Banday, Ozaira Qadri, Arif Bashir, Nazia Hilal, Nida-i-Fatima, Stephen Rader & Khalid Majid Fazili. (2021) The molecular mechanism and functional diversity of UPR signaling sensor IRE1. Life Sciences 265, pages 118740.
Crossref
Xueran Chen, Hao Li, Xiaoqing Fan, Chenggang Zhao, Kaiqin Ye, Zhiyang Zhao, Lizhu Hu, Huihui Ma, Hongzhi Wang & Zhiyou Fang. (2020) Protein Palmitoylation Regulates Cell Survival by Modulating XBP1 Activity in Glioblastoma Multiforme. Molecular Therapy - Oncolytics 17, pages 518-530.
Crossref
Thoufiqul Alam Riaz, Raghu Patil Junjappa, Mallikarjun Handigund, Jannatul Ferdous, Hyung-Ryong Kim & Han-Jung Chae. (2020) Role of Endoplasmic Reticulum Stress Sensor IRE1α in Cellular Physiology, Calcium, ROS Signaling, and Metaflammation. Cells 9:5, pages 1160.
Crossref
Mariavittoria Pizzinga, Robert F. Harvey, Gavin D. Garland, Ryan Mordue, Veronica Dezi, Manasa Ramakrishna, Aristeidis Sfakianos, Mie Monti, Thomas E. Mulroney, Tuija Poyry & Anne E. Willis. (2019) The cell stress response: extreme times call for post‐transcriptional measures. WIREs RNA 11:3.
Crossref
Yinghong Pan, Heather Ballance, Huan Meng, Naomi Gonzalez, Sam-Moon Kim, Leymaan Abdurehman, Brian York, Xi Chen, Yisrael Schnytzer, Oren Levy, Clifford C. Dacso, Colleen A. McClung, Bert W. O’Malley, Silvia Liu & Bokai Zhu. (2020) 12-h clock regulation of genetic information flow by XBP1s. PLOS Biology 18:1, pages e3000580.
Crossref
Benjamin P. Johnston & Craig McCormick. (2019) Herpesviruses and the Unfolded Protein Response. Viruses 12:1, pages 17.
Crossref
Sylwia Bartoszewska, Aleksandra Cabaj, Michał Dąbrowski, James F. Collawn & Rafal Bartoszewski. (2019) miR‐34c‐5p modulates X‐box–binding protein 1 (XBP1) expression during the adaptive phase of the unfolded protein response . The FASEB Journal 33:10, pages 11541-11554.
Crossref
Zhi Zheng, Yuxi Shang, Jiahui Tao, Jun Zhang & Bingdong Sha. (2019) Endoplasmic Reticulum Stress Signaling Pathways: Activation and Diseases. Current Protein & Peptide Science 20:9, pages 935-943.
Crossref
Rui Xu, Jia Zhou, Xian-zhi Du, Xiang-dong Zhou, Qi Li, Juliy M. Perelman & Victor P. Kolosov. (2019) The role of the XBP-1/AGR2 signaling pathway in the regulation of airway Mucin5ac hypersecretion under hypoxia. Experimental Cell Research 382:1, pages 111442.
Crossref
Nir Gonen, Niv Sabath, Christopher B. Burge & Reut Shalgi. (2019) Widespread PERK-dependent repression of ER targets in response to ER stress. Scientific Reports 9:1.
Crossref
Yasunobu Ishikawa, Sorin Fedeles, Arnaud Marlier, Chao Zhang, Anna-Rachel Gallagher, Ann-Hwee Lee & Stefan Somlo. (2019) Spliced XBP1 Rescues Renal Interstitial Inflammation Due to Loss of Sec63 in Collecting Ducts. Journal of the American Society of Nephrology 30:3, pages 443-459.
Crossref
Duxan Arancibia, Pedro Zamorano & María Estela Andrés. (2018) CDNF induces the adaptive unfolded protein response and attenuates endoplasmic reticulum stress-induced cell death. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1865:11, pages 1579-1589.
Crossref
Yu Mi Woo, Yeonui Kwak, Sim Namkoong, Katla Kristjánsdóttir, Seung Ha Lee, Jun Hee Lee & Hojoong Kwak. (2018) TED-Seq Identifies the Dynamics of Poly(A) Length during ER Stress. Cell Reports 24:13, pages 3630-3641.e7.
Crossref
Alaa Shaheen. (2018) Effect of the unfolded protein response on ER protein export: a potential new mechanism to relieve ER stress. Cell Stress and Chaperones 23:5, pages 797-806.
Crossref
Maria Tsachaki, Natasa Mladenovic, Hana Štambergové, Julia Birk & Alex Odermatt. (2018) Hexose‐6‐phosphate dehydrogenase controls cancer cell proliferation and migration through pleiotropic effects on the unfolded‐protein response, calcium homeostasis, and redox balance. The FASEB Journal 32:5, pages 2690-2705.
Crossref
Guizhen ZhaoYi FuZeyu CaiFang YuZe GongRongbo DaiYanhua HuLingfang ZengQingbo XuWei Kong. (2017) Unspliced XBP1 Confers VSMC Homeostasis and Prevents Aortic Aneurysm Formation via FoxO4 Interaction. Circulation Research 121:12, pages 1331-1345.
Crossref
Woo-Gyun Choi, Jaeseok Han, Ji-Hyeon Kim, Mi-Jeong Kim, Jae-Woo Park, Benbo Song, Hee-Jeong Cha, Hye-Seon Choi, Hun-Taeg Chung, In-Kyu Lee, Tae-Sik Park, Maria Hatzoglou, Hueng-Sik Choi, Hyun Ju Yoo, Randal J. Kaufman & Sung Hoon Back. (2017) eIF2α phosphorylation is required to prevent hepatocyte death and liver fibrosis in mice challenged with a high fructose diet. Nutrition & Metabolism 14:1.
Crossref
Bo-Jhih Guan, Vincent van Hoef, Raul Jobava, Orna Elroy-Stein, Leos S. Valasek, Marie Cargnello, Xing-Huang Gao, Dawid Krokowski, William C. Merrick, Scot R. Kimball, Anton A. Komar, Antonis E. Koromilas, Anthony Wynshaw-Boris, Ivan Topisirovic, Ola Larsson & Maria Hatzoglou. (2017) A Unique ISR Program Determines Cellular Responses to Chronic Stress. Molecular Cell 68:5, pages 885-900.e6.
Crossref
Masuko Kobori, Yumiko Takahashi, Mutsumi Sakurai, Yinhua Ni, Guanliang Chen, Mayumi Nagashimada, Shuichi Kaneko & Tsuguhito Ota. (2017) Hepatic Transcriptome Profiles of Mice with Diet-Induced Nonalcoholic Steatohepatitis Treated with Astaxanthin and Vitamin E. International Journal of Molecular Sciences 18:3, pages 593.
Crossref
Jing Gong, Xing-zhi Wang, Tao Wang, Jiao-jiao Chen, Xiao-yuan Xie, Hui Hu, Fang Yu, Hui-lin Liu, Xing-yan Jiang & Han-dong Fan. (2017) Molecular signal networks and regulating mechanisms of the unfolded protein response内质网应激的信号通路以及调控机制. Journal of Zhejiang University-SCIENCE B 18:1, pages 1-14.
Crossref
Céline PhilippeAlexandre DubracCathy QuelenAurore DesquesnesLoic Van Den BergheChristèle SéguraThomas FilleronStéphane PyronnetHervé PratsPierre BroussetChristian Touriol. (2016) PERK mediates the IRES-dependent translational activation of mRNAs encoding angiogenic growth factors after ischemic stress. Science Signaling 9:426.
Crossref
Gun West, Josef Gullmets, Laura Virtanen, Song Ping Li, Anni Keinänen, Takeshi Shimi, Monika Mauermann, Tiina Heliö, Maija Kaartinen, Laura Ollila, Johanna Kuusisto, John E. Eriksson, Robert D. Goldman, Harald Herrmann & Pekka Taimen. (2016) Deleterious assembly of mutant p.S143P lamin A/C causes ER stress in familial dilated cardiomyopathy. Journal of Cell Science.
Crossref
Kristin Moore & Julie Hollien. (2015) Ire1-mediated decay in mammalian cells relies on mRNA sequence, structure, and translational status. Molecular Biology of the Cell 26:16, pages 2873-2884.
Crossref
Liliana Matos, Alexandra Monteiro Gouveia & Henrique Almeida. (2015) ER Stress Response in Human Cellular Models of Senescence. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 70:8, pages 924-935.
Crossref
Dawid Krokowski, Raul Jobava, Bo-Jhih Guan, Kenneth Farabaugh, Jing Wu, Mithu Majumder, Massimiliano G. Bianchi, Martin D. Snider, Ovidio Bussolati & Maria Hatzoglou. (2015) Coordinated Regulation of the Neutral Amino Acid Transporter SNAT2 and the Protein Phosphatase Subunit GADD34 Promotes Adaptation to Increased Extracellular Osmolarity. Journal of Biological Chemistry 290:29, pages 17822-17837.
Crossref
Antonis E. Koromilas. (2015) Roles of the translation initiation factor eIF2α serine 51 phosphorylation in cancer formation and treatment. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1849:7, pages 871-880.
Crossref
Mithu Majumder, Daniel Mitchell, Sergei Merkulov, Jing Wu, Bo-Jhih Guan, Martin D. Snider, Dawid Krokowski, Vivien C. Yee & Maria Hatzoglou. (2015) Residues required for phosphorylation of translation initiation factor eIF2α under diverse stress conditions are divergent between yeast and human. The International Journal of Biochemistry & Cell Biology 59, pages 135-141.
Crossref
Rong WuQing-Hai ZhangYan-Ju LuKun RenGuang-Hui Yi. (2015) Involvement of the IRE1α-XBP1 Pathway and XBP1s-Dependent Transcriptional Reprogramming in Metabolic Diseases. DNA and Cell Biology 34:1, pages 6-18.
Crossref
Jennifer Jurkin, Theresa Henkel, Anne Færch Nielsen, Martina Minnich, Johannes Popow, Therese Kaufmann, Katrin Heindl, Thomas Hoffmann, Meinrad Busslinger & Javier Martinez. (2014) The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells . The EMBO Journal 33:24, pages 2922-2936.
Crossref
Xavier Palomer, Eva Capdevila-Busquets, Gerard Garreta, Mercy M. Davidson & Manuel Vázquez-Carrera. (2014) PPARα atenúa el estrés del retículo endoplasmático inducido por palmitato en células cardíacas humanas por medio de la inducción de la actividad AMPK. Clínica e Investigación en Arteriosclerosis 26:6, pages 255-267.
Crossref
Bo-Jhih Guan, Dawid Krokowski, Mithu Majumder, Christine L. Schmotzer, Scot R. Kimball, William C. Merrick, Antonis E. Koromilas & Maria Hatzoglou. (2014) Translational Control during Endoplasmic Reticulum Stress beyond Phosphorylation of the Translation Initiation Factor eIF2α. Journal of Biological Chemistry 289:18, pages 12593-12611.
Crossref
Joseph W. Brewer. (2013) Regulatory crosstalk within the mammalian unfolded protein response. Cellular and Molecular Life Sciences 71:6, pages 1067-1079.
Crossref
Robert R.H. Anholt & Mary Anna Carbone. (2013) A molecular mechanism for glaucoma: endoplasmic reticulum stress and the unfolded protein response. Trends in Molecular Medicine 19:10, pages 586-593.
Crossref
Kristin A. Moore, Joshua J. Plant, Deepika Gaddam, Jonathan Craft & Julie Hollien. (2013) Regulation of Sumo mRNA during Endoplasmic Reticulum Stress. PLoS ONE 8:9, pages e75723.
Crossref
Dawid Krokowski, Jaeseok Han, Mridusmita Saikia, Mithu Majumder, Celvie L. Yuan, Bo-Jhih Guan, Elena Bevilacqua, Ovidio Bussolati, Stefan Bröer, Peter Arvan, Marek Tchórzewski, Martin D. Snider, Michelle Puchowicz, Colleen M. Croniger, Scot R. Kimball, Tao Pan, Antonis E. Koromilas, Randal J. Kaufman & Maria Hatzoglou. (2013) A Self-defeating Anabolic Program Leads to β-Cell Apoptosis in Endoplasmic Reticulum Stress-induced Diabetes via Regulation of Amino Acid Flux. Journal of Biological Chemistry 288:24, pages 17202-17213.
Crossref
Mridusmita Saikia, Dawid Krokowski, Bo-Jhih Guan, Pavel Ivanov, Marc Parisien, Guo-fu Hu, Paul Anderson, Tao Pan & Maria Hatzoglou. (2012) Genome-wide Identification and Quantitative Analysis of Cleaved tRNA Fragments Induced by Cellular Stress. Journal of Biological Chemistry 287:51, pages 42708-42725.
Crossref
Monique Barel, Karin Meibom, Iharilalao Dubail, Joaquin Botella & Alain Charbit. (2012) Francisella tularensis regulates the expression of the amino acid transporter SLC1A5 in infected THP-1 human monocytes . Cellular Microbiology 14:11, pages 1769-1783.
Crossref
Andrew Byrd & Joseph Brewer. (2012) Intricately Regulated: A Cellular Toolbox for Fine-Tuning XBP1 Expression and Activity. Cells 1:4, pages 738-753.
Crossref
Andrew E. Byrd, Ileana V. Aragon & Joseph W. Brewer. (2012) MicroRNA-30c-2* limits expression of proadaptive factor XBP1 in the unfolded protein response. Journal of Cell Biology 196:6, pages 689-698.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.