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Research Article

A Persistent RNA-DNA Hybrid Is Formed during Transcription at a Phylogenetically Conserved Mitochondrial DNA Sequence

Baoji XuDepartment of Developmental Biology, Beckman Center, Stanford University School of Medicine, Stanford, California94305-5427
&
David A. ClaytonDepartment of Developmental Biology, Beckman Center, Stanford University School of Medicine, Stanford, California94305-5427
Pages 580-589 | Received 06 Sep 1994, Accepted 18 Oct 1994, Published online: 30 Mar 2023

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Maria Falkenberg & Claes M. Gustafsson. (2020) Mammalian mitochondrial DNA replication and mechanisms of deletion formation. Critical Reviews in Biochemistry and Molecular Biology 55:6, pages 509-524.
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Xiufeng Jin, Zhi Cheng, Bo Wang, Tung on Yau, Ze Chen, Stephen C. Barker, Defu Chen, Wenjun Bu, Daqing Sun & Shan Gao. (2020) Precise annotation of human, chimpanzee, rhesus macaque and mouse mitochondrial genomes leads to insight into mitochondrial transcription in mammals. RNA Biology 17:3, pages 395-402.
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Weidong Li, Xiao Chen, Wenai Liu, Renjie Sun & Haolang Zhou. (2016) Complete mitochondrial genome of the Yellow-spotted skate Okamejei hollandi (Rajiformes: Rajidae). Mitochondrial DNA Part A 27:4, pages 2883-2884.
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Deepankar Roy & Michael R. Lieber. (2009) G Clustering Is Important for the Initiation of Transcription-Induced R-Loops In Vitro, whereas High G Density without Clustering Is Sufficient Thereafter. Molecular and Cellular Biology 29:11, pages 3124-3133.
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Ryan A. Irvine, Noritaka Adachi, Darryl K. Shibata, Geoffrey D. Cassell, Kefei Yu, Zarir E. Karanjawala, Chih-Lin Hsieh & Michael R. Lieber. (2005) Generation and Characterization of Endonuclease G Null Mice. Molecular and Cellular Biology 25:1, pages 294-302.
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Ti Cai, Tracey R. Reilly, Michael Cerio & Mark E. Schmitt. (1999) Mutagenesis of SNM1, Which Encodes a Protein Component of the Yeast RNase MRP, Reveals a Role for This Ribonucleoprotein Endoribonuclease in Plasmid Segregation. Molecular and Cellular Biology 19:11, pages 7857-7869.
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Eric Van Dyck & David A. Clayton. (1998) Transcription-Dependent DNA Transactions in the Mitochondrial Genome of a Yeast Hypersuppressive Petite Mutant. Molecular and Cellular Biology 18:5, pages 2976-2985.
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Articles from other publishers (96)

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Christoph Freyer, Paula Clemente & Anna Wredenberg. 2018. RNA Metabolism in Mitochondria. RNA Metabolism in Mitochondria 17 46 .
Kanchanjunga Prasai, Lucy C. Robinson, Rona S. Scott, Kelly Tatchell & Lynn Harrison. (2017) Evidence for double-strand break mediated mitochondrial DNA replication in Saccharomyces cerevisiae. Nucleic Acids Research 45:13, pages 7760-7773.
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Laura J. BaileyAidan J. Doherty. (2017) Mitochondrial DNA replication: a PrimPol perspective. Biochemical Society Transactions 45:2, pages 513-529.
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Frédéric Chédin. (2016) Nascent Connections: R-Loops and Chromatin Patterning. Trends in Genetics 32:12, pages 828-838.
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Josiah T. Wagner, Florisela Herrejon Chavez & Jason E. Podrabsky. (2016) Mitochondrial DNA Sequence and Lack of Response to Anoxia in the Annual Killifish Austrofundulus limnaeus. Frontiers in Physiology 7.
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Inge KühlMaria MirandaViktor PosseDusanka MilenkovicArnaud MourierStefan J. Siira, Nina A. BonekampUlla NeumannAleksandra FilipovskaPaola Loguercio PolosaClaes M. GustafssonNils-Göran Larsson. (2016) POLRMT regulates the switch between replication primer formation and gene expression of mammalian mtDNA. Science Advances 2:8.
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Aparna Ramachandran, Divya Nandakumar, Aishwarya P. Deshpande, Thomas P. Lucas, Ramanagouda R-Bhojappa, Guo-Qing Tang, Kevin Raney, Y. Whitney Yin & Smita S. Patel. (2016) The Yeast Mitochondrial RNA Polymerase and Transcription Factor Complex Catalyzes Efficient Priming of DNA Synthesis on Single-stranded DNA. Journal of Biological Chemistry 291:32, pages 16828-16839.
Crossref
Claes M. GustafssonMaria FalkenbergNils-Göran Larsson. (2016) Maintenance and Expression of Mammalian Mitochondrial DNA. Annual Review of Biochemistry 85:1, pages 133-160.
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I. O. Mazunin, S. A. Levitskii, M. V. Patrushev & P. A. Kamenski. (2015) Mitochondrial matrix processes. Biochemistry (Moscow) 80:11, pages 1418-1428.
Crossref
Elisabeth Jemt, Örjan Persson, Yonghong Shi, Majda Mehmedovic, Jay P. Uhler, Marcela Dávila López, Christoph Freyer, Claes M. Gustafsson, Tore Samuelsson & Maria Falkenberg. (2015) Regulation of DNA replication at the end of the mitochondrial D-loop involves the helicase TWINKLE and a conserved sequence element. Nucleic Acids Research 43:19, pages 9262-9275.
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Eugenia Sanchez-Sandoval, Corina Diaz-Quezada, Gilberto Velazquez, Luis F. Arroyo-Navarro, Norineli Almanza-Martinez, Carlos H. Trasviña-Arenas & Luis G. Brieba. (2015) Yeast mitochondrial RNA polymerase primes mitochondrial DNA polymerase at origins of replication and promoter sequences. Mitochondrion 24, pages 22-31.
Crossref
Viktor Posse, Saba Shahzad, Maria Falkenberg, B. Martin Hällberg & Claes M. Gustafsson. (2015) TEFM is a potent stimulator of mitochondrial transcription elongation in vitro. Nucleic Acids Research 43:5, pages 2615-2624.
Crossref
David J. Spector. (2015) UL84-independent replication of human cytomegalovirus strains conferred by a single codon change in UL122. Virology 476, pages 345-354.
Crossref
Javier Miralles Fusté, Yonghong Shi, Sjoerd Wanrooij, Xuefeng Zhu, Elisabeth Jemt, Örjan Persson, Nasim Sabouri, Claes M. Gustafsson & Maria Falkenberg. (2014) In Vivo Occupancy of Mitochondrial Single-Stranded DNA Binding Protein Supports the Strand Displacement Mode of DNA Replication. PLoS Genetics 10:12, pages e1004832.
Crossref
Sanjay Kumar Bharti, Joshua A. Sommers, Jun Zhou, Daniel L. Kaplan, Johannes N. Spelbrink, Jean-Louis Mergny & Robert M. BroshJr.Jr.. (2014) DNA Sequences Proximal to Human Mitochondrial DNA Deletion Breakpoints Prevalent in Human Disease Form G-quadruplexes, a Class of DNA Structures Inefficiently Unwound by the Mitochondrial Replicative Twinkle Helicase. Journal of Biological Chemistry 289:43, pages 29975-29993.
Crossref
Miguel M. Fonseca, D. James Harris & David Posada. (2014) The Inversion of the Control Region in Three Mitogenomes Provides Further Evidence for an Asymmetric Model of Vertebrate mtDNA Replication. PLoS ONE 9:9, pages e106654.
Crossref
Ke-wei Zheng, Ren-yi Wu, Yi-de He, Shan Xiao, Jia-yu Zhang, Jia-quan Liu, Yu-hua Hao & Zheng Tan. (2014) A competitive formation of DNA:RNA hybrid G-quadruplex is responsible to the mitochondrial transcription termination at the DNA replication priming site. Nucleic Acids Research 42:16, pages 10832-10844.
Crossref
Kaalak Reddy, Monika H.M. Schmidt, Jaimie M. Geist, Neha P. Thakkar, Gagan B. Panigrahi, Yuh-Hwa Wang & Christopher E. Pearson. (2014) Processing of double-R-loops in (CAG)·(CTG) and C9orf72 (GGGGCC)·(GGCCCC) repeats causes instability. Nucleic Acids Research 42:16, pages 10473-10487.
Crossref
Meng Cheng, Zhanjun Guo, Haiping Li, Zheng Li, Chunxiao Li & Cuizhi Geng. (2014) Identification of sequence polymorphisms in the mitochondrial displacement loop as risk factors for sporadic and familial breast cancer. Tumor Biology 35:5, pages 4773-4777.
Crossref
Jia-yu Zhang, Ke-wei Zheng, Shan Xiao, Yu-hua Hao & Zheng Tan. (2014) Mechanism and Manipulation of DNA:RNA Hybrid G-Quadruplex Formation in Transcription of G-Rich DNA. Journal of the American Chemical Society 136:4, pages 1381-1390.
Crossref
Boris P. Belotserkovskii, Sergei M. Mirkin & Philip C. Hanawalt. (2013) DNA Sequences That Interfere with Transcription: Implications for Genome Function and Stability. Chemical Reviews 113:11, pages 8620-8637.
Crossref
Hallie Wimberly, Chandan Shee, P. C. Thornton, Priya Sivaramakrishnan, Susan M. Rosenberg & P. J. Hastings. (2013) R-loops and nicks initiate DNA breakage and genome instability in non-growing Escherichia coli. Nature Communications 4:1.
Crossref
Man Yu, Yanfang Wan & Qinghua Zou. (2013) Reduced mitochondrial DNA copy number in Chinese patients with osteosarcoma. Translational Research 161:3, pages 165-171.
Crossref
P. H. Wanrooij, J. P. Uhler, Y. Shi, F. Westerlund, M. Falkenberg & C. M. Gustafsson. (2012) A hybrid G-quadruplex structure formed between RNA and DNA explains the extraordinary stability of the mitochondrial R-loop. Nucleic Acids Research 40:20, pages 10334-10344.
Crossref
Xuning Emily Guo, Chi-Fen Chen, Dennis Ding-Hwa Wang, Aram Sandaldjian Modrek, Vy Hoai Phan, Wen-Hwa Lee & Phang-Lang Chen. (2011) Uncoupling the Roles of the SUV3 Helicase in Maintenance of Mitochondrial Genome Stability and RNA Degradation. Journal of Biological Chemistry 286:44, pages 38783-38794.
Crossref
Andrew J. Rennekamp & Paul M. Lieberman. (2011) Initiation of Epstein-Barr Virus Lytic Replication Requires Transcription and the Formation of a Stable RNA-DNA Hybrid Molecule at OriLyt. Journal of Virology 85:6, pages 2837-2850.
Crossref
Kaalak Reddy, Mandy Tam, Richard P. Bowater, Miriam Barber, Matthew Tomlinson, Kerrie Nichol Edamura, Yuh-Hwa Wang & Christopher E. Pearson. (2011) Determinants of R-loop formation at convergent bidirectionally transcribed trinucleotide repeats. Nucleic Acids Research 39:5, pages 1749-1762.
Crossref
Ruixing Zhang, Fengbin Zhang, Cuiju Wang, Shunxiang Wang, Yih-Horng Shiao & Zhanjun Guo. (2010) Identification of sequence polymorphism in the D-Loop region of mitochondrial DNA as a risk factor for hepatocellular carcinoma with distinct etiology. Journal of Experimental & Clinical Cancer Research 29:1.
Crossref
Paulina H. Wanrooij, Jay P. UhlerTomas SimonssonMaria Falkenberg & Claes M. Gustafsson. (2010) G-quadruplex structures in RNA stimulate mitochondrial transcription termination and primer formation. Proceedings of the National Academy of Sciences 107:37, pages 16072-16077.
Crossref
Joachim M. Gerhold, Anu Aun, Tiina Sedman, Priit Jõers & Juhan Sedman. (2010) Strand Invasion Structures in the Inverted Repeat of Candida albicans Mitochondrial DNA Reveal a Role for Homologous Recombination in Replication. Molecular Cell 39:6, pages 851-861.
Crossref
Man Yu, Yanfang Wan & Qinghua Zou. (2010) Decreased copy number of mitochondrial DNA in Ewing's sarcoma. Clinica Chimica Acta 411:9-10, pages 679-683.
Crossref
George E. Parris. (2010) Developmental diseases and the hypothetical Master Development Program. Medical Hypotheses 74:3, pages 564-573.
Crossref
Javier Miralles Fusté, Sjoerd Wanrooij, Elisabeth Jemt, Caroline E. Granycome, Tricia J. Cluett, Yonghong Shi, Neli Atanassova, Ian J. Holt, Claes M. Gustafsson & Maria Falkenberg. (2010) Mitochondrial RNA Polymerase Is Needed for Activation of the Origin of Light-Strand DNA Replication. Molecular Cell 37:1, pages 67-78.
Crossref
Jin-Bor Chen, Tsu-Kung Lin, Shang-Chih Liao, Wen-Chin Lee, Lung-Chih Lee, Chia-Wei Liou, Pei-Wen Wang & Mao-Meng Tiao. (2009) Lack of association between mutations of gene-encoding mitochondrial D310 (displacement loop) mononucleotide repeat and oxidative stress in chronic dialysis patients in Taiwan. Journal of Negative Results in BioMedicine 8:1.
Crossref
J. M. Facucho-Oliveira & J. C. St. John. (2009) The Relationship Between Pluripotency and Mitochondrial DNA Proliferation During Early Embryo Development and Embryonic Stem Cell Differentiation. Stem Cell Reviews and Reports 5:2, pages 140-158.
Crossref
George E. Parris. (2009) A hypothetical Master Development Program for multi-cellular organisms: Ontogeny and phylogeny. Bioscience Hypotheses 2:1, pages 3-12.
Crossref
Timothy A. Brown, Ariana N. Tkachuk & David A. Clayton. (2008) Native R-loops Persist throughout the Mouse Mitochondrial DNA Genome. Journal of Biological Chemistry 283:52, pages 36743-36751.
Crossref
Wendy K. Pogozelski, Leah D. Fletcher, Carolyn A. Cassar, David A. Dunn, Ian A. Trounce & Carl A. Pinkert. (2008) The mitochondrial genome sequence of Mus terricolor: Comparison with Mus musculus domesticus and implications for xenomitochondrial mouse modeling. Gene 418:1-2, pages 27-33.
Crossref
Joao M. Facucho-Oliveira, Jon Alderson, Emma C. Spikings, Stuart Egginton & Justin C. St. John. (2007) Mitochondrial DNA replication during differentiation of murine embryonic stem cells. Journal of Cell Science 120:22, pages 4025-4034.
Crossref
Maria FalkenbergNils-Göran LarssonClaes M. Gustafsson. (2007) DNA Replication and Transcription in Mammalian Mitochondria. Annual Review of Biochemistry 76:1, pages 679-699.
Crossref
A.J. Harvey, T.C. Gibson, T.M. Quebedeaux & C.A. Brenner. 2007. The Mitochondrion in the Germline and Early Development. The Mitochondrion in the Germline and Early Development 229 249 .
R. C. Scarpulla. 2007. Handbook of Neurochemistry and Molecular Neurobiology. Handbook of Neurochemistry and Molecular Neurobiology 789 811 .
Nicholas D. Bonawitz, David A. Clayton & Gerald S. Shadel. (2006) Initiation and Beyond: Multiple Functions of the Human Mitochondrial Transcription Machinery. Molecular Cell 24:6, pages 813-825.
Crossref
E.C. Spikings, J. Alderson & J.C.St. John. (2006) Transmission of mitochondrial DNA following assisted reproduction and nuclear transfer. Human Reproduction Update 12:4, pages 401-415.
Crossref
Xuan Hoi Pham, Géraldine Farge, Yonghong Shi, Martina Gaspari, Claes M. Gustafsson & Maria Falkenberg. (2006) Conserved Sequence Box II Directs Transcription Termination and Primer Formation in Mitochondria. Journal of Biological Chemistry 281:34, pages 24647-24652.
Crossref
Marc Drolet. (2006) Growth inhibition mediated by excess negative supercoiling: the interplay between transcription elongation, R-loop formation and DNA topology. Molecular Microbiology 59:3, pages 723-730.
Crossref
Maria A. Graziewicz, Matthew J. Longley & William C. Copeland. (2005) DNA Polymerase γ in Mitochondrial DNA Replication and Repair. Chemical Reviews 106:2, pages 383-405.
Crossref
Valdemar Máximo, Jorge Lima, Paula Soares, Tiago Botelho, Lígia Gomes & Manuel Sobrinho-Simões. (2005) Mitochondrial D-Loop instability in thyroid tumours is not a marker of malignancy. Mitochondrion 5:5, pages 333-340.
Crossref
Yue Wang, Vincent W.S. Liu, Wei-Cheng Xue, Percy C.K. Tsang, Annie N.Y. Cheung & Hextan Y.S. Ngan. (2005) The increase of mitochondrial DNA content in endometrial adenocarcinoma cells: A quantitative study using laser-captured microdissected tissues. Gynecologic Oncology 98:1, pages 104-110.
Crossref
YUE WANG, VINCENT W.S. LIU, HEXTAN Y.S. NGAN & PHILLIP NAGLEY. (2005) Frequent Occurrence of Mitochondrial Microsatellite Instability in the D-Loop Region of Human Cancers. Annals of the New York Academy of Sciences 1042:1, pages 123-129.
Crossref
Richard C. Scarpulla. 2005. Oxidative Phosphorylation in Health and Disease. Oxidative Phosphorylation in Health and Disease 28 42 .
Michelle L. Duquette, Priya Handa, Jack A. Vincent, Andrew F. Taylor & Nancy Maizels. (2004) Intracellular transcription of G-rich DNAs induces formation of G-loops, novel structures containing G4 DNA. Genes & Development 18:13, pages 1618-1629.
Crossref
Jozef Nosek & Ľubomír Tomáška. (2003) Mitochondrial genome diversity: evolution of the molecular architecture and replication strategy. Current Genetics 44:2, pages 73-84.
Crossref
Montserrat Sánchez-Céspedes. (2003) Mitochondrial DNA alterations in human tumorsAlteraciones en el ADN mitocondrial de tumores humanos. Revista de Oncología 5:1, pages 15-20.
Crossref
Veena VijayanathanThresia ThomasLeonard H. SigalT.J. Thomas. (2002) Direct Measurement of the Association Constant of HER2/ neu Antisense Oligonucleotide to Its Target RNA Sequence Using a Molecular Beacon . Antisense and Nucleic Acid Drug Development 12:4, pages 225-233.
Crossref
Xiao Ming Zuo, G Desmond Clark-Walker & Xin Jie Chen. (2002) The Mitochondrial Nucleoid Protein, Mgm101p, of Saccharomyces cerevisiae Is Involved in the Maintenance of ρ+ and ori/rep -Devoid Petite Genomes but Is Not Required for Hypersuppressive ρ− mtDNA . Genetics 160:4, pages 1389-1400.
Crossref
Tetsuji Ohno, Shuyo Umeda, Naotaka Hamasaki & Dongchon Kang. (2000) Binding of Human Mitochondrial Transcription Factor A, an HMG Box Protein, to a Four-Way DNA Junction. Biochemical and Biophysical Research Communications 271:2, pages 492-498.
Crossref
Nicolas Lecrenier & Francoise Foury. (2000) New features of mitochondrial DNA replication system in yeast and man. Gene 246:1-2, pages 37-48.
Crossref
Gerald S. Shadel. (1999) Yeast as a Model for Human mtDNA Replication. The American Journal of Human Genetics 65:5, pages 1230-1237.
Crossref
Yuanhong Wang & Gerald S. Shadel. (1999) Stability of the mitochondrial genome requires an amino-terminal domain of yeast mitochondrial RNA polymerase. Proceedings of the National Academy of Sciences 96:14, pages 8046-8051.
Crossref
Yoichiro Kai, Kenichi Miyako, Tsuyoshi Muta, Shuyo Umeda, Takashi Irie, Naotaka Hamasaki, Koichiro Takeshige & Dongchon Kang. (1999) Mitochondrial DNA replication in human T lymphocytes is regulated primarily at the H-strand termination site. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1446:1-2, pages 126-134.
Crossref
Vijaya Gopal, Luis G Brieba, Richard Guajardo, William T McAllister & Rui Sousa. (1999) Characterization of structural features important for T7 RNAP elongation complex stability reveals competing complex conformations and a role for the non-template strand in RNA displacement. Journal of Molecular Biology 290:2, pages 411-431.
Crossref
Takashi Ohsato, Tsuyoshi Muta, Atsushi Fukuoh, Hideo Shinagawa, Naotaka Hamasaki & Dongchon Kang. (1999) R-Loop in the Replication Origin of Human Mitochondrial DNA Is Resolved by RecG, a Holliday Junction-Specific Helicase. Biochemical and Biophysical Research Communications 255:1, pages 1-5.
Crossref
Kenichi Miyako, Takashi Irie, Tsuyoshi Muta, Shuyo Umeda, Yoichiro Kai, Toshiyuki Fujiwara, Koichiro Takeshige & Dongchon Kang. (1999) 1-Methyl-4-phenylpyridinium ion (MPP + ) selectively inhibits the replication of mitochondrial DNA . European Journal of Biochemistry 259:1-2, pages 412-418.
Crossref
Katharina Hein, Matthias G.O. Lorenz, Gregor Siebenkotten, Katja Petry, Rainer Christine & Andreas Radbruch. (1998) Processing of Switch Transcripts Is Required for Targeting of Antibody Class Switch Recombination. Journal of Experimental Medicine 188:12, pages 2369-2374.
Crossref
Daniel Y. Lee & David A. Clayton. (1998) Initiation of Mitochondrial DNA Replication by Transcription and R-loop Processing. Journal of Biological Chemistry 273:46, pages 30614-30621.
Crossref
Claude Bruand & S. Dusko Ehrlich. (1998) Transcription-driven DNA replication of plasmid pAMβ1 in Bacillus subtilis . Molecular Microbiology 30:1, pages 135-145.
Crossref
Mark N. Prichard, Sanju Jairath, Mark E. T. PenfoldStephen St. Jeor, Marlene C. Bohlman & Gregory S. Pari. (1998) Identification of Persistent RNA-DNA Hybrid Structures within the Origin of Replication of Human Cytomegalovirus. Journal of Virology 72:9, pages 6997-7004.
Crossref
Lesley Kenyon & Carlos T. Moraes. (1997) Expanding the functional human mitochondrial DNA database by the establishment of primate xenomitochondrial cybrids. Proceedings of the National Academy of Sciences 94:17, pages 9131-9135.
Crossref
Gerald S. Shadel & David A. Clayton. (1997) MITOCHONDRIAL DNA MAINTENANCE IN VERTEBRATES. Annual Review of Biochemistry 66:1, pages 409-435.
Crossref
Dongchon Kang, Kenichi Miyako, Yoichiro Kai, Takashi Irie & Koichiro Takeshige. (1997) In Vivo Determination of Replication Origins of Human Mitochondrial DNA by Ligation-mediated Polymerase Chain Reaction. Journal of Biological Chemistry 272:24, pages 15275-15279.
Crossref
Eric Massé, Pauline Phoenix & Marc Drolet. (1997) DNA Topoisomerases Regulate R-loop Formation during Transcription of the rrnB Operon in Escherichia coli. Journal of Biological Chemistry 272:19, pages 12816-12823.
Crossref
D Y Lee & D A Clayton. (1997) RNase mitochondrial RNA processing correctly cleaves a novel R loop at the mitochondrial DNA leading-strand origin of replication.. Genes & Development 11:5, pages 582-592.
Crossref
Kelly Carles-Kinch & Kenneth N Kreuzer. (1997) RNA-DNA hybrid formation at a bacteriophage T4 replication origin. Journal of Molecular Biology 266:5, pages 915-926.
Crossref
Daniel Y. Lee & David A. Clayton. (1996) Properties of a Primer RNA-DNA Hybrid at the Mouse Mitochondrial DNA Leading-strand Origin of Replication. Journal of Biological Chemistry 271:39, pages 24262-24269.
Crossref
L HuangY ZhuD G Anders. (1996) The variable 3' ends of a human cytomegalovirus oriLyt transcript (SRT) overlap an essential, conserved replicator element. Journal of Virology 70:8, pages 5272-5281.
Crossref
S. Jeong‐Yu & D. A. Clayton. (1996) Regulation and function of the mitochondrial genome. Journal of Inherited Metabolic Disease 19:4, pages 443-451.
Crossref
Janet Stavnezer. 1996. 79 146 .
Tracey H. Reilly & Mark E. Schmitt. (1996) The yeast,Saccharomyces cerevisiae, RNase P/MRP ribonucleoprotein endoribonuclease family. Molecular Biology Reports 22:2-3, pages 87-93.
Crossref
Janet L. Paluh & David A. Clayton. (1995) Schizosaccharomyces pombe RNase MRP RNA is homologous to metazoan RNase MRP RNAs and may provide clues to interrelationships between RNase MRP and RNase P. Yeast 11:13, pages 1249-1264.
Crossref
Stefan Binder, Frank Hatzack & Axel Brennicke. (1995) A Novel Pea Mitochondrial in Vitro Transcription System Recognizes Homologous and Heterologous mRNA and tRNA Promoters. Journal of Biological Chemistry 270:38, pages 22182-22189.
Crossref
Lilyann Novak Frazer & David Moore. (1995) One stop mycology. Mycological Research 99:7, pages 887-896.
Crossref

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