Advanced search
Publication Cover
Molecular and Cellular Biology Volume 15, 1995 - Issue 6
Submit an article Journal homepage
8
Views
163
CrossRef citations to date
0
Altmetric
Research Article

14-3-3 Is Not Essential for Raf-1 Function: Identification of Raf-1 Proteins That Are Biologically Activated in a 14-3-3- and Ras-Independent Manner

Neil R. MichaudMolecular Mechanisms of Carcinogenesis Laboratory, ABL-Basic Research Program, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland21702-1201
,
John R. FabianMolecular Mechanisms of Carcinogenesis Laboratory, ABL-Basic Research Program, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland21702-1201
,
Karen D. MathesMolecular Mechanisms of Carcinogenesis Laboratory, ABL-Basic Research Program, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland21702-1201
&
Deborah K. MorrisonMolecular Mechanisms of Carcinogenesis Laboratory, ABL-Basic Research Program, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland21702-1201
Pages 3390-3397 | Received 30 Jan 1995, Accepted 30 Mar 1995, Published online: 30 Mar 2023

Citations (163)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (10)

Yvonne Light, Hugh Paterson & Richard Marais. (2002) 14-3-3 Antagonizes Ras-Mediated Raf-1 Recruitment to the Plasma Membrane To Maintain Signaling Fidelity. Molecular and Cellular Biology 22:14, pages 4984-4996.
Read now
Amardeep S. Dhillon, Claire Pollock, Helge Steen, Peter E. Shaw, Harald Mischak & Walter Kolch. (2002) Cyclic AMP-Dependent Kinase Regulates Raf-1 Kinase Mainly by Phosphorylation of Serine 259. Molecular and Cellular Biology 22:10, pages 3237-3246.
Read now
Paul Shapiro. (2002) Ras-MAP Kinase Signaling Pathways and Control of Cell Proliferation: Relevance to Cancer Therapy. Critical Reviews in Clinical Laboratory Sciences 39:4-5, pages 285-330.
Read now
Tomoyo Okada, Chang-Deng Hu, Tai-Guang Jin, Ken-ichi Kariya, Yuriko Yamawaki-Kataoka & Tohru Kataoka. (1999) The Strength of Interaction at the Raf Cysteine-Rich Domain Is a Critical Determinant of Response of Raf to Ras Family Small GTPases. Molecular and Cellular Biology 19:9, pages 6057-6064.
Read now
Martina Daub, Johannes Jöckel, Thomas Quack, Christoph K. Weber, Frank Schmitz, Ulf R. Rapp, Alfred Wittinghofer & Christoph Block. (1998) The RafC1 Cysteine-Rich Domain Contains Multiple Distinct Regulatory Epitopes Which Control Ras-Dependent Raf Activation. Molecular and Cellular Biology 18:11, pages 6698-6710.
Read now
John A. Thorson, Lily W. K. Yu, Alice L. Hsu, Neng-Yao Shih, Paul R. Graves, J. William Tanner, Paul M. Allen, Helen Piwnica-Worms & Andrey S. Shaw. (1998) 14-3-3 Proteins Are Required for Maintenance of Raf-1 Phosphorylation and Kinase Activity. Molecular and Cellular Biology 18:9, pages 5229-5238.
Read now
Sandrine Roy, Robert A. McPherson, Ann Apolloni, Jun Yan, Annette Lane, Jodi Clyde-Smith & John F. Hancock. (1998) 14-3-3 Facilitates Ras-Dependent Raf-1 Activation In Vitro and In Vivo. Molecular and Cellular Biology 18:7, pages 3947-3955.
Read now
Nahum Meller, Yun-Cai Liu, Tassie L. Collins, Nathalie Bonnefoy-Bérard, Gottfried Baier, Noah Isakov & Amnon Altman. (1996) Direct Interaction between Protein Kinase Cθ (PKCθ) and 14-3-3τ in T Cells: 14-3-3 Overexpression Results in Inhibition of PKCθ Translocation and Function†. Molecular and Cellular Biology 16:10, pages 5782-5791.
Read now
Harald Mischak, Thomas Seitz, Petra Janosch, Manfred Eulitz, Helge Steen, Miriam Schellerer, Alex Philipp & Walter Kolch. (1996) Negative Regulation of Raf-1 by Phosphorylation of Serine 621. Molecular and Cellular Biology 16:10, pages 5409-5418.
Read now
Tomas Jelinek, Paul Dent, Thomas W. Sturgill & Michael J. Weber. (1996) Ras-Induced Activation of Raf-1 Is Dependent on Tyrosine Phosphorylation. Molecular and Cellular Biology 16:3, pages 1027-1034.
Read now

Articles from other publishers (153)

Kenji Okamoto & Yasushi Sako. (2023) Two Closed Conformations of CRAF Require the 14-3-3 Binding Motifs and Cysteine-Rich Domain to be Intact in Live Cells. Journal of Molecular Biology 435:6, pages 167989.
Crossref
Hossam Moustafa Darrag, Hani Taher Almuhanna, Emadaldeen Hamad Hakami & Sameer M. Alhojaily. (2022) Analysis of Volatile Secondary Metabolites in Ocimum basilicum Cell Suspensions: Inhibition, In Silico Molecular Docking, and an ADMET Analysis against Proteolytic Enzymes of Rhynchophorus ferrugineus. Plants 11:21, pages 2949.
Crossref
Jingtong Zhao & Zhijun Luo. (2022) Discovery of Raf Family Is a Milestone in Deciphering the Ras-Mediated Intracellular Signaling Pathway. International Journal of Molecular Sciences 23:9, pages 5158.
Crossref
Hossam Moustafa Darrag, Hani Taher Almuhanna & Emadaldeen Hamad Hakami. (2022) Secondary Metabolites in Basil, Bio-Insecticide, Inhibition Effect, and In Silico Molecular Docking against Proteolytic Enzymes of the Red Palm Weevil (Rhynchophorus ferrugineus). Plants 11:8, pages 1087.
Crossref
E. Giusto, T. A. Yacoubian, E. Greggio & L. Civiero. (2021) Pathways to Parkinson’s disease: a spotlight on 14-3-3 proteins. npj Parkinson's Disease 7:1.
Crossref
Mingzhen Zhang, Hyunbum Jang, Zhigang Li, David B. Sacks & Ruth Nussinov. (2021) B-Raf autoinhibition in the presence and absence of 14-3-3. Structure 29:7, pages 768-777.e2.
Crossref
Hossam Moustafa Darrag, Mohammed Refdan Alhajhoj & Hany Ezzat Khalil. (2021) Bio-Insecticide of Thymus vulgaris and Ocimum basilicum Extract from Cell Suspensions and Their Inhibitory Effect against Serine, Cysteine, and Metalloproteinases of the Red Palm Weevil (Rhynchophorus ferrugineus). Insects 12:5, pages 405.
Crossref
Mingzhen Zhang, Hyunbum Jang & Ruth Nussinov. (2021) PI3K Driver Mutations: A Biophysical Membrane-Centric Perspective. Cancer Research 81:2, pages 237-247.
Crossref
Özge Karayel, Peng Xu, Isabell Bludau, Senthil Velan Bhoopalan, Yu Yao, Freitas Colaco Ana Rita, Alberto Santos, Brenda A Schulman, Arno F Alpi, Mitchell J Weiss & Matthias Mann. (2020) Integrative proteomics reveals principles of dynamic phosphosignaling networks in human erythropoiesis. Molecular Systems Biology 16:12.
Crossref
Kenji Okamoto, Kayo Hibino & Yasushi Sako. (2020) In-cell single-molecule FRET measurements reveal three conformational state changes in RAF protein. Biochimica et Biophysica Acta (BBA) - General Subjects 1864:2, pages 129358.
Crossref
Eunyoung Park, Shaun Rawson, Kunhua Li, Byeong-Won Kim, Scott B. Ficarro, Gonzalo Gonzalez-Del Pino, Humayun Sharif, Jarrod A. Marto, Hyesung Jeon & Michael J. Eck. (2019) Architecture of autoinhibited and active BRAF–MEK1–14-3-3 complexes. Nature 575:7783, pages 545-550.
Crossref
Ruth Nussinov, Chung-Jung Tsai & Hyunbum Jang. (2019) Does Ras Activate Raf and PI3K Allosterically?. Frontiers in Oncology 9.
Crossref
Elizabeth M. Terrell & Deborah K. Morrison. (2019) Ras-Mediated Activation of the Raf Family Kinases. Cold Spring Harbor Perspectives in Medicine 9:1, pages a033746.
Crossref
Ruth Nussinov, Mingzhen Zhang, Chung-Jung Tsai, Tsung-Jen Liao, David Fushman & Hyunbum Jang. (2018) Autoinhibition in Ras effectors Raf, PI3Kα, and RASSF5: a comprehensive review underscoring the challenges in pharmacological intervention. Biophysical Reviews 10:5, pages 1263-1282.
Crossref
Liang Chen, Wei Bing Leng, De Zhi Li, Hong Wei Xia, Min Ren, Qiu Lin Tang, Qi Yong Gong, Fa Bao Gao & Feng Bi. (2017) Noninvasive Imaging of Ras Activity by Monomolecular Biosensor Based on Split-Luciferase Complementary Assay. Scientific Reports 7:1.
Crossref
Ping Wee & Zhixiang Wang. (2017) Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways. Cancers 9:5, pages 52.
Crossref
Anirban Ghosh, Bhisma Narayan Ratha, Nilanjan Gayen, Kamal H. Mroue, Rajiv K. Kar, Atin K. Mandal & Anirban Bhunia. (2015) Biophysical Characterization of Essential Phosphorylation at the Flexible C-Terminal Region of C-Raf with 14-3-3ζ Protein. PLOS ONE 10:8, pages e0135976.
Crossref
Hugo Lavoie & Marc Therrien. (2015) Regulation of RAF protein kinases in ERK signalling. Nature Reviews Molecular Cell Biology 16:5, pages 281-298.
Crossref
Su An, Yang Yang, Richard Ward, Ying Liu, Xiao-Xi Guo & Tian-Rui Xu. (2015) Raf-interactome in tuning the complexity and diversity of Raf function. FEBS Journal 282:1, pages 32-53.
Crossref
D Liu, Y Huang, D Bu, A D Liu, L Holmberg, Y Jia, C Tang, J Du & H Jin. (2014) Sulfur dioxide inhibits vascular smooth muscle cell proliferation via suppressing the Erk/MAP kinase pathway mediated by cAMP/PKA signaling. Cell Death & Disease 5:5, pages e1251-e1251.
Crossref
Niko Hensel, Inga Stockbrügger, Sebastian Rademacher, Natasha Broughton, Hella Brinkmann, Claudia Grothe & Peter Claus. (2014) Bilateral crosstalk of rho- and extracellular-signal-regulated-kinase (ERK) pathways is confined to an unidirectional mode in spinal muscular atrophy (SMA). Cellular Signalling 26:3, pages 540-548.
Crossref
Alexandra K. Gardino & Michael B. Yaffe. 2015. Molecular Oncology. Molecular Oncology 293 304 .
H H Choi, C Gully, C-H Su, G Velazquez-Torres, P-C Chou, C Tseng, R Zhao, L Phan, T Shaiken, J Chen, S C Yeung & M-H Lee. (2011) COP9 signalosome subunit 6 stabilizes COP1, which functions as an E3 ubiquitin ligase for 14-3-3σ. Oncogene 30:48, pages 4791-4801.
Crossref
Jing ZhaoYuhong DuJohn R. Horton, Anup K. Upadhyay, Bin LouYan BaiXing Zhang, Lupei DuMinyong LiBinghe WangLixin Zhang, Joseph T. Barbieri, Fadlo R. KhuriXiaodong Cheng & Haian Fu. (2011) Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor. Proceedings of the National Academy of Sciences 108:39, pages 16212-16216.
Crossref
Chun-Hui Su, Ruiying Zhao, Fanmao Zhang, Changju Qu, Bo Chen, Yin-Hsun Feng, Liem Phan, Jian Chen, Hua Wang, Huamin Wang, Sai-Ching J. Yeung & Mong-Hong Lee. (2011) 14-3-3σ Exerts Tumor-Suppressor Activity Mediated by Regulation of COP1 Stability. Cancer Research 71:3, pages 884-894.
Crossref
Juan J. Bonfiglio, Giuseppina Maccarrone, Christiane Rewerts, Florian Holsboer, Eduardo Arzt, Christoph W. Turck & Susana Silberstein. (2011) Characterization of the B-Raf interactome in mouse hippocampal neuronal cells. Journal of Proteomics 74:2, pages 186-198.
Crossref
Christian M. Udell, Thanashan Rajakulendran, Frank Sicheri & Marc Therrien. (2010) Mechanistic principles of RAF kinase signaling. Cellular and Molecular Life Sciences 68:4, pages 553-565.
Crossref
Chun-Hui Su, Ruiying Zhao, Guermarie Velazquez-Torres, Jian Chen, Christopher Gully, Sai-Ching J Yeung & Mong-Hong Lee. (2010) Nuclear export regulation of COP1 by 14-3-3σ in response to DNA damage. Molecular Cancer 9:1.
Crossref
Vijayababu M. Radhakrishnan & Jesse D. Martinez. (2010) 14-3-3γ Induces Oncogenic Transformation by Stimulating MAP Kinase and PI3K Signaling. PLoS ONE 5:7, pages e11433.
Crossref
Stephen J. Smerdon & Michael B. Yaffe. 2010. Handbook of Cell Signaling. Handbook of Cell Signaling 539 550 .
Amardeep S. Dhillon, Yan Yan Yip, G. Joan Grindlay, Julian L. Pakay, Marc Dangers, Meike Hillmann, William Clark, Andrew Pitt, Harald Mischak & Walter Kolch. (2009) The C-terminus of Raf-1 acts as a 14-3-3-dependent activation switch. Cellular Signalling 21:11, pages 1645-1651.
Crossref
Jinling Zhang, Yinghua Lu, Lin Wang, Hongxin Zhang, Rongrong Li, Lin Wang & Stefan Wolfl. (2009) Single Linkage Clustering Fit for Establishing Theoretical MAPK/Erk Signaling Pathway in Human Soft Tissue Sarcoma Samples. Single Linkage Clustering Fit for Establishing Theoretical MAPK/Erk Signaling Pathway in Human Soft Tissue Sarcoma Samples.
Samudra S. Gangopadhyay, Edouard Kengni, Sarah Appel, Cynthia Gallant, Hak Rim Kim, Paul Leavis, Jon DeGnore & Kathleen G. Morgan. (2009) Smooth Muscle Archvillin Is an ERK Scaffolding Protein. Journal of Biological Chemistry 284:26, pages 17607-17615.
Crossref
Mengwei Zang, Jun Gong, Lingqi Luo, Jing Zhou, Xiaoqin Xiang, Wei Huang, Qiren Huang, Xixi Luo, Martin Olbrot, Yihong Peng, Changyan Chen & Zhijun Luo. (2008) Characterization of Ser338 Phosphorylation for Raf-1 Activation. Journal of Biological Chemistry 283:46, pages 31429-31437.
Crossref
Lucas R. Jagemann, Luís G. Pérez-Rivas, E. Josué Ruiz, Juan A. Ranea, Francisca Sánchez-Jiménez, Ángel R. Nebreda, Emilio Alba & José Lozano. (2008) The Functional Interaction of 14-3-3 Proteins with the ERK1/2 Scaffold KSR1 Occurs in an Isoform-specific Manner. Journal of Biological Chemistry 283:25, pages 17450-17462.
Crossref
Bin Wang, Yanmei Yang & Peter A. Friedman. (2008) Na/H Exchange Regulatory Factor 1, a Novel AKT-associating Protein, Regulates Extracellular Signal-regulated Kinase Signaling through a B-Raf–Mediated Pathway. Molecular Biology of the Cell 19:4, pages 1637-1645.
Crossref
Yasuhiko Koga & Mitsuo Ikebe. (2008) A Novel Regulatory Mechanism of Myosin Light Chain Phosphorylation via Binding of 14-3-3 to Myosin Phosphatase. Molecular Biology of the Cell 19:3, pages 1062-1071.
Crossref
Jianrong Wang & Andrew Yen. (2008) A MAPK-positive Feedback Mechanism for BLR1 Signaling Propels Retinoic Acid-triggered Differentiation and Cell Cycle Arrest. Journal of Biological Chemistry 283:7, pages 4375-4386.
Crossref
Zenggang Li, Jing Zhao, Yuhong Du, Hae Ryoun Park, Shi-Yong Sun, Leon Bernal-Mizrachi, Alastair Aitken, Fadlo R. Khuri & Haian Fu. (2008) Down-regulation of 14-3-3ζ suppresses anchorage-independent growth of lung cancer cells through anoikis activation. Proceedings of the National Academy of Sciences 105:1, pages 162-167.
Crossref
Patricija Hawle, Danielle Horst, Jan Paul Bebelman, Xiao Xian Yang, Marco Siderius & Saskia M. van der Vies. (2007) Cdc37p Is Required for Stress-Induced High-Osmolarity Glycerol and Protein Kinase C Mitogen-Activated Protein Kinase Pathway Functionality by Interaction with Hog1p and Slt2p (Mpk1p). Eukaryotic Cell 6:3, pages 521-532.
Crossref
Pablo Rodriguez-Viciana, Juan Oses-Prieto, Alma Burlingame, Mike Fried & Frank McCormick. (2006) A Phosphatase Holoenzyme Comprised of Shoc2/Sur8 and the Catalytic Subunit of PP1 Functions as an M-Ras Effector to Modulate Raf Activity. Molecular Cell 22:2, pages 217-230.
Crossref
Y. Takahashi. 2006. Handbook of Neurochemistry and Molecular Neurobiology. Handbook of Neurochemistry and Molecular Neurobiology 249 270 .
Deborah K. Morrison & Ira O. Daar. 2006. RAS Family GTPases. RAS Family GTPases 67 93 .
Dave BridgesGreg B. G. Moorhead. (2005) 14-3-3 Proteins: A Number of Functions for a Numbered Protein. Science's STKE 2005:296.
Crossref
Samuel J. Clokie, Kin Y. Cheung, Shaun Mackie, Rodolfo Marquez, Alex H. Peden & Alastair Aitken. (2005) BCR kinase phosphorylates 14-3-3 Tau on residue 233. FEBS Journal 272:15, pages 3767-3776.
Crossref
Nicolas Dumaz & Richard Marais. (2005) Integrating signals between cAMP and the RAS/RAF/MEK/ERK signalling pathways. Based on The Anniversary Prize of the Gesellschaft fur Biochemie und Molekularbiologie Lecture delivered on 5 July 2003 at the Special FEBS Meeting in Brussels. FEBS Journal 272:14, pages 3491-3504.
Crossref
Christopher J. Haney, Gregor Grass, Sylvia Franke & Christopher Rensing. (2005) New developments in the understanding of the cation diffusion facilitator family. Journal of Industrial Microbiology & Biotechnology 32:6, pages 215-226.
Crossref
P. Rafiee, Y Shi, J. Su, K. A. PritchardJr.Jr., J. S. Tweddell & J. E. Baker. (2004) Erythropoietin protects the infant heart against ischemia?reperfusion injury by triggering multiple signaling pathways. Basic Research in Cardiology 100:3, pages 187-197.
Crossref
Susanne Urschel, Florian Bassermann, Ren-Yuan Bai, Silvia Münch, Christian Peschel & Justus Duyster. (2005) Phosphorylation of Grb10 Regulates Its Interaction with 14-3-3. Journal of Biological Chemistry 280:17, pages 16987-16993.
Crossref
John E. Baker. (2005) Erythropoietin mimics ischemic preconditioning. Vascular Pharmacology 42:5-6, pages 233-241.
Crossref
Markus Spiliotis, Dennis Tappe, Stefan Brückner, Hans-Ulrich Mösch & Klaus Brehm. (2005) Molecular cloning and characterization of Ras- and Raf-homologues from the fox-tapeworm Echinococcus multilocularis. Molecular and Biochemical Parasitology 139:2, pages 225-237.
Crossref
Dawn L. Darling, Jessica Yingling & Anthony Wynshaw‐Boris. 2005. 281 315 .
Steven M Chan, Joerg Ermann, Leon Su, C Garrison Fathman & Paul J Utz. (2004) Protein microarrays for multiplex analysis of signal transduction pathways. Nature Medicine 10:12, pages 1390-1396.
Crossref
Erik Wilker & Michael B. Yaffe. (2004) 14-3-3 Proteins—a focus on cancer and human disease. Journal of Molecular and Cellular Cardiology 37:3, pages 633-642.
Crossref
Dave BridgesGreg B. G. Moorhead. (2004) 14-3-3 Proteins: A Number of Functions for a Numbered Protein. Science's STKE 2004:242.
Crossref
Tanawat Jirakulaporn & Anthony J. Muslin. (2004) Cation Diffusion Facilitator Proteins Modulate Raf-1 Activity. Journal of Biological Chemistry 279:26, pages 27807-27815.
Crossref
Mirko Hekman, Stefan Wiese, Renate Metz, Stefan Albert, Jakob Troppmair, Joachim Nickel, Michael Sendtner & Ulf R. Rapp. (2004) Dynamic Changes in C-Raf Phosphorylation and 14-3-3 Protein Binding in Response to Growth Factor Stimulation. Journal of Biological Chemistry 279:14, pages 14074-14086.
Crossref
Paul T.C Wan, Mathew J Garnett, S.Mark Roe, Sharlene Lee, Dan Niculescu-Duvaz, Valerie M Good, Cancer Genome Project, C.Michael Jones, Christopher J Marshall, Caroline J Springer, David Barford & Richard Marais. (2004) Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF. Cell 116:6, pages 855-867.
Crossref
Gautam Kao, Simon Tuck, David Baillie & Meera V. Sundaram. (2004) C. elegans SUR-6/PR55 cooperates with LET-92/protein phosphatase 2A and promotes Raf activity independently of inhibitory Akt phosphorylation sites . Development 131:4, pages 755-765.
Crossref
L S Steelman, S C Pohnert, J G Shelton, R A Franklin, F E Bertrand & J A McCubrey. (2004) JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis. Leukemia 18:2, pages 189-218.
Crossref
James Whelan & Enrico Schleiff. 2004. Plant Mitochondria: From Genome to Function. Plant Mitochondria: From Genome to Function 31 54 .
Huira Chong & Kun-Liang Guan. (2003) Regulation of Raf through Phosphorylation and N Terminus-C Terminus Interaction. Journal of Biological Chemistry 278:38, pages 36269-36276.
Crossref
Megan E. Cavet, Stephanie Lehoux & Bradford C. Berk. (2003) 14-3-3β Is a p90 Ribosomal S6 Kinase (RSK) Isoform 1-binding Protein That Negatively Regulates RSK Kinase Activity. Journal of Biological Chemistry 278:20, pages 18376-18383.
Crossref
Anthony K.F Liou, Robert S Clark, David C Henshall, Xiao-Ming Yin & Jun Chen. (2003) To die or not to die for neurons in ischemia, traumatic brain injury and epilepsy: a review on the stress-activated signaling pathways and apoptotic pathways. Progress in Neurobiology 69:2, pages 103-142.
Crossref
Stephen J. Smerdon & Michael B. Yaffe. 2003. Handbook of Cell Signaling. Handbook of Cell Signaling 505 511 .
Chiharu Ito, Eiji Kusano, Yusuke Furukawa, Hisashi Yamamoto, Shin-Ichi Takeda, Tetsu Akimoto, Osamu Iimura, Yasuhiro Ando & Yasushi Asano. (2002) Modulation of the erythropoietin-induced proliferative pathway by cAMP in vascular smooth muscle cells. American Journal of Physiology-Cell Physiology 283:6, pages C1715-C1721.
Crossref
J Brognard & P A Dennis. (2002) Variable apoptotic response of NSCLC cells to inhibition of the MEK/ERK pathway by small molecules or dominant negative mutants. Cell Death & Differentiation 9:9, pages 893-904.
Crossref
Melanie T. Hartsough, Deborah K. Morrison, Massimiliano Salerno, Diane Palmieri, Taoufik Ouatas, Michael Mair, Jilma Patrick & Patricia S. Steeg. (2002) Nm23-H1 Metastasis Suppressor Phosphorylation of Kinase Suppressor of Ras via a Histidine Protein Kinase Pathway. Journal of Biological Chemistry 277:35, pages 32389-32399.
Crossref
Edmond Y. W. Chan, Stacey L. Stang, Drell A. Bottorff & James C. Stone. (2002) Mutations in conserved regions 1, 2, and 3 of Raf-1 that activate transforming activity. Molecular Carcinogenesis 33:4, pages 189-197.
Crossref
Markus Kubicek, Margit Pacher, Dietmar Abraham, Klaus Podar, Manfred Eulitz & Manuela Baccarini. (2002) Dephosphorylation of Ser-259 Regulates Raf-1 Membrane Association. Journal of Biological Chemistry 277:10, pages 7913-7919.
Crossref
Michael B Yaffe. (2002) How do 14-3-3 proteins work? - Gatekeeper phosphorylation and the molecular anvil hypothesis. FEBS Letters 513:1, pages 53-57.
Crossref
Virginia Hsu, Cheri L Zobel, Eric J Lambie, Tim Schedl & Kerry Kornfeld. (2002) Caenorhabditis elegans lin-45 raf Is Essential for Larval Viability, Fertility and the Induction of Vulval Cell Fates . Genetics 160:2, pages 481-492.
Crossref
Guri Tzivion & Joseph Avruch. (2002) 14-3-3 Proteins: Active Cofactors in Cellular Regulation by Serine/Threonine Phosphorylation. Journal of Biological Chemistry 277:5, pages 3061-3064.
Crossref
Jennifer A. Brennan, Deanna J. Volle, Oleg V. Chaika & Robert E. Lewis. (2002) Phosphorylation Regulates the Nucleocytoplasmic Distribution of Kinase Suppressor of Ras. Journal of Biological Chemistry 277:7, pages 5369-5377.
Crossref
Jürgen Müller & Deborah K. Morrison. 2002. G Protein Pathways - Part C, Effector Mechanisms. G Protein Pathways - Part C, Effector Mechanisms 490 498 .
Hark Vikis & Kun-Liang Guan. 2002. Genetic Engineering. Genetic Engineering 49 66 .
Renee Emkey & C. Ronald Kahn. 2011. Comprehensive Physiology. Comprehensive Physiology 413 433 .
Kori Radke, Kimberly Johnson, Rong Guo, Anne Davidson & Linda Ambrosio. (2001) Drosophila-Raf Acts to Elaborate Dorsoventral Pattern in the Ectoderm of Developing Embryos . Genetics 159:3, pages 1031-1044.
Crossref
Guri Tzivion, Ying H Shen & Jun Zhu. (2001) 14-3-3 proteins; bringing new definitions to scaffolding. Oncogene 20:44, pages 6331-6338.
Crossref
Giovanna Berruti & Enzo Martegani. (2001) MSJ-1, a Mouse Testis-Specific DnaJ Protein, Is Highly Expressed in Haploid Male Germ Cells and Interacts with the Testis-Specific Heat Shock Protein Hsp70-21. Biology of Reproduction 65:2, pages 488-495.
Crossref
Zhu Chen, Tara Beers Gibson, Fred Robinson, Loraine Silvestro, Gray Pearson, Bing-e Xu, Angelique Wright, Colleen Vanderbilt & Melanie H. Cobb. (2001) MAP Kinases. Chemical Reviews 101:8, pages 2449-2476.
Crossref
Sandra König, Bernard Guibert, Cecile Morice, Philippe Vernier & Jean Vianney Barnier. (2001) Phosphorylation by PKA of a site unique to B-Raf kinase. Comptes Rendus de l'Académie des Sciences - Series III - Sciences de la Vie 324:8, pages 673-681.
Crossref
Montserrat Jaumot & John F Hancock. (2001) Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions. Oncogene 20:30, pages 3949-3958.
Crossref
Stephanie Lehoux, Jun-ichi Abe, Jennifer A. Florian & Bradford C. Berk. (2001) 14-3-3 Binding to Na+/H+ Exchanger Isoform-1 Is Associated with Serum-dependent Activation of Na+/H+ Exchange. Journal of Biological Chemistry 276:19, pages 15794-15800.
Crossref
Gray Pearson, Fred Robinson, Tara Beers Gibson, Bing-e Xu, Mahesh Karandikar, Kevin Berman & Melanie H. Cobb. (2001) Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*. Endocrine Reviews 22:2, pages 153-183.
Crossref
Yoshimi Takai, Takuya Sasaki & Takashi Matozaki. (2001) Small GTP-Binding Proteins. Physiological Reviews 81:1, pages 153-208.
Crossref
Mengwei Zang, Christine A. Waelde, Xiaoqin Xiang, Aja Rana, Rong Wen & Zhijun Luo. (2001) Microtubule Integrity Regulates Pak Leading to Ras-independent Activation of Raf-1. Journal of Biological Chemistry 276:27, pages 25157-25165.
Crossref
Petra JanoschArnd Kieser, Manfred Eulitz, Josip Lovric, Guido Sauer, Manuela Reichert, Fotini Gounari, Dirk Büscher, Manuela Baccarini, Harald Mischak & Walter Kolch. (2000) The Raf‐1 kinase associates with vimentin kinases and regulates the structure of vimentin filaments. The FASEB Journal 14:13, pages 2008-2021.
Crossref
Wansong Qiu, Shunhui Zhuang, Friederike C. von Lintig, Gerry R. Boss & Renate B. Pilz. (2000) Cell Type-specific Regulation of B-Raf Kinase by cAMP and 14-3-3 Proteins. Journal of Biological Chemistry 275:41, pages 31921-31929.
Crossref
Cynthia Hayne, Guri Tzivion & Zhijun Luo. (2000) Raf-1/MEK/MAPK Pathway Is Necessary for the G2/M Transition Induced by Nocodazole. Journal of Biological Chemistry 275:41, pages 31876-31882.
Crossref
Takashi Kuromori & Masayuki Yamamoto. (2000) Members of the Arabidopsis 14-3-3 gene family trans-complement two types of defects in fission yeast. Plant Science 158:1-2, pages 155-161.
Crossref
Dietmar Abraham, Klaus Podar, Margit Pacher, Markus Kubicek, Natascha Welzel, Brian A. Hemmings, Stephen M. Dilworth, Harald Mischak, Walter Kolch & Manuela Baccarini. (2000) Raf-1-associated Protein Phosphatase 2A as a Positive Regulator of Kinase Activation. Journal of Biological Chemistry 275:29, pages 22300-22304.
Crossref
Hiroyoshi Sendoh, Chang-Deng Hu, Dongmei Wu, Chunhua Song, Yuriko Yamawaki-Kataoka, Joji Kotani, Tomoyo Okada, Fumi Shima, Ken-ichi Kariya & Tohru Kataoka. (2000) Role of Raf-1 Conserved Region 2 in Regulation of Ras-Dependent Raf-1 Activation. Biochemical and Biophysical Research Communications 271:3, pages 596-602.
Crossref
Haian FuRomesh R. SubramanianShane C. Masters. (2000) 14-3-3 Proteins: Structure, Function, and Regulation. Annual Review of Pharmacology and Toxicology 40:1, pages 617-647.
Crossref
Melanie C. MacNicol, Anthony J. Muslin & Angus M. MacNicol. (2000) Disruption of the 14-3-3 Binding Site within the B-Raf Kinase Domain Uncouples Catalytic Activity from PC12 Cell Differentiation. Journal of Biological Chemistry 275:6, pages 3803-3809.
Crossref
Chengshi Jin, Alan F. Lau & Kendra Dean Martyn. (2000) Identification of Connexin-Interacting Proteins: Application of the Yeast Two-Hybrid Screen. Methods 20:2, pages 219-231.
Crossref
Tamar Megidish, Akikazu Hamaguchi, Kazuhisa Iwabuchi & Sen-Itiroh Hakomori. 2000. Sphingolipid Metabolism and Cell Signaling, Part B. Sphingolipid Metabolism and Cell Signaling, Part B 381 387 .
Véronique Baldin. 2000. Progress in Cell Cycle Research. Progress in Cell Cycle Research 49 60 .
Sven ZimmermannKarin Moelling. (1999) Phosphorylation and Regulation of Raf by Akt (Protein Kinase B). Science 286:5445, pages 1741-1744.
Crossref
Shaosong Zhang, Heming Xing & Anthony J. Muslin. (1999) Nuclear Localization of Protein Kinase U-α Is Regulated by 14-3-3. Journal of Biological Chemistry 274:35, pages 24865-24872.
Crossref
Lixin Zhang, Jing Chen & Haian Fu. (1999) Suppression of apoptosis signal-regulating kinase 1-induced cell death by 14-3-3 proteins. Proceedings of the National Academy of Sciences 96:15, pages 8511-8515.
Crossref
Michael V. Autieri & Christopher J. Carbone. (1999) 14-3-3gamma Interacts with and Is Phosphorylated by Multiple Protein Kinase C Isoforms in PDGF-Stimulated Human Vascular Smooth Muscle Cells. DNA and Cell Biology 18:7, pages 555-564.
Crossref
Robert A McPherson, Angus Harding, Sandrine Roy, Annette Lane & John F Hancock. (1999) Interactions of c-Raf-1 with phosphatidylserine and 14-3-3. Oncogene 18:26, pages 3862-3869.
Crossref
A. Douglas Laird, Deborah K. Morrison & David Shalloway. (1999) Characterization of Raf-1 Activation in Mitosis. Journal of Biological Chemistry 274:7, pages 4430-4439.
Crossref
CHRISTIAN WIDMANN, SPENCER GIBSON, MATTHEW B. JARPE & GARY L. JOHNSON. (1999) Mitogen-Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human. Physiological Reviews 79:1, pages 143-180.
Crossref
Michael Gjedde Palmgren, Anja Thoe Fuglsang & Thomas Jahn. 1999. EBO Experimental Biology Online Annual 1998. EBO Experimental Biology Online Annual 1998 37 58 .
Richard E. CutlerJr.Jr., Robert M. Stephens, Misty R. Saracino & Deborah K. Morrison. (1998) Autoregulation of the Raf-1 serine/threonine kinase. Proceedings of the National Academy of Sciences 95:16, pages 9214-9219.
Crossref
David G. Winkler, Richard E. CutlerJr.Jr., Jonelle K. Drugan, Sharon Campbell, Deborah K. Morrison & Jonathan A. Cooper. (1998) Identification of Residues in the Cysteine-rich Domain of Raf-1 That Control Ras Binding and Raf-1 Activity. Journal of Biological Chemistry 273:34, pages 21578-21584.
Crossref
Guri Tzivion, Zhijun Luo & Joseph Avruch. (1998) A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity. Nature 394:6688, pages 88-92.
Crossref
Patricia Bauman & Charles F. Albright. (1998) Functional analysis of domains in the Byr2 kinase. Biochimie 80:7, pages 621-625.
Crossref
Carlo Petosa, Shane C. Masters, Laurie A. Bankston, Jan Pohl, Bingcheng Wang, Haian Fu & Robert C. Liddington. (1998) 14-3-3ζ Binds a Phosphorylated Raf Peptide and an Unphosphorylated Peptide via Its Conserved Amphipathic Groove. Journal of Biological Chemistry 273:26, pages 16305-16310.
Crossref
Haining Wang, Lixin Zhang, Robert Liddington & Haian Fu. (1998) Mutations in the Hydrophobic Surface of an Amphipathic Groove of 14-3-3ζ Disrupt Its Interaction with Raf-1 Kinase. Journal of Biological Chemistry 273:26, pages 16297-16304.
Crossref
Efthimios M. C. Skoulakis & Ronald L. Davis. (1998) 14-3-3 proteins in neuronal development and function. Molecular Neurobiology 16:3, pages 269-284.
Crossref
David C. CalverleyTerrance J. KavanaghGerald J. Roth. (1998) Human Signaling Protein 14-3-3ζ Interacts With Platelet Glycoprotein Ib Subunits Ibα and Ibβ. Blood 91:4, pages 1295-1303.
Crossref
Gary R. Fanger, Christian Widmann, Amy C. Porter, Sue Sather, Gary L. Johnson & Richard R. Vaillancourt. (1998) 14-3-3 Proteins Interact with Specific MEK Kinases. Journal of Biological Chemistry 273:6, pages 3476-3483.
Crossref
Sharon C.W. Luk, Sai-ming Ngai, Stephen K.W. Tsui, Kwok-keung Chan, Kwok-pui Fung, Cheuk-yu Lee & Mary M.Y. Waye. (1998) Developmental regulation of 14-3-3 ε isoform in rat heart. Journal of Cellular Biochemistry 68:2, pages 195-199.
Crossref
Atsushi Kosaki, Kazunori Yamada, Junko Suga, Akira Otaka & Hideshi Kuzuya. (1998) 14-3-3β Protein Associates with Insulin Receptor Substrate 1 and Decreases Insulin-stimulated Phosphatidylinositol 3′-Kinase Activity in 3T3L1 Adipocytes. Journal of Biological Chemistry 273:2, pages 940-944.
Crossref
Timothy S. Lewis, Paul S. Shapiro & Natalie G. Ahn. 1998. 49 139 .
Neil R. Michaud, Marc Therrien, Angela Cacace, Lisa C. Edsall, Sarah Spiegel, Gerald M. Rubin & Deborah K. Morrison. (1997) KSR stimulates Raf-1 activity in a kinase-independent manner. Proceedings of the National Academy of Sciences 94:24, pages 12792-12796.
Crossref
Birgit K. Jaitner, Jörg Becker, Thomas Linnemann, Christian Herrmann, Alfred Wittinghofer & Christoph Block. (1997) Discrimination of Amino Acids Mediating Ras Binding from Noninteracting Residues Affecting Raf Activation by Double Mutant Analysis. Journal of Biological Chemistry 272:47, pages 29927-29933.
Crossref
Thierry Dubois, Christian Rommel, Steven Howell, Ulrike Steinhussen, Yasmina Soneji, Nick Morrice, Karin Moelling & Alastair Aitken. (1997) 14-3-3 Is Phosphorylated by Casein Kinase I on Residue 233. Journal of Biological Chemistry 272:46, pages 28882-28888.
Crossref
Meirav Matto-Yelin, Alastair Aitken & Shoshana Ravid. (1997) 14–3-3 Inhibits the Dictyostelium Myosin II Heavy-Chain-specific Protein Kinase C Activity by a Direct Interaction: Identification of the 14–3-3 Binding Domain . Molecular Biology of the Cell 8:10, pages 1889-1899.
Crossref
Shao-Hui Zhang, Ryuji Kobayashi, Paul R. Graves, Helen Piwnica-Worms & Nicholas K. Tonks. (1997) Serine Phosphorylation-dependent Association of the Band 4.1-related Protein-tyrosine Phosphatase PTPH1 with 14-3-3ॆ Protein. Journal of Biological Chemistry 272:43, pages 27281-27287.
Crossref
Utpal Banik, Guo-An Wang, Paul D. Wagner & Seymour Kaufman. (1997) Interaction of Phosphorylated Tryptophan Hydroxylase with 14-3-3 Proteins. Journal of Biological Chemistry 272:42, pages 26219-26225.
Crossref
Liang Tao, Torsten Nielsen, Paula Friedlander, Maria Zannis-Hadjopoulos & Gerald Price. (1997) Differential DNA replication origin activities in human normal skin fibroblast and HeLa cell lines 1 1Edited by J. Karn. Journal of Molecular Biology 273:3, pages 509-518.
Crossref
Tohru Ichimura, Mitsuki Ito, Chiharu Itagaki, Masuhiro Takahashi, Tsuneyosi Horigome, Saburo Omata, Shigeo Ohno & Toshiaki Isobe. (1997) The 14-3-3 protein binds its target proteins with a common site located towards the C-terminus. FEBS Letters 413:2, pages 273-276.
Crossref
Geoffrey J. Clark, Jonelle K. Drugan, Kent L. Rossman, John W. Carpenter, Kelley Rogers-Graham, Haian Fu, Channing J. Der & Sharon L. Campbell. (1997) 14-3-3 ζ Negatively Regulates Raf-1 Activity by Interactions with the Raf-1 Cysteine-rich Domain. Journal of Biological Chemistry 272:34, pages 20990-20993.
Crossref
Sandrine Roy, Annette Lane, Jun Yan, Robert McPherson & John F. Hancock. (1997) Activity of Plasma Membrane-recruited Raf-1 Is Regulated by Ras via the Raf Zinc Finger. Journal of Biological Chemistry 272:32, pages 20139-20145.
Crossref
Peter H Sugden & Angela Clerk. (1997) Regulation of the ERK Subgroup of MAP Kinase Cascades Through G Protein-Coupled Receptors. Cellular Signalling 9:5, pages 337-351.
Crossref
Christian Rommel, Gerald Radziwill, Karin Moelling & Ernst Hafen. (1997) Negative regulation of Raf activity by binding of 14-3-3 to the amino terminus of Raf in vivo. Mechanisms of Development 64:1-2, pages 95-104.
Crossref
Radclyffe L Roberts, Hans-Ulrich Mösch & Gerald R Fink. (1997) 14-3-3 Proteins Are Essential for RAS/MAPK Cascade Signaling during Pseudohyphal Development in S. cerevisiae. Cell 89:7, pages 1055-1065.
Crossref
L Kockel, G Vorbrüggen, H Jäckle, M Mlodzik & D Bohmann. (1997) Requirement for Drosophila 14-3-3 zeta in Raf-dependent photoreceptor development.. Genes & Development 11:9, pages 1140-1147.
Crossref
H C Chang & G M Rubin. (1997) 14-3-3 epsilon positively regulates Ras-mediated signaling in Drosophila.. Genes & Development 11:9, pages 1132-1139.
Crossref
David Stokoe & Frank McCormick. (1997) Activation of c-Raf-1 by Ras and Src through different mechanisms: activation in vivo and in vitro . The EMBO Journal 16:9, pages 2384-2396.
Crossref
Lixin Zhang, Haining Wang, Dong Liu, Robert Liddington & Haian Fu. (1997) Raf-1 Kinase and Exoenzyme S Interact with 14-3-3ζ through a Common Site Involving Lysine 49. Journal of Biological Chemistry 272:21, pages 13717-13724.
Crossref
Heming Xing, Kerry Kornfeld & Anthony J. Muslin. (1997) The protein kinase KSR interacts with 14-3-3 protein and Raf. Current Biology 7:5, pages 294-300.
Crossref
Ann Craparo, Robert Freund & Thomas A. Gustafson. (1997) 14-3-3 (ϵ) Interacts with the Insulin-like Growth Factor I Receptor and Insulin Receptor Substrate I in a Phosphoserine-dependent Manner. Journal of Biological Chemistry 272:17, pages 11663-11669.
Crossref
Yun-Cai Liu, Yuhong Liu, Chris Elly, Hideaki Yoshida, Stanley Lipkowitz & Amnon Altman. (1997) Serine Phosphorylation of Cbl Induced by Phorbol Ester Enhances Its Association with 14-3-3 Proteins in T Cells via a Novel Serine-rich 14-3-3-binding Motif. Journal of Biological Chemistry 272:15, pages 9979-9985.
Crossref
Deborah K Morrison & Richard E CutlerJrJr. (1997) The complexity of Raf-1 regulation. Current Opinion in Cell Biology 9:2, pages 174-179.
Crossref
David A. Wassarman & Marc Therrien. 1997. 1 41 .
Robin Hesketh. 1997. The Oncogene & Tumour Suppressor Gene Factsbook. The Oncogene & Tumour Suppressor Gene Factsbook 309 318 .
Javor P. Stolarov & Michael H. Wigler. 1997. Interacting Protein Domains. Interacting Protein Domains 143 146 .
K BrockhausS PlazaD J PintelJ RommelaereN Salomé. (1996) Nonstructural proteins NS2 of minute virus of mice associate in vivo with 14-3-3 protein family members. Journal of Virology 70:11, pages 7527-7534.
Crossref
M Therrien, N R Michaud, G M Rubin & D K Morrison. (1996) KSR modulates signal propagation within the MAPK cascade.. Genes & Development 10:21, pages 2684-2695.
Crossref
Greg Moorhead, Pauline Douglas, Nick Morrice, Marie Scarabel, Alastair Aitken & Carol MacKintosh. (1996) Phosphorylated nitrate reductase from spinach leaves is inhibited by 14-3-3 proteins and activated by fusicoccin. Current Biology 6:9, pages 1104-1113.
Crossref
Claudius Vincenz & Vishva M. Dixit. (1996) 14-3-3 Proteins Associate with A20 in an Isoform-specific Manner and Function Both as Chaperone and Adapter Molecules. Journal of Biological Chemistry 271:33, pages 20029-20034.
Crossref
Yun-Cai Liu, Chris Elly, Hideaki Yoshida, Nathalie Bonnefoy-Berard & Amnon Altman. (1996) Activation-modulated Association of 14–3–3 Proteins with Cbl in T Cells. Journal of Biological Chemistry 271:24, pages 14591-14595.
Crossref
Sujoy Ghosh, Jay C. Strum, Vicki A. Sciorra, Larry Daniel & Robert M. Bell. (1996) Raf-1 Kinase Possesses Distinct Binding Domains for Phosphatidylserine and Phosphatidic Acid. Journal of Biological Chemistry 271:14, pages 8472-8480.
Crossref
Anthony J Muslin, J.William Tanner, Paul M Allen & Andrey S Shaw. (1996) Interaction of 14-3-3 with Signaling Proteins Is Mediated by the Recognition of Phosphoserine. Cell 84:6, pages 889-897.
Crossref
Gary W. Reuther & Ann Marie Pendergast. 1996. Advances in Research and Applications. Advances in Research and Applications 149 175 .
Christian Herrmann & Nicolas Nassar. (1996) Ras and its effectors. Progress in Biophysics and Molecular Biology 66:1, pages 1-41.
Crossref
Tohru Ichimura, Junji Uchiyama, Okiyuki Kunihiro, Mitsuki Ito, Tsuneyoshi Horigome, Saburo Omata, Fumiko Shinkai, Hiroyuki Kaji & Toshiaki Isobe. (1995) Identification of the Site of Interaction of the 14-3-3 Protein with Phosphorylated Tryptophan Hydroxylase. Journal of Biological Chemistry 270:48, pages 28515-28518.
Crossref
Richard Marais & Chris Marshall. (1995) 14-3-3 proteins: structure resolved, functions less clear. Structure 3:8, pages 751-753.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.