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Research Article

14-3-3 Is Not Essential for Raf-1 Function: Identification of Raf-1 Proteins That Are Biologically Activated in a 14-3-3- and Ras-Independent Manner

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Pages 3390-3397 | Received 30 Jan 1995, Accepted 30 Mar 1995, Published online: 30 Mar 2023

REFERENCES

  • Aitken, A., D. B. Collinge, B. P. H. van Heusden, T. Isobe, P. H. Roseboom, G. Rosenfeld, and J. Soll. 1992. 14-3-3 proteins: a highly conserved, widespread family of eukaryotic proteins. Trends Biochem. Sci. 17:498–501.
  • Cleghon, V., and D. K. Morrison. 1994. Raf-1 interacts with Fyn and Src in a non-phosphotyrosine-dependent manner. J. Biol. Chem. 269:17749–17755.
  • Dent, P., Y.-H. Chow, J. Wu, D. K. Morrison, R. Jove, and T. W. Sturgill. 1994. Expression, purification, and characterization of recombinant MAP kinase kinases, MKK1 and MKK2. Biochem. J. 303:105–112.
  • Dent, P., and T. W. Sturgill. 1994. Activation of (His)6-Raf-1 in vitro by partially purified plasma membranes from v-Ras-transformed and serum-stimulated fibroblasts. Proc. Natl. Acad. Sci. USA 91:9544–9548.
  • Dickson, B., F. Sprenger, D. Morrison, and E. Hafen. 1992. Raf functions downstream of Ras1 in the Sevenless signal transduction pathway. Nature (London) 360:600–603.
  • Fabian, J. R., I. O. Daar, and D. K. Morrison. 1993. Critical tyrosine residues regulate the enzymatic and biological activity of the Raf-1 kinase. Mol. Cell. Biol. 13:7170–7179.
  • Fabian, J. R., D. K. Morrison, and I. Daar. 1993. Requirement for Raf and MAP kinase function during the maturation of Xenopus oocytes. J. Cell Biol. 122:645–652.
  • Fabian, J. R., A. B. Vojtek, J. A. Cooper, and D. K. Morrison. 1994. A single amino acid change in Raf-1 inhibits Ras binding and alters Raf-1 function. Proc. Natl. Acad. Sci. USA 91:5982–5986.
  • Fantl, W. J., A. J. Muslin, A. Kikuchi, J. A. Martin, A. M. MacNicol, R. W. Gross, and L. T. Williams. 1994. Activation of Raf-1 by 14-3-3 proteins. Nature (London) 371:612–614.
  • Finney, R., S. Robbins, and M. J. Bishop. 1993. Association of Ras and Raf-1 in a complex correlates with activation of a signal transduction pathway. Curr. Biol. 3:805–812.
  • Ford, J. C., F. AlKhodairy, E. Fotou, K. S. Sheldrick, D. J. F. Griffiths, and A. M. Carr. 1994. 14-3-3 protein homologs required for the DNA damage checkpoint in fission yeast. Science 265:533–535.
  • Freed, E., M. Symons, S. G. Macdonald, F. McCormick, and R. Ruggieri. 1994. Binding of 14-3-3 proteins to the protein kinase Raf and effects on its activation. Science 265:1713–1716.
  • Fu, H., J. Coburn, and J. Collier. 1993. The eukaryotic host factor that activates exoenzyme S of Pseudomonas aeruginosa is a member of the 14-3-3 protein family. Proc. Natl. Acad. Sci. USA 90:2320–2324.
  • Fu, H., K. Xia, D. C. Pallas, C. Cui, K. Conroy, R. P. Narsimhan, H. Mamon, R. J. Collier, and T. M. Roberts. 1994. Interaction of the protein kinase Raf-1 with 14-3-3 proteins. Science 266:126–129.
  • Furukawa, Y., N. Ikuta, S. Omata, T. Yamauchi, T. Isobe, and T. Ichimura. 1993. Demonstration of the phosphorylation-dependent interaction of tryp-tophan hydroxylase with the 14-3-3 protein. Biochem. Biophys. Res. Com-mun. 194:144–149.
  • Hallberg, B., S. I. Rayter, and J. Downward. 1994. Interaction of Ras and Raf in intact mammalian cells upon extracellular stimulation. J. Biol. Chem. 269:3913–3916.
  • Han, M., A. Golden, Y. Han, and P. W. Sternberg. 1993. C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation. Nature (London) 363:137–140.
  • Heidecker, G., J. L. Cleveland, T. Beck, M. Huieihel, W. Kolch, S. M. Storm, and U. R. Reddy. 1989. Role of raf and myc oncogenes in signal transduction, p. 339–374. In N. H. Colburn (ed.), Genes and signal transduction in multistage carcinogenesis. Marcel Dekker, Inc., New York.
  • Heidecker, G., M. Huleihel, J. L. Cleveland, W. Kolch, T. W. Beck, P. Lloyd, T. Pawson, and U. R. Rapp. 1990. Mutational activation of c-raf-1 and definition of the minimal transforming sequence. Mol. Cell. Biol. 10:2503–2512.
  • Heidecker, G., W. Kolch, D. K. Morrison, and U. R. Rapp. 1991. The role of Raf-1 phosphorylation in signal transduction. Adv. Cancer Res. 58:53–73.
  • Irie, K., Y. Gotoh, B. M. Yashar, B. Errede, E. Nishida, and K. Matsumoto. 1994. Stimulatory effects of yeast and mammalian 14-3-3 proteins on the Raf protein kinase. Science 265:1716–1719.
  • Koide, H., T. Satoh, M. Nakafuku, and Y. Kaziro. 1993. GTP-dependent association of Raf-1 with Ha-Ras: identification of Raf as a target downstream of Ras in mammalian cells. Proc. Natl. Acad. Sci. USA 90:8683–8686.
  • Kolch, W., G. Heidecker, G. Kochs, R. Hummel, H. Vahidi, H. Mischak, G. Finkenzeller, D. Marme, and U. R. Rapp. 1993. Protein kinase Cα activates Raf-1 by direct phosphorylation. Nature (London) 364:249–252.
  • Krieg, P. A., and D. A. Melton. 1984. Functional messenger RNAs are produced by SP6 in vitro transcription of cloned cDNAS. Nucleic Acids Res. 12:7057–7070.
  • Kyriakis, J. M., T. L. Force, U. R. Rapp, J. V. Bonventre, and J. Avruch. 1993. Mitogen regulation of c-Raf-1 protein kinase activity toward mitogen-activated protein kinase-kinase. J. Biol. Chem. 268:16009–16019.
  • Leevers, S. J., H. F. Paterson, and C. J. Marshall. 1994. Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane. Nature (London) 369:411–414.
  • Moodie, S. A., B. M. Willumsen, M. J. Weber, and A. Wolfman. 1993. Complexes of Ras-GTP with Raf-1 and mitogen-activated protein kinase kinase. Science 260:1658–1661.
  • Moodie, S. A., and A. Wolfman. 1994. The 3Rs of life: Ras, Raf and growth regulation. Trends Genet. 10:44–48.
  • Morrison, D. K. 1990. The Raf-1 kinase as a transducer of mitogenic signals. Cancer Cells 2:377–382.
  • Morrison, D. K. 1994. 14-3-3: modulators of signaling proteins? Science 266:56–57.
  • Morrison, D. K., G. Heidecker, U. R. Rapp, and T. D. Copeland. 1993. Identification of the major phosphorylation sites of the Raf-1 kinase. J. Biol. Chem. 268:17309–17316.
  • Nishida, E., and Y. Gotoh. 1993. The MAP kinase cascade is essential for diverse signal transduction pathways. Trends Biochem. Sci. 18:128–131.
  • Pallas, D. C., H. Fu, L. C. Haehnel, W. Weller, R. J. Collier, and T. M. Roberts. 1994. Association of polyomavirus middle tumor antigen with 14-3-3 proteins. Science 265:535–537.
  • Pumiglia, K., Y.-H. Chow, J. Fabian, D. Morrison, S. Decker, and R. Jove. 1995. Raf-1 N-terminal sequences necessary for the Ras-Raf interaction and signal transduction. Mol. Cell. Biol. 15:398–406.
  • Rapp, U. R. 1991. Role of Raf-1 serine/threonine protein kinase in growth factor signal transduction. Oncogene 6:495–500.
  • Rapp, U. R., G. Heidecker, M. Huleihel, J. L. Cleveland, W. C. Choi, T. Pawson, J. N. Ihle, and W. B. Anderson. 1988. raf family serine/threonine protein kinase in mitogen signal transduction. Cold Spring Harbor Symp. Quant. Biol. 53:173–184.
  • Reuther, G. W., H. Fu, L. D. Cripe, R. J. Collier, and A. M. Pendergast. 1994. Association of the protein kinases c-Bcr and Bcr-Abl with proteins of the 14-3-3 family. Science 266:129–133.
  • Roberts, T. M. 1992. A signal chain of events. Nature (London) 360:534–535.
  • Smith, M. R., S. J. DeGudicibus, and D. W. Stacey. 1986. Requirement for c-ras proteins during viral oncogene transformation. Nature (London) 320: 540–543.
  • Stanton, V. P., Jr., D. W. Nichols, A. P. Laudano, and G. M. Cooper. 1989. Definition of the human raf amino-terminal regulatory region by deletion mutagenesis. Mol. Cell. Biol. 9:639–647.
  • Stokoe, D., S. G. Macdonald, K. Cadwallader, M. Symons, and J. F. Hancock. 1994. Activation of Raf as a result of recruitment to the plasma membrane. Science 264:1463–1467.
  • Troppmair, J., J. T. Bruder, H. App, H. Cai, L. Liptak, J. Szeberenyi, G. M. Cooper, and U. R. Rapp. 1992. Ras controls coupling of growth factor receptors and protein kinase C in the membrane to Raf-1 and B-Raf protein serine kinases in the cytosol. Oncogene 7:1867–1873.
  • Tsuda, L., Y. H. Inoue, M.-A. Yoo, M. Mizuno, M. Hata, Y.-M. Lim, T. Adachi-Yamada, H. Ryo, Y. Masamune, and Y. Nishida. 1993. A protein kinase similar to MAP kinase activator acts downstream of the Raf kinase in Drosophila. Cell 72:407–414.
  • Van Aelst, L., M. Barr, S. Marcus, A. Polverino, and M. Wigler. 1993. Complex formation between Ras and Raf and other protein kinases. Proc. Natl. Acad. Sci. USA 90:6213–6217.
  • Vojtek, A. B., S. M. Hollenberg, and J. A. Cooper. 1993. Mammalian Ras interacts directly with the serine/threonine kinase Raf. Cell 74:205–214.
  • Warne, P. H., P. R. Viciana, and J. Downward. 1993. Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro. Nature (London) 364:352–355.
  • Wigler, M., A. Pellicer, S. Silverstein, and R. Axel. 1978. Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor. Cell 14:723–731.
  • Williams, N. G., T. M. Roberts, and P. Li. 1992. Both p21ras and pp60v-src are required, but neither alone is sufficient, to activate the Raf-1 kinase. Proc. Natl. Acad. Sci. USA 89:2922–2926.
  • Wood, K. W., C. Sarnecki, T. M. Roberts, and J. Blenis. 1992. ras mediates nerve growth factor receptor modulation and three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK. Cell 68:1041–1050.
  • Zhang, X. F., J. Settleman, J. M. Kyriakis, E. Takeuchi-Suzuki, S. J. Elledge, M. S. Marshall, J. T. Bruder, U. R. Rapp, and J. Avruch. 1993. Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1. Nature (London) 364:308–313.

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