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Research Article

Constitutive Activation of S6 Kinase by Deletion of Amino-Terminal Autoinhibitory and Rapamycin Sensitivity Domains

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Pages 405-413 | Received 28 Jul 1995, Accepted 19 Oct 1995, Published online: 29 Mar 2023

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Eric Jonasch & Michel Choueiri. 2013. Renal Cell Carcinoma. Renal Cell Carcinoma 317 337 .
Mushtaq A Beigh, Mehvish Showkat, Mahboob ul Hussain, Shafat A Latoo, Sheikh T Majeed & Khurshid I Andrabi. (2012) Rapamycin inhibition of baculovirus recombinant (BVr) ribosomal protein S6 kinase (S6K1) is mediated by an event other than phosphorylation. Cell Communication and Signaling 10:1.
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Michel Choueiri & Philip Mack. 2012. Kidney Cancer. Kidney Cancer 209 223 .
Rohini Dhar, Shalini D. Persaud, Joe R. Mireles & Alakananda Basu. (2009) Proteolytic Cleavage of p70 Ribosomal S6 Kinase by Caspase-3 during DNA Damage-Induced Apoptosis. Biochemistry 48:7, pages 1474-1480.
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L S Steelman, S L Abrams, J Whelan, F E Bertrand, D E Ludwig, J Bäsecke, M Libra, F Stivala, M Milella, A Tafuri, P Lunghi, A Bonati, A M Martelli & J A McCubrey. (2008) Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia. Leukemia 22:4, pages 686-707.
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Phillip C. Moschella, Vijay U. Rao, Paul J. McDermott & Dhandapani Kuppuswamy. (2007) Regulation of mTOR and S6K1 activation by the nPKC isoforms, PKCε and PKCδ, in adult cardiac muscle cells. Journal of Molecular and Cellular Cardiology 43:6, pages 754-766.
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Levy Kopelovich, Judith R. Fay, Caroline C. Sigman & James A. Crowell. (2007) The Mammalian Target of Rapamycin Pathway as a Potential Target for Cancer Chemoprevention. Cancer Epidemiology, Biomarkers & Prevention 16:7, pages 1330-1340.
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James A. McCubrey, Linda S. Steelman, Richard A. Franklin, Steven L. Abrams, William H. Chappell, Ellis W.T. Wong, Brian D. Lehmann, David M. Terrian, Jorg Basecke, Franca Stivala, Massimo Libra, Camilla Evangelisti & Alberto M. Martelli. (2007) Targeting the RAF/MEK/ERK, PI3K/AKT and P53 pathways in hematopoietic drug resistance. Advances in Enzyme Regulation 47:1, pages 64-103.
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Antonia Ávila-Flores, Teresa Santos, Esther Rincón & Isabel Mérida. (2005) Modulation of the Mammalian Target of Rapamycin Pathway by Diacylglycerol Kinase-produced Phosphatidic Acid. Journal of Biological Chemistry 280:11, pages 10091-10099.
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Ly Q. Hong-Brown, C. Randell Brown & Charles H. Lang. (2004) Indinavir impairs protein synthesis and phosphorylations of MAPKs in mouse C 2 C 12 myocytes . American Journal of Physiology-Cell Physiology 287:5, pages C1482-C1492.
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Ning Gao, Daniel C. Flynn, Zhuo Zhang, Xiao-Song Zhong, Valerie Walker, Ke Jian Liu, Xianglin Shi & Bing-Hua Jiang. (2004) G 1 cell cycle progression and the expression of G 1 cyclins are regulated by PI3K/AKT/mTOR/p70S6K1 signaling in human ovarian cancer cells . American Journal of Physiology-Cell Physiology 287:2, pages C281-C291.
Crossref
Diane C Fingar & John Blenis. (2004) Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 23:18, pages 3151-3171.
Crossref
M. Aoki & P. K. Vogt. 2004. TOR. TOR 321 338 .
Shigeru Minoguchi, Mayu Minoguchi & Akihiko Yoshimura. (2003) Differential control of the NIMA-related kinases, Nek6 and Nek7, by serum stimulation. Biochemical and Biophysical Research Communications 301:4, pages 899-906.
Crossref
Xiao-Feng Le, Walter N Hittelman, Jiaxin Liu, Amanda McWatters, Chun Li, Gordon B Mills & Robert C BastJrJr. (2003) Paclitaxel induces inactivation of p70 S6 kinase and phosphorylation of Thr421 and Ser424 via multiple signaling pathways in mitosis. Oncogene 22:4, pages 484-497.
Crossref
José L. Crespo & Michael N. Hall. (2002) Elucidating TOR Signaling and Rapamycin Action: Lessons from Saccharomyces cerevisiae . Microbiology and Molecular Biology Reviews 66:4, pages 579-591.
Crossref
Frédéric Pene, Yann-Erick Claessens, Odile Muller, Franck Viguié, Patrick Mayeux, François Dreyfus, Catherine Lacombe & Didier Bouscary. (2002) Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma. Oncogene 21:43, pages 6587-6597.
Crossref
Yoshihiro Iijima, Martin Laser, Hirokazu Shiraishi, Christopher D. Willey, Balasubramanian Sundaravadivel, Lin Xu, Paul J. McDermott & Dhandapani Kuppuswamy. (2002) c-Raf/MEK/ERK Pathway Controls Protein Kinase C-mediated p70S6K Activation in Adult Cardiac Muscle Cells. Journal of Biological Chemistry 277:25, pages 23065-23075.
Crossref
Sivaprakasam Balasubramanian, Tatiana Efimova & Richard L. Eckert. (2002) Green Tea Polyphenol Stimulates a Ras, MEKK1, MEK3, and p38 Cascade to Increase Activator Protein 1 Factor-dependent Involucrin Gene Expression in Normal Human Keratinocytes. Journal of Biological Chemistry 277:3, pages 1828-1836.
Crossref
Ana González-Garcı́a, Elia Garrido, Carmen Hernández, Beatriz Alvarez, Concepción Jiménez, Doreen A. Cantrell, Nicholas Pullen & Ana C. Carrera. (2002) A New Role for the p85-Phosphatidylinositol 3-Kinase Regulatory Subunit Linking FRAP to p70 S6 Kinase Activation. Journal of Biological Chemistry 277:2, pages 1500-1508.
Crossref
Shile Huang & Peter J. Houghton. (2001) Mechanisms of resistance to rapamycins. Drug Resistance Updates 4:6, pages 378-391.
Crossref
Mathieu Miron & Nahum Sonenberg. (2001) Regulation of Translation via TOR Signaling: Insights from Drosophila melanogaster. The Journal of Nutrition 131:11, pages 2988S-2993S.
Crossref
Peter K Vogt. (2001) PI 3-kinase, mTOR, protein synthesis and cancer. Trends in Molecular Medicine 7:11, pages 482-484.
Crossref
Dennis J Templeton. (2001) Protein kinases: Getting NEKed for S6K activation. Current Biology 11:15, pages R596-R599.
Crossref
Brian Raught, Anne-Claude Gingras & Nahum Sonenberg. (2001) The target of rapamycin (TOR) proteins. Proceedings of the National Academy of Sciences 98:13, pages 7037-7044.
Crossref
Anne-Claude Gingras, Brian Raught & Nahum Sonenberg. (2001) Regulation of translation initiation by FRAP/mTOR. Genes & Development 15:7, pages 807-826.
Crossref
Masahiro Aoki, Erik Blazek & Peter K. Vogt. (2000) A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt. Proceedings of the National Academy of Sciences 98:1, pages 136-141.
Crossref
Brian K. Law, Peter Nørgaard & Harold L. Moses. (2000) Farnesyltransferase Inhibitor Induces Rapid Growth Arrest and Blocks p70s6k Activation by Multiple Stimuli. Journal of Biological Chemistry 275:15, pages 10796-10801.
Crossref
Davey B. Parekh, Wolfgang Ziegler & Peter J. Parker. (2000) Multiple pathways control protein kinase C phosphorylation. The EMBO Journal 19:4, pages 496-503.
Crossref
Louis A. Parrott & Dennis J. Templeton. (1999) Osmotic Stress Inhibits p70/85 S6 Kinase through Activation of a Protein Phosphatase. Journal of Biological Chemistry 274:35, pages 24731-24736.
Crossref
Teresa Iglesias & Enrique Rozengurt. (1999) Protein kinase D activation by deletion of its cysteine-rich motifs. FEBS Letters 454:1-2, pages 53-56.
Crossref
W.H. Ziegler, D.B. Parekh, J.A. Le Good, R.D.H. Whelan, J.J. Kelly, M. Frech, B.A. Hemmings & P.J. Parker. (1999) Rapamycin-sensitive phosphorylation of PKC on a carboxy-terminal site by an atypical PKC complex. Current Biology 9:10, pages 522-529.
Crossref
Masayuki Matsushita & Angus C. Nairn. (1999) Inhibition of the Ca2+/Calmodulin-dependent Protein Kinase I Cascade by cAMP-dependent Protein Kinase. Journal of Biological Chemistry 274:15, pages 10086-10093.
Crossref
Hsiu-Ling Li, William Davis & Ellen Puré. (1999) Suboptimal Cross-linking of Antigen Receptor Induces Syk-dependent Activation of p70S6 Kinase through Protein Kinase C and Phosphoinositol 3-Kinase. Journal of Biological Chemistry 274:14, pages 9812-9820.
Crossref
Martin Laser, Vijaykumar S. Kasi, Masayoshi Hamawaki, George CooperIVIV, Charlene M. Kerr & Dhandapani Kuppuswamy. (1998) Differential Activation of p70 and p85 S6 Kinase Isoforms during Cardiac Hypertrophy in the Adult Mammal. Journal of Biological Chemistry 273:38, pages 24610-24619.
Crossref
Tatiana Efimova, Peter LaCelle, Jean F. Welter & Richard L. Eckert. (1998) Regulation of Human Involucrin Promoter Activity by a Protein Kinase C, Ras, MEKK1, MEK3, p38/RK, AP1 Signal Transduction Pathway. Journal of Biological Chemistry 273:38, pages 24387-24395.
Crossref
Patrick B. Dennis, Nicholas Pullen, Richard B. Pearson, Sara C. Kozma & George Thomas. (1998) Phosphorylation Sites in the Autoinhibitory Domain Participate in p70s6k Activation Loop Phosphorylation. Journal of Biological Chemistry 273:24, pages 14845-14852.
Crossref
Nelly Marmy Conus, Brian A. Hemmings & Richard B. Pearson. (1998) Differential Regulation by Calcium Reveals Distinct Signaling Requirements for the Activation of Akt and p70S6k. Journal of Biological Chemistry 273:8, pages 4776-4782.
Crossref
Julian Gomez-Cambronero & Christina Veatch. (1996) Emerging paradigms in granulocyte-macrophage colony-stimulating factor signaling. Life Sciences 59:25-26, pages 2099-2111.
Crossref
Timothy R Brazelton & Morris Randall E. (1996) Molecular mechanisms of action of new xenobiotic immunosuppressive drugs: tacrolimus (FK506), sirolimus (rapamycin), mycophenolate mofetil and leflunomide. Current Opinion in Immunology 8:5, pages 710-720.
Crossref

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