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Molecular and Cellular Biology Volume 16, 1996 - Issue 10
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Research Article

Evidence for In Vivo Phosphorylation of the Grb2 SH2-Domain Binding Site on Focal Adhesion Kinase by Src-Family Protein-Tyrosine Kinases

David D. SchlaepferMolecular Biology and Virology Laboratory, Salk Institute for Biological Studies, La Jolla, California92037
&
Tony HunterMolecular Biology and Virology Laboratory, Salk Institute for Biological Studies, La Jolla, California92037Correspondence[email protected]
Pages 5623-5633 | Received 19 Apr 1996, Accepted 24 Jun 1996, Published online: 29 Mar 2023

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Bertha C. Elias, Sujoy Bhattacharya, Ramesh R. Ray & Leonard R. Johnson. (2010) Polyamine-dependent activation of Rac1 is stimulated by focal adhesion-mediated Tiam1 activation. Cell Adhesion & Migration 4:3, pages 419-430.
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M. A. Westhoff, B. Serrels, V. J. Fincham, M. C. Frame & N. O. Carragher. (2004) Src-Mediated Phosphorylation of Focal Adhesion Kinase Couples Actin and Adhesion Dynamics to Survival Signaling. Molecular and Cellular Biology 24:18, pages 8113-8133.
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Renee D. Read, Erika A. Bach & Ross L. Cagan. (2004) Drosophila C-Terminal Src Kinase Negatively Regulates Organ Growth and Cell Proliferation through Inhibition of the Src, Jun N-Terminal Kinase, and STAT Pathways. Molecular and Cellular Biology 24:15, pages 6676-6689.
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Jill M. Dunty, Veronica Gabarra-Niecko, Michelle L. King, Derek F. J. Ceccarelli, Michael J. Eck & Michael D. Schaller. (2004) FERM Domain Interaction Promotes FAK Signaling. Molecular and Cellular Biology 24:12, pages 5353-5368.
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Lee Ann Cooper, Tang-Long Shen & Jun-Lin Guan. (2003) Regulation of Focal Adhesion Kinase by Its Amino-Terminal Domain through an Autoinhibitory Interaction. Molecular and Cellular Biology 23:22, pages 8030-8041.
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Madeleine Toutant, Alicia Costa, Jeanne-Marie Studler, Gress Kadaré, Michèle Carnaud & Jean-Antoine Girault. (2002) Alternative Splicing Controls the Mechanisms of FAK Autophosphorylation. Molecular and Cellular Biology 22:22, pages 7731-7743.
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Michael Schaeffer, Michaela Schneiderbauer, Sascha Weidler, Rosário Tavares, Markus Warmuth, Gabriele de Vos & Michael Hallek. (2001) Signaling through a Novel Domain of gp130 Mediates Cell Proliferation and Activation of Hck and Erk Kinases. Molecular and Cellular Biology 21:23, pages 8068-8081.
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James D. Owen, Paul J. Ruest, David W. Fry & Steven K. Hanks. (1999) Induced Focal Adhesion Kinase (FAK) Expression in FAK-Null Cells Enhances Cell Spreading and Migration Requiring Both Auto- and Activation Loop Phosphorylation Sites and Inhibits Adhesion-Dependent Tyrosine Phosphorylation of Pyk2. Molecular and Cellular Biology 19:7, pages 4806-4818.
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David D. Schlaepfer, K. C. Jones & Tony Hunter. (1998) Multiple Grb2-Mediated Integrin-Stimulated Signaling Pathways to ERK2/Mitogen-Activated Protein Kinase: Summation of Both c-Src- and Focal Adhesion Kinase-Initiated Tyrosine Phosphorylation Events. Molecular and Cellular Biology 18:5, pages 2571-2585.
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Alan Richardson, Rajesh K. Malik, Jeffrey D. Hildebrand & J. Thomas Parsons. (1997) Inhibition of Cell Spreading by Expression of the C-Terminal Domain of Focal Adhesion Kinase (FAK) Is Rescued by Coexpression of Src or Catalytically Inactive FAK: a Role for Paxillin Tyrosine Phosphorylation. Molecular and Cellular Biology 17:12, pages 6906-6914.
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David D. Schlaepfer, Martin A. Broome & Tony Hunter. (1997) Fibronectin-Stimulated Signaling from a Focal Adhesion Kinase–c-Src Complex: Involvement of the Grb2, p130, and Nck Adaptor Proteins. Molecular and Cellular Biology 17:3, pages 1702-1713.
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