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Research Article

Phosphorylation of Tyrosine 720 in the Platelet-Derived Growth Factor α Receptor Is Required for Binding of Grb2 and SHP-2 but Not for Activation of Ras or Cell Proliferation

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Pages 6926-6936 | Received 12 Jul 1995, Accepted 13 Sep 1996, Published online: 29 Mar 2023

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Serge Haan, Christelle Bahlawane, Jiali Wang, Petr V Nazarov, Arnaud Muller, René Eulenfeld, Claude Haan, Catherine Rolvering, Laurent Vallar, Venkata P Satagopam, Thomas Sauter & Monique Yvonne Wiesinger. (2015) The oncogenic FIP1L1-PDGFRα fusion protein displays skewed signaling properties compared to its wild-type PDGFRα counterpart. JAK-STAT 4:1.
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Hetian Lei & Andrius Kazlauskas. (2014) A Reactive Oxygen Species-Mediated, Self-Perpetuating Loop Persistently Activates Platelet-Derived Growth Factor Receptor α. Molecular and Cellular Biology 34:1, pages 110-122.
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Anne Moenning, Richard Jäger, Angela Egert, Wolfram Kress, Eva Wardelmann & Hubert Schorle. (2009) Sustained Platelet-Derived Growth Factor Receptor α Signaling in Osteoblasts Results in Craniosynostosis by Overactivating the Phospholipase C-γ Pathway. Molecular and Cellular Biology 29:3, pages 881-891.
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Stephan Rosenkranz & Andrius Kazlauskas. (1999) Evidence for Distinct Signaling Properties and Biological Responses Induced by the PDGF Receptor α and β Subtypes. Growth Factors 16:3, pages 201-216.
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S P Gorantla, K Zirlik, A Reiter, C Yu, A L Illert, N Von Bubnoff & J Duyster. (2015) F604S exchange in FIP1L1-PDGFRA enhances FIP1L1-PDGFRA protein stability via SHP-2 and SRC: a novel mode of kinase inhibitor resistance. Leukemia 29:8, pages 1763-1770.
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Laura A. Noël, Florence A. Arts, Carmen P. Montano-Almendras, Luk Cox, Olga Gielen, Federica Toffalini, Catherine Y. Marbehant, Jan Cools & Jean-Baptiste Demoulin. (2014) The tyrosine phosphatase SHP2 is required for cell transformation by the receptor tyrosine kinase mutants FIP1L1-PDGFRα and PDGFRα D842V. Molecular Oncology 8:3, pages 728-740.
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Chad D. Walls, Anton Iliuk, Yunpeng Bai, Mu Wang, W. Andy Tao & Zhong-Yin Zhang. (2013) Phosphatase of Regenerating Liver 3 (PRL3) Provokes a Tyrosine Phosphoproteome to Drive Prometastatic Signal Transduction. Molecular & Cellular Proteomics 12:12, pages 3759-3777.
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Nicolas Bisson, D Andrew James, Gordana Ivosev, Stephen A Tate, Ron Bonner, Lorne Taylor & Tony Pawson. (2011) Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor. Nature Biotechnology 29:7, pages 653-658.
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Anselm T. Bäumer, Henrik ten Freyhaus, Heinrich Sauer, Maria Wartenberg, Kai Kappert, Petra Schnabel, Christian Konkol, Jürgen Hescheler, Marius Vantler & Stephan Rosenkranz. (2008) Phosphatidylinositol 3-Kinase-dependent Membrane Recruitment of Rac-1 and p47phox Is Critical for α-Platelet-derived Growth Factor Receptor-induced Production of Reactive Oxygen Species. Journal of Biological Chemistry 283:12, pages 7864-7876.
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Denise Smith, Takeshi Shimamura, Stephanie Barbera & Bruce E. Bejcek. (2007) NF-κB controls growth of glioblastomas/astrocytomas. Molecular and Cellular Biochemistry 307:1-2, pages 141-147.
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Benedetta A. PallanteInga DuignanDaniel OkinAndrew ChinMichael C. BressanTakashi MikawaJay M. Edelberg. (2007) Bone Marrow Oct3/4 + Cells Differentiate Into Cardiac Myocytes via Age-Dependent Paracrine Mechanisms . Circulation Research 100:1.
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Marius Vantler, Michael Huntgeburth, Evren Caglayan, Henrik ten Freyhaus, Petra Schnabel & Stephan Rosenkranz. (2006) PI3-kinase/Akt-dependent antiapoptotic signaling by the PDGF α receptor is negatively regulated by Src family kinases. FEBS Letters 580:30, pages 6769-6776.
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Diana Imhof, Anne-Sophie Wavreille, Andreas May, Martin Zacharias, Susheela Tridandapani & Dehua Pei. (2006) Sequence Specificity of SHP-1 and SHP-2 Src Homology 2 Domains. Journal of Biological Chemistry 281:29, pages 20271-20282.
Crossref
Wei-Hui Xu, Yong-Sheng Wang, Guo-Zhen Liu, Xiuhua Chen, Porntip Tinjuangjun, Li-Ya Pi & Wen-Yuan Song. (2006) The autophosphorylated Ser686, Thr688, and Ser689 residues in the intracellular juxtamembrane domain of XA21 are implicated in stability control of rice receptor-like kinase. The Plant Journal 45:5, pages 740-751.
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Kuei-Tien Chen, Jen-Der Lin, Miaw-Jene Liou, Hsiao-Fen Weng, C.Allen Chang & Err-Cheng Chan. (2006) An aberrant autocrine activation of the platelet-derived growth factor α-receptor in follicular and papillary thyroid carcinoma cell lines. Cancer Letters 231:2, pages 192-205.
Crossref
Linda Schneider, Christian A. Clement, Stefan C. Teilmann, Gregory J. Pazour, Else K. Hoffmann, Peter Satir & Søren T. Christensen. (2005) PDGFRαα Signaling Is Regulated through the Primary Cilium in Fibroblasts. Current Biology 15:20, pages 1861-1866.
Crossref
Melanie Van Stry, Andrius Kazlauskas, Stuart L. Schreiber & Karen Symes. (2005) Distinct effectors of platelet-derived growth factor receptor-α signaling are required for cell survival during embryogenesis. Proceedings of the National Academy of Sciences 102:23, pages 8233-8238.
Crossref
Mary ARNAUD, Rym MZALI, Franck GESBERT, Catherine CROUIN, Christine GUENZI, Claudine VERMOT-DESROCHES, John WIJDENES, Geneviève COURTOIS, Olivier BERNARD & Jacques BERTOGLIO. (2004) Interaction of the tyrosine phosphatase SHP-2 with Gab2 regulates Rho-dependent activation of the c- fos serum response element by interleukin-2 . Biochemical Journal 382:2, pages 545-556.
Crossref
M.V. Kovalenko & Andrius Kazlauskas. 2003. Handbook of Cell Signaling. Handbook of Cell Signaling 397 404 .
Tzu-Ching Meng, Toshiyuki Fukada & Nicholas K Tonks. (2002) Reversible Oxidation and Inactivation of Protein Tyrosine Phosphatases In Vivo. Molecular Cell 9:2, pages 387-399.
Crossref
Diana L. Esposito, Yunhua Li, Alessandro Cama & Michael J. Quon. (2001) Tyr612 and Tyr632 in Human Insulin Receptor Substrate-1 Are Important for Full Activation of Insulin-Stimulated Phosphatidylinositol 3-Kinase Activity and Translocation of GLUT4 in Adipose Cells*. Endocrinology 142:7, pages 2833-2840.
Crossref
S. H. Ong, Y. R. Hadari, N. Gotoh, G. R. Guy, J. Schlessinger & I. Lax. (2001) Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins. Proceedings of the National Academy of Sciences 98:11, pages 6074-6079.
Crossref
Richard A Klinghoffer, Peter F Mueting-Nelsen, Alexander Faerman, Moshe Shani & Philippe Soriano. (2001) The Two PDGF Receptors Maintain Conserved Signaling In Vivo despite Divergent Embryological Functions. Molecular Cell 7:2, pages 343-354.
Crossref
Samir Ali & Suhad Ali. (2000) Recruitment of the Protein-tyrosine Phosphatase SHP-2 to the C-terminal Tyrosine of the Prolactin Receptor and to the Adaptor Protein Gab2. Journal of Biological Chemistry 275:50, pages 39073-39080.
Crossref
Roya Hooshmand-Rad, Lingge Lu, Carl-Henrik Heldin, Lena Claesson-Welsh & Michael Welsh. (2000) Platelet-Derived Growth Factor-Mediated Signaling through the Shb Adaptor Protein: Effects on Cytoskeletal Organization. Experimental Cell Research 257:2, pages 245-254.
Crossref
Yi-Zhe Wang, Walker Wharton, Roy Garcia, Alan Kraker, Richard Jove & W J Pledger. (2000) Activation of Stat3 preassembled with platelet-derived growth factor β receptors requires Src kinase activity. Oncogene 19:17, pages 2075-2085.
Crossref
Ali Jazayeri, James McGee, Takeshi Shimamura, Scott B. Cross & Bruce E. Bejcek. (2000) SHP-2 Can Suppress Transformation Induced by Platelet-Derived Growth Factor. Experimental Cell Research 254:2, pages 197-203.
Crossref
Amy Bernard & Andrius Kazlauskas. (1999) Phosphospecific Antibodies Reveal Temporal Regulation of Platelet-Derived Growth Factor β Receptor Signaling. Experimental Cell Research 253:2, pages 704-712.
Crossref
Stephan Rosenkranz, Kris A. DeMali, Julie A. Gelderloos, Chantal Bazenet & Andrius Kazlauskas. (1999) Identification of the Receptor-associated Signaling Enzymes That Are Required for Platelet-derived Growth Factor-AA-dependent Chemotaxis and DNA Synthesis. Journal of Biological Chemistry 274:40, pages 28335-28343.
Crossref
Sachiko Miyake, Karen P. Mullane-Robinson, Nancy L. Lill, Patrice Douillard & Hamid Band. (1999) Cbl-mediated Negative Regulation of Platelet-derived Growth Factor Receptor-dependent Cell Proliferation. Journal of Biological Chemistry 274:23, pages 16619-16628.
Crossref
Michele A McTigue, John A Wickersham, Chris Pinko, Richard E Showalter, Camran V Parast, Anna Tempczyk-Russell, Michael R Gehring, Barbara Mroczkowski, Chen-Chen Kan, J Ernest Villafranca & Krzysztof Appelt. (1999) Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis. Structure 7:3, pages 319-330.
Crossref
Yanhua Hu, Güunther Böck, Georg Wick & Qingbo Xu. (1998) Activation of PDGF receptor α in vascular smooth muscle cells by mechanical stress. The FASEB Journal 12:12, pages 1135-1142.
Crossref
Carl-Henrik Heldin, Arne Östman & Lars Rönnstrand. (1998) Signal transduction via platelet-derived growth factor receptors. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1378:1, pages F79-F113.
Crossref
Kazuhiro Nakamura & John C. Cambier. (1998) B Cell Antigen Receptor (BCR)-Mediated Formation of a SHP-2-pp120 Complex and Its Inhibition by FeγRIIB1-BCR Coligation. The Journal of Immunology 161:2, pages 684-691.
Crossref
Sachiko Miyake, Mark L. LupherJr.Jr., Brian Druker & Hamid Band. (1998) The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor α. Proceedings of the National Academy of Sciences 95:14, pages 7927-7932.
Crossref
R. Hooshmand-RadK. YokoteC.H. HeldinL. Claesson-Welsh. (1998) PDGF alpha-receptor mediated cellular responses are not dependent on Src family kinases in endothelial cells. Journal of Cell Science 111:5, pages 607-614.
Crossref
Julie A. Gelderloos, Stephan Rosenkranz, Chantal Bazenet & Andrius Kazlauskas. (1998) A Role for Src in Signal Relay by the Platelet-derived Growth Factor α Receptor. Journal of Biological Chemistry 273:10, pages 5908-5915.
Crossref
Jean-Pierre Montmayeur, Mindaugas Valius, Jackie Vandenheede & Andrius Kazlauskas. (1997) The Platelet-derived Growth Factor β Receptor Triggers Multiple Cytoplasmic Signaling Cascades That Arrive at the Nucleus as Distinguishable Inputs. Journal of Biological Chemistry 272:51, pages 32670-32678.
Crossref

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