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Molecular and Cellular Biology Volume 16, 1996 - Issue 2
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Research Article

Protein-DNA Interactions at the Major and Minor Promoters of the Divergently Transcribed dhfr and rep3 Genes during the Chinese Hamster Ovary Cell Cycle

Julie Wells1 Program in Cell and Molecular Biology, University of Vermont College of Medicine, Burlington, Vermont05405;2 Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont05405
,
Paul Held2 Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont05405
,
Sharon Illenye2 Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont05405
&
Nicholas H. Heintz1 Program in Cell and Molecular Biology, University of Vermont College of Medicine, Burlington, Vermont05405;2 Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont05405Correspondence[email protected]
Pages 634-647 | Received 19 Sep 1995, Accepted 15 Nov 1995, Published online: 29 Mar 2023

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Takayo Sasaki, Sunita Ramanathan, Yukiko Okuno, Chiharu Kumagai, Seemab S. Shaikh & David M. Gilbert. (2006) The Chinese Hamster Dihydrofolate Reductase Replication Origin Decision Point Follows Activation of Transcription and Suppresses Initiation of Replication within Transcription Units. Molecular and Cellular Biology 26:3, pages 1051-1062.
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Young-Chae Chang, Sharon Illenye & Nicholas H. Heintz. (2001) Cooperation of E2F-p130 and Sp1-pRb Complexes in Repression of the Chinese Hamster dhfr Gene. Molecular and Cellular Biology 21:4, pages 1121-1131.
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Julie Wells, Kathryn E. Boyd, Christopher J. Fry, Stephanie M. Bartley & Peggy J. Farnham. (2000) Target Gene Specificity of E2F and Pocket Protein Family Members in Living Cells. Molecular and Cellular Biology 20:16, pages 5797-5807.
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Frederick A. Dick, Elizabeth Sailhamer & Nicholas J. Dyson. (2000) Mutagenesis of the pRB Pocket Reveals that Cell Cycle Arrest Functions Are Separable from Binding to Viral Oncoproteins. Molecular and Cellular Biology 20:10, pages 3715-3727.
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Guus Hateboer, Albrecht Wobst, Birgit Otzen Petersen, Laurent Le Cam, Elena Vigo, Claude Sardet & Kristian Helin. (1998) Cell Cycle-Regulated Expression of Mammalian CDC6 Is Dependent on E2F. Molecular and Cellular Biology 18:11, pages 6679-6697.
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Yunxia Tao, Robert F. Kassatly, W. Douglas Cress & Jonathan M. Horowitz. (1997) Subunit Composition Determines E2F DNA-Binding Site Specificity. Molecular and Cellular Biology 17:12, pages 6994-7007.
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Jia-Rui Wu & David M. Gilbert. (1997) The Replication Origin Decision Point Is a Mitogen-Independent, 2-Aminopurine-Sensitive, G1-Phase Event That Precedes Restriction Point Control. Molecular and Cellular Biology 17:8, pages 4312-4321.
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Christopher J. Fry, Jill E. Slansky & Peggy J. Farnham. (1997) Position-Dependent Transcriptional Regulation of the Murine Dihydrofolate Reductase Promoter by the E2F Transactivation Domain. Molecular and Cellular Biology 17:4, pages 1966-1976.
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Articles from other publishers (35)

Hong LiQiang Li, Yixuan Zhang, Wenting Liu, Bo Gu, Taro Narumi, Kin Lung Siu, Ji Youn Youn, Peiqing LiuXia Yang & Hua Cai. (2019) Novel Treatment of Hypertension by Specifically Targeting E2F for Restoration of Endothelial Dihydrofolate Reductase and eNOS Function Under Oxidative Stress. Hypertension 73:1, pages 179-189.
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Julie Wells, Miguel N. Rivera, Woo Jae Kim, Kristen Starbuck & Daniel A. Haber. (2010) The Predominant WT1 Isoform (+KTS) Encodes a DNA-Binding Protein Targeting the Planar Cell Polarity Gene Scribble in Renal Podocytes . Molecular Cancer Research 8:7, pages 975-985.
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Michael C. FlickingerMariam Naciri & Mohamed Al-Rubeai. 2009. Encyclopedia of Industrial Biotechnology. Encyclopedia of Industrial Biotechnology.
Alayne L Schroll & Nicholas H Heintz. (2004) Chemical footprinting of structural and functional elements of dhfr oriβ during the CHOC 400 cell cycle. Gene 332, pages 139-147.
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Ziqiang Yuan, Harriet Schellekens, Loraine Warner, Yvonne Janssen-Heininger, Peter Burch & Nicholas H. Heintz. (2003) Reactive Nitrogen Species Block Cell Cycle Re-Entry through Sustained Production of Hydrogen Peroxide. American Journal of Respiratory Cell and Molecular Biology 28:6, pages 705-712.
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Kwan-Kyu Park, Seok-Woo Rue, In-Seon Lee, Hyun-Chul Kim, In-Kyu Lee, Jong Deok Ahn, Hyun-Soo Kim, Tae-Shick Yu, Jong-Young Kwak, Nicholas H Heintz, Junji Magae & Young-Chae Chang. (2003) Modulation of Sp1-dependent transcription by a cis-acting E2F element in dhfr promoter. Biochemical and Biophysical Research Communications 306:1, pages 239-243.
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Scott W. Blume, Zheng Meng, Kedar Shrestha, Richard C. Snyder & Peter D. Emanuel. (2003) The 5?-untranslated RNA of the human dhfr minor transcript alters transcription pre-initiation complex assembly at the major (core) promoter. Journal of Cellular Biochemistry 88:1, pages 165-180.
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T I Kuschak, B C Kuschak, C L Taylor, J A Wright, F Wiener & S Mai. (2002) c-Myc initiates illegitimate replication of the ribonucleotide reductase R2 gene. Oncogene 21:6, pages 909-920.
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Jolanta Polanowska, Eric Fabbrizio, Laurent Le Cam, Didier Trouche, Stephane Emiliani, Raphael Herrera & Claude Sardet. (2001) The periodic down regulation of Cyclin E gene expression from exit of mitosis to end of G1 is controlled by a deacetylase- and E2F-associated bipartite repressor element. Oncogene 20:31, pages 4115-4127.
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Eva Haidweger, Michael Novy & Hans Rotheneder. (2001) Modulation of Sp1 activity by a cyclin A/CDK complex. Journal of Molecular Biology 306:2, pages 201-212.
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Young-Chae Chang, Hiroo Nakajima, Sharon Illenye, Yun-Sik Lee, Nobuko Honjo, Tazuko Makiyama, Ikuya Fujiwara, Naruhiko Mizuta, Kiyoshi Sawai, Kaname Saida, Youji Mitsui, Nicholas H Heintz & Junji Magae. (2000) Caspase-dependent apoptosis by ectopic expression of E2F-4. Oncogene 19:41, pages 4713-4720.
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V Facchinetti, R Lopa, F Spreafico, F Bolognese, R Mantovani, F Tavner, R Watson, M Introna & J Golay. (2000) Isolation and characterization of the human A-myb promoter: regulation by NF-Y and Sp1. Oncogene 19:34, pages 3931-3940.
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Frederic Jehan & Hector F. DeLuca. (2000) The Mouse Vitamin D Receptor Is Mainly Expressed through an Sp1-Driven Promoter in Vivo. Archives of Biochemistry and Biophysics 377:2, pages 273-283.
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T A Lee & P J Farnham. (2000) Exogenous E2F expression is growth inhibitory before, during, and after cellular transformation. Oncogene 19:18, pages 2257-2268.
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Heiko Müller & Kristian Helin. (2000) The E2F transcription factors: key regulators of cell proliferation. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1470:1, pages M1-M12.
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Hans Rotheneder, Sibylle Geymayer & Eva Haidweger. (1999) Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter 1 1Edited by M. Yaniv. Journal of Molecular Biology 293:5, pages 1005-1015.
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Mark J. Hickman & Leona D. Samson. (1999) Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents. Proceedings of the National Academy of Sciences 96:19, pages 10764-10769.
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Erika R. Lukas, Stephanie M. Bartley, Carrie R. Graveel, Zobeida M. Diaz, Nicholas Dyson, Ed Harlow, Lili Yamasaki & Peggy J. Farnham. (1999) No effect of loss of E2F1 on liver regeneration or hepatocarcinogenesis in C57BL/6J or C3H/HeJ mice. Molecular Carcinogenesis 25:4, pages 295-303.
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James T Drummond. (1999) Genomic amplification of the human DHFR/MSH3 locus remodels mismatch recognition and repair activities. Advances in Enzyme Regulation 39:1, pages 129-141.
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Christopher J. Fry, Angela Pearson, Erik Malinowski, Stephanie M. Bartley, Jack Greenblatt & Peggy J. Farnham. (1999) Activation of the Murine Dihydrofolate Reductase Promoter by E2F1. Journal of Biological Chemistry 274:22, pages 15883-15891.
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Patrizia Lavia & Pidder Jansen-Dürr. (1999) E2F target genes and cell-cycle checkpoint control. BioEssays 21:3, pages 221-230.
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Junji Magae, Sharon Illenye, Young-Chae Chang, Youji Mitsui & Nicholas H Heintz. (1999) Association with E2F-1 governs intracellular trafficking and polyubiquitination of DP-1. Oncogene 18:3, pages 593-605.
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Adrian R. Black, David Jensen, Shiaw-Yih Lin & Jane Clifford Azizkhan. (1999) Growth/Cell Cycle Regulation of Sp1 Phosphorylation. Journal of Biological Chemistry 274:3, pages 1207-1215.
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Leonid A. Sitailo, Alexander M. Zagariya, Patrick J. Arnold, Gayatri Vedantam & David W. Hecht. (1998) The Bacteroides fragilis BtgA Mobilization Protein Binds to the oriT Region of pBFTM10 . Journal of Bacteriology 180:18, pages 4922-4928.
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Giancarlo Marra, Ingram Iaccarino, Teresa Lettieri, Giuseppe Roscilli, Paola Delmastro & Josef Jiricny. (1998) Mismatch repair deficiency associated with overexpression of the MSH3 gene . Proceedings of the National Academy of Sciences 95:15, pages 8568-8573.
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Kristian Helin. (1998) Regulation of cell proliferation by the E2F transcription factors. Current Opinion in Genetics & Development 8:1, pages 28-35.
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Cheryl Taylor & Sabine Mai. (1998) c-Myc-Associated Genomic Instability of the Dihydrofolate Reductase Locus in Vivo. Cancer Detection <html_ent glyph="@amp;" ascii="&"/> Prevention 22:4, pages 350-356.
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L. Yamasaki. 1998. Cell Cycle Control. Cell Cycle Control 199 227 .
Stella Tommasi & Gerd P. Pfeifer. (1997) Constitutive Protection of E2F Recognition Sequences in the Human Thymidine Kinase Promoter during Cell Cycle Progression. Journal of Biological Chemistry 272:48, pages 30483-30490.
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David E. Jensen, Adrian R. Black, Andrew G. Swick & Jane Clifford Azizkhan. (1997) Distinct roles for Sp1 and E2F sites in the growth/cell cycle regulation of the DHFR promoter. Journal of Cellular Biochemistry 67:1, pages 24-31.
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Julie M. Wells, Sharon Illenye, Junji Magae, Chin-Lee Wu & Nicholas H. Heintz. (1997) Accumulation of E2F-4·DP-1 DNA Binding Complexes Correlates with Induction of dhfr Gene Expression during the G1 to S Phase Transition. Journal of Biological Chemistry 272:7, pages 4483-4492.
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C. Taylor, A. Jalava & S. Mai. 1997. C-Myc in B-Cell Neoplasia. C-Myc in B-Cell Neoplasia 201 207 .
Claude Sardet, Laurent LeCam, Eric Fabbrizio & Marc Vidal. 1997. Oncogenes as Transcriptional Regulators. Oncogenes as Transcriptional Regulators 1 62 .
J. MagaeC.L. WuS. IllenyeE. HarlowN.H. Heintz. (1996) Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members. Journal of Cell Science 109:7, pages 1717-1726.
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Irma Sánchez & Brian D Dynlacht. (1996) Transcriptional control of the cell cycle. Current Opinion in Cell Biology 8:3, pages 318-324.
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