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Molecular and Cellular Biology Volume 16, 1996 - Issue 5
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Research Article

The Full Oncogenic Activity of Ret/ptc2 Depends on Tyrosine 539, a Docking Site for Phospholipase Cγ

Maria Grazia Borrello1 Divisione di Oncologia Sperimentale A, Istituto Nazionale Tumori, Milan, ItalyCorrespondence[email protected]
,
Luisella Alberti1 Divisione di Oncologia Sperimentale A, Istituto Nazionale Tumori, Milan, Italy
,
Elena Arighi1 Divisione di Oncologia Sperimentale A, Istituto Nazionale Tumori, Milan, Italy
,
Italia Bongarzone1 Divisione di Oncologia Sperimentale A, Istituto Nazionale Tumori, Milan, Italy
,
Carlo Battistini2 Oncology and Immunology Preclinical Research, Pharmacia & Upjohn Research, Nerviano, Italy
,
Alberto Bardelli3 Dipartimento di Scienze Biomediche e Oncologia, Università di Torino, Turin, Italy
,
Barbara Pasini4 Laboratorio di Genetica Molecolare, Istituto Giannina Gaslini, Genoa, Italy
,
Claudia Piutti2 Oncology and Immunology Preclinical Research, Pharmacia & Upjohn Research, Nerviano, Italy
,
Maria Grazia Rizzetti1 Divisione di Oncologia Sperimentale A, Istituto Nazionale Tumori, Milan, Italy
,
Piera Mondellini1 Divisione di Oncologia Sperimentale A, Istituto Nazionale Tumori, Milan, Italy
,
Maria Teresa Radice1 Divisione di Oncologia Sperimentale A, Istituto Nazionale Tumori, Milan, Italy
&
Marco A. Pierotti1 Divisione di Oncologia Sperimentale A, Istituto Nazionale Tumori, Milan, Italy
 show all
Pages 2151-2163 | Received 25 Sep 1995, Accepted 20 Feb 1996, Published online: 29 Mar 2023

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Mariantonia Nacchio, Pasquale Pisapia, Francesco Pepe, Gianluca Russo, Elena Vigliar, Tommaso Porcelli, Cristina Luongo, Antonino Iaccarino, Fabio Pagni, Domenico Salvatore, Giancarlo Troncone, Umberto Malapelle & Claudio Bellevicine. (2022) Predictive molecular pathology in metastatic thyroid cancer: the role of RET fusions. Expert Review of Endocrinology & Metabolism 17:2, pages 167-178.
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Mayumi Jijiwa, Toshifumi Fukuda, Kumi Kawai, Akari Nakamura, Kei Kurokawa, Yoshiki Murakumo, Masatoshi Ichihara & Masahide Takahashi. (2004) A Targeting Mutation of Tyrosine 1062 in Ret Causes a Marked Decrease of Enteric Neurons and Renal Hypoplasia. Molecular and Cellular Biology 24:18, pages 8026-8036.
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R. M. Melillo, M. Santoro, S.-H. Ong, M. Billaud, A. Fusco, Y. R. Hadari, J. Schlessinger & I. Lax. (2001) Docking Protein FRS2 Links the Protein Tyrosine Kinase RET and Its Oncogenic Forms with the Mitogen-Activated Protein Kinase Signaling Cascade. Molecular and Cellular Biology 21:13, pages 4177-4187.
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Kyle Durick, Gordon N. Gill & Susan S. Taylor. (1998) Shc and Enigma Are Both Required for Mitogenic Signaling by Ret/ptc2. Molecular and Cellular Biology 18:4, pages 2298-2308.
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