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Molecular and Cellular Biology Volume 16, 1996 - Issue 6
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Research Article

Activation Mechanism of the Multifunctional Transcription Factor Repressor-Activator Protein 1 (Rap1p)

Carolyn M. DrazinicDepartment of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, Florida32610-0266
,
Jeffrey B. SmerageDepartment of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, Florida32610-0266
,
M. Cecilia LópezDepartment of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, Florida32610-0266
&
Henry V. BakerDepartment of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, Florida32610-0266Correspondence[email protected]
Pages 3187-3196 | Received 11 Dec 1995, Accepted 08 Mar 1996, Published online: 29 Mar 2023

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Yu Zhao, Kerri B. McIntosh, Dipayan Rudra, Stephan Schawalder, David Shore & Jonathan R. Warner. (2006) Fine-Structure Analysis of Ribosomal Protein Gene Transcription. Molecular and Cellular Biology 26:13, pages 4853-4862.
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Ian R. Graham, Robin A. Haw, Karen G. Spink, Kathryn A. Halden & Alistair Chambers. (1999) In Vivo Analysis of Functional Regions within Yeast Rap1p. Molecular and Cellular Biology 19:11, pages 7481-7490.
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Martijn Rep, Vladimír Reiser, Ulrike Gartner, Johan M. Thevelein, Stefan Hohmann, Gustav Ammerer & Helmut Ruis. (1999) Osmotic Stress-Induced Gene Expression in Saccharomyces cerevisiae Requires Msn1p and the Novel Nuclear Factor Hot1p. Molecular and Cellular Biology 19:8, pages 5474-5485.
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Liuning Yu & Randall H. Morse. (1999) Chromatin Opening and Transactivator Potentiation by RAP1 in Saccharomyces cerevisiae. Molecular and Cellular Biology 19:8, pages 5279-5288.
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Alexander M. Erkine, Christopher C. Adams, Tuba Diken & David S. Gross. (1996) Heat Shock Factor Gains Access to the Yeast HSC82 Promoter Independently of Other Sequence-Specific Factors and Antagonizes Nucleosomal Repression of Basal and Induced Transcription. Molecular and Cellular Biology 16:12, pages 7004-7017.
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Aaron T Spivak & Gary D Stormo. (2016) Combinatorial Cis -regulation in Saccharomyces Species . G3 Genes|Genomes|Genetics 6:3, pages 653-667.
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Gajendra Kumar Azad, Vikash Singh, Shivani Baranwal, Mayur Jankiram Thakare & Raghuvir S. Tomar. (2014) The transcription factor Rap1p is required for tolerance to cell‐wall perturbing agents and for cell‐wall maintenance in Saccharomyces cerevisiae . FEBS Letters 589:1, pages 59-67.
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Dawn H. Nagel, Jose L. Pruneda-Paz & Steve A. Kay. (2014) FBH1 affects warm temperature responses in the Arabidopsis circadian clock . Proceedings of the National Academy of Sciences 111:40, pages 14595-14600.
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John Blazeck & Hal S. Alper. (2013) Promoter engineering: Recent advances in controlling transcription at the most fundamental level. Biotechnology Journal 8:1, pages 46-58.
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Mythily Ganapathi, Michael J. Palumbo, Suraiya A. Ansari, Qiye He, Kyle Tsui, Corey Nislow & Randall H. Morse. (2011) Extensive role of the general regulatory factors, Abf1 and Rap1, in determining genome-wide chromatin structure in budding yeast. Nucleic Acids Research 39:6, pages 2032-2044.
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Christopher Askew, Adnane Sellam, Elias Epp, Hervé Hogues, Alaka Mullick, André Nantel & Malcolm Whiteway. (2009) Transcriptional Regulation of Carbohydrate Metabolism in the Human Pathogen Candida albicans. PLoS Pathogens 5:10, pages e1000612.
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Panagiota T. Foteinou, Eric Yang, Georges K. Saharidis, Marianthi G. Ierapetritou & Ioannis P. Androulakis. (2007) A mixed-integer optimization framework for the synthesis and analysis of regulatory networks. Journal of Global Optimization 43:2-3, pages 263-276.
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Mourad Bendjennat & P. Anthony Weil. (2008) The Transcriptional Repressor Activator Protein Rap1p Is a Direct Regulator of TATA-binding Protein. Journal of Biological Chemistry 283:13, pages 8699-8710.
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Subhrajit Biswas, Patrick Van Dijck & Asis Datta. (2007) Environmental Sensing and Signal Transduction Pathways Regulating Morphopathogenic Determinants of Candida albicans . Microbiology and Molecular Biology Reviews 71:2, pages 348-376.
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Arunadevi Yarragudi, Laura Wegener Parfrey & Randall H. Morse. (2007) Genome-wide analysis of transcriptional dependence and probable target sites for Abf1 and Rap1 in Saccharomyces cerevisiae. Nucleic Acids Research 35:1, pages 193-202.
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Derek Y Chiang, David A Nix, Ryan K Shultzaberger, Audrey P Gasch & Michael B Eisen. (2006) Flexible promoter architecture requirements for coactivator recruitment. BMC Molecular Biology 7:1.
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Tomohiro Kainou, Tomoko Shinzato, Kentaro Sasaki, Youji Mitsui, Yuko Giga-Hama, Hiromichi Kumagai & Hiroshi Uemura. (2006) Spsgt1, a new essential gene ofSchizosaccharomyces pombe, is involved in carbohydrate metabolism. Yeast 23:1, pages 35-53.
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Hiromi Sasaki, Tomoko Kishimoto, Takayuki Mizuno, Tomoko Shinzato & Hiroshi Uemura. (2005) Expression ofGCR1, the transcriptional activator of glycolytic enzyme genes in the yeastSaccharomyces cerevisiae, is positively autoregulated by Gcr1p. Yeast 22:4, pages 305-319.
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Hiromi Sasaki & Hiroshi Uemura. (2005) Influence of low glycolytic activities ingcr1 andgcr2 mutants on the expression of other metabolic pathway genes inSaccharomyces cerevisiae. Yeast 22:2, pages 111-127.
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Marie Jeppsson, Björn Johansson, Peter Ruhdal Jensen, Bärbel Hahn-Hägerdal & Marie F. Gorwa-Grauslund. (2003) The level of glucose-6-phosphate dehydrogenase activity strongly influences xylose fermentation and inhibitor sensitivity in recombinant Saccharomyces cerevisiae strains . Yeast 20:15, pages 1263-1272.
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S. Türkel, T. Turgut, M. C. López, H. Uemura & H. V. Baker. (2003) Mutations in GCR1 affect SUC2 gene expression in Saccharomyces cerevisiae. Molecular Genetics and Genomics 268:6, pages 825-831.
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B. Piña, J. Fernández-Larrea, N. García-Reyero & F.-Z. Idrissi. (2003) The different (sur)faces of Rap1p. Molecular Genetics and Genomics 268:6, pages 791-798.
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Veronica De Sanctis, Sabrina La Terra, Alessandro Bianchi, David Shore, Luciano Burderi, Ernesto Di Mauro & Rodolfo Negri. (2002) In Vivo Topography of Rap1p–DNA Complex at Saccharomyces cerevisiae TEF2 UASRPG During Transcriptional Regulation. Journal of Molecular Biology 318:2, pages 333-349.
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Liuning Yu, Nevin Sabet, Alistair Chambers & Randall H. Morse. (2001) The N-terminal and C-terminal Domains of RAP1 Are Dispensable for Chromatin Opening and GCN4-mediated HIS4 Activation in Budding Yeast. Journal of Biological Chemistry 276:35, pages 33257-33264.
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Robin Haw, Aruna Devi Yarragudi & Hiroshi Uemura. (2001) Isolation ofGCR1, a major transcription factor of glycolytic genes inSaccharomyces cerevisiae, fromKluyveromyces lactis. Yeast 18:8, pages 729-735.
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Juliet L Reid, Vishwanath R Iyer, Patrick O Brown & Kevin Struhl. (2000) Coordinate Regulation of Yeast Ribosomal Protein Genes Is Associated with Targeted Recruitment of Esa1 Histone Acetylase. Molecular Cell 6:6, pages 1297-1307.
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M. Cecilia López & Henry V. Baker. (2000) Understanding the Growth Phenotype of the Yeast gcr1 Mutant in Terms of Global Genomic Expression Patterns . Journal of Bacteriology 182:17, pages 4970-4978.
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Joachim F. Ernst. (2000) Transcription factors in Candida albicans – environmental control of morphogenesis. Microbiology 146:8, pages 1763-1774.
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Takashi Sato, M.Cecilia Lopez, Shigemi Sugioka, Yoshifumi Jigami, Henry V. Baker & Hiroshi Uemura. (1999) The E-box DNA binding protein Sgc1p suppresses the gcr2 mutation, which is involved in transcriptional activation of glycolytic genes in Saccharomyces cerevisiae . FEBS Letters 463:3, pages 307-311.
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Fátima-Zahra Idrissi, Juan B. Fernández-Larrea & Benjamin Piñ. (1998) Structural and functional heterogeneity of rap1p complexes with telomeric and UASrpg-like DNA sequences. Journal of Molecular Biology 284:4, pages 925-935.
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M. Cecilia López, Jeffery B. Smerage & Henry V. Baker. (1998) Multiple domains of repressor activator protein 1 contribute to facilitated binding of glycolysis regulatory protein 1. Proceedings of the National Academy of Sciences 95:24, pages 14112-14117.
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D Wotton & D Shore. (1997) A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae.. Genes & Development 11:6, pages 748-760.
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Nobuya Ishii, Mutumi Yamamoto, Hans-Werner Lahm, Shinnji Lizumi, Fumie Yoshihara, Hironobu Nakayama, Mikio Arisawa & Yuhko Aoki. (1997) A DNA-binding protein from Candida albicans that binds to the RPG box of Saccharomyces cerevisiae and the telomeric repeat sequence of C. albicans. Microbiology 143:2, pages 417-427.
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