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Molecular and Cellular Biology Volume 16, 1996 - Issue 7
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Research Article

Formation of Extrachromosomal Circular Amplicons with Direct or Inverted Duplications in Drug-Resistant Leishmania tarentolae

Katherine GrondinCentre de Recherche en Infectiologie du Centre Hospitalier de l’Université Laval and Département de Microbiologie, Faculté de Médecine, Université Laval, Québec, Canada
,
Gaétan RoyCentre de Recherche en Infectiologie du Centre Hospitalier de l’Université Laval and Département de Microbiologie, Faculté de Médecine, Université Laval, Québec, Canada
&
Marc OuelletteCentre de Recherche en Infectiologie du Centre Hospitalier de l’Université Laval and Département de Microbiologie, Faculté de Médecine, Université Laval, Québec, CanadaCorrespondence[email protected]
Pages 3587-3595 | Received 24 Jan 1996, Accepted 25 Apr 1996, Published online: 29 Mar 2023

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Hisashi Tanaka, Yi Cao, Donald A. Bergstrom, Charles Kooperberg, Stephen J. Tapscott & Meng-Chao Yao. (2007) Intrastrand Annealing Leads to the Formation of a Large DNA Palindrome and Determines the Boundaries of Genomic Amplification in Human Cancer. Molecular and Cellular Biology 27:6, pages 1993-2002.
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Articles from other publishers (37)

Gaétan Roy, Arijit Bhattacharya, Philippe Leprohon & Marc Ouellette. (2021) Decreased glutamate transport in acivicin resistant Leishmania tarentolae. PLOS Neglected Tropical Diseases 15:12, pages e0010046.
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Wen-Wei Zhang, Patrick Lypaczewski & Greg Matlashewski. 2020. Trypanosomatids. Trypanosomatids 199 224 .
Wen-Wei Zhang & Greg Matlashewski. (2019) Single-Strand Annealing Plays a Major Role in Double-Strand DNA Break Repair following CRISPR-Cas9 Cleavage in Leishmania . mSphere 4:4.
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Amir Hossein Zahirnia, Ali Bordbar, Sahar Ebrahimi, Adel Spotin, Somayeh Mohammadi, Seyedeh Maryam Ghafari, Setareh Ahmadvand, Negar Jabbari, Ahmad Reza Esmaeili Rastaghi & Parviz Parvizi. (2018) Predominance of Leishmania major and rare occurrence of Leishmania tropica with haplotype variability at the center of Iran. The Brazilian Journal of Infectious Diseases 22:4, pages 278-287.
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F. Dumetz, B. Cuypers, H. Imamura, D. Zander, E. D’Haenens, I. Maes, M. A. Domagalska, J. Clos, J.-C. Dujardin & G. De Muylder. (2018) Molecular Preadaptation to Antimony Resistance in Leishmania donovani on the Indian Subcontinent. mSphere 3:2.
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Manu Vanaerschot, Franck Dumetz, Marlene Jara, Jean-Claude Dujardin & Alicia Ponte-Sucre. 2018. Drug Resistance in Leishmania Parasites. Drug Resistance in Leishmania Parasites 341 366 .
Juliana B.F. Garcia, João P.Vieira da Rocha, Héllida M. Costa-Silva, Ceres L. Alves, Carlos R. Machado & Angela K. Cruz. (2016) Leishmania major and Trypanosoma cruzi present distinct DNA damage responses. Molecular and Biochemical Parasitology 207:1, pages 23-32.
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Rubens Monte-Neto, Marie-Claude N. Laffitte, Philippe Leprohon, Priscila Reis, Frédéric Frézard & Marc Ouellette. (2015) Intrachromosomal Amplification, Locus Deletion and Point Mutation in the Aquaglyceroporin AQP1 Gene in Antimony Resistant Leishmania (Viannia) guyanensis. PLOS Neglected Tropical Diseases 9:2, pages e0003476.
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Marie-Claude N. Laffitte, Marie-Michelle Genois, Angana Mukherjee, Danielle Légaré, Jean-Yves Masson & Marc Ouellette. (2014) Formation of Linear Amplicons with Inverted Duplications in Leishmania Requires the MRE11 Nuclease. PLoS Genetics 10:12, pages e1004805.
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Jean-Michel Ubeda, Frédéric Raymond, Angana Mukherjee, Marie Plourde, Hélène Gingras, Gaétan Roy, Andréanne Lapointe, Philippe Leprohon, Barbara Papadopoulou, Jacques Corbeil & Marc Ouellette. (2014) Genome-Wide Stochastic Adaptive DNA Amplification at Direct and Inverted DNA Repeats in the Parasite Leishmania. PLoS Biology 12:5, pages e1001868.
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Marie-Michelle Genois, Eric R. Paquet, Marie-Claude N. Laffitte, Ranjan Maity, Amélie Rodrigue, Marc Ouellette & Jean-Yves Masson. (2014) DNA Repair Pathways in Trypanosomatids: from DNA Repair to Drug Resistance. Microbiology and Molecular Biology Reviews 78:1, pages 40-73.
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Frédéric Frézard, Rubens Monte-Neto & Priscila G. Reis. (2014) Antimony transport mechanisms in resistant leishmania parasites. Biophysical Reviews 6:1, pages 119-132.
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Jeziel D. Damasceno, Vinicius S. Nunes & Luiz R. O. Tosi. (2013) LmHus1 is required for the DNA damage response in Leishmania major and forms a complex with an unusual Rad9 homologue . Molecular Microbiology 90:5, pages 1074-1087.
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Angana Mukherjee, Sébastien Boisvert, Rubens Lima do Monte-Neto, Adriano C. Coelho, Frederic Raymond, Rita Mukhopadhyay, Jacques Corbeil & Marc Ouellette. (2013) Telomeric gene deletion and intrachromosomal amplification in antimony-resistant Leishmania . Molecular Microbiology 88:1, pages 189-202.
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E.J.R. Vasconcelos, M.C. Terrão, J.C. Ruiz, R.Z.N. Vêncio & A.K. Cruz. (2012) In silico identification of conserved intercoding sequences in Leishmania genomes: Unraveling putative cis-regulatory elements. Molecular and Biochemical Parasitology 183:2, pages 140-150.
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Ronald Guillermo Peláez, Carlos Enrrique Muskus Lopez, Patricia Cuervo & Marcel Marín-Villa. (2012) Expresión diferencial de proteínas en Leishmania (Viannia) panamensis asociadas con mecanismos de resistencia a antimoniato de meglumina. Biomédica 32:3.
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Tim Downing, Hideo Imamura, Saskia Decuypere, Taane G. Clark, Graham H. Coombs, James A. Cotton, James D. Hilley, Simonne de Doncker, Ilse Maes, Jeremy C. Mottram, Mike A. Quail, Suman Rijal, Mandy Sanders, Gabriele Schönian, Olivia Stark, Shyam Sundar, Manu Vanaerschot, Christiane Hertz-Fowler, Jean-Claude Dujardin & Matthew Berriman. (2011) Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance . Genome Research 21:12, pages 2143-2156.
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Angana Mukherjee, Lance D. Langston & Marc Ouellette. (2011) Intrachromosomal tandem duplication and repeat expansion during attempts to inactivate the subtelomeric essential gene GSH1 in Leishmania. Nucleic Acids Research 39:17, pages 7499-7511.
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Rubens L. do Monte-Neto, Adriano C. Coelho, Frédéric Raymond, Danielle Légaré, Jacques Corbeil, Maria N. Melo, Frédéric Frézard & Marc Ouellette. (2011) Gene Expression Profiling and Molecular Characterization of Antimony Resistance in Leishmania amazonensis. PLoS Neglected Tropical Diseases 5:5, pages e1167.
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Vinicius S. Nunes, Jeziel D. Damasceno, Raimundo Freire & Luiz R.O. Tosi. (2011) The Hus1 homologue of Leishmania major encodes a nuclear protein that participates in DNA damage response. Molecular and Biochemical Parasitology 177:1, pages 65-69.
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Fakhri Jeddi, Renaud Piarroux & Charles Mary. (2011) Antimony Resistance in Leishmania , Focusing on Experimental Research . Journal of Tropical Medicine 2011, pages 1-15.
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P. Leprohon, D. Legare, F. Raymond, E. Madore, G. Hardiman, J. Corbeil & M. Ouellette. (2009) Gene expression modulation is associated with gene amplification, supernumerary chromosomes and chromosome loss in antimony-resistant Leishmania infantum. Nucleic Acids Research 37:5, pages 1387-1399.
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Fabricio C. Dias, Jeronimo C. Ruiz, Wilton C. Z. Lopes, Fabio M. Squina, Adriana Renzi, Angela K. Cruz & Luiz R. O. Tosi. (2007) Organization of H locus conserved repeats in Leishmania (Viannia) braziliensis correlates with lack of gene amplification and drug resistance. Parasitology Research 101:3, pages 667-676.
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Hisashi Tanaka, Donald A Bergstrom, Meng-Chao Yao & Stephen J Tapscott. (2005) Widespread and nonrandom distribution of DNA palindromes in cancer cells provides a structural platform for subsequent gene amplification. Nature Genetics 37:3, pages 320-327.
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Adriana Parodi-Talice, Jose Marı́a Araújo, Cristina Torres, Jose Marı́a Pérez-Victoria, Francisco Gamarro & Santiago Castanys. (2003) The overexpression of a new ABC transporter in Leishmania is related to phospholipid trafficking and reduced infectivity. Biochimica et Biophysica Acta (BBA) - Biomembranes 1612:2, pages 195-207.
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Charles Anacleto, Maria C. B. Abdo, Adlane V. B. Ferreira, Silvane M. F. Murta, Álvaro J. Romanha, Ana Paula Fernandes & Elizabeth S. A. Moreira. (2003) Structural and functional analysis of an amplification containing a PGPA gene in a glucantime-resistant Leishmania (Viannia) guyanensis cell line. Parasitology Research 90:2, pages 110-118.
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Marc Ouellette, Jolyne Drummelsmith, Amal El Fadili, Christoph Kündig, Dave Richard & Gaétan Roy. (2002) Pterin transport and metabolism in Leishmania and related trypanosomatid parasites. International Journal for Parasitology 32:4, pages 385-398.
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Elizabeth B. Albrecht, Aaron B. Hunyady, George R. Stark & Thomas E. Patterson. (2000) Mechanisms of sod2 Gene Amplification in Schizosaccharomyces pombe . Molecular Biology of the Cell 11:3, pages 873-886.
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C. Kundig, E. Leblanc, B. Papadopoulou & M. Ouellette. (1999) Role of the locus and of the resistance gene on gene amplification frequency in methotrexate resistant Leishmania tarentolae. Nucleic Acids Research 27:18, pages 3653-3659.
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John A. Flaspohler, Kayde Lemley & Marilyn Parsons. (1999) A dominant negative mutation in the GIM1 gene of Leishmania donovani is responsible for defects in glycosomal protein localization. Molecular and Biochemical Parasitology 99:1, pages 117-128.
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Yi Lisa Lyu, Ching-Tai Lin & Leroy F Liu. (1999) Inversion/dimerization of plasmids mediated by inverted repeats 1 1Edited by M. Gottesman. Journal of Molecular Biology 285:4, pages 1485-1501.
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K. Grondin, C. Kundig, G. Roy & M. Ouellette. (1998) Linear amplicons as precursors of amplified circles in methotrexate-resistant Leishmania tarentolae. Nucleic Acids Research 26:14, pages 3370-3378.
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Barbara Papadopoulou, Christoph Kündig, Ajay Singh & Marc Ouellette. (1998) Drug resistance in Leishmania: similarities and differences to other organisms. Drug Resistance Updates 1:4, pages 266-278.
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Danielle Légaré, Barbara Papadopoulou, Gaétan Roy, Rita Mukhopadhyay, Anass Haimeur, Saibal Dey, Katherine Grondin, Christian Brochu, Barry P. Rosen & Marc Ouellette. (1997) Efflux Systems and Increased Trypanothione Levels in Arsenite-ResistantLeishmania. Experimental Parasitology 87:3, pages 275-282.
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Edda Rayko. (1997) Organization, generation and replication of amphimeric genomes: a review. Gene 199:1-2, pages 1-18.
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M. Segovia & G. Ortiz. (1997) LD1 amplifications in Leishmania. Parasitology Today 13:9, pages 342-348.
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David K Butler, Lauren E Yasuda & Meng-Chao Yao. (1996) Induction of Large DNA Palindrome Formation in Yeast: Implications for Gene Amplification and Genome Stability in Eukaryotes. Cell 87:6, pages 1115-1122.
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