17
Views
149
CrossRef citations to date
0
Altmetric
Research Article

Human Rad50 Is Physically Associated with Human Mre11: Identification of a Conserved Multiprotein Complex Implicated in Recombinational DNA Repair

, , , , , & show all
Pages 4832-4841 | Received 03 Apr 1996, Accepted 10 Jun 1996, Published online: 29 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (11)

Olga Kostianets, Maksym Shyyan, Stepan Vasil’ovich Antoniuk, Valeriy Filonenko & Ramziya Kiyamova. (2017) Panel of SEREX-defined antigens for breast cancer autoantibodies profile detection. Biomarkers 22:2, pages 149-156.
Read now
Olga Kostianets, Maksym Shyian, Demidov Sergiy, Stepan Antoniuk, Ivan Gout, Valeriy Filonenko & Ramziya Kiyamova. (2012) Serological Analysis of SEREX-Defined Medullary Breast Carcinoma-Associated Antigens. Cancer Investigation 30:7, pages 519-527.
Read now
Karen Cerosaletti, Jocyndra Wright & Patrick Concannon. (2006) Active Role for Nibrin in the Kinetics of Atm Activation. Molecular and Cellular Biology 26:5, pages 1691-1699.
Read now
Bertrand Llorente & Lorraine S. Symington. (2004) The Mre11 Nuclease Is Not Required for 5′ to 3′ Resection at Multiple HO-Induced Double-Strand Breaks. Molecular and Cellular Biology 24:21, pages 9682-9694.
Read now
Olga K. Mirzoeva & John H. J. Petrini. (2001) DNA Damage-Dependent Nuclear Dynamics of the Mre11 Complex. Molecular and Cellular Biology 21:1, pages 281-288.
Read now
Sylvie Moreau, John R. Ferguson & Lorraine S. Symington. (1999) The Nuclease Activity of Mre11 Is Required for Meiosis but Not for Mating Type Switching, End Joining, or Telomere Maintenance. Molecular and Cellular Biology 19:1, pages 556-566.
Read now
Yuko Yamaguchi-Iwai, Eiichiro Sonoda, Jean-Marie Buerstedde, Olga Bezzubova, Ciaran Morrison, Minoru Takata, Akira Shinohara & Shunichi Takeda. (1998) Homologous Recombination, but Not DNA Repair, Is Reduced in Vertebrate Cells Deficient in RAD52. Molecular and Cellular Biology 18:11, pages 6430-6435.
Read now
Rolf Kooistra, Kees Vreeken, José B. M. Zonneveld, Anja de Jong, Jan C. J. Eeken, Chris J. Osgood, Jean-Marie Buerstedde, Paul H. M. Lohman & Albert Pastink. (1997) The Drosophila melanogaster RAD54 Homolog, DmRAD54, Is Involved in the Repair of Radiation Damage and Recombination. Molecular and Cellular Biology 17:10, pages 6097-6104.
Read now
Richard S. Maser, Kirsten J. Monsen, Benjamin E. Nelms & John H. J. Petrini. (1997) hMre11 and hRad50 Nuclear Foci Are Induced During the Normal Cellular Response to DNA Double-Strand Breaks †. Molecular and Cellular Biology 17:10, pages 6087-6096.
Read now
Ercan Akgün, Jeffrey Zahn, Susan Baumes, Greg Brown, Feng Liang, Peter J. Romanienko, Susanna Lewis & Maria Jasin. (1997) Palindrome Resolution and Recombination in the Mammalian Germ Line. Molecular and Cellular Biology 17:9, pages 5559-5570.
Read now
Wim Jongmans, Michèle Vuillaume, Krystyna Chrzanowska, Dominique Smeets, Karl Sperling & Janet Hall. (1997) Nijmegen Breakage Syndrome Cells Fail To Induce the p53-Mediated DNA Damage Response following Exposure to Ionizing Radiation. Molecular and Cellular Biology 17:9, pages 5016-5022.
Read now

Articles from other publishers (138)

Aaliya Anwaar, Ashok K. Varma & Reshita Baruah. (2023) In Silico-Based Structural Evaluation to Categorize the Pathogenicity of Mutations Identified in the RAD Class of Proteins. ACS Omega 8:11, pages 10266-10277.
Crossref
Emma Lund Johansen, Christine Fribert Thusgaard, Mads Thomassen, Susanne Eriksen Boonen & Kirsten Marie Jochumsen. (2022) Germline pathogenic variants associated with ovarian cancer: A historical overview. Gynecologic Oncology Reports 44, pages 101105.
Crossref
Sijie Liu & Daochun Kong. (2020) End resection: a key step in homologous recombination and DNA double-strand break repair. Genome Instability & Disease 2:1, pages 39-50.
Crossref
Alanna R. Kaplan & Peter M. Glazer. 2020. 187 213 .
Yongtai Bai, Weibin Wang, Siyu Li, Jun Zhan, Hanxiao Li, Meimei Zhao, Xiao Albert Zhou, Shiwei Li, Xiaoman Li, Yanfei Huo, Qinjian Shen, Mei Zhou, Hongquan Zhang, Jianyuan Luo, Patrick Sung, Wei-Guo Zhu, Xingzhi Xu & Jiadong Wang. (2019) C1QBP Promotes Homologous Recombination by Stabilizing MRE11 and Controlling the Assembly and Activation of MRE11/RAD50/NBS1 Complex. Molecular Cell 75:6, pages 1299-1314.e6.
Crossref
Hae Ryung Chang, Anudari Munkhjargal, Myung-Jin Kim, Seon Young Park, Eunyoung Jung, Jae-Ha Ryu, Young Yang, Jong-Seok Lim & Yonghwan Kim. (2018) The functional roles of PML nuclear bodies in genome maintenance. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 809, pages 99-107.
Crossref
Stefan J. Barfeld, Alfonso Urbanucci, Harri M. Itkonen, Ladan Fazli, Jessica L. Hicks, Bernd Thiede, Paul S. Rennie, Srinivasan Yegnasubramanian, Angelo M. DeMarzo & Ian G. Mills. (2017) c-Myc Antagonises the Transcriptional Activity of the Androgen Receptor in Prostate Cancer Affecting Key Gene Networks. EBioMedicine 18, pages 83-93.
Crossref
Arwa A. Abugable, Dahlia A. Awwad, Dalia Fleifel, Mohamed M. Ali, Sherif El-Khamisy & Menattallah Elserafy. 2017. Personalised Medicine. Personalised Medicine 157 178 .
Susanne B. Breitkopf, Min Yuan, Katja P. Helenius, Costas A. Lyssiotis & John M. Asara. (2015) Triomics Analysis of Imatinib-Treated Myeloma Cells Connects Kinase Inhibition to RNA Processing and Decreased Lipid Biosynthesis. Analytical Chemistry 87:21, pages 10995-11006.
Crossref
Petr Cejka. (2015) DNA End Resection: Nucleases Team Up with the Right Partners to Initiate Homologous Recombination. Journal of Biological Chemistry 290:38, pages 22931-22938.
Crossref
Jessica S. Brown & Stephen P. Jackson. (2015) Ubiquitylation, neddylation and the DNA damage response. Open Biology 5:4, pages 150018.
Crossref
A. Sandoval-Cabrera, A.L. Zarzosa-Álvarez, R.M. Martínez-Miguel & R.M. Bermúdez-Cruz. (2015) MR (Mre11-Rad50) complex in Giardia duodenalis: In vitro characterization and its response upon DNA damage. Biochimie 111, pages 45-57.
Crossref
Marie-Claude N. Laffitte, Marie-Michelle Genois, Angana Mukherjee, Danielle Légaré, Jean-Yves Masson & Marc Ouellette. (2014) Formation of Linear Amplicons with Inverted Duplications in Leishmania Requires the MRE11 Nuclease. PLoS Genetics 10:12, pages e1004805.
Crossref
Anna Rojowska, Katja Lammens, Florian U Seifert, Carolin Direnberger, Heidi Feldmann & Karl‐Peter Hopfner. (2014) Structure of the Rad50 DNA double‐strand break repair protein in complex with DNA . The EMBO Journal 33:23, pages 2847-2859.
Crossref
Bianca Schröder‐Heurich, Britta Wieland, Martin F. Lavin, Detlev Schindler & Thilo Dörk. (2013) Protective role of RAD50 on chromatin bridges during abnormal cytokinesis. The FASEB Journal 28:3, pages 1331-1341.
Crossref
Olga Kostianets, Stepan Antoniuk, Valeriy Filonenko & Ramziya Kiyamova. (2012) Immunohistochemical analysis of medullary breast carcinoma autoantigens in different histological types of breast carcinomas. Diagnostic Pathology 7:1.
Crossref
Karl-Peter Hopfner, Derk Bemeleit & Katja Lammens. 2011. Encyclopedia of Inorganic and Bioinorganic Chemistry. Encyclopedia of Inorganic and Bioinorganic Chemistry.
Young Bong Park, Jina Chae, Young Chang Kim & Yunje Cho. (2011) Crystal Structure of Human Mre11: Understanding Tumorigenic Mutations. Structure 19:11, pages 1591-1602.
Crossref
R. Pérez, A. Cuadrado, I. P. Chen, H. Puchta, N. Jouve & A. De Bustos. (2010) The Rad50 genes of diploid and polyploid wheat species. Analysis of homologue and homoeologue expression and interactions with Mre11. Theoretical and Applied Genetics 122:2, pages 251-262.
Crossref
T. C. Thomson, K. E. Fitzpatrick & J. Johnson. (2010) Intrinsic and extrinsic mechanisms of oocyte loss. Molecular Human Reproduction 16:12, pages 916-927.
Crossref
Bogdan I. Gerashchenko, Gerirose Gooding & Joseph R. Dynlacht. (2010) Hyperthermia alters the interaction of proteins of the Mre11 complex in irradiated cells. Cytometry Part A 77A:10, pages 940-952.
Crossref
Brandon J. Lamarche, Nicole I. Orazio & Matthew D. Weitzman. (2010) The MRN complex in double-strand break repair and telomere maintenance. FEBS Letters 584:17, pages 3682-3695.
Crossref
Mahalakshmi Krishnamurthy, Serkalem Tadesse, Katharina Rothmaier & Peter L. Graumann. (2010) A novel SMC-like protein, SbcE (YhaN), is involved in DNA double-strand break repair and competence in Bacillus subtilis. Nucleic Acids Research 38:2, pages 455-466.
Crossref
L. Chang, Y.Y. Liu, B. Zhu, Y. Li, H. Hua, Y.H. Wang, J. Zhang, Z. Jiang & Z.R. Wang. (2009) High expression of the circadian gene mPer2 diminishes the radiosensitivity of NIH 3T3 cells. Brazilian Journal of Medical and Biological Research 42:10, pages 882-891.
Crossref
Helen E Bryant, Eva Petermann, Niklas Schultz, Ann-Sofie Jemth, Olga Loseva, Natalia Issaeva, Fredrik Johansson, Serena Fernandez, Peter McGlynn & Thomas Helleday. (2009) PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination. The EMBO Journal 28:17, pages 2601-2615.
Crossref
Alexander M. Many, Christina S. Melki, Oleksandr P. Savytskyy, Daniel S. Maillet, Sonia N. Acharya & Miriam E. Zolan. (2009) Meiotic localization of Mre11 and Rad50 in wild type, spo11-1, and MRN complex mutants of Coprinus cinereus. Chromosoma 118:4, pages 471-486.
Crossref
Waleed M. Abuzeid, Xiaoling Jiang, Guoli Shi, Hui Wang, David Paulson, Koji Araki, David Jungreis, James Carney, Bert W. O’MalleyJr.Jr. & Daqing Li. (2009) Molecular disruption of RAD50 sensitizes human tumor cells to cisplatin-based chemotherapy. Journal of Clinical Investigation 119:7, pages 1974-1985.
Crossref
Mireille Tittel-Elmer, Constance Alabert, Philippe Pasero & Jennifer A Cobb. (2009) The MRX complex stabilizes the replisome independently of the S phase checkpoint during replication stress. The EMBO Journal 28:8, pages 1142-1156.
Crossref
Bogdan I. Gerashchenko & Joseph R. Dynlacht. (2009) A tool for enhancement and scoring of DNA repair foci. Cytometry Part A 75A:3, pages 245-252.
Crossref
Gitte De Boeck, Ramses G Forsyth, Marleen Praet & Pancras CW Hogendoorn. (2009) Telomere-associated proteins: cross-talk between telomere maintenance and telomere-lengthening mechanisms. The Journal of Pathology 217:3, pages 327-344.
Crossref
Sonia N Acharya, Alexander M Many, Andrew P Schroeder, Felicia M Kennedy, Oleksandr P Savytskyy, Jennifer T Grubb, Jack A Vincent, Elizabeth A Friedle, Martina Celerin, Daniel S Maillet, Heather J Palmerini, Megan A Greischar, Gabriel Moncalian, R Scott Williams, John A Tainer & Miriam E Zolan. (2008) Coprinus cinereus rad50 Mutants Reveal an Essential Structural Role for Rad50 in Axial Element and Synaptonemal Complex Formation, Homolog Pairing and Meiotic Recombination . Genetics 180:4, pages 1889-1907.
Crossref
Kamila Czornak, Sanaullah Chughtai & Krystyna H. Chrzanowska. (2008) Mystery of DNA repair: the role of the MRN complex and ATM kinase in DNA damage repair. Journal of Applied Genetics 49:4, pages 383-396.
Crossref
Karl-Peter Hopfner, Derk Bemeleit & Katja Lammens. 2006. Handbook of Metalloproteins. Handbook of Metalloproteins.
Shomita S. Mathew & Eileen Bridge. (2008) Nbs1-dependent binding of Mre11 to adenovirus E4 mutant viral DNA is important for inhibiting DNA replication. Virology 374:1, pages 11-22.
Crossref
Sarah L. Donahue, Azah A. Tabah, Kyle Schmitz, Ashley Aaron & Colin Campbell. (2007) Defective Signal Joint Recombination in Fanconi Anemia Fibroblasts Reveals a Role for Rad50 in V(D)J Recombination. Journal of Molecular Biology 370:3, pages 449-458.
Crossref
Junqing Zhou, Chang UK Lim, Jian Jian Li, Lu Cai & Ying Zhang. (2006) The role of NBS1 in the modulation of PIKK family proteins ATM and ATR in the cellular response to DNA damage. Cancer Letters 243:1, pages 9-15.
Crossref
Kristina Trenz, Eloise Smith, Sarah Smith & Vincenzo Costanzo. (2006) ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks. The EMBO Journal 25:8, pages 1764-1774.
Crossref
Jean-Yves Bleuyard, Maria E. Gallego & Charles I. White. (2006) Recent advances in understanding of the DNA double-strand break repair machinery of plants. DNA Repair 5:1, pages 1-12.
Crossref
Errol C. Friedberg, Graham C. Walker, Wolfram Siede, Richard D. Wood, Roger A. Schultz & Tom Ellenberger. 2005. DNA Repair and Mutagenesis. DNA Repair and Mutagenesis 711 750 .
Yi-Kuang Chuang, Wern-Cherng Cheng, Steven D. Goodman, Yu-Ting Chang, Jau-Tsuen Kao, Chun-Nan Lee, Keh-Sung Tsai & Woei-horng Fang. (2005) Nick-Directed Repair of Palindromic Loop Mismatches in Human Cell Extracts. Journal of Biomedical Science 12:4, pages 659-669.
Crossref
Jong-Pil Hong, Sang Mi Kim, Moon Young Ryu, Sunghwa Choe, Phun Bum Park, Gynheung An & Woo Taek Kim. (2005) Structure and expression ofOsMRE11 in rice. Journal of Plant Biology 48:2, pages 229-236.
Crossref
Jodi R. Alt, Alyssa Bouska, Mario R. Fernandez, Ronald L. Cerny, Hua Xiao & Christine M. Eischen. (2005) Mdm2 Binds to Nbs1 at Sites of DNA Damage and Regulates Double Strand Break Repair. Journal of Biological Chemistry 280:19, pages 18771-18781.
Crossref
Seong-Tae Kim. (2005) Protein kinase CK2 interacts with Chk2 and phosphorylates Mre11 on serine 649. Biochemical and Biophysical Research Communications 331:1, pages 247-252.
Crossref
Ritsuko Iwanaga, Hideyuki Komori & Kiyoshi Ohtani. (2004) Differential regulation of expression of the mammalian DNA repair genes by growth stimulation. Oncogene 23:53, pages 8581-8590.
Crossref
Zuzana Dudášová, Andrej Dudáš & Miroslav Chovanec. (2004) Non-homologous end-joining factors of Saccharomyces cerevisiae . FEMS Microbiology Reviews 28:5, pages 581-601.
Crossref
Hao Mimi Tran, Guoli Shi, Gouyan Li, James P. Carney, Bert O'MalleyJr.Jr. & Daqing Li. (2016) Mutant Nbs1 Enhances Cisplatin‐Induced DNA Damage and Cytotoxicity in Head and Neck Cancer. Otolaryngology–Head and Neck Surgery 131:4, pages 477-484.
Crossref
Travis H. Stracker, Jan-Willem F. Theunissen, Monica Morales & John H.J. Petrini. (2004) The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together. DNA Repair 3:8-9, pages 845-854.
Crossref
Marcin M Gorski, Ron J Romeijn, Jan C.J Eeken, Anja W.M de Jong, Bert L van Veen, Karoly Szuhai, Leon H Mullenders, Wouter Ferro & Albert Pastink. (2004) Disruption of Drosophila Rad50 causes pupal lethality, the accumulation of DNA double-strand breaks and the induction of apoptosis in third instar larvae. DNA Repair 3:6, pages 603-615.
Crossref
Joshua D. Seno & Joseph R. Dynlacht. (2004) Intracellular redistribution and modification of proteins of the Mre11/Rad50/Nbs1 DNA repair complex following irradiation and heat-shock. Journal of Cellular Physiology 199:2, pages 157-170.
Crossref
Andrej Dudáš & Miroslav Chovanec. (2004) DNA double-strand break repair by homologous recombination. Mutation Research/Reviews in Mutation Research 566:2, pages 131-167.
Crossref
L. A. Casselton & M. Riquelme. 2004. Genetics and Biotechnology. Genetics and Biotechnology 37 52 .
Jan-Willem F Theunissen, Mark I Kaplan, Patricia A Hunt, Bret R Williams, David O Ferguson, Frederick W Alt & John H.J Petrini. (2003) Checkpoint Failure and Chromosomal Instability without Lymphomagenesis in Mre11ATLD1/ATLD1 Mice. Molecular Cell 12:6, pages 1511-1523.
Crossref
Hyun Kook, Kyu Youn Ahn, Song Eun Lee, Hee Sam Na & Kyung Keun Kim. (2003) Nitric oxide-dependent cytoskeletal changes and inhibition of endothelial cell migration contribute to the suppression of angiogenesis by RAD50 gene transfer. FEBS Letters 553:1-2, pages 56-62.
Crossref
Karen M. Cerosaletti & Patrick Concannon. (2003) Nibrin Forkhead-associated Domain and Breast Cancer C-terminal Domain Are Both Required for Nuclear Focus Formation and Phosphorylation. Journal of Biological Chemistry 278:24, pages 21944-21951.
Crossref
George Martin, Fuki Hisama & Sherman WeissmanMartin Digweed & Eberhard Fritz. 2003. Chromosomal Instability and Aging. Chromosomal Instability and Aging.
Martin Digweed & Karl Sperling. 2003. Molekularmedizinische Grundlagen von hämatologischen Neoplasien. Molekularmedizinische Grundlagen von hämatologischen Neoplasien 3 38 .
Kara A. NybergRhett J. MichelsonCharles W. PutnamTed A. Weinert. (2002) Toward Maintaining the Genome: DNA Damage and Replication Checkpoints. Annual Review of Genetics 36:1, pages 617-656.
Crossref
Lorraine S. Symington. (2002) Role of RAD52 Epistasis Group Genes in Homologous Recombination and Double-Strand Break Repair . Microbiology and Molecular Biology Reviews 66:4, pages 630-670.
Crossref
Koji Nakanishi, Toshiyasu Taniguchi, Velvizhi Ranganathan, Helen V. New, Lisa A. Moreau, Maria Stotsky, Christopher G. Mathew, Michael B. Kastan, David T. Weaver & Alan D. D'Andrea. (2002) Interaction of FANCD2 and NBS1 in the DNA damage response. Nature Cell Biology 4:12, pages 913-920.
Crossref
Larry H Thompson & David Schild. (2002) Recombinational DNA repair and human disease. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 509:1-2, pages 49-78.
Crossref
Elena Kolomietz, M. Stephen Meyn, Ajay Pandita & Jeremy A. Squire. (2002) The role ofAlu repeat clusters as mediators of recurrent chromosomal aberrations in tumors. Genes, Chromosomes and Cancer 35:2, pages 97-112.
Crossref
Carla F. Bender, Michael L. Sikes, Ruth Sullivan, Leslie Erskine Huye, Michelle M. Le Beau, David B. Roth, Olga K. Mirzoeva, Eugene M. Oltz & John H. J. Petrini. (2002) Cancer predisposition and hematopoietic failure in Rad50 S/S mice . Genes & Development 16:17, pages 2237-2251.
Crossref
John C. Connelly & David R.F. Leach. (2002) Tethering on the brink: the evolutionarily conserved Mre11–Rad50 complex. Trends in Biochemical Sciences 27:8, pages 410-418.
Crossref
Daniele Zink, Christoph Mayr, Christine Janz & Lisa Wiesmüller. (2002) Association of p53 and MSH2 with recombinative repair complexes during S phase. Oncogene 21:31, pages 4788-4800.
Crossref
Damien D'Amours & Stephen P. Jackson. (2002) The MRE11 complex: at the crossroads of DNA repair and checkpoint signalling. Nature Reviews Molecular Cell Biology 3:5, pages 317-327.
Crossref
S Daoudal-Cotterell, M.E Gallego & C.I White. (2002) The plant Rad50-Mre11 protein complex. FEBS Letters 516:1-3, pages 164-166.
Crossref
Roberta Carbone, Mark Pearson, Saverio Minucci & Pier Giuseppe Pelicci. (2002) PML NBs associate with the hMre11 complex and p53 at sites of irradiation induced DNA damage. Oncogene 21:11, pages 1633-1640.
Crossref
Patrick W. Dunne & Jorge A. Piedrahita. 2002. Principles of Cloning. Principles of Cloning 227 246 .
Edward L. Loechler, Bryan Henry & Kwang-Young Seo. 2002. The Molecular Basis of Human Cancer. The Molecular Basis of Human Cancer 203 222 .
Martijn de Jager, John van Noort, Dik C. van Gent, Cees Dekker, Roland Kanaar & Claire Wyman. (2001) Human Rad50/Mre11 Is a Flexible Complex that Can Tether DNA Ends. Molecular Cell 8:5, pages 1129-1135.
Crossref
Paula E. Cohen & Jeffrey W. Pollard. (2001) Regulation of meiotic recombination and prophase I progression in mammals. BioEssays 23:11, pages 996-1009.
Crossref
Paola Grandi, Michail Eltsov, Inga Nielsen & Ivan Raška. (2001) DNA double-strand breaks induce formation of RP-A/Ku foci on in vitro reconstituted Xenopus sperm nuclei . Journal of Cell Science 114:18, pages 3345-3357.
Crossref
Albert Pastink, Jan C.J. Eeken & Paul H.M. Lohman. (2001) Genomic integrity and the repair of double-strand DNA breaks. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 480-481, pages 37-50.
Crossref
Grant S. Stewart, James I.K. Last, Tatjara Stankovic, Neva Haites, Alexa M.J. Kidd, Philip J. Byrd & A. Malcolm R. Taylor. (2001) Residual Ataxia Telangiectasia Mutated Protein Function in Cells from Ataxia Telangiectasia Patients, with 5762ins137 and 7271T→G Mutations, Showing a Less Severe Phenotype. Journal of Biological Chemistry 276:32, pages 30133-30141.
Crossref
Karen M. Vasquez, Kathleen Marburger, Zsofia Intody & John H. Wilson. (2001) Manipulating the mammalian genome by homologous recombination. Proceedings of the National Academy of Sciences 98:15, pages 8403-8410.
Crossref
Wei-Guo Zhu, Joshua D. Seno, Brian D. Beck & Joseph R. Dynlacht. (2001) Translocation of MRE11 from the Nucleus to the Cytoplasm as a Mechanism of Radiosensitization by Heat 1 . Radiation Research 156:1, pages 95-102.
Crossref
Vincenzo Costanzo, Kirsten Robertson, Marina Bibikova, Edward Kim, Domenico Grieco, Max Gottesman, Dana Carroll & Jean Gautier. (2001) Mre11 Protein Complex Prevents Double-Strand Break Accumulation during Chromosomal DNA Replication. Molecular Cell 8:1, pages 137-147.
Crossref
Elaine M. TaylorJeelan S. MoghrabyJennifer H. LeesBep Smit, Peter B. Moens & Alan R. Lehmann. (2001) Characterization of a Novel Human SMC Heterodimer Homologous to the Schizosaccharomyces pombe Rad18/Spr18 Complex . Molecular Biology of the Cell 12:6, pages 1583-1594.
Crossref
Takehiko Usui, Hideyuki Ogawa & John H.J Petrini. (2001) A DNA Damage Response Pathway Controlled by Tel1 and the Mre11 Complex. Molecular Cell 7:6, pages 1255-1266.
Crossref
Karl-Peter Hopfner, Annette Karcher, Lisa Craig, Tammy T. Woo, James P. Carney & John A. Tainer. (2001) Structural Biochemistry and Interaction Architecture of the DNA Double-Strand Break Repair Mre11 Nuclease and Rad50-ATPase. Cell 105:4, pages 473-485.
Crossref
Jun Xiao, Chang-Ching Liu, Phang-Lang Chen & Wen-Hwa Lee. (2001) RINT-1, a Novel Rad50-interacting Protein, Participates in Radiation-induced G2/M Checkpoint Control. Journal of Biological Chemistry 276:9, pages 6105-6111.
Crossref
Maria E. Gallego, M. Jeanneau, Fabienne Granier, David Bouchez, Nichole Bechtold & I. White. (2001) Disruption of the Arabidopsis RAD50 gene leads to plant sterility and MMS sensitivity . The Plant Journal 25:1, pages 31-41.
Crossref
Scott Keeney. 2001. 1 53 .
Erica M. Seitz, Cynthia A. Haseltine & Stephen C. Kowalczykowski. 2001. Ancient Microbes, Extreme Environments, and the Origin of Life. Ancient Microbes, Extreme Environments, and the Origin of Life 101 169 .
Orlando J. Miller & Eeva ThermanOrlando J. Miller & Eeva Therman. 2001. Human Chromosomes. Human Chromosomes 385 403 .
Orlando J. Miller & Eeva ThermanOrlando J. Miller & Eeva Therman. 2001. Human Chromosomes. Human Chromosomes 141 155 .
Amiram Ronen & Barry W. Glickman. (2001) Human DNA repair genes. Environmental and Molecular Mutagenesis 37:3, pages 241-283.
Crossref
Guikai Wu, Wen-Hwa Lee & Phang-Lang Chen. (2000) NBS1 and TRF1 Colocalize at Promyelocytic Leukemia Bodies during Late S/G2 Phases in Immortalized Telomerase-negative Cells. Journal of Biological Chemistry 275:39, pages 30618-30622.
Crossref
Ciaran Morrison & Shunichi Takeda. (2000) Genetic analysis of homologous DNA recombination in vertebrate somatic cells. The International Journal of Biochemistry & Cell Biology 32:8, pages 817-831.
Crossref
Xu-Dong Zhu, Bernhard Küster, Matthias Mann, John H.J. Petrini & Titia de Lange. (2000) Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres. Nature Genetics 25:3, pages 347-352.
Crossref
Bijan Fouladi, Charles A. Waldren, Björn Rydberg & Priscilla K. Cooper. (2000) Comparison of Repair of DNA Double-Strand Breaks in Identical Sequences in Primary Human Fibroblast and Immortal Hamster–Human Hybrid Cells Harboring a Single Copy of Human Chromosome 11. Radiation Research 153:6, pages 795-804.
Crossref
John HJ Petrini. (2000) The Mre11 complex and ATM: collaborating to navigate S phase. Current Opinion in Cell Biology 12:3, pages 293-296.
Crossref
Karl-Peter Hopfner, Annette Karcher, David S. Shin, Lisa Craig, L.Matthew Arthur, James P. Carney & John A. Tainer. (2000) Structural Biology of Rad50 ATPase. Cell 101:7, pages 789-800.
Crossref
Patrick Sung, Kelly Miguel Trujillo & Stephen Van Komen. (2000) Recombination factors of Saccharomyces cerevisiae. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 451:1-2, pages 257-275.
Crossref
T. DE LANGE & J.H.J. PETRINI. (2000) A New Connection at Human Telomeres: Association of the Mre11 Complex with TRF2. Cold Spring Harbor Symposia on Quantitative Biology 65:0, pages 265-274.
Crossref
K.-P. HOPFNER, S.S. PARIKH & J.A. TAINER. (2000) Envisioning the Fourth Dimension of the Genetic Code: The Structural Biology of Macromolecular Recognition and Conformational Switching in DNA Repair. Cold Spring Harbor Symposia on Quantitative Biology 65:0, pages 113-126.
Crossref
Gopal K Dasika, Suh-Chin J Lin, Song Zhao, Patrick Sung, Alan Tomkinson & Eva Y-H P Lee. (2000) DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis. Oncogene 18:55, pages 7883-7899.
Crossref
Grant S Stewart, Richard S Maser, Tanja Stankovic, Debra A Bressan, Mark I Kaplan, Nikolaas G.J Jaspers, Anja Raams, Philip J Byrd, John H.J Petrini & A.Malcolm R Taylor. (1999) The DNA Double-Strand Break Repair Gene hMRE11 Is Mutated in Individuals with an Ataxia-Telangiectasia-like Disorder. Cell 99:6, pages 577-587.
Crossref
K. Mezhevaya, T. A. Winters & R. D. Neumann. (1999) Gene targeted DNA double-strand break induction by 125l-labeled triplex-forming oligonucleotides is highly mutagenic following repair in human cells. Nucleic Acids Research 27:21, pages 4282-4290.
Crossref
Wolfgang Goedecke, Maureen Eijpe, Hildo H. Offenberg, Mirjam van Aalderen & Christa Heyting. (1999) Mre11 and Ku70 interact in somatic cells, but are differentially expressed in early meiosis. Nature Genetics 23:2, pages 194-198.
Crossref
L Kevin Lewis, James W Westmoreland & Michael A Resnick. (1999) Repair of Endonuclease-Induced Double-Strand Breaks in Saccharomyces cerevisiae: Essential Role for Genes Associated with Nonhomologous End-Joining. Genetics 152:4, pages 1513-1529.
Crossref
Qing ZhongChi-Fen ChenShang LiYumay ChenChuan-Cheng WangJun XiaoPhang-Lang ChenZ. Dave SharpWen-Hwa Lee. (1999) Association of BRCA1 with the hRad50-hMre11-p95 Complex and the DNA Damage Response. Science 285:5428, pages 747-750.
Crossref
K.K. Kim, B.A. Shin, K.H. Seo, P.N. Kim, J.T. Koh, J.H. Kim & B.R. Park. (1999) Molecular cloning and characterization of splice variants of human RAD50 gene. Gene 235:1-2, pages 59-67.
Crossref
Guangbin Luo, Michelle S. Yao, Carla F. Bender, Michael Mills, Anthony R. Bladl, Allan Bradley & John H. J. Petrini. (1999) Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation . Proceedings of the National Academy of Sciences 96:13, pages 7376-7381.
Crossref
Ute Moll, Raymond Lau, Michael A Sypes, Malini M Gupta & Carl W Anderson. (1999) DNA-PK, the DNA-activated protein kinase, is differentially expressed in normal and malignant human tissues. Oncogene 18:20, pages 3114-3126.
Crossref
John H.J. Petrini. (1999) The Mammalian Mre11-Rad50-Nbs1 Protein Complex: Integration of Functions in the Cellular DNA–Damage Response. The American Journal of Human Genetics 64:5, pages 1264-1269.
Crossref
Laura Salem, Natalie Walter & Robert Malone. (1999) Suppressor Analysis of the Saccharomyces cerevisiae Gene REC104 Reveals a Genetic Interaction With REC102. Genetics 151:4, pages 1261-1272.
Crossref
John Thacker. (1999) Repair of ionizing radiation damage in mammalian cells. Alternative pathways and their fidelity. Comptes Rendus de l'Académie des Sciences - Series III - Sciences de la Vie 322:2-3, pages 103-108.
Crossref
David F. Rogan, David J. Cousins & Dontcho Z. Staynov. (1999) Intergenic Transcription Occurs throughout the Human IL-4/IL-13 Gene Cluster. Biochemical and Biophysical Research Communications 255:3, pages 556-561.
Crossref
M. Chamankhah & W. Xiao. (1999) Formation of the yeast Mre11-Rad50-Xrs2 complex is correlated with DNA repair and telomere maintenance. Nucleic Acids Research 27:10, pages 2072-2079.
Crossref
Małgorzata Z Zdzienicka. (1999) Mammalian X-ray-sensitive mutants which are defective in non-homologous (illegitimate) DNA double-strand break repair. Biochimie 81:1-2, pages 107-116.
Crossref
Larry H Thompson & David Schild. (1999) The contribution of homologous recombination in preserving genome integrity in mammalian cells. Biochimie 81:1-2, pages 87-105.
Crossref
Larry H. Thompson. 1999. DNA Repair Protocols. DNA Repair Protocols 57 85 .
S. Wilson, M. Tavassoli & F. Z. Watts. (1998) Schizosaccharomyces pombe Rad32 protein: a phosphoprotein with an essential phosphoesterase motif required for repair of DNA double strand breaks. Nucleic Acids Research 26:23, pages 5261-5269.
Crossref
Mahmood Chamankhah, Ying-Fei Wei & Wei Xiao. (1998) Isolation of hMRE11B: failure to complement yeast mre11 defects due to species-specific protein interactions. Gene 225:1-2, pages 107-116.
Crossref
Munenori Furuse, Yuko Nagase, Hideo Tsubouchi, Kimiko Murakami-Murofushi, Takehiko Shibata & Kunihiro Ohta. (1998) Distinct roles of two separable in vitro activities of yeast Mre11 in mitotic and meiotic recombination . The EMBO Journal 17:21, pages 6412-6425.
Crossref
Debra A Bressan, Heidi A Olivares, Benjamin E Nelms & John H J Petrini. (1998) Alteration of N-Terminal Phosphoesterase Signature Motifs Inactivates Saccharomyces cerevisiae Mre11. Genetics 150:2, pages 591-600.
Crossref
Susan E Critchlow & Stephen P Jackson. (1998) DNA end-joining: from yeast to man. Trends in Biochemical Sciences 23:10, pages 394-398.
Crossref
Kelly M. Trujillo, Shyng-Shiou F. Yuan, Eva Y.-H. P. Lee & Patrick Sung. (1998) Nuclease Activities in a Complex of Human Recombination and DNA Repair Factors Rad50, Mre11, and p95. Journal of Biological Chemistry 273:34, pages 21447-21450.
Crossref
John C. Connelly, Lucy A. Kirkham & David R. F. Leach. (1998) The SbcCD nuclease of Escherichia coli is a structural maintenance of chromosomes (SMC) family protein that cleaves hairpin DNA . Proceedings of the National Academy of Sciences 95:14, pages 7969-7974.
Crossref
Tanya T. Paull & Martin Gellert. (1998) The 3′ to 5′ Exonuclease Activity of Mre11 Facilitates Repair of DNA Double-Strand Breaks. Molecular Cell 1:7, pages 969-979.
Crossref
James P Carney, Richard S Maser, Heidi Olivares, Elizabeth M Davis, Michelle Le Beau, John R YatesIIIIII, Lara Hays, William F Morgan & John H.J Petrini. (1998) The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response. Cell 93:3, pages 477-486.
Crossref
Raymonda Varon, Christine Vissinga, Matthias Platzer, Karen M Cerosaletti, Krystyna H Chrzanowska, Kathrin Saar, Georg Beckmann, Eva Seemanová, Paul R Cooper, Norma J Nowak, Markus Stumm, Corry M.R Weemaes, Richard A Gatti, Richard K Wilson, Martin Digweed, André Rosenthal, Karl Sperling, Patrick Concannon & André Reis. (1998) Nibrin, a Novel DNA Double-Strand Break Repair Protein, Is Mutated in Nijmegen Breakage Syndrome. Cell 93:3, pages 467-476.
Crossref
Benjamin E. NelmsRichard S. MaserJames F. MacKayMax G. LagallyJohn H. J. Petrini. (1998) In Situ Visualization of DNA Double-Strand Break Repair in Human Fibroblasts. Science 280:5363, pages 590-592.
Crossref
Douglas L. Pittman, John Cobb, Kerry J. Schimenti, Lawriston A. Wilson, Deborah M. Cooper, Ember Brignull, Mary Ann Handel & John C. Schimenti. (1998) Meiotic Prophase Arrest with Failure of Chromosome Synapsis in Mice Deficient for Dmc1 , a Germline-Specific RecA Homolog. Molecular Cell 1:5, pages 697-705.
Crossref
Kathleen N Smith & Alain Nicolas. (1998) Recombination at work for meiosis. Current Opinion in Genetics & Development 8:2, pages 200-211.
Crossref
Yasumasa Tsukamoto & Hideo Ikeda. (2003) Double‐strand break repair mediated by DNA end‐joining. Genes to Cells 3:3, pages 135-144.
Crossref
Kunihiro Ohta, Alain Nicolas, Munenori Furuse, Akira Nabetani, Hideyuki Ogawa & Takehiko Shibata. (1998) Mutations in the MRE11 , RAD50 , XRS2 , and MRE2 genes alter chromatin configuration at meiotic DNA double-stranded break sites in premeiotic and meiotic cells . Proceedings of the National Academy of Sciences 95:2, pages 646-651.
Crossref
Fiona E. Benson, Peter Baumann & Stephen C. West. (1998) Synergistic actions of Rad51 and Rad52 in recombination and DNA repair. Nature 391:6665, pages 401-404.
Crossref
J. A. Holme, C. Bjørge, M. Trbojevic, A.-K. Olsen, G. Brunborg, E. J. Søderlund, M. Bjørås, E. Seeberg, T. Scholz, E. Dybing & R. Wiger. 1998. Diversification in Toxicology — Man and Environment. Diversification in Toxicology — Man and Environment 151 160 .
G. Shirleen Roeder. (1997) Meiotic chromosomes: it takes two to tango. Genes & Development 11:20, pages 2600-2621.
Crossref
Eric A. Hendrickson. (1997) Cell-Cycle Regulation of Mammalian DNA Double-Strand-Break Repair. The American Journal of Human Genetics 61:4, pages 795-800.
Crossref
P. Kannouche, G. Pinon-Lataillade, P. Mauffrey, C. Faucher, D.S.F. Biard & J.F. Angulo. (1997) Overexpression of kin17 protein forms intranuclear foci in mammalian cells. Biochimie 79:9-10, pages 599-606.
Crossref
Knud Nairz & Franz Klein. (1997) mre11S —a yeast mutation that blocks double-strand-break processing and permits nonhomologous synapsis in meiosis . Genes & Development 11:17, pages 2272-2290.
Crossref
Mubasher E Dar, Thomas A Winters & Timothy J Jorgensen. (1997) Identification of defective illegitimate recombinational repair of oxidatively-induced DNA double-strand breaks in ataxia-telangiectasia cells. Mutation Research/DNA Repair 384:3, pages 169-179.
Crossref
M. Z. Zdzienicka. (1997) Molecular processes and radiosensitivityMolekulare Prozesse und Radiosensitivität. Strahlentherapie und Onkologie 173:9, pages 457-461.
Crossref
John C. Connelly, Erica S. de Leau, Ewa A. Okely & David R.F. Leach. (1997) Overexpression, Purification, and Characterization of the SbcCD Protein from Escherichia coli. Journal of Biological Chemistry 272:32, pages 19819-19826.
Crossref
Weiwen Guo, Volker Adams, Jestina Mason & Edward R.B. McCabe. (1997) Identification of a Ferritin Light Chain Pseudogene Near the Glycerol Kinase Locus in Xp21 by cDNA Amplification for Identification of Genomic Expressed Sequences. Biochemical and Molecular Medicine 60:2, pages 169-173.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.