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Research Article

Hepatocyte Nuclear Factor 4 Expression Overcomes Repression of the Hepatic Phenotype in Dedifferentiated Hepatoma Cells

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Pages 1913-1922 | Received 08 Nov 1996, Accepted 09 Jan 1997, Published online: 29 Mar 2023

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Crossref
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Crossref
Christopher A. Wiwi, Minita Gupte & David J. Waxman. (2004) Sexually Dimorphic P450 Gene Expression in Liver-Specific Hepatocyte Nuclear Factor 4α-Deficient Mice. Molecular Endocrinology 18:8, pages 1975-1987.
Crossref
Nadège Briançon, Alain Bailly, Frédéric Clotman, Patrick Jacquemin, Frédéric P. Lemaigre & Mary C. Weiss. (2004) Expression of the α7 Isoform of Hepatocyte Nuclear Factor (HNF) 4 Is Activated by HNF6/OC-2 and HNF1 and Repressed by HNF4α1 in the Liver. Journal of Biological Chemistry 279:32, pages 33398-33408.
Crossref
Jaspreet S Sidhu, Fei Liu & Curtis J Omiecinski. (2004) Phenobarbital responsiveness as a uniquely sensitive indicator of hepatocyte differentiation status: requirement of dexamethasone and extracellular matrix in establishing the functional integrity of cultured primary rat hepatocytes. Experimental Cell Research 292:2, pages 252-264.
Crossref
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Crossref
Elizabeth E. RomeroUmaima MarviZachary E. NimanDavid A. Roth. (2003) The vitamin K–dependent γ-glutamyl carboxylase gene contains a TATA-less promoter with a novel upstream regulatory element. Blood 102:4, pages 1333-1339.
Crossref
Fereshteh Parviz, Christine Matullo, Wendy D Garrison, Laura Savatski, John W Adamson, Gang Ning, Klaus H Kaestner, Jennifer M Rossi, Kenneth S Zaret & Stephen A Duncan. (2003) Hepatocyte nuclear factor 4α controls the development of a hepatic epithelium and liver morphogenesis. Nature Genetics 34:3, pages 292-296.
Crossref
A Watt. (2003) HNF4: A central regulator of hepatocyte differentiation and function. Hepatology 37:6, pages 1249-1253.
Crossref
Hideki Chiba, Tomoko Gotoh, Takashi Kojima, Seiro Satohisa, Keisuke Kikuchi, Makoto Osanai & Norimasa Sawada. (2003) Hepatocyte nuclear factor (HNF)-4α triggers formation of functional tight junctions and establishment of polarized epithelial morphology in F9 embryonal carcinoma cells. Experimental Cell Research 286:2, pages 288-297.
Crossref
Maria Elena Torres-Padilla & Mary C Weiss. (2003) Effects of interactions of hepatocyte nuclear factor 4α isoforms with coactivators and corepressors are promoter-specific. FEBS Letters 539:1-3, pages 19-23.
Crossref
Xianming Yu & Janet E. Mertz. (2003) Distinct Modes of Regulation of Transcription of Hepatitis B Virus by the Nuclear Receptors HNF4α and COUP-TF1. Journal of Virology 77:4, pages 2489-2499.
Crossref
Taro E. Akiyama & Frank J. Gonzalez. (2003) Regulation of P450 genes by liver-enriched transcription factors and nuclear receptors. Biochimica et Biophysica Acta (BBA) - General Subjects 1619:3, pages 223-234.
Crossref
Chia-Ning Shen, Marko E. Horb, Jonathan M.W. Slack & David Tosh. (2003) Transdifferentiation of pancreas to liver. Mechanisms of Development 120:1, pages 107-116.
Crossref
Stephen A Duncan. (2003) Mechanisms controlling early development of the liver. Mechanisms of Development 120:1, pages 19-33.
Crossref
Maria Elena Torres-Padilla, Frances M. Sladek & Mary C. Weiss. (2002) Developmentally Regulated N-terminal Variants of the Nuclear Receptor Hepatocyte Nuclear Factor 4α Mediate Multiple Interactions through Coactivator and Corepressor-Histone Deacetylase Complexes. Journal of Biological Chemistry 277:47, pages 44677-44687.
Crossref
Yusuke Inoue, Graham P. Hayhurst, Junko Inoue, Masataka Mori & Frank J. Gonzalez. (2002) Defective Ureagenesis in Mice Carrying a Liver-specific Disruption of Hepatocyte Nuclear Factor 4α (HNF4α). Journal of Biological Chemistry 277:28, pages 25257-25265.
Crossref
Makoto Osanai, Hideki Chiba, Takashi Kojima, Masato Fujibe, Kazuhide Kuwahara, Hiromichi Kimura, Masaaki Satoh & Norimasa Sawada. (2002) Hepatocyte Nuclear Factor (HNF)-4α Induces Expression of Endothelial Fas Ligand (FasL) to Prevent Cancer Cell Transmigration: A Novel Defense Mechanism of Endothelium against Cancer Metastasis. Japanese Journal of Cancer Research 93:5, pages 532-541.
Crossref
Takafumi Naiki, Masahito Nagaki, Yoshihiro Shidoji, Hisanori Kojima, Motoaki Imose, Tomohiro Kato, Nobuko Ohishi, Kunio Yagi & Hisataka Moriwaki. (2002) Analysis of Gene Expression Profile Induced by Hepatocyte Nuclear Factor 4α in Hepatoma Cells Using an Oligonucleotide Microarray. Journal of Biological Chemistry 277:16, pages 14011-14019.
Crossref
Xianming Yu & Janet E. Mertz. (2001) Critical Roles of Nuclear Receptor Response Elements in Replication of Hepatitis B Virus. Journal of Virology 75:23, pages 11354-11364.
Crossref
Maria Elena Torres-Padilla, Catherine Fougère-Deschatrette & Mary C Weiss. (2001) Expression of HNF4α isoforms in mouse liver development is regulated by sequential promoter usage and constitutive 3′ end splicing. Mechanisms of Development 109:2, pages 183-193.
Crossref
Hidekazu Nakabayashi, Yoshikazu Koyama, Masaharu Sakai, Hong Mei Li, Norman C.W. Wong & Shinzo Nishi. (2001) Glucocorticoid Stimulates Primate but Inhibits Rodent α-Fetoprotein Gene Promoter. Biochemical and Biophysical Research Communications 287:1, pages 160-172.
Crossref
G.A. Bulla, E. Givens, S. Brown, B. Oladiran & D. Kraus. (2001) A common regulatory locus affects both HNF4/HNF1(α) pathway activation and sensitivity to LPS-mediated apoptosis in rat hepatoma cells. Journal of Cell Science 114:6, pages 1205-1212.
Crossref
María J. Gómez-Lechón, Teresa Donato, Ramiro Jover, Cristina Rodriguez, Xavier Ponsoda, Denize Glaise, José V. Castell & Christiane Guguen-Guillouzo. (2001) Expression and induction of a large set of drug-metabolizing enzymes by the highly differentiated human hepatoma cell line BC2. European Journal of Biochemistry 268:5, pages 1448-1459.
Crossref
Frances M. Sladek & Shawn D. Seidel. 2001. Nuclear Receptors and Genetic Disease. Nuclear Receptors and Genetic Disease 309 361 .
Chia-Ning Shen, Jonathan M. W. Slack & David Tosh. (2000) Molecular basis of transdifferentiation of pancreas to liver. Nature Cell Biology 2:12, pages 879-887.
Crossref
Yu-Jui Yvonne Wan, Yan Cai, Catherine Cowan & Thomas R Magee. (2000) Fatty acyl-CoAs inhibit retinoic acid-induced apoptosis in Hep3B cells. Cancer Letters 154:1, pages 19-27.
Crossref
Mojgan Rastegar, Frédéric P Lemaigre & Guy G Rousseau. (2000) Control of gene expression by growth hormone in liver: key role of a network of transcription factors. Molecular and Cellular Endocrinology 164:1-2, pages 1-4.
Crossref
Mojgan Rastegar, Guy G. Rousseau & Frédéric P. Lemaigre. (2000) CCAAT/Enhancer-Binding Protein-α Is a Component of the Growth Hormone-Regulated Network of Liver Transcription Factors*. Endocrinology 141:5, pages 1686-1692.
Crossref
Aránzazu Sánchez, Alberto M Álvarez, Roser Pagan, César Roncero, Senén Vilaró, Manuel Benito & Isabel Fabregat. (2000) Fibronectin regulates morphology, cell organization and gene expression of rat fetal hepatocytes in primary culture. Journal of Hepatology 32:2, pages 242-250.
Crossref
Steffen Massa, Steffen Junker & Patrick Matthias. (2000) Molecular mechanisms of extinction: old findings and new ideas. The International Journal of Biochemistry & Cell Biology 32:1, pages 23-40.
Crossref
Maria José Gómez-Lechón, Ramiro Jover, Teresa Donato, Xavier Ponsoda & José V. Castell. 2000. Signaling Through the Cell Matrix. Signaling Through the Cell Matrix 89 104 .
G DARLINGTON. (1999) Molecular mechanisms of liver development and differentiation. Current Opinion in Cell Biology 11:6, pages 678-682.
Crossref
Pierre Rollini & R. E. K. Fournier. (1999) The HNF-4/HNF-1α transactivation cascade regulates gene activity and chromatin structure of the human serine protease inhibitor gene cluster at 14q32.1. Proceedings of the National Academy of Sciences 96:18, pages 10308-10313.
Crossref
G.I. Abelev & T.L. Eraiser. (1999) Cellular aspects of alpha-fetoprotein reexpression in tumors. Seminars in Cancer Biology 9:2, pages 95-107.
Crossref
C.oncetta C DiRusso, P.aul N Black & J.ames D Weimar. (1999) Molecular inroads into the regulation and metabolism of fatty acids, lessons from bacteria. Progress in Lipid Research 38:2, pages 129-197.
Crossref
Y. Hayashi, W. Wang, T. Ninomiya, H. Nagano, K. Ohta & H. Itoh. (1999) Liver enriched transcription factors and differentiation of hepatocellular carcinoma. Molecular Pathology 52:1, pages 19-24.
Crossref
Patrick Jacquemin, Vincent J. Lannoy, Guy G. Rousseau & Frédéric P. Lemaigre. (1999) OC-2, a Novel Mammalian Member of the ONECUT Class of Homeodomain Transcription Factors Whose Function in Liver Partially Overlaps with That of Hepatocyte Nuclear Factor-6. Journal of Biological Chemistry 274:5, pages 2665-2671.
Crossref
Gary A. Bulla, Jacqueline R. Batanian, Hannah M. Young, Nicole Bradley, Nosheen Kazi & Bassem R. Haddad. (1998) Rescue of the HNF4 → HNF1α Pathway in Hepatoma Variant Cells Containing Human Chromosome 12. Genomics 54:3, pages 398-407.
Crossref
Francesca M. Spagnoli, Laura Amicone, Marco Tripodi & Mary C. Weiss. (1998) Identification of a Bipotential Precursor Cell in Hepatic Cell Lines Derived from Transgenic Mice Expressing Cyto-Met in the Liver. Journal of Cell Biology 143:4, pages 1101-1112.
Crossref
A. BaillyG. SpathV. BenderM.C. Weiss. (1998) Phenotypic effects of the forced expression of HNF4 and HNF1alpha are conditioned by properties of the recipient cell. Journal of Cell Science 111:16, pages 2411-2421.
Crossref
Zizheng Dong, Xiaofu Wang, Qingzheng Zhao, Courtney M. TownsendJr.Jr. & B. Mark Evers. (1998) DNA methylation contributes to expression of the human neurotensin/neuromedin N gene. American Journal of Physiology-Gastrointestinal and Liver Physiology 274:3, pages G535-G543.
Crossref
Gerald F. Späth & Mary C. Weiss. (1998) Hepatocyte Nuclear Factor 4 Provokes Expression of Epithelial Marker Genes, Acting As a Morphogen in Dedifferentiated Hepatoma Cells. Journal of Cell Biology 140:4, pages 935-946.
Crossref
H. Nakhei, A. Lingott, I. Lemm & G. U. Ryffel. (1998) An alternative splice variant of the tissue specific transcription factor HNF4  predominates in undifferentiated murine cell types. Nucleic Acids Research 26:2, pages 497-504.
Crossref
Joan C. Rodrı&#x;guez, José A. Ortiz, Fausto G. Hegardt & Diego Haro. (1998) The Hepatocyte Nuclear Factor 4 (HNF-4) Represses the Mitochondrial HMG-CoA Synthase Gene. Biochemical and Biophysical Research Communications 242:3, pages 692-696.
Crossref
Claire Landry, Frédéric Clotman, Takeshi Hioki, Hiroaki Oda, Jacques J. Picard, Frédéric P. Lemaigre & Guy G. Rousseau. (1997) HNF-6 Is Expressed in Endoderm Derivatives and Nervous System of the Mouse Embryo and Participates to the Cross-Regulatory Network of Liver-Enriched Transcription Factors. Developmental Biology 192:2, pages 247-257.
Crossref
Laurence Suaud, Bertrand Joseph, Pierre Formstecher & Bernard Laine. (1997) mRNA Expression of HNF-4 Isoforms and of HNF-1α/HNF-1β Variants and Differentiation of Human Cell Lines That Mimic Highly Specialized Phenotypes of Intestinal Epithelium. Biochemical and Biophysical Research Communications 235:3, pages 820-825.
Crossref

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