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Molecular and Cellular Biology Volume 17, 1997 - Issue 6
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Research Article

The Signal Response of IκBα Is Regulated by Transferable N- and C-Terminal Domains

Keith BrownLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland20892-1876
,
Guido FranzosoLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland20892-1876
,
Lucia BaldiLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland20892-1876
,
Louise CarlsonLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland20892-1876
,
Laura MillsLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland20892-1876
,
Yi-Chaung LinLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland20892-1876
,
Susan Gerstberger
&
Ulrich SiebenlistLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland20892-1876Correspondence[email protected]
 show all
Pages 3021-3027 | Received 30 Jul 1996, Accepted 28 Feb 1997, Published online: 29 Mar 2023

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Shelby O'Connor, Stuart D. Shumway, Ian J. Amanna, Colleen E. Hayes & Shigeki Miyamoto. (2004) Regulation of Constitutive p50/c-Rel Activity via Proteasome Inhibitor-Resistant IκBα Degradation in B Cells. Molecular and Cellular Biology 24:11, pages 4895-4908.
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David C. Hay, Graham D. Kemp, Catherine Dargemont & Ronald T. Hay. (2001) Interaction between hnRNPA1 and IκBα Is Required for Maximal Activation of NF-κB-Dependent Transcription. Molecular and Cellular Biology 21:10, pages 3482-3490.
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Mark A. Gregory & Stephen R. Hann. (2000) c-Myc Proteolysis by the Ubiquitin-Proteasome Pathway: Stabilization of c-Myc in Burkitt's Lymphoma Cells. Molecular and Cellular Biology 20:7, pages 2423-2435.
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Michèle Algarté, Hakju Kwon, Pierre Génin & John Hiscott. (1999) Identification by In Vivo Genomic Footprinting of a Transcriptional Switch Containing NF-κB and Sp1 That Regulates the IκBα Promoter. Molecular and Cellular Biology 19:9, pages 6140-6153.
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Zhen Li & Gary J. Nabel. (1997) A New Member of the IκB Protein Family, IκBε, Inhibits RelA (p65)-Mediated NF-κB Transcription. Molecular and Cellular Biology 17:10, pages 6184-6190.
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Manuel S. Rodriguez, Jill Thompson, Ronald T. Hay & Catherine Dargemont. (1999) Nuclear Retention of IκBα Protects It from Signal-induced Degradation and Inhibits Nuclear Factor κB Transcriptional Activation. Journal of Biological Chemistry 274:13, pages 9108-9115.
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Rongtuan Lin & John Hiscott. 1999. A Molecular and Cellular View of Protein Kinase CK2. A Molecular and Cellular View of Protein Kinase CK2 169 180 .
Shiva Malek, Tom Huxford & Gourisankar Ghosh. (1998) IκBα Functions through Direct Contacts with the Nuclear Localization Signals and the DNA Binding Sequences of NF-κB. Journal of Biological Chemistry 273:39, pages 25427-25435.
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James R. Burke, Kenneth R. Miller, Marcia K. Wood & Chester A. Meyers. (1998) The Multisubunit IκB Kinase Complex Shows Random Sequential Kinetics and Is Activated by the C-terminal Domain of IκBα. Journal of Biological Chemistry 273:20, pages 12041-12046.
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F. G. Wulczyn, D. Krappmann & C. Scheidereit. (1998) Signal-dependent degradation of I B  is mediated by an inducible destruction box that can be transferred to NF- B, Bcl-3 or p53. Nucleic Acids Research 26:7, pages 1724-1730.
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Hakju Kwon, Nadine Pelletier, Carmela DeLuca, Pierre Genin, Sonia Cisternas, Rongtuan Lin, Mark A. Wainberg & John Hiscott. (1998) Inducible Expression of IκBα Repressor Mutants Interferes with NF-κB Activity and HIV-1 Replication in Jurkat T Cells. Journal of Biological Chemistry 273:13, pages 7431-7440.
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