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Molecular and Cellular Biology Volume 17, 1997 - Issue 8
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Research Article

The Replication Origin Decision Point Is a Mitogen-Independent, 2-Aminopurine-Sensitive, G1-Phase Event That Precedes Restriction Point Control

Jia-Rui WuDepartment of Biochemistry and Molecular Biology, SUNY Health Science Center, Syracuse, New York13210
&
David M. GilbertDepartment of Biochemistry and Molecular Biology, SUNY Health Science Center, Syracuse, New York13210Correspondence[email protected]
Pages 4312-4321 | Received 21 Nov 1996, Accepted 05 May 1997, Published online: 29 Mar 2023

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Takayo Sasaki, Anatoliy Li, Peter J. Gillespie, J. Julian Blow & David M. Gilbert. (2011) Evidence for a mammalian late-G1 phase inhibitor of replication licensing distinct from geminin or Cdk activity. Nucleus 2:5, pages 455-464.
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Takayo Sasaki, Sunita Ramanathan, Yukiko Okuno, Chiharu Kumagai, Seemab S. Shaikh & David M. Gilbert. (2006) The Chinese Hamster Dihydrofolate Reductase Replication Origin Decision Point Follows Activation of Transcription and Suppresses Initiation of Replication within Transcription Units. Molecular and Cellular Biology 26:3, pages 1051-1062.
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Cong-Jun Li & Melvin L. DePamphilis. (2002) Mammalian Orc1 Protein Is Selectively Released from Chromatin and Ubiquitinated during the S-to-M Transition in the Cell Division Cycle. Molecular and Cellular Biology 22:1, pages 105-116.
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Takehiko Kobayashi, Theo Rein & Melvin L. DePamphilis. (1998) Identification of Primary Initiation Sites for DNA Replication in the Hamster Dihydrofolate Reductase Gene Initiation Zone. Molecular and Cellular Biology 18:6, pages 3266-3277.
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Articles from other publishers (33)

Shengyan Xiang, Damon R. Reed & Mark G. Alexandrow. (2022) The CMG helicase and cancer: a tumor “engine” and weakness with missing mutations. Oncogene 42:7, pages 473-490.
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Molly R. Gordon, Daniel A. Bartlett & David M. Gilbert. 2018. Nuclear Architecture and Dynamics. Nuclear Architecture and Dynamics 407 434 .
Marius Reinhart & M. Cristina Cardoso. (2016) A journey through the microscopic ages of DNA replication. Protoplasma 254:3, pages 1151-1162.
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Juan Carlos Rivera-Mulia & David M. Gilbert. (2016) Replicating Large Genomes: Divide and Conquer. Molecular Cell 62:5, pages 756-765.
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Stephen Dalton. (2015) Linking the Cell Cycle to Cell Fate Decisions. Trends in Cell Biology 25:10, pages 592-600.
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Nihan Kara, Manzar Hossain, Supriya G. Prasanth & Bruce Stillman. (2015) Orc1 Binding to Mitotic Chromosomes Precedes Spatial Patterning during G1 Phase and Assembly of the Origin Recognition Complex in Human Cells. Journal of Biological Chemistry 290:19, pages 12355-12369.
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Dorota Rybaczek. (2014) Ultrastructural changes associated with the induction of premature chromosome condensation in Vicia faba root meristem cells. Plant Cell Reports 33:9, pages 1547-1564.
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Manickavinayaham Swarnalatha, Anup Kumar Singh & Vijay Kumar. (2012) The epigenetic control of E-box and Myc-dependent chromatin modifications regulate the licensing of lamin B2 origin during cell cycle. Nucleic Acids Research 40:18, pages 9021-9035.
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Yoav Lubelsky, Takayo Sasaki, Marjorie A. Kuipers, Isabelle Lucas, Michelle M. Le Beau, Sandra Carignon, Michelle Debatisse, Joseph A. Prinz, Jonathan H. Dennis & David M. Gilbert. (2011) Pre-replication complex proteins assemble at regions of low nucleosome occupancy within the Chinese hamster dihydrofolate reductase initiation zone. Nucleic Acids Research 39:8, pages 3141-3155.
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Marjorie A. Kuipers, Timothy J. Stasevich, Takayo Sasaki, Korey A. Wilson, Kristin L. Hazelwood, James G. McNally, Michael W. Davidson & David M. Gilbert. (2011) Highly stable loading of Mcm proteins onto chromatin in living cells requires replication to unload. Journal of Cell Biology 192:1, pages 29-41.
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William C. Burhans & Nicholas H. Heintz. (2009) The cell cycle is a redox cycle: Linking phase-specific targets to cell fate. Free Radical Biology and Medicine 47:9, pages 1282-1293.
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Wenge Zhu & Melvin L. DePamphilis. (2009) Selective Killing of Cancer Cells by Suppression of Geminin Activity. Cancer Research 69:11, pages 4870-4877.
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David Y Takeda & Anindya Dutta. (2005) DNA replication and progression through S phase. Oncogene 24:17, pages 2827-2843.
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Melvin L DePamphilis. (2003) The ‘ORC cycle’: a novel pathway for regulating eukaryotic DNA replication. Gene 310, pages 1-15.
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Feng Li, Jianhua Chen, Eduardo Solessio & David M. Gilbert. (2003) Spatial distribution and specification of mammalian replication origins during G1 phase. Journal of Cell Biology 161:2, pages 257-266.
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Susan M. Keezer & David M. Gilbert. (2002) Sensitivity of the Origin Decision Point to Specific Inhibitors of Cellular Signaling and Metabolism. Experimental Cell Research 273:1, pages 54-64.
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Susan M. Keezer & David M. Gilbert. (2002) Evidence for a pre-restriction point Cdk3 activity. Journal of Cellular Biochemistry 85:3, pages 545-552.
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A.K. Bielinsky & S.A. Gerbi. (2001) Where it all starts: eukaryotic origins of DNA replication. Journal of Cell Science 114:4, pages 643-651.
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W.-H. Sun, M. Hola, N. Baldwin, K. Pedley & R.F. Brooks. (2001) Heterogeneity in nuclear transport does not affect the timing of DNA synthesis in quiescent mammalian nuclei induced to replicate in Xenopus egg extracts . Cell Proliferation 34:1, pages 55-67.
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Jia-Rui Wu & David M. Gilbert. (2000) Lovastatin arrests CHO cells between the origin decision point and the restriction point. FEBS Letters 484:2, pages 108-112.
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Liang Tao, Zhifeng Dong, Michael Leffak, Maria Zannis-Hadjopoulos & Gerald Price. (2000) Major DNA replication initiation sites in thec-myc locus in human cells. Journal of Cellular Biochemistry 78:3, pages 442-457.
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P. Comizzoli, B. Marquant-Le Guienne, Y. Heyman & J.P. Renard. (2000) Onset of the First S-Phase Is Determined by a Paternal Effect During the G1-Phase in Bovine Zygotes1. Biology of Reproduction 62:6, pages 1677-1684.
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Cong-Jun Li, Joseph A. Bogan, Darren A. Natale & Melvin L. DePamphilis. (2000) Selective activation of pre-replication complexes in vitro at specific sites in mammalian nuclei. Journal of Cell Science 113:5, pages 887-898.
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W. SunM. HolaK. PedleyS. TadaJ.J. BlowI.T. TodorovS.E. KearseyR.F. Brooks. (2000) The replication capacity of intact mammalian nuclei in Xenopus egg extracts declines with quiescence, but the residual DNA synthesis is independent of Xenopus MCM proteins. Journal of Cell Science 113:4, pages 683-695.
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Zhi Hong Lu, Hongzhi Xu & Gregory H. Leno. (1999) DNA Replication in Quiescent Cell Nuclei: Regulation by the Nuclear Envelope and Chromatin Structure. Molecular Biology of the Cell 10:12, pages 4091-4106.
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Daniela S Dimitrova & David M Gilbert. (1999) The Spatial Position and Replication Timing of Chromosomal Domains Are Both Established in Early G1 Phase. Molecular Cell 4:6, pages 983-993.
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Melvin L. DePamphilis. (1999) Replication origins in metazoan chromosomes: fact or fiction?. BioEssays 21:1, pages 5-16.
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D.S. DimitrovaD.M. Gilbert. (1998) Regulation of mammalian replication origin usage in Xenopus egg extract. Journal of Cell Science 111:19, pages 2989-2998.
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Philippe Pasero & Susan M Gasser. (1998) New systems for replicating DNA in vitro. Current Opinion in Cell Biology 10:3, pages 304-310.
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Rajan Munshi & Gregory H. Leno. (1998) Replication of Nuclei from Cycling and Quiescent Mammalian Cells in 6-DMAP-TreatedXenopusEgg Extract. Experimental Cell Research 240:2, pages 321-332.
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David M Gilbert. (1998) Replication origins in yeast versus metazoa: separation of the haves and the have nots. Current Opinion in Genetics & Development 8:2, pages 194-199.
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Melvin L. DePamphilis. (1998) Initiation of DNA replication in eukaryotic chromosomes. Journal of Cellular Biochemistry 72:S30-31, pages 8-17.
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Jia-Rui Wu, Guanhua Yu & David M. Gilbert. (1997) Origin-Specific Initiation of Mammalian Nuclear DNA Replication in aXenopusCell-Free System. Methods 13:3, pages 313-324.
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