Advanced search
Publication Cover
Molecular and Cellular Biology Volume 17, 1997 - Issue 8
Submit an article Journal homepage
9
Views
251
CrossRef citations to date
0
Altmetric
Research Article

Multiple Control Elements Mediate Activation of the Murine and Human Interleukin 12 p40 Promoters: Evidence of Functional Synergy between C/EBP and Rel Proteins

Scott E. PlevyHoward Hughes Medical Institute and Department of Microbiology and Immunology, UCLA School of Medicine, Los Angeles, California90095-1662;Inflammatory Bowel Disease Center, Cedars-Sinai Medical Center, Los Angeles, California90048
,
James H. M. GemberlingHoward Hughes Medical Institute and Department of Microbiology and Immunology, UCLA School of Medicine, Los Angeles, California90095-1662
,
Sang HsuGenetics Institute, Inc., Cambridge, Massachusetts02140
,
Andrew J. DornerGenetics Institute, Inc., Cambridge, Massachusetts02140
&
Stephen T. SmaleHoward Hughes Medical Institute and Department of Microbiology and Immunology, UCLA School of Medicine, Los Angeles, California90095-1662Correspondence[email protected]
Pages 4572-4588 | Received 29 Jan 1997, Accepted 15 May 1997, Published online: 29 Mar 2023

Citations (251)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (11)

Zlatka Georgieva Dobreva, Lyuba Dineva Miteva & Spaska Angelova Stanilova. (2009) The inhibition of JNK and p38 MAPKs downregulates IL-10 and differentially affects c-Jun gene expression in human monocytes. Immunopharmacology and Immunotoxicology 31:2, pages 195-201.
Read now
Timothy J. Atkinson. (2008) Toll-Like Receptors, Transduction-Effector Pathways, and Disease Diversity: Evidence of an Immunobiological Paradigm Explaining All Human Illness?. International Reviews of Immunology 27:4, pages 255-281.
Read now
Liang Zhou, Aaron A. Nazarian, Jian Xu, Dean Tantin, Lynn M. Corcoran & Stephen T. Smale. (2007) An Inducible Enhancer Required for Il12b Promoter Activity in an Insulated Chromatin Environment. Molecular and Cellular Biology 27:7, pages 2698-2712.
Read now
Katharina Kreymborg, Ulrike Böhlmann & Burkhard Becher. (2005) IL-23: changing the verdict on IL-12 function in inflammation and autoimmunity. Expert Opinion on Therapeutic Targets 9:6, pages 1123-1136.
Read now
Francois Vigneault & Sylvain L Guérin. (2005) Regulation of gene expression: probing DNA–protein interactions in vivo and in vitro. Expert Review of Proteomics 2:5, pages 705-718.
Read now
Bok Yun Kang, Shi-Chuen Miaw & I-Cheng Ho. (2005) ROG Negatively Regulates T-Cell Activation but Is Dispensable for Th-Cell Differentiation. Molecular and Cellular Biology 25:2, pages 554-562.
Read now
Liang Zhou, Aaron A. Nazarian & Stephen T. Smale. (2004) Interleukin-10 Inhibits Interleukin-12 p40 Gene Transcription by Targeting a Late Event in the Activation Pathway. Molecular and Cellular Biology 24:6, pages 2385-2396.
Read now
Michelle N. Bradley, Liang Zhou & Stephen T. Smale. (2003) C/EBPβ Regulation in Lipopolysaccharide-Stimulated Macrophages. Molecular and Cellular Biology 23:14, pages 4841-4858.
Read now
Tapani Ronni, Vishal Agarwal, Michael Haykinson, Margaret E. Haberland, Genhong Cheng & Stephen T. Smale. (2003) Common Interaction Surfaces of the Toll-Like Receptor 4 Cytoplasmic Domain Stimulate Multiple Nuclear Targets. Molecular and Cellular Biology 23:7, pages 2543-2555.
Read now
Alexander Zagariya, Shubhangee Mungre, Rosa Lovis, Michael Birrer, Scott Ness, Bayar Thimmapaya & Richard Pope. (1998) Tumor Necrosis Factor Alpha Gene Regulation: Enhancement of C/EBPβ-Induced Activation by c-Jun. Molecular and Cellular Biology 18:5, pages 2815-2824.
Read now
Jian-Ming Li, Xing Shen, Patrick Pei-Chih Hu & Xiao-Fan Wang. (1998) Transforming Growth Factor β Stimulates the Human Immunodeficiency Virus 1 Enhancer and Requires NF-κB Activity. Molecular and Cellular Biology 18:1, pages 110-121.
Read now

Articles from other publishers (240)

Dhiraj Gurjar, Sananda Kumar Patra, Neelam Bodhale, Nibedita Lenka & Bhaskar Saha. (2022) Leishmania intercepts IFN-γR signaling at multiple levels in macrophages. Cytokine 157, pages 155956.
Crossref
A. V. Feoktistov, S. G. Georgieva & N. V. Soshnikova. (2022) Role of the SWI/SNF Chromatin Remodeling Complex in Regulation of Inflammation Gene Expression. Molecular Biology 56:2, pages 182-195.
Crossref
Andreas Nerlich, Nina Janze & Ralph Goethe. (2021) Analysis of Il36a induction by C/EBPβ via a half-CRE•C/EBP element in murine macrophages in dependence of its CpG methylation level. Genes & Immunity 22:7-8, pages 313-321.
Crossref
Jun Ma, Xiangyu Yang & Xiaoping Chen. (2021) C/EBPβ is a key transcription factor of ox-LDL inducing THP-1 cells to release multiple pro-inflammatory cytokines. Inflammation Research 70:10-12, pages 1191-1199.
Crossref
Vega Zamora, Juan Carlos Andreu-Ballester, Marta Rodero & Carmen Cuéllar. (2021) Anisakis simplex: Immunomodulatory effects of larval antigens on the activation of Toll like Receptors. International Immunopharmacology 100, pages 108120.
Crossref
Hisashi Kanemaru, Yukari Mizukami, Akira Kaneko, Hidemi Tagawa, Toshihiro Kimura, Haruka Kuriyama, Soichiro Sawamura, Ikko Kajihara, Katsunari Makino, Azusa Miyashita, Jun Aoi, Takamitsu Makino, Shinichi Masuguchi, Satoshi Fukushima & Hironobu Ihn. (2021) A mechanism of cooling hot tumors: Lactate attenuates inflammation in dendritic cells. iScience 24:9, pages 103067.
Crossref
Hervé Lecoeur, Thibault Rosazza, Kossiwa Kokou, Hugo Varet, Jean-Yves Coppée, Arezou Lari, Pierre-Henri Commère, Robert Weil, Guangxun Meng, Genevieve Milon, Gerald F. Späth & Eric Prina. (2020) Leishmania amazonensis Subverts the Transcription Factor Landscape in Dendritic Cells to Avoid Inflammasome Activation and Stall Maturation. Frontiers in Immunology 11.
Crossref
Bo Zhang, Yeong Min Choi, Junwoo Lee, In Sook An, Li Li, Congfen He, Yinmao Dong, Seunghee Bae & Hong Meng. (2019) Toll-like receptor 2 plays a critical role in pathogenesis of acne vulgaris. Biomedical Dermatology 3:1.
Crossref
Arin L Zirnheld, Marine Villard, Alisha M Harrison, Michele M Kosiewicz & Pascale Alard. (2019) β-Catenin stabilization in NOD dendritic cells increases IL-12 production and subsequent induction of IFN-γ-producing T cells. Journal of Leukocyte Biology 106:6, pages 1349-1358.
Crossref
Fengjie LiuYukinori Endo, Tatiana Romantseva, Wells W. WuAdovi Akue, Rong-Fong ShenHana GoldingMarina Zaitseva. (2019) T cell–derived soluble glycoprotein GPIbα mediates PGE 2 production in human monocytes activated with the vaccine adjuvant MDP . Science Signaling 12:602.
Crossref
Nicola Tamassia, Fabio Arruda-Silva, Helen L Wright, Robert J Moots, Elisa Gardiman, Francisco Bianchetto-Aguilera, Sara Gasperini, Manuela Capone, Laura Maggi, Francesco Annunziato, Steven W Edwards & Marco A Cassatella. (2019) Human neutrophils activated via TLR8 promote Th17 polarization through IL-23. Journal of Leukocyte Biology 105:6, pages 1155-1165.
Crossref
Xiang Chen, Pengfei Wang, Chao Zhao, Lulu Yan, Heizhao Lin & Lihua Qiu. (2018) Molecular characterization and functional analysis of IL-12p40 from Chinese sea bass (Lateolabrax maculatus) under biotic and abiotic stresses. Fish & Shellfish Immunology 83, pages 373-385.
Crossref
Hisashi Kanemaru, Fumihiro Yamane, Hiroki Tanaka, Kazuhiko Maeda, Takashi Satoh & Shizuo Akira. (2018) BATF2 activates DUSP2 gene expression and up-regulates NF-κB activity via phospho-STAT3 dephosphorylation. International Immunology 30:6, pages 255-265.
Crossref
Hisashi Kanemaru, Fumihiro YamaneKiyoharu FukushimaTakanori MatsukiTakahiro KawasakiIsao EbinaKanako Kuniyoshi, Hiroki Tanaka, Kenta Maruyama, Kazuhiko Maeda, Takashi Satoh & Shizuo Akira. (2017) Antitumor effect of Batf2 through IL-12 p40 up-regulation in tumor-associated macrophages . Proceedings of the National Academy of Sciences 114:35.
Crossref
Saioa Márquez, José Javier Fernández, Eli Terán-Cabanillas, Carmen Herrero, Sara Alonso, Alicia Azogil, Olimpio Montero, Takao Iwawaki, Juan R. Cubillos-Ruiz, Nieves Fernández & Mariano Sánchez Crespo. (2017) Endoplasmic Reticulum Stress Sensor IRE1α Enhances IL-23 Expression by Human Dendritic Cells. Frontiers in Immunology 8.
Crossref
Quanju Zhao, Qinglin Du, Fang Wei, Jianping Xie & Xiaojing Ma. (2017) An Infectious Disease–Associated Il12b Polymorphism Regulates IL-12/23 p40 Transcription Involving Poly(ADP-Ribose) Polymerase 1 . The Journal of Immunology 198:7, pages 2935-2942.
Crossref
Barbara Lipert, Mateusz Wilamowski, Andrzej Gorecki & Jolanta Jura. (2017) MCPIP1, alias Regnase-1 binds and cleaves mRNA of C/EBPβ. PLOS ONE 12:3, pages e0174381.
Crossref
Zhibin Yu, Chen Huang, Qiong Zhang & Wen-hai Feng. (2016) Porcine reproductive and respiratory syndrome virus (PRRSV) induces IL-12p40 production through JNK-AP-1 and NF-κB signaling pathways. Virus Research 225, pages 73-81.
Crossref
Hua Zheng, Yi Ban, Fang Wei & Xiaojing Ma. 2016. Regulation of Cytokine Gene Expression in Immunity and Diseases. Regulation of Cytokine Gene Expression in Immunity and Diseases 117 138 .
Michelle A. Favila, Nicholas S. Geraci, Asha Jayakumar, Suzanne Hickerson, Janet Mostrom, Salvatore J. Turco, Stephen M. Beverley & Mary Ann McDowell. (2015) Differential Impact of LPG-and PG-Deficient Leishmania major Mutants on the Immune Response of Human Dendritic Cells. PLOS Neglected Tropical Diseases 9:12, pages e0004238.
Crossref
Marta Pulido-Salgado, Jose M. Vidal-Taboada & Josep Saura. (2015) C/EBPβ and C/EBPδ transcription factors: Basic biology and roles in the CNS. Progress in Neurobiology 132, pages 1-33.
Crossref
Qian Liu, Yong Zhu, Wai Khang Yong, Newman Siu Kwan Sze, Nguan Soon Tan & Jeak Ling Ding. (2015) Cutting Edge: Synchronization of IRF1, JunB, and C/EBPβ Activities during TLR3–TLR7 Cross-Talk Orchestrates Timely Cytokine Synergy in the Proinflammatory Response. The Journal of Immunology 195:3, pages 801-805.
Crossref
Andreas Nerlich, Nanthapon Ruangkiattikul, Kristin Laarmann, Nina Janze, Oliver Dittrich-Breiholz, Michael Kracht & Ralph Goethe. (2015) C/EBPβ is a transcriptional key regulator of IL-36α in murine macrophages. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1849:8, pages 966-978.
Crossref
Chisato Sakuma, Mitsuru Sato, Takato Takenouchi & Hiroshi Kitani. (2015) Specific binding of the WASP N-terminal domain to Btk is critical for TLR2 signaling in macrophages. Molecular Immunology 63:2, pages 328-336.
Crossref
Xiaojing Ma, Wenjun Yan, Hua Zheng, Qinglin Du, Lixing Zhang, Yi Ban, Na Li & Fang Wei. (2015) Regulation of IL-10 and IL-12 production and function in macrophages and dendritic cells. F1000Research 4, pages 1465.
Crossref
Seong-Joon Koh, Ji Won Kim, Byeong Gwan Kim, Kook Lae Lee, Jong Pil Im & Joo Sung Kim. (2014) Fluoxetine Inhibits Hyperresponsive Lamina Propria Mononuclear Cells and Bone Marrow-Derived Dendritic Cells, and Ameliorates Chronic Colitis in IL-10-Deficient Mice. Digestive Diseases and Sciences 60:1, pages 101-108.
Crossref
Renate Louw-du Toit, Janet P. Hapgood & Donita Africander. (2014) Medroxyprogesterone Acetate Differentially Regulates Interleukin (IL)-12 and IL-10 in a Human Ectocervical Epithelial Cell Line in a Glucocorticoid Receptor (GR)-dependent Manner. Journal of Biological Chemistry 289:45, pages 31136-31149.
Crossref
Alexandre Bougdour, Isabelle Tardieux & Mohamed-Ali Hakimi. (2014) T oxoplasma exports dense granule proteins beyond the vacuole to the host cell nucleus and rewires the host genome expression . Cellular Microbiology 16:3, pages 334-343.
Crossref
Taku Kobayashi, Erin C. Steinbach, Steven M. Russo, Katsuyoshi Matsuoka, Tomonori Nochi, Nitsan Maharshak, Luke B. Borst, Bruce Hostager, J. Victor Garcia-Martinez, Paul B. Rothman, Masaki Kashiwada, Shehzad Z. Sheikh, Peter J. Murray & Scott E. Plevy. (2014) NFIL3-Deficient Mice Develop Microbiota-Dependent, IL-12/23–Driven Spontaneous Colitis. The Journal of Immunology 192:4, pages 1918-1927.
Crossref
Lin Xiao, Suzana Kovac, Mike Chang, Arthur Shulkes, Graham S Baldwin & Oneel Patel. (2014) Zinc ions upregulate the hormone gastrin via an E-box motif in the proximal gastrin promoter. Journal of Molecular Endocrinology 52:1, pages 29-42.
Crossref
Magdalena Niedzielska, Barbara Bodendorfer, Sandra Münch, Alexander Eichner, Marcus Derigs, Olivia da Costa, Astrid Schweizer, Frauke Neff, Lars Nitschke, Tim Sparwasser, Stephen M. Keyse & Roland Lang. (2014) Gene Trap Mice Reveal an Essential Function of Dual Specificity Phosphatase Dusp16/MKP-7 in Perinatal Survival and Regulation of Toll-like Receptor (TLR)-induced Cytokine Production. Journal of Biological Chemistry 289:4, pages 2112-2126.
Crossref
Carla Caldas Marques, Morgana T. Castelo-Branco, Rodrigo G. Pacheco, Fernanda Buongusto, Alyson do RosárioJr.Jr., Alberto Schanaider, Robson Coutinho-Silva & Heitor S.P. de Souza. (2014) Prophylactic systemic P2X7 receptor blockade prevents experimental colitis. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1842:1, pages 65-78.
Crossref
S.D.N.K. Bathige, Navaneethaiyer Umasuthan, Ilson Whang, Bong-Soo Lim, Hyung-Bok Jung & Jehee Lee. (2013) Evidences for the involvement of an invertebrate goose-type lysozyme in disk abalone immunity: Cloning, expression analysis and antimicrobial activity. Fish & Shellfish Immunology 35:5, pages 1369-1379.
Crossref
Ling Gu, Huan Ning, Xuesong Qian, Qi Huang, Rong Hou, Rajaa Almourani, Mingui Fu, Perry J. Blackshear & Jianguo Liu. (2013) Suppression of IL-12 Production by Tristetraprolin through Blocking NF-кB Nuclear Translocation. The Journal of Immunology 191:7, pages 3922-3930.
Crossref
Nguyen Thao, Nguyen Cuong, Bui Luyen, Tran Quang, Tran Hanh, Sohyun Kim, Young-Sang Koh, Nguyen Nam, Phan Van Kiem, Chau Van Minh & Young Kim. (2013) Anti-Inflammatory Components of the Starfish Astropecten polyacanthus. Marine Drugs 11:8, pages 2917-2926.
Crossref
Maria A. BlahoianuAli A.R. RahimiNiranjala GajanayakaMaya KozlowskiJonathan B. AngelAshok Kumar. (2013) Engagement of CD14 Sensitizes Primary Monocytes to IFN-γ to Produce IL-12/23p40 and IL-23 Through p38 Mitogen-Activated Protein Kinase and Independent of the Janus Kinase/Signal Transducers and Activators of Transcription Signaling. Journal of Interferon & Cytokine Research 33:8, pages 434-445.
Crossref
Tran Hong Quang, Nguyen Thi Thanh Ngan, Chau Van Minh, Phan Van Kiem, Nguyen Xuan Nhiem, Bui Huu Tai, Nguyen Phuong Thao, Doobyeong Chae, Vivek Bhakta Mathema, Young-Sang Koh, Je-Hyun Lee, Seo Young Yang & Young Ho Kim. (2013) Inhibitory effects of oleanane-type triterpenes and saponins from the stem bark of Kalopanax pictus on LPS-stimulated pro-inflammatory cytokine production in bone marrow-derived dendritic cells. Archives of Pharmacal Research 36:3, pages 327-334.
Crossref
Nguyen Phuong Thao, Nguyen Hoai Nam, Nguyen Xuan Cuong, Tran Hong Quang, Pham The Tung, Le Duc Dat, Doobyeong Chae, Sohyun Kim, Young-Sang Koh, Phan Van Kiem, Chau Van Minh & Young Ho Kim. (2013) Anti-inflammatory norditerpenoids from the soft coral Sinularia maxima. Bioorganic & Medicinal Chemistry Letters 23:1, pages 228-231.
Crossref
Ryuji Koshiba, Hideyuki Yanai, Atsushi Matsuda, Ayana Goto, Akira Nakajima, Hideo Negishi, Junko Nishio, Stephen T. Smale & Tadatsugu Taniguchi. (2013) Regulation of cooperative function of the Il12b enhancer and promoter by the interferon regulatory factors 3 and 5. Biochemical and Biophysical Research Communications 430:1, pages 95-100.
Crossref
Young-Chang Cho, Sung Ho Lee, Mina Lee, Hyun Jung Kim, Min-ho Oak, Ik-Soo Lee & Bok Yun Kang. (2012) Enhanced IL-12p40 production in LPS-stimulated macrophages by inhibiting JNK activation by artemisinin. Archives of Pharmacal Research 35:11, pages 1961-1968.
Crossref
Michael F. Carey, Craig L. Peterson & Stephen T. Smale. (2012) Confirming the Functional Importance of a Protein–DNA Interaction. Cold Spring Harbor Protocols 2012:7, pages pdb.top070060.
Crossref
Hideo Negishi, Hideyuki Yanai, Akira Nakajima, Ryuji Koshiba, Koji Atarashi, Atsushi Matsuda, Kosuke Matsuki, Shoji Miki, Takahiro Doi, Alan Aderem, Junko Nishio, Stephen T Smale, Kenya Honda & Tadatsugu Taniguchi. (2012) Cross-interference of RLR and TLR signaling pathways modulates antibacterial T cell responses. Nature Immunology 13:7, pages 659-666.
Crossref
Haixia Xu, Jimmy Zhu, Sinead Smith, Julia Foldi, Baohong Zhao, Allen Y Chung, Hasina Outtz, Jan Kitajewski, Chao Shi, Silvio Weber, Paul Saftig, Yueming Li, Keiko Ozato, Carl P Blobel, Lionel B Ivashkiv & Xiaoyu Hu. (2012) Notch–RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization. Nature Immunology 13:7, pages 642-650.
Crossref
Johannes G. Bode, Christian Ehlting & Dieter Häussinger. (2012) The macrophage response towards LPS and its control through the p38MAPK–STAT3 axis. Cellular Signalling 24:6, pages 1185-1194.
Crossref
Yina Zhu, Dominic van Essen & Simona Saccani. (2012) Cell-Type-Specific Control of Enhancer Activity by H3K9 Trimethylation. Molecular Cell 46:4, pages 408-423.
Crossref
Houda Z. Elloumi, Nitsan Maharshak, Kavitha N. Rao, Taku Kobayashi, Hyungjin S. Ryu, Marcus Mühlbauer, Fengling Li, Christian Jobin & Scott E. Plevy. (2012) A Cell Permeable Peptide Inhibitor of NFAT Inhibits Macrophage Cytokine Expression and Ameliorates Experimental Colitis. PLoS ONE 7:3, pages e34172.
Crossref
Stephen T. Smale. (2012) Dimer-specific regulatory mechanisms within the NF-κB family of transcription factors. Immunological Reviews 246:1, pages 193-204.
Crossref
Michael F. Carey, Craig L. Peterson & Stephen T. Smale. (2012) Identifying cis -Acting DNA Elements within a Control Region . Cold Spring Harbor Protocols 2012:3, pages pdb.top068171.
Crossref
Marian Ponce, Emilio Salas-Leiton, Ana Garcia-Cegarra, Anais Boglino, Olivier Coste, Carlos Infante, Enric Gisbert, Laureana Rebordinos & Manuel Manchado. (2011) Genomic characterization, phylogeny and gene regulation of g-type lysozyme in sole (Solea senegalensis). Fish & Shellfish Immunology 31:6, pages 925-937.
Crossref
Phan Van Kiem, Nguyen Thi Kim Thuy, Hoang Le Tuan Anh, Nguyen Xuan Nhiem, Chau Van Minh, Pham Hai Yen, Ninh Khac Ban, Dan Thuy Hang, Bui Huu Tai, Nguyen Van Tuyen, Vivek Bhakta Mathema, Young-Sang Koh & Young Ho Kim. (2011) Chemical constituents of the rhizomes of Hedychium coronarium and their inhibitory effect on the pro-inflammatory cytokines production LPS-stimulated in bone marrow-derived dendritic cells. Bioorganic & Medicinal Chemistry Letters 21:24, pages 7460-7465.
Crossref
Nguyen Xuan Nhiem, Phan Van Kiem, Chau Van Minh, Bui Huu Tai, Tran Hong Quang, Kwang Su Soung, Jung-Eun Koo, Young-Sang Koh & Young Ho Kim. (2011) Anti-inflammatory activity on LPS-stimulated dendritic cells of lupanetype triterpenoids from the leaves of Acanthopanax koreanum. Archives of Pharmacal Research 34:10, pages 1593-1598.
Crossref
Shin‐Heng Chiou, Payam Shahi, Ryan T Wagner, Hongbo Hu, Natalia Lapteva, Mamatha Seethammagari, Shao‐Cong Sun, Jonathan M Levitt & David M Spencer. (2011) The E3 ligase c‐Cbl regulates dendritic cell activation. EMBO reports 12:9, pages 971-979.
Crossref
Subhas Das, Jennifer Kelschenbach, Richard Charboneau, Roderick A. Barke & Sabita Roy. (2011) Morphine Withdrawal Stress Modulates Lipopolysaccharide-induced Interleukin 12 p40 (IL-12p40) Expression by Activating Extracellular Signal-regulated Kinase 1/2, Which Is Further Potentiated by Glucocorticoids. Journal of Biological Chemistry 286:34, pages 29806-29817.
Crossref
Petra Gynther, Sari Toropainen, Juha M. Matilainen, Sabine Seuter, Carsten Carlberg & Sami Väisänen. (2011) Mechanism of 1α,25-dihydroxyvitamin D3-dependent repression of interleukin-12B. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1813:5, pages 810-818.
Crossref
Junichi Tsukada, Yasuhiro Yoshida, Yoshihiko Kominato & Philip E. Auron. (2011) The CCAAT/enhancer (C/EBP) family of basic-leucine zipper (bZIP) transcription factors is a multifaceted highly-regulated system for gene regulation. Cytokine 54:1, pages 6-19.
Crossref
Nguyen Huu Tung, Tran Hong Quang, Jeong-Hyun Son, Jung-Eun Koo, Hye-Jin Hong, Young-Sang Koh, Gyu Yong Song & Young Ho Kim. (2011) Inhibitory effect of ginsenosides from steamed ginseng-leaves and flowers on the LPS-stimulated IL-12 production in bone marrow-derived dendritic cells. Archives of Pharmacal Research 34:4, pages 681-685.
Crossref
Shuzhen Liu, Xuanming Shi, Isabel Bauer, Juliane Günther & Hans-Martin Seyfert. (2011) Lingual antimicrobial peptide and IL-8 expression are oppositely regulated by the antagonistic effects of NF-κB p65 and C/EBPβ in mammary epithelial cells. Molecular Immunology 48:6-7, pages 895-908.
Crossref
Mübeccel Akdis, Simone Burgler, Reto Crameri, Thomas Eiwegger, Hiroyuki Fujita, Enrique Gomez, Sven Klunker, Norbert Meyer, Liam O’Mahony, Oscar Palomares, Claudio Rhyner, Nadia Quaked, Anna Schaffartzik, Willem Van De Veen, Sabine Zeller, Maya Zimmermann & Cezmi A. Akdis. (2011) Interleukins, from 1 to 37, and interferon-γ: Receptors, functions, and roles in diseases. Journal of Allergy and Clinical Immunology 127:3, pages 701-721.e70.
Crossref
Robert E. Palermo, L. Jean Patterson, Lauri D. Aicher, Marcus J. Korth, Marjorie Robert-Guroff & Michael G. Katze. (2011) Genomic Analysis Reveals Pre- and Postchallenge Differences in a Rhesus Macaque AIDS Vaccine Trial: Insights into Mechanisms of Vaccine Efficacy. Journal of Virology 85:2, pages 1099-1116.
Crossref
Jeong Ah Kim, Seo Young Yang, Jung-Eun Koo, Young-Sang Koh & Young Ho Kim. (2010) Lupane-type triterpenoids from the steamed leaves of Acanthopanax koreanum and their inhibitory effects on the LPS-stimulated pro-inflammatory cytokine production in bone marrow-derived dendritic cells. Bioorganic & Medicinal Chemistry Letters 20:22, pages 6703-6707.
Crossref
Jiyan Zhang, Ning Zhu, Qingyang Wang, Jing Wang, Yuanfang Ma, Chunxia Qiao, Yan Li, Xinying Li, Bing Su & Beifen Shen. (2010) MEKK3 Overexpression Contributes to the Hyperresponsiveness of IL-12–Overproducing Cells and CD4+ T Conventional Cells in Nonobese Diabetic Mice. The Journal of Immunology 185:6, pages 3554-3563.
Crossref
Nguyen Huu Tung, Seok Bean Song, Gyu Yong Song, Jeong-Ah Kim, Jung-Eun Koo, Hee-Kyoung Kang, Young-Sang Koh & Young Ho Kim. (2010) Inhibitory effect of ginsenosides from ginseng leaves and flowers on the LPS-stimulated IL-12 production in bone marrow-derived dendritic cells. Food Science and Biotechnology 19:4, pages 1119-1122.
Crossref
Diane Antonios, Philippe Rousseau, Alexandre Larangé, Saadia Kerdine-Römer & Marc Pallardy. (2010) Mechanisms of IL-12 Synthesis by Human Dendritic Cells Treated with the Chemical Sensitizer NiSO4. The Journal of Immunology 185:1, pages 89-98.
Crossref
Young-Chang Cho, Kwang Youl Lee, Bok Yun Kang & Haeng Soon Park. (2010) Enhanced IL-12p40 production by phenylarsine oxide is mediated by cAMP response element in macrophages. Archives of Pharmacal Research 33:5, pages 745-751.
Crossref
Shehzad Z. Sheikh, Katsuyoshi Matsuoka, Taku Kobayashi, Fengling Li, Tara Rubinas & Scott E. Plevy. (2010) Cutting Edge: IFN-γ Is a Negative Regulator of IL-23 in Murine Macrophages and Experimental Colitis. The Journal of Immunology 184:8, pages 4069-4073.
Crossref
Yan Zhang & Xiaojing Ma. (2010) Triptolide Inhibits IL-12/IL-23 Expression in APCs via CCAAT/Enhancer-Binding Protein α. The Journal of Immunology 184:7, pages 3866-3877.
Crossref
Koen Vandenbroeck, Iraide Alloza, Massimo Gadina & Patrick Matthys. (2004) Inhibiting cytokines of the interleukin-12 family: recent advances and novel challenges. Journal of Pharmacy and Pharmacology 56:2, pages 145-160.
Crossref
Stephen T. Smale. (2010) Transfection by Electroporation of RAW 264.7 Macrophages. Cold Spring Harbor Protocols 2010:2, pages pdb.prot5374.
Crossref
Christopher P. Sullivan, Stephanie E. Seidl, Celeste B. Rich, Michel Raymondjean & Barbara M. Schreiber. (2010) Secretory Phospholipase A2, Group IIA Is a Novel Serum Amyloid A Target Gene. Journal of Biological Chemistry 285:1, pages 565-575.
Crossref
Weicheng Liu, Xinshou Ouyang, Jianjun Yang, Jianguo Liu, Qingshan Li, Yongpeng Gu, Masayuki Fukata, Tony Lin, John Cijiang He, Maria Abreu, Jay C. Unkeless, Lloyd Mayer & Huabao Xiong. (2009) AP-1 Activated by Toll-like Receptors Regulates Expression of IL-23 p19. Journal of Biological Chemistry 284:36, pages 24006-24016.
Crossref
Yong-Chen Lu, Ira Kim, Elizabeth Lye, Fang Shen, Nobutaka Suzuki, Shinobu Suzuki, Steve Gerondakis, Shizuo Akira, Sarah L. Gaffen, Wen-Chen Yeh & Pamela S. Ohashi. (2009) Differential Role for c-Rel and C/EBPβ/δ in TLR-Mediated Induction of Proinflammatory Cytokines. The Journal of Immunology 182:11, pages 7212-7221.
Crossref
Marta Torroella-Kouri, Risset Silvera, Dayron Rodriguez, Raul Caso, Alwi Shatry, Shannon Opiela, Dan Ilkovitch, Reto A. Schwendener, Vijaya Iragavarapu-Charyulu, Yoslayma Cardentey, Natasa Strbo & Diana M. Lopez. (2009) Identification of a Subpopulation of Macrophages in Mammary Tumor–Bearing Mice That Are Neither M1 nor M2 and Are Less Differentiated. Cancer Research 69:11, pages 4800-4809.
Crossref
Shaival H Davé, Jeremy S Tilstra, Katsuyoshi Matsuoka, Fengling Li, Richard A DeMarco, Donna Beer-Stolz, Antonia R Sepulveda, Mitchell P Fink, Michael T Lotze & Scott E Plevy. (2009) Ethyl pyruvate decreases HMGB1 release and ameliorates murine colitis. Journal of Leukocyte Biology 86:3, pages 633-643.
Crossref
Eriko Takeshima, Koh Tomimori, Hiromitsu Teruya, Chie Ishikawa, Masachika Senba, Daniele D'Ambrosio, Fukunori Kinjo, Hitomi Mimuro, Chihiro Sasakawa, Toshiya Hirayama, Jiro Fujita & Naoki Mori. (2009) Helicobacter pylori -Induced Interleukin-12 p40 Expression . Infection and Immunity 77:4, pages 1337-1348.
Crossref
Serena Ghisletti, Wendy Huang, Kristen Jepsen, Chris Benner, Gary Hardiman, Michael G. Rosenfeld & Christopher K. Glass. (2009) Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways. Genes & Development 23:6, pages 681-693.
Crossref
Wei Ma, Sasmita Mishra, Niranjala Gajanayaka, Jonathan B. Angel & Ashok Kumar. (2009) HIV-1 Nef Inhibits Lipopolysaccharide-induced IL-12p40 Expression by Inhibiting JNK-activated NFκB in Human Monocytic Cells. Journal of Biological Chemistry 284:12, pages 7578-7587.
Crossref
Alexandre Cloutier, Chantal Guindi, Pierre Larivée, Claire M. Dubois, Abdelaziz Amrani & Patrick P. McDonald. (2009) Inflammatory Cytokine Production by Human Neutrophils Involves C/EBP Transcription Factors. The Journal of Immunology 182:1, pages 563-571.
Crossref
Zlatka Dobreva, Spaska Stanilova & Lyuba Miteva. (2009) The influence of JNK and P38 MAPK inhibition on IL-12P40 and IL-23 production depending on IL12B promoter polymorphism. Cellular and Molecular Biology Letters 14:4.
Crossref
Xiaoping Duan, Hui Guan, Ying Cao & Eugenie S. Kleinerman. (2009) Murine bone marrow-derived mesenchymal stem cells as vehicles for interleukin-12 gene delivery into Ewing sarcoma tumors. Cancer 115:1, pages 13-22.
Crossref
Lyudmila Lyakh, Giorgio Trinchieri, Lisa Provezza, Giuseppe Carra & Franca Gerosa. (2008) Regulation of interleukin-12/interleukin-23 production and the T-helper 17 response in humans. Immunological Reviews 226:1, pages 112-131.
Crossref
Pascal Lefevre, James Witham, Claire E. Lacroix, Peter N. Cockerill & Constanze Bonifer. (2008) The LPS-Induced Transcriptional Upregulation of the Chicken Lysozyme Locus Involves CTCF Eviction and Noncoding RNA Transcription. Molecular Cell 32:1, pages 129-139.
Crossref
Jesús Argueta-Donohué, Nuria Carrillo, Leonardo Valdés-Reyes, Alejandro Zentella, Magdalena Aguirre-García, Ingeborg Becker & Laila Gutiérrez-Kobeh. (2008) Leishmania mexicana: Participation of NF-κB in the differential production of IL-12 in dendritic cells and monocytes induced by lipophosphoglycan (LPG). Experimental Parasitology 120:1, pages 1-9.
Crossref
Nooruddin Khan, Kaiser Alam, Shekhar C. Mande, Vijaya Lakshmi Valluri, Seyed E. Hasnain & Sangita Mukhopadhyay. (2008) Mycobacterium tuberculosis heat shock protein 60 modulates immune response to PPD by manipulating the surface expression of TLR2 on macrophages . Cellular Microbiology 10:8, pages 1711-1722.
Crossref
Claire Billerey-Larmonier, Jennifer K. Uno, Nicolas Larmonier, Anna J. Midura, Barbara Timmermann, Fayez K. Ghishan & Pawel R. Kiela. (2008) Protective effects of dietary curcumin in mouse model of chemically induced colitis are strain dependent. Inflammatory Bowel Diseases 14:6, pages 780-793.
Crossref
Asha Jayakumar, Michael J. Donovan, Vinita Tripathi, Marcelo Ramalho-Ortigao & Mary Ann McDowell. (2008) Leishmania major Infection Activates NF-κB and Interferon Regulatory Factors 1 and 8 in Human Dendritic Cells . Infection and Immunity 76:5, pages 2138-2148.
Crossref
Young Jun Kang, Jianming Chen, Motoyuki Otsuka, Johann Mols, Shuxun Ren, Yinbin Wang & Jiahuai Han. (2008) Macrophage Deletion of p38α Partially Impairs Lipopolysaccharide-Induced Cellular Activation. The Journal of Immunology 180:7, pages 5075-5082.
Crossref
Jennifer Kelschenbach, Jana Ninkovic, Jinghua Wang, Anitha Krishnan, Richard Charboneau, Roderick A. Barke & Sabita Roy. (2008) Morphine Withdrawal Inhibits IL-12 Induction in a Macrophage Cell Line through a Mechanism That Involves cAMP. The Journal of Immunology 180:6, pages 3670-3679.
Crossref
K. Wimmers, K. G. Kumar, K. Schellander & S. Ponsuksili. (2008) Porcine IL12A and IL12B gene mapping, variation and evidence of association with lytic complement and blood leucocyte proliferation traits. International Journal of Immunogenetics 35:1, pages 75-85.
Crossref
Fernando Correa, Fabian Docagne, Diego Clemente, Leyre Mestre, Christoph Becker & Carmen Guaza. (2008) Anandamide inhibits IL-12p40 production by acting on the promoter repressor element GA-12: possible involvement of the COX-2 metabolite prostamide E2. Biochemical Journal 409:3, pages 761-770.
Crossref
Kareena L Schnabl, John E Van Aerde, Alan BR Thomson & Michael T Clandinin. (2008) Necrotizing enterocolitis: A multifactorial disease with no cure. World Journal of Gastroenterology 14:14, pages 2142.
Crossref
Konrad A. Bode, Kate Schroder, David A. Hume, Timothy Ravasi, Klaus Heeg, Matthew J. Sweet & Alexander H. Dalpke. (2007) Histone deacetylase inhibitors decrease Toll-like receptor-mediated activation of proinflammatory gene expression by impairing transcription factor recruitment. Immunology 122:4, pages 596-606.
Crossref
Setsuko Mise-Omata, Etsushi Kuroda, Junko Niikura, Uki Yamashita, Yuichi Obata & Takahiro S. Doi. (2007) A Proximal κB Site in the IL-23 p19 Promoter Is Responsible for RelA- and c-Rel-Dependent Transcription. The Journal of Immunology 179:10, pages 6596-6603.
Crossref
Masahiro Yamamoto, Satoshi Uematsu, Toru Okamoto, Yoshiharu Matsuura, Shintaro Sato, Himanshu Kumar, Takashi Satoh, Tatsuya Saitoh, Kiyoshi Takeda, Ken J. Ishii, Osamu Takeuchi, Taro Kawai & Shizuo Akira. (2007) Enhanced TLR-mediated NF-IL6–dependent gene expression by Trib1 deficiency. Journal of Experimental Medicine 204:9, pages 2233-2239.
Crossref
Laura E. Roberts, Mehdi A. Fini, Noi Derkash & Richard M. Wright. (2007) PD98059 enhanced insulin, cytokine, and growth factor activation of xanthine oxidoreductase in epithelial cells involves STAT3 and the glucocorticoid receptor. Journal of Cellular Biochemistry 101:6, pages 1567-1587.
Crossref
Ching-Aeng Lim, Fei Yao, Joyce Jing-Yi Wong, Joshy George, Han Xu, Kuo Ping Chiu, Wing-Kin Sung, Leonard Lipovich, Vinsensius B. Vega, Joanne Chen, Atif Shahab, Xiao Dong Zhao, Martin Hibberd, Chia-Lin Wei, Bing Lim, Huck-Hui Ng, Yijun Ruan & Keh-Chuang Chin. (2007) Genome-wide Mapping of RELA(p65) Binding Identifies E2F1 as a Transcriptional Activator Recruited by NF-κB upon TLR4 Activation. Molecular Cell 27:4, pages 622-635.
Crossref
Swamy Kumar Polumuri, Vladimir Y. Toshchakov & Stefanie N. Vogel. (2007) Role of Phosphatidylinositol-3 Kinase in Transcriptional Regulation of TLR-Induced IL-12 and IL-10 by Fcγ Receptor Ligation in Murine Macrophages. The Journal of Immunology 179:1, pages 236-246.
Crossref
Bo Huang, Jie Zhao, Shiqian Shen, Hongxing Li, Kai-Li He, Guan-Xin Shen, Lloyd Mayer, Jay Unkeless, Dong Li, Ye Yuan, Gui-Mei Zhang, Huabao Xiong & Zuo-Hua Feng. (2007) Listeria monocytogenes Promotes Tumor Growth via Tumor Cell Toll-Like Receptor 2 Signaling . Cancer Research 67:9, pages 4346-4352.
Crossref
Wei Ma, Sasmita Mishra, Katrina Gee, Jyoti P. Mishra, Devki Nandan, Neil E. Reiner, Jonathan B. Angel & Ashok Kumar. (2007) Cyclosporin A and FK506 Inhibit IL-12p40 Production through the Calmodulin/Calmodulin-dependent Protein Kinase-activated Phosphoinositide 3-Kinase in Lipopolysaccharide-stimulated Human Monocytic Cells. Journal of Biological Chemistry 282:18, pages 13351-13362.
Crossref
Luca Pompei, Sihyug Jang, Beata Zamlynny, Sharada Ravikumar, Amanda McBride, Somia Perdow Hickman & Padmini Salgame. (2007) Disparity in IL-12 Release in Dendritic Cells and Macrophages in Response to Mycobacterium tuberculosis Is Due to Use of Distinct TLRs . The Journal of Immunology 178:8, pages 5192-5199.
Crossref
Chandra Sekhar Boddupalli, Sudip Ghosh, Sheikh Showkat Rahim, Shiny Nair, Nasreen Z. Ehtesham, Seyed E. Hasnain & Sangita Mukhopadhyay. (2007) Nitric oxide inhibits interleukin-12 p40 through p38 MAPK-mediated regulation of calmodulin and c-rel. Free Radical Biology and Medicine 42:5, pages 686-697.
Crossref
Jihong Xu & Paul D. Drew. (2007) Peroxisome Proliferator-Activated Receptor-γ Agonists Suppress the Production of IL-12 Family Cytokines by Activated Glia. The Journal of Immunology 178:3, pages 1904-1913.
Crossref
Chauncey J. Spooner, Xiangrong Guo, Peter F. Johnson & Richard C. Schwartz. (2007) Differential roles of C/EBPβ regulatory domains in specifying MCP-1 and IL-6 transcription. Molecular Immunology 44:6, pages 1384-1392.
Crossref
Chauncey J. Spooner, Thomas Sebastian, Jon D. Shuman, Srinivasan Durairaj, Xiangrong Guo, Peter F. Johnson & Richard C. Schwartz. (2007) C/EBPβ serine 64, a phosphoacceptor site, has a critical role in LPS-induced IL-6 and MCP-1 transcription. Cytokine 37:2, pages 119-127.
Crossref
Wim Vanden Berghe, ’Matladi N. Ndlovu, Ruben Hoya-Arias, Nathalie Dijsselbloem, Sarah Gerlo & Guy Haegeman. (2006) Keeping up NF-κB appearances: Epigenetic control of immunity or inflammation-triggered epigenetics. Biochemical Pharmacology 72:9, pages 1114-1131.
Crossref
Rong He, Larry W. Shepard, Jia Chen, Zhixing K. Pan & Richard D. Ye. (2006) Serum Amyloid A Is an Endogenous Ligand That Differentially Induces IL-12 and IL-23. The Journal of Immunology 177:6, pages 4072-4079.
Crossref
Shinji Saito, Motohiro Matsuura & Yoshikazu Hirai. (2006) Regulation of Lipopolysaccharide-Induced Interleukin-12 Production by Activation of Repressor Element GA-12 through Hyperactivation of the ERK Pathway. Clinical and Vaccine Immunology 13:8, pages 876-883.
Crossref
Fang Shen, Zihua Hu, Jaya Goswami & Sarah L. Gaffen. (2006) Identification of Common Transcriptional Regulatory Elements in Interleukin-17 Target Genes. Journal of Biological Chemistry 281:34, pages 24138-24148.
Crossref
Yi-Na Zhu, Yi-Fu Yang, Shiro Ono, Xiang-Gen Zhong, Yong-Hong Feng, Yong-Xin Ren, Jia Ni, Yun-Feng Fu, Wei Tang & Jian-Ping Zuo. (2006) Differential expression of inducible nitric oxide synthase and IL-12 between peritoneal and splenic macrophages stimulated with LPS plus IFN-γ is associated with the activation of extracellular signal-related kinase. International Immunology 18:6, pages 981-990.
Crossref
Jie Zhao, Hee Jeong Kong, Hongxing Li, Bo Huang, Min Yang, Chen Zhu, Milena Bogunovic, Feng Zheng, Lloyd Mayer, Keiko Ozato, Jay Unkeless & Huabao Xiong. (2006) IRF-8/Interferon (IFN) Consensus Sequence-binding Protein Is Involved in Toll-like Receptor (TLR) Signaling and Contributes to the Cross-talk between TLR and IFN-γ Signaling Pathways. Journal of Biological Chemistry 281:15, pages 10073-10080.
Crossref
Pulak Tripathi, Rajat Madan, Claire Chougnet, Senad Divanovic, Xiaojing Ma, Larry M. Wahl, Thomas Gajewski, Christopher L. Karp & David A. Hildeman. (2006) An adenoviral vector for probing promoter activity in primary immune cells. Journal of Immunological Methods 311:1-2, pages 19-30.
Crossref
Chiang W. Lee, Soumaya Bennouna & Eric Y. Denkers. (2006) Screening for Toxoplasma gondii -Regulated Transcriptional Responses in Lipopolysaccharide-Activated Macrophages . Infection and Immunity 74:3, pages 1916-1923.
Crossref
Hai-Jing Sun, Xin Xu, Xiu-Li Wang, Liang Wei, Fen Li, Jun Lu & Bai-Qu Huang. (2006) Transcription Factors Ets2 and Sp1 Act Synergistically with Histone Acetyltransferase p300 in Activating Human Interleukin-12 p40 Promoter. Acta Biochimica et Biophysica Sinica 38:3, pages 194-200.
Crossref
Katherine J. Seymour, Laura E. Roberts, Mehdi A. Fini, Lisa A. Parmley, Tatiana L. Oustitch & Richard M. Wright. (2006) Stress Activation of Mammary Epithelial Cell Xanthine Oxidoreductase Is Mediated by p38 MAPK and CCAAT/Enhancer-binding Protein-β. Journal of Biological Chemistry 281:13, pages 8545-8558.
Crossref
Nooruddin KhanSheikh Showkat RahimChandra Sekhar BoddupalliSheikh GhousunnissaSamavedan PadmaNiteen PathakDorairajan ThiagarajanSeyed E. HasnainSangita Mukhopadhyay. (2006) Hydrogen peroxide inhibits IL-12 p40 induction in macrophages by inhibiting c-rel translocation to the nucleus through activation of calmodulin protein. Blood 107:4, pages 1513-1520.
Crossref
Elaine Y Chung, Sun Jung Kim & Xiao Jing Ma. (2006) Regulation of cytokine production during phagocytosis of apoptotic cells. Cell Research 16:2, pages 154-161.
Crossref
Katinka Stoffels, Lut Overbergh, Annapaula Giulietti, Lieve Verlinden, Roger Bouillon & Chantal Mathieu. (2005) Immune Regulation of 25-Hydroxyvitamin-D3-1α-Hydroxylase in Human Monocytes. Journal of Bone and Mineral Research 21:1, pages 37-47.
Crossref
Paul O. Hassa & Michael O. Hottiger. 2006. Poly(ADP-Ribosyl)ation. Poly(ADP-Ribosyl)ation 75 90 .
Cristina M. Tato & Christopher A. Hunter. 2006. NF-κB/Rel Transcription Factor Family. NF-κB/Rel Transcription Factor Family 91 111 .
Refaat A.F. Hegazi, Kavitha N. Rao, Aqila Mayle, Antonia R. Sepulveda, Leo E. Otterbein & Scott E. Plevy. (2005) Carbon monoxide ameliorates chronic murine colitis through a heme oxygenase 1–dependent pathway. Journal of Experimental Medicine 202:12, pages 1703-1713.
Crossref
Dhananjaya V. KalvakolanuSanjit K. Roy. (2005) CCAAT/Enhancer Binding Proteins and Interferon Signaling Pathways. Journal of Interferon & Cytokine Research 25:12, pages 757-769.
Crossref
Sushil Kumar Pathak, Sanchita Basu, Asima Bhattacharyya, Shresh Pathak, Manikuntala Kundu & Joyoti Basu. (2005) Mycobacterium tuberculosis Lipoarabinomannan-mediated IRAK-M Induction Negatively Regulates Toll-like Receptor-dependent Interleukin-12 p40 Production in Macrophages. Journal of Biological Chemistry 280:52, pages 42794-42800.
Crossref
Marta Torroella-Kouri, Xiaojing Ma, Giselle Perry, Milena Ivanova, Pedro J. Cejas, Jennifer L. Owen, Vijaya Iragavarapu-Charyulu & Diana M. Lopez. (2005) Diminished Expression of Transcription Factors Nuclear Factor κB and CCAAT/Enhancer Binding Protein Underlies a Novel Tumor Evasion Mechanism Affecting Macrophages of Mammary Tumor–Bearing Mice. Cancer Research 65:22, pages 10578-10584.
Crossref
Shomyseh Sanjabi, Kevin J. Williams, Simona Saccani, Liang Zhou, Alexander Hoffmann, Gourisankar Ghosh, Steve Gerondakis, Gioacchino Natoli & Stephen T. Smale. (2005) A c-Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation. Genes & Development 19:18, pages 2138-2151.
Crossref
Anindita Ukil, Aruna Biswas, Tapasi Das & Pijush K. Das. (2005) 18β-Glycyrrhetinic Acid Triggers Curative Th1 Response and Nitric Oxide Up-Regulation in Experimental Visceral Leishmaniasis Associated with the Activation of NF-κB. The Journal of Immunology 175:2, pages 1161-1169.
Crossref
Jun Lu, Haijing Sun, Xiuli Wang, Chunyan Liu, Xin Xu, Fen Li & Baiqu Huang. (2005) Interleukin-12 p40 promoter activity is regulated by the reversible acetylation mediated by HDAC1 and p300. Cytokine 31:1, pages 46-51.
Crossref
Huabao Xiong, Hongxing Li, Hee Jeong Kong, Yibang Chen, Jie Zhao, Sidong Xiong, Bo Huang, Hua Gu, Lloyd Mayer, Keiko Ozato & Jay C. Unkeless. (2005) Ubiquitin-dependent Degradation of Interferon Regulatory Factor-8 Mediated by Cbl Down-regulates Interleukin-12 Expression. Journal of Biological Chemistry 280:25, pages 23531-23539.
Crossref
Michael J. Gray, Mirjana Poljakovic, Diane Kepka-Lenhart & Sidney M. MorrisJr.Jr.. (2005) Induction of arginase I transcription by IL-4 requires a composite DNA response element for STAT6 and C/EBPβ. Gene 353:1, pages 98-106.
Crossref
Bok Yun Kang, Eugene Kim & Tae Sung Kim. (2005) Regulatory mechanisms and their therapeutic implications of interleukin-12 production in immune cells. Cellular Signalling 17:6, pages 665-673.
Crossref
Atsushi Chino, Hiroaki Sakurai, Min-Kyung Choo, Keiichi Koizumi, Yutaka Shimada, Katsutoshi Terasawa & Ikuo Saiki. (2005) Juzentaihoto, a Kampo medicine, enhances IL-12 production by modulating Toll-like receptor 4 signaling pathways in murine peritoneal exudate macrophages. International Immunopharmacology 5:5, pages 871-882.
Crossref
Leesun Kim, Laura Del Rio, Barbara A. Butcher, Trine H. Mogensen, Søren R. Paludan, Richard A. Flavell & Eric Y. Denkers. (2005) p38 MAPK Autophosphorylation Drives Macrophage IL-12 Production during Intracellular Infection. The Journal of Immunology 174:7, pages 4178-4184.
Crossref
Sheikh Showkat Rahim, Nooruddin Khan, Chandra Sekhar Boddupalli, Seyed E. Hasnain & Sangita Mukhopadhyay. (2005) Interleukin-10 (IL-10) mediated suppression of IL-12 production in RAW 264.7 cells also involves c-rel transcription factor. Immunology 114:3, pages 313-321.
Crossref
Frank HoentjenR. Balfour SartorMichitaka OzakiChristian Jobin. (2005) STAT3 regulates NF-κB recruitment to the IL-12p40 promoter in dendritic cells. Blood 105:2, pages 689-696.
Crossref
Wendy T. Watford, Bruce D. Hissong, Jay H. Bream, Yuka Kanno, Linda Muul & John J. O'Shea. (2004) Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4. Immunological Reviews 202:1, pages 139-156.
Crossref
Haijing Sun, Jun Lu, Liang Wei, Xiuli Wang, Xin Xu, Mei Dong & Baiqu Huang. (2004) Histone acetyltransferase activity of p300 enhances the activation of IL-12 p40 promoter. Molecular Immunology 41:12, pages 1241-1246.
Crossref
Kelly H. Soanes, Kevin Figuereido, Robert C. Richards, Neil R. Mattatall & K. Vanya Ewart. (2004) Sequence and expression of C-type lectin receptors in Atlantic salmon (Salmo salar). Immunogenetics 56:8, pages 572-584.
Crossref
Nicola J. Mason, Jim Fiore, Takashi Kobayashi, Katherine S. Masek, Yongwon Choi & Christopher A. Hunter. (2004) TRAF6-Dependent Mitogen-Activated Protein Kinase Activation Differentially Regulates the Production of Interleukin-12 by Macrophages in Response to Toxoplasma gondii . Infection and Immunity 72:10, pages 5662-5667.
Crossref
Huabao Xiong, Hongxing Li, Yibang Chen, Jie Zhao & Jay C. Unkeless. (2004) Interaction of TRAF6 with MAST205 Regulates NF-κB Activation and MAST205 Stability. Journal of Biological Chemistry 279:42, pages 43675-43683.
Crossref
Liv M. I. Austenaa, Harald Carlsen, Aase Ertesvag, George Alexander, Heidi K. Blomhoff & Rune Blomhoff. (2004) Vitamin A status significantly alters nuclear factor‐κ B activity assessed by in vivo imaging. The FASEB Journal 18:11, pages 1255-1257.
Crossref
K Stoffels, L Overbergh, A Giulietti, A Kasran, R Bouillon, C Gysemans & C Mathieu. (2004) NOD macrophages produce high levels of inflammatory cytokines upon encounter of apoptotic or necrotic cells. Journal of Autoimmunity 23:1, pages 9-15.
Crossref
K A CHAMBERS, R J PARKS & J B ANGEL. (2004) Disruption of MAP kinase activation and nuclear factor binding to the IL-12 p40 promoter in HIV-infected myeloid cells. Clinical and Experimental Immunology 137:2, pages 329-340.
Crossref
Makoto Matsumoto, Derek Einhaus, Elizabeth S. Gold & Alan Aderem. (2004) Simvastatin Augments Lipopolysaccharide-Induced Proinflammatory Responses in Macrophages by Differential Regulation of the c-Fos and c-Jun Transcription Factors. The Journal of Immunology 172:12, pages 7377-7384.
Crossref
D. N. Dao, L. Kremer, Y. Guérardel, A. Molano, W. R. JacobsJr.Jr., S. A. Porcelli & V. Briken. (2004) Mycobacterium tuberculosis Lipomannan Induces Apoptosis and Interleukin-12 Production in Macrophages . Infection and Immunity 72:4, pages 2067-2074.
Crossref
Qi Luo, Xiaojing Ma, Sharon M. Wahl, James J. Bieker, Merlin Crossley & Luis J. Montaner. (2004) Activation and Repression of Interleukin-12 p40 Transcription by Erythroid Kruppel-like Factor in Macrophages. Journal of Biological Chemistry 279:18, pages 18451-18456.
Crossref
Huabao Xiong, Chen Zhu, Fengling Li, Refaat Hegazi, Kaili He, Mark Babyatsky, Anthony J. Bauer & Scott E. Plevy. (2004) Inhibition of Interleukin-12 p40 Transcription and NF-κB Activation by Nitric Oxide in Murine Macrophages and Dendritic Cells. Journal of Biological Chemistry 279:11, pages 10776-10783.
Crossref
Katalin Karikó, Houping Ni, John Capodici, Marc Lamphier & Drew Weissman. (2004) mRNA Is an Endogenous Ligand for Toll-like Receptor 3. Journal of Biological Chemistry 279:13, pages 12542-12550.
Crossref
Hui Zhou, Huabao Xiong, Hongxing Li, Scott E. Plevy, Paul D. Walden, Massimo Sassaroli, Glenn D. Prestwich & Jay C. Unkeless. (2004) Microtubule-Associated Serine/Threonine Kinase-205 kDa and Fcγ Receptor Control IL-12 p40 Synthesis and NF-κB Activation. The Journal of Immunology 172:4, pages 2559-2568.
Crossref
Amy C. Morrison, Caleph B. Wilson, Manujendra Ray & Pamela H. Correll. (2004) Macrophage-Stimulating Protein, the Ligand for the Stem Cell-Derived Tyrosine Kinase/RON Receptor Tyrosine Kinase, Inhibits IL-12 Production by Primary Peritoneal Macrophages Stimulated with IFN-γ and Lipopolysaccharide. The Journal of Immunology 172:3, pages 1825-1832.
Crossref
Inka Albrecht, Thomas Tapmeier, Stefan Zimmermann, Markus Frey, Klaus Heeg & Alexander Dalpke. (2004) Toll‐like receptors differentially induce nucleosome remodelling at the IL‐12p40 promoter. EMBO reports 5:2, pages 172-177.
Crossref
Wei Ma, Katrina Gee, Wilfred Lim, Kelly Chambers, Jonathan B. Angel, Maya Kozlowski & Ashok Kumar. (2004) Dexamethasone Inhibits IL-12p40 Production in Lipopolysaccharide-Stimulated Human Monocytic Cells by Down-Regulating the Activity of c-Jun N-Terminal Kinase, the Activation Protein-1, and NF-κB Transcription Factors. The Journal of Immunology 172:1, pages 318-330.
Crossref
Daiju Ichikawa, Ayako Matsui, Miwa Imai, Yoshiko Sonoda & Tadashi Kasahara. (2004) Effect of Various Catechins on the IL-12p40 Production by Murine Peritoneal Macrophages and a Macrophage Cell Line, J774.1. Biological and Pharmaceutical Bulletin 27:9, pages 1353-1358.
Crossref
Patrick P Mcdonald. 2004. Advances in Immunology Volume 82. Advances in Immunology Volume 82 1 48 .
Doo-Sik Kim, Jung Ho Han & Hyung-Joo Kwon. (2003) NF-κB and c-Jun-dependent regulation of macrophage inflammatory protein-2 gene expression in response to lipopolysaccharide in RAW 264.7 cells. Molecular Immunology 40:9, pages 633-643.
Crossref
Eric Y Denkers. (2003) From cells to signaling cascades: manipulation of innate immunity by Toxoplasma gondii . FEMS Immunology & Medical Microbiology 39:3, pages 193-203.
Crossref
Jianguo Liu, Shanjin Cao, Lisa M. Herman & Xiaojing Ma. (2003) Differential Regulation of Interleukin (IL)-12 p35 and p40 Gene Expression and Interferon (IFN)-γ–primed IL-12 Production by IFN Regulatory Factor 1. Journal of Experimental Medicine 198:8, pages 1265-1276.
Crossref
Chen Zhu, Kavitha Rao, Huabao Xiong, Khatuna Gagnidze, Fengling Li, Curt Horvath & Scott Plevy. (2003) Activation of the Murine Interleukin-12 p40 Promoter by Functional Interactions between NFAT and ICSBP. Journal of Biological Chemistry 278:41, pages 39372-39382.
Crossref
Wendy T Watford, Masato Moriguchi, Akio Morinobu & John J O’Shea. (2003) The biology of IL-12: coordinating innate and adaptive immune responses. Cytokine & Growth Factor Reviews 14:5, pages 361-368.
Crossref
Dhananjaya V. Kalvakolanu. (2003) Alternate interferon signaling pathways. Pharmacology & Therapeutics 100:1, pages 1-29.
Crossref
Christoph Becker, Stefan Wirtz, Manfred Blessing, Jaana Pirhonen, Dennis Strand, Oliver Bechthold, Julia Frick, Peter R. Galle, Ingo Autenrieth & Markus F. Neurath. (2003) Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells. Journal of Clinical Investigation 112:5, pages 693-706.
Crossref
Michal F. Tomczak, Susan E. Erdman, Theofilos Poutahidis, Arlin B. Rogers, Hilda Holcombe, Benjamin Plank, James G. Fox & Bruce H. Horwitz. (2003) NF-κB Is Required Within the Innate Immune System to Inhibit Microflora-Induced Colitis and Expression of IL-12 p40. The Journal of Immunology 171:3, pages 1484-1492.
Crossref
Michael Martin, Robert E. Schifferle, Natalia Cuesta, Stefanie N. Vogel, Jannet Katz & Suzanne M. Michalek. (2003) Role of the Phosphatidylinositol 3 Kinase-Akt Pathway in the Regulation of IL-10 and IL-12 by Porphyromonas gingivalis Lipopolysaccharide . The Journal of Immunology 171:2, pages 717-725.
Crossref
Helen S. Goodridge, William Harnett, Foo Y. Liew & Margaret M. Harnett. (2003) Differential regulation of interleukin-12 p40 and p35 induction via Erk mitogen-activated protein kinase-dependent and -independent mechanisms and the implications for bioactive IL-12 and IL-23 responses. Immunology 109:3, pages 415-425.
Crossref
Stanislas GorielyDominique DemontéSéverine NizetDominique De WitFabienne WillemsMichel GoldmanCarine Van Lint. (2003) Human IL-12(p35) gene activation involves selective remodeling of a single nucleosome within a region of the promoter containing critical Sp1-binding sites. Blood 101:12, pages 4894-4902.
Crossref
Jiajian Liu & David I. Beller. (2003) Distinct Pathways for NF-κB Regulation Are Associated with Aberrant Macrophage IL-12 Production in Lupus- and Diabetes-Prone Mouse Strains. The Journal of Immunology 170:9, pages 4489-4496.
Crossref
Thomas M. Petro. (2003) Modulation of IL-12 p35 and p40 promoter activity by smokeless tobacco extract is associated with an effect upon activation of NF-κB but not IRF transcription factors. International Immunopharmacology 3:5, pages 735-745.
Crossref
Cristina M. Tato, Alejandro Villarino, Jorge H. Caamaño, Mark Boothby & Christopher A. Hunter. (2003) Inhibition of NF-κB Activity in T and NK Cells Results in Defective Effector Cell Expansion and Production of IFN-γ Required for Resistance to Toxoplasma gondii . The Journal of Immunology 170:6, pages 3139-3146.
Crossref
Nilamadhab Mishra, Christopher M. Reilly, Doris R. Brown, Phil Ruiz & Gary S. Gilkeson. (2003) Histone deacetylase inhibitors modulate renal disease in the MRL-lpr/lpr mouse. Journal of Clinical Investigation 111:4, pages 539-552.
Crossref
Nilamadhab Mishra, Christopher M. Reilly, Doris R. Brown, Phil Ruiz & Gary S. Gilkeson. (2003) Histone deacetylase inhibitors modulate renal disease in the MRL-lpr/lpr mouse. Journal of Clinical Investigation 111:4, pages 539-552.
Crossref
Giorgio Trinchieri. (2003) Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nature Reviews Immunology 3:2, pages 133-146.
Crossref
Huabao Xiong, Chen Zhu, Hongxing Li, Frank Chen, Lloyd Mayer, Keiko Ozato, Jay C. Unkeless & Scott E. Plevy. (2003) Complex Formation of the Interferon (IFN) Consensus Sequence-binding Protein with IRF-1 Is Essential for Murine Macrophage IFN-γ-induced iNOS Gene Expression. Journal of Biological Chemistry 278:4, pages 2271-2277.
Crossref
Marco Mirani, Ilia Elenkov, Simona Volpi, Naoki Hiroi, George P. Chrousos & Tomoshige Kino. (2002) HIV-1 Protein Vpr Suppresses IL-12 Production from Human Monocytes by Enhancing Glucocorticoid Action: Potential Implications of Vpr Coactivator Activity for the Innate and Cellular Immunity Deficits Observed in HIV-1 Infection. The Journal of Immunology 169:11, pages 6361-6368.
Crossref
Peter Borger, Judith L. Black & Michael Roth. (2002) Asthma and the CCAAT-enhancer binding proteins: A holistic view on airway inflammation and remodeling. Journal of Allergy and Clinical Immunology 110:6, pages 841-846.
Crossref
Yadi Tan, Jing-Shi Zhang & Leaf Huang. (2002) Codelivery of NF-κB Decoy-Related Oligodeoxynucleotide Improves LPD-Mediated Systemic Gene Transfer. Molecular Therapy 6:6, pages 804-812.
Crossref
Shanjin Cao, Jianguo Liu, Marta Chesi, Peter Leif Bergsagel, I-Cheng Ho, Raymond P. Donnelly & Xiaojing Ma. (2002) Differential Regulation of IL-12 and IL-10 Gene Expression in Macrophages by the Basic Leucine Zipper Transcription Factor c-Maf Fibrosarcoma. The Journal of Immunology 169:10, pages 5715-5725.
Crossref
Atsuko Masumi, Satoshi Tamaoki, I-Ming Wang, Keiko Ozato & Katsutoshi Komuro. (2002) IRF-8/ICSBP and IRF-1 cooperatively stimulate mouse IL-12 promoter activity in macrophages. FEBS Letters 531:2, pages 348-353.
Crossref
K. Roxstrom-Lindquist, I. Lindstrom-Dinnetz, J. Olesen, Y. Engstrom & I. Faye. (2002) An intron enhancer activates the immunoglobulin-related Hemolin gene in Hyalophora cecropia. Insect Molecular Biology 11:5, pages 505-515.
Crossref
Barbara A. Butcher & Eric Y. Denkers. (2002) Mechanism of Entry Determines the Ability of Toxoplasma gondii To Inhibit Macrophage Proinflammatory Cytokine Production . Infection and Immunity 70:9, pages 5216-5224.
Crossref
Lei Zhao, Carolyn A. Cuff, Erin Moss, Ulrike Wille, Tillmann Cyrus, Eric A. Klein, Domenico Praticò, Daniel J. Rader, Christopher A. Hunter, Ellen Puré & Colin D. Funk. (2002) Selective Interleukin-12 Synthesis Defect in 12/15-Lipoxygenase-deficient Macrophages Associated with Reduced Atherosclerosis in a Mouse Model of Familial Hypercholesterolemia. Journal of Biological Chemistry 277:38, pages 35350-35356.
Crossref
Mary Bradford, Arin J. Schroeder, Herbert C. Morse, Stefanie N. Vogel & John S. Cowdery. (2002) CpG DNA induced IL-12 p40 gene activation is independent of STAT1 activation or production of interferon consensus sequence binding protein. Journal of Biomedical Science 9:6, pages 688-696.
Crossref
Jenny Kim, Maria-Teresa Ochoa, Stephan R. Krutzik, Osamu Takeuchi, Satoshi Uematsu, Annaliza J. Legaspi, Hans D. Brightbill, Diana Holland, William J. Cunliffe, Shizuo Akira, Peter A. Sieling, Paul J. Godowski & Robert L. Modlin. (2002) Activation of Toll-Like Receptor 2 in Acne Triggers Inflammatory Cytokine Responses. The Journal of Immunology 169:3, pages 1535-1541.
Crossref
Jiajian Liu & David Beller. (2002) Aberrant Production of IL-12 by Macrophages from Several Autoimmune-Prone Mouse Strains Is Characterized by Intrinsic and Unique Patterns of NF-κB Expression and Binding to the IL-12 p40 Promoter. The Journal of Immunology 169:1, pages 581-586.
Crossref
C. M. Tato & C. A. Hunter. (2002) Host-Pathogen Interactions: Subversion and Utilization of the NF-κB Pathway during Infection. Infection and Immunity 70:7, pages 3311-3317.
Crossref
Leonid E. Lerner, Yekaterina E. Gribanova, Leigh Whitaker, Barry E. Knox & Debora B. Farber. (2002) The Rod cGMP-phosphodiesterase β-Subunit Promoter Is a Specific Target for Sp4 and Is Not Activated by Other Sp Proteins or CRX. Journal of Biological Chemistry 277:29, pages 25877-25883.
Crossref
Ae-Kyung Yi, Jae-Geun Yoon, Seon-Ju Yeo, Soon-Cheol Hong, B. Keith English & Arthur M. Krieg. (2002) Role of Mitogen-Activated Protein Kinases in CpG DNA-Mediated IL-10 and IL-12 Production: Central Role of Extracellular Signal-Regulated Kinase in the Negative Feedback Loop of the CpG DNA-Mediated Th1 Response. The Journal of Immunology 168:9, pages 4711-4720.
Crossref
Kendra Speirs, Jorge Caamano, Michael H. Goldschmidt, Christopher A. Hunter & Phillip Scott. (2002) NF-κB2 Is Required for Optimal CD40-Induced IL-12 Production but Dispensable for Th1 Cell Differentiation. The Journal of Immunology 168:9, pages 4406-4413.
Crossref
Bok Yun Kang, Su Wol Chung, Daeho Cho & Tae Sung Kim. (2002) Involvement of p38 mitogen-activated protein kinase in the induction of interleukin-12 p40 production in mouse macrophages by berberine, a benzodioxoloquinolizine alkaloid. Biochemical Pharmacology 63:10, pages 1901-1910.
Crossref
Barbara Gorgoni, Diego Maritano, Paola Marthyn, Marco Righi & Valeria Poli. (2002) C/EBPβ Gene Inactivation Causes Both Impaired and Enhanced Gene Expression and Inverse Regulation of IL-12 p40 and p35 mRNAs in Macrophages . The Journal of Immunology 168:8, pages 4055-4062.
Crossref
Miriam Wittmann, Petra Kienlin, Susanne Mommert, Alexander Kapp & Thomas Werfel. (2002) Suppression of IL-12 Production by Soluble CD40 Ligand: Evidence for Involvement of the p44/42 Mitogen-Activated Protein Kinase Pathway. The Journal of Immunology 168:8, pages 3793-3800.
Crossref
Stephen T. SmaleAmanda G. Fisher. (2002) Chromatin Structure and Gene Regulation in the Immune System. Annual Review of Immunology 20:1, pages 427-462.
Crossref
Nicola Mason, Julio Aliberti, Jorge C. Caamano, Hsiou-Chi Liou & Christopher A. Hunter. (2002) Cutting Edge: Identification of c-Rel-Dependent and -Independent Pathways of IL-12 Production During Infectious and Inflammatory Stimuli. The Journal of Immunology 168:6, pages 2590-2594.
Crossref

Displaying 200 of 251 citing articles. Use the download link below to view the full list of citing articles.

Download full citations list

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.