Citations (195)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (15)
Dylan M. Marchione, Benjamin A. Garcia & John Wojcik. (2019) Proteomic approaches for cancer epigenetics research. Expert Review of Proteomics 16:1, pages 33-47.
Read now
Read now
Evan R Barry, Gareth N Corry & Theodore P Rasmussen. (2010) Targeting DOT1L action and interactions in leukemia: the role of DOT1L in transformation and development. Expert Opinion on Therapeutic Targets 14:4, pages 405-418.
Read now
Read now
Paul M. Ayton, Everett H. Chen & Michael L. Cleary. (2004) Binding to Nonmethylated CpG DNA Is Essential for Target Recognition, Transactivation, and Myeloid Transformation by an MLL Oncoprotein. Molecular and Cellular Biology 24:23, pages 10470-10478.
Read now
Read now
Akihiko Yokoyama, Zhong Wang, Joanna Wysocka, Mrinmoy Sanyal, Deborah J. Aufiero, Issay Kitabayashi, Winship Herr & Michael L. Cleary. (2004) Leukemia Proto-Oncoprotein MLL Forms a SET1-Like Histone Methyltransferase Complex with Menin To Regulate Hox Gene Expression. Molecular and Cellular Biology 24:13, pages 5639-5649.
Read now
Read now
Bernd B. Zeisig, Tom Milne, María-Paz García-Cuéllar, Silke Schreiner, Mary-Ellen Martin, Uta Fuchs, Arndt Borkhardt, Sumit K. Chanda, John Walker, Richard Soden, Jay L. Hess & Robert K. Slany. (2004) Hoxa9 and Meis1 Are Key Targets for MLL-ENL-Mediated Cellular Immortalization. Molecular and Cellular Biology 24:2, pages 617-628.
Read now
Read now
Emma C. Collins, Alexandre Appert, Linda Ariza-McNaughton, Richard Pannell, Yoshihiro Yamada & Terence H. Rabbitts. (2002) Mouse Af9 Is a Controller of Embryo Patterning, Like Mll, Whose Human Homologue Fuses with AF9 after Chromosomal Translocation in Leukemia. Molecular and Cellular Biology 22:20, pages 7313-7324.
Read now
Read now
Chi Wai So & Michael L. Cleary. (2002) MLL-AFX Requires the Transcriptional Effector Domains of AFX To Transform Myeloid Progenitors and Transdominantly Interfere with Forkhead Protein Function. Molecular and Cellular Biology 22:18, pages 6542-6552.
Read now
Read now
Jay L. Hess & Plamen Kossev. (2002) Molecular Genetics of Benign Tumors. Cancer Investigation 20:3, pages 362-372.
Read now
Read now
Roger T. Luo, Catherine Lavau, Changchun Du, Federico Simone, Paul E. Polak, Shin Kawamata & Michael J. Thirman. (2001) The Elongation Domain of ELL Is Dispensable but Its ELL-Associated Factor 1 Interaction Domain Is Essential for MLL-ELL-Induced Leukemogenesis. Molecular and Cellular Biology 21:16, pages 5678-5687.
Read now
Read now
Keri Fair, Melanie Anderson, Elena Bulanova, Huaifeng Mi, Maximilian Tropschug & Manuel O. Diaz. (2001) Protein Interactions of the MLL PHD Fingers Modulate MLL Target Gene Regulation in Human Cells. Molecular and Cellular Biology 21:10, pages 3589-3597.
Read now
Read now
Patricia Ernst, Jing Wang, Mary Huang, Richard H. Goodman & Stanley J. Korsmeyer. (2001) MLL and CREB Bind Cooperatively to the Nuclear Coactivator CREB-Binding Protein. Molecular and Cellular Biology 21:7, pages 2249-2258.
Read now
Read now
Kimihiko Sano. (2001) Structure of AF3p21, a New Member of Mixed Lineage Leukemia (MLL) Fusion Partner Proteins-Implication for MLL-Induced Leukemogenesis. Leukemia & Lymphoma 42:4, pages 595-602.
Read now
Read now
Kui Shin Voo, Diana L. Carlone, Britta M. Jacobsen, Anna Flodin & David G. Skalnik. (2000) Cloning of a Mammalian Transcriptional Activator That Binds Unmethylated CpG Motifs and Shares a CXXC Domain with DNA Methyltransferase, Human Trithorax, and Methyl-CpG Binding Domain Protein 1. Molecular and Cellular Biology 20:6, pages 2108-2121.
Read now
Read now
Haskell T. Adler, Rebecca Chinery, Daniel Y. Wu, Steven J. Kussick, John M. Payne, Albert J. Fornace$suffix/text()$suffix/text() & Douglas C. Tkachuk. (1999) Leukemic HRX Fusion Proteins Inhibit GADD34-Induced Apoptosis and Associate with the GADD34 and hSNF5/INI1 Proteins. Molecular and Cellular Biology 19:10, pages 7050-7060.
Read now
Read now
Brigitte Bourachot, Moshe Yaniv & Christian Muchardt. (1999) The Activity of Mammalian brm/SNF2α Is Dependent on a High-Mobility-Group Protein I/Y-Like DNA Binding Domain. Molecular and Cellular Biology 19:6, pages 3931-3939.
Read now
Read now
Articles from other publishers (180)
Hsiangyu Hu, Nirmalya Saha, Yuting Yang, Ejaz Ahmad, Lauren Lachowski, Uttar Shrestha, Vidhya Premkumar, James Ropa, Lili Chen, Blaine Teahan, Sierrah Grigsby, Rolf Marschalek, Zaneta Nikolovska-Coleska & Andrew G. Muntean. (2022) The ENL YEATS epigenetic reader domain critically links MLL-ENL to leukemic stem cell frequency in t(11;19) Leukemia. Leukemia 37:1, pages 190-201.
Crossref
Crossref
Elzbieta Poreba, Krzysztof Lesniewicz & Julia Durzynska. (2022) Histone–lysine N-methyltransferase 2 (KMT2) complexes – a new perspective. Mutation Research/Reviews in Mutation Research 790, pages 108443.
Crossref
Crossref
Atsushi Onodera, Masahiro Kiuchi, Kota Kokubo & Toshinori Nakayama. (2021) Epigenetic regulation of inflammation by CxxC domain‐containing proteins*. Immunological Reviews 305:1, pages 137-151.
Crossref
Crossref
Radoslaw Wesolowski, Elisabeth Kowenz-Leutz, Karin Zimmermann, Dorothea Dörr, Maria Hofstätter, Robert K Slany, Alexander Mildner & Achim Leutz. (2020)
Myeloid transformation by
MLL
-
ENL
depends strictly on C/EBP
. Life Science Alliance 4:1, pages e202000709.
Crossref
Crossref
Elzbieta Poreba, Krzysztof Lesniewicz & Julia Durzynska. (2020) Aberrant Activity of Histone–Lysine N-Methyltransferase 2 (KMT2) Complexes in Oncogenesis. International Journal of Molecular Sciences 21:24, pages 9340.
Crossref
Crossref
Juerg Schwaller. (2020) Learning from mouse models of MLL fusion gene-driven acute leukemia. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1863:8, pages 194550.
Crossref
Crossref
Satoshi Takahashi & Akihiko Yokoyama. (2020) The molecular functions of common and atypical MLL fusion protein complexes. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1863:7, pages 194548.
Crossref
Crossref
Patricia Santofimia-Castaño, Bruno Rizzuti, Yi Xia, Olga Abian, Ling Peng, Adrián Velázquez-Campoy, José L. Neira & Juan Iovanna. (2019) Targeting intrinsically disordered proteins involved in cancer. Cellular and Molecular Life Sciences 77:9, pages 1695-1707.
Crossref
Crossref
Ke Liu & Jinrong Min. (2020) Structural Basis for the Recognition of Non-methylated DNA by the CXXC Domain. Journal of Molecular Biology 432:6, pages 1674-1686.
Crossref
Crossref
Robert K. Slany. (2020) MLL fusion proteins and transcriptional control. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1863:3, pages 194503.
Crossref
Crossref
Denise Ragusa, Evgeny M. Makarov, Oliver Britten, Daniela Moralli, Catherine M. Green & Sabrina Tosi. (2019) The RS4;11 cell line as a model for leukaemia with t(4;11)(q21;q23): Revised characterisation of cytogenetic features. CANCER REPORTS 2:5.
Crossref
Crossref
Richard J. Fagan & Andrew K. Dingwall. (2019) COMPASS Ascending: Emerging clues regarding the roles of MLL3/KMT2C and MLL2/KMT2D proteins in cancer. Cancer Letters 458, pages 56-65.
Crossref
Crossref
Akihiko Yokoyama. (2019) RNA Polymerase II-Dependent Transcription Initiated by Selectivity Factor 1: A Central Mechanism Used by MLL Fusion Proteins in Leukemic Transformation. Frontiers in Genetics 9.
Crossref
Crossref
Jianbiao Zhou, Yvonne Ng & Wee-Joo Chng. (2018) ENL: structure, function, and roles in hematopoiesis and acute myeloid leukemia. Cellular and Molecular Life Sciences 75:21, pages 3931-3941.
Crossref
Crossref
Vaia Stavropoulou, Marwa Almosailleakh, Hélène Royo, Jean-François Spetz, Sabine Juge, Laurent Brault, Patrick Kopp, Michelina Iacovino, Michael Kyba, Alexandar Tzankov, Michael B. Stadler, Gianni Cazzaniga, Antoine H.F.M. Peters & Juerg Schwaller. (2018) A Novel Inducible Mouse Model of MLL-ENL-driven Mixed-lineage Acute Leukemia. HemaSphere 2:4, pages e51.
Crossref
Crossref
Katrin Hetzner, Maria-Paz Garcia-Cuellar, Christian Büttner & Robert K. Slany. (2018) The interaction of ENL with PAF1 mitigates polycomb silencing and facilitates murine leukemogenesis. Blood 131:6, pages 662-673.
Crossref
Crossref
J. N. Nichol, M. Kinal & W. H. MillerJr.Jr.. 2018. Neoplastic Diseases of the Blood. Neoplastic Diseases of the Blood
161
177
.
Teerapong Siriboonpiputtana, Bernd B Zeisig, Magdalena Zarowiecki, Tsz Kan Fung, Maria Mallardo, Chiou‐Tsun Tsai, Priscilla Nga Ieng Lau, Quoc Chinh Hoang, Pedro Veiga, Jo Barnes, Claire Lynn, Amanda Wilson, Boris Lenhard & Chi Wai Eric So. (2017) Transcriptional memory of cells of origin overrides β‐catenin requirement of MLL cancer stem cells. The EMBO Journal 36:21, pages 3139-3155.
Crossref
Crossref
Thomas A. Milne. (2017) Mouse models of MLL leukemia: recapitulating the human disease. Blood 129:16, pages 2217-2223.
Crossref
Crossref
Amanda C. Winters & Kathrin M. Bernt. (2017) MLL-Rearranged Leukemias—An Update on Science and Clinical Approaches. Frontiers in Pediatrics 5.
Crossref
Crossref
Akihiko Yokoyama. (2017) Transcriptional activation by MLL fusion proteins in leukemogenesis. Experimental Hematology 46, pages 21-30.
Crossref
Crossref
R K Slany. (2016) The molecular mechanics of mixed lineage leukemia. Oncogene 35:40, pages 5215-5223.
Crossref
Crossref
Lili Chen, Yuqing Sun, Jingya Wang, Hui Jiang & Andrew G. Muntean. (2016) Differential regulation of the c-Myc/Lin28 axis discriminates subclasses of rearranged MLL leukemia. Oncotarget 7:18, pages 25208-25223.
Crossref
Crossref
Kana Hasegawa, Satomi Tanaka, Fumihiro Fujiki, Soyoko Morimoto, Katsuhiko Nakano, Hiroko Kinoshita, Atsushi Okumura, Yuka Fujioka, Rika Urakawa, Hiroko Nakajima, Naoya Tatsumi, Jun Nakata, Satoshi Takashima, Sumiyuki Nishida, Akihiro Tsuboi, Yoshihiro Oka, Yusuke Oji, Eiji Miyoshi, Takako Hirata, Atsushi Kumanogoh, Haruo Sugiyama & Naoki Hosen. (2016) Glycosylation Status of CD43 Protein Is Associated with Resistance of Leukemia Cells to CTL-Mediated Cytolysis. PLOS ONE 11:3, pages e0152326.
Crossref
Crossref
Kana Hasegawa, Satomi Tanaka, Fumihiro Fujiki, Soyoko Morimoto, Hiroko Nakajima, Naoya Tatsumi, Jun Nakata, Satoshi Takashima, Sumiyuki Nishida, Akihiro Tsuboi, Yoshihiro Oka, Yusuke Oji, Atsushi Kumanogoh, Haruo Sugiyama & Naoki Hosen. (2015) An Immunocompetent Mouse Model for MLL/AF9 Leukemia Reveals the Potential of Spontaneous Cytotoxic T-Cell Response to an Antigen Expressed in Leukemia Cells. PLOS ONE 10:12, pages e0144594.
Crossref
Crossref
Hiroshi Okuda, Akinori Kanai, Shinji Ito, Hirotaka Matsui & Akihiko Yokoyama. (2015) AF4 uses the SL1 components of RNAP1 machinery to initiate MLL fusion- and AEP-dependent transcription. Nature Communications 6:1.
Crossref
Crossref
Akihiko Yokoyama. (2015) Molecular mechanisms of MLL-associated leukemia. International Journal of Hematology 101:4, pages 352-361.
Crossref
Crossref
Sergio Burillo-Sanz, Rosario Morales-Camacho, María Teresa Vargas, Estrella Carrillo, Inmaculada Pérez-Soto & José Raúl García-Lozano. (2015) A new rearrangement giving rise to a very rare MLL-MLLT10 fusion mRNA in an infant acute myeloid leukemia. Cancer Genetics 208:3, pages 101-102.
Crossref
Crossref
Bin E. Li & Patricia Ernst. (2014) Two decades of leukemia oncoprotein epistasis: the MLL1 paradigm for epigenetic deregulation in leukemia. Experimental Hematology 42:12, pages 995-1012.
Crossref
Crossref
J Nakata, K Nakano, A Okumura, Y Mizutani, H Kinoshita, M Iwai, K Hasegawa, S Morimoto, F Fujiki, N Tatsumi, H Nakajima, Y Nakae, S Nishida, A Tsuboi, Y Oji, Y Oka, H Sugiyama, A Kumanogoh & N Hosen. (2013) In vivo eradication of MLL/ENL leukemia cells by NK cells in the absence of adaptive immunity. Leukemia 28:6, pages 1316-1325.
Crossref
Crossref
Aravind Basavapathruni, Edward J. Olhava, Scott R. Daigle, Carly A. Therkelsen, Lei Jin, P. Ann Boriack-Sjodin, Christina J. Allain, Christine R. Klaus, Alejandra Raimondi, Margaret Porter Scott, Angelos Dovletoglou, Victoria M. Richon, Roy M. Pollock, Robert A. Copeland, Mikel P. Moyer, Richard Chesworth, Paul G. Pearson & Nigel J. Waters. (2014) Nonclinical pharmacokinetics and metabolism of EPZ-5676, a novel DOT1L histone methyltransferase inhibitor. Biopharmaceutics & Drug Disposition 35:4, pages 237-252.
Crossref
Crossref
Robert K. Slany. 2014. Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development. Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development
175
204
.
Jun Zhang, Christopher S. Seet, Clare Sun, Jing Li, Dewen You, Andrew Volk, Peter Breslin, Xingyu Li, Wei Wei, Zhijian Qian, Nancy J. Zeleznik-Le, Zhou Zhang & Jiwang Zhang. (2013) p27kip1 maintains a subset of leukemia stem cells in the quiescent state in murine MLL-leukemia. Molecular Oncology 7:6, pages 1069-1082.
Crossref
Crossref
Chenxi Shen, Stephanie Y. Jo, Chenzhong Liao, Jay L. Hess & Zaneta Nikolovska-Coleska. (2013) Targeting Recruitment of Disruptor of Telomeric Silencing 1-like (DOT1L). Journal of Biological Chemistry 288:42, pages 30585-30596.
Crossref
Crossref
Scott R. Daigle, Edward J. Olhava, Carly A. Therkelsen, Aravind Basavapathruni, Lei Jin, P. Ann Boriack-Sjodin, Christina J. Allain, Christine R. Klaus, Alejandra Raimondi, Margaret Porter Scott, Nigel J. Waters, Richard Chesworth, Mikel P. Moyer, Robert A. Copeland, Victoria M. Richon & Roy M. Pollock. (2013) Potent inhibition of DOT1L as treatment of MLL-fusion leukemia. Blood 122:6, pages 1017-1025.
Crossref
Crossref
Xiaofeng Ding, Zijian Yang, Fangliang Zhou, Fangmei Wang, Xinxin Li, Cheng Chen, Xiaofeng Li, Xiang Hu, Shuanglin Xiang & Jian Zhang. (2013) Transcription factor AP-2α regulates acute myeloid leukemia cell proliferation by influencing Hoxa gene expression. The International Journal of Biochemistry & Cell Biology 45:8, pages 1647-1656.
Crossref
Crossref
Guilhem Faure & Isabelle Callebaut. (2013) Identification of hidden relationships from the coupling of Hydrophobic Cluster Analysis and Domain Architecture information. Bioinformatics 29:14, pages 1726-1733.
Crossref
Crossref
Zejuan LiZhiyu ZhangYuanyuan LiStephen ArnovitzPing ChenHao HuangXi JiangGia-Ming HongRejani B. KunjammaHaomin RenChunjiang HeChong-Zhi WangAbdel G. ElkahlounPeter J. M. ValkKonstanze Döhner, Mary Beth NeillyLars Bullinger, Ruud DelwelBob LöwenbergPaul P. LiuRichard Morgan, Janet D. RowleyChun-Su YuanJianjun Chen. (2013) PBX3 is an important cofactor of HOXA9 in leukemogenesis. Blood 121:8, pages 1422-1431.
Crossref
Crossref
R A Copeland, M P Moyer & V M Richon. (2012) Targeting genetic alterations in protein methyltransferases for personalized cancer therapeutics. Oncogene 32:8, pages 939-946.
Crossref
Crossref
Anne ForandLaurent Beck, Christine LeroyAlice RousseauValérie BoitezIsabelle CohenGeneviève Courtois, Olivier Hermine & Gérard Friedlander. (2013) EKLF-driven PIT1 expression is critical for mouse erythroid maturation in vivo and in vitro. Blood 121:4, pages 666-678.
Crossref
Crossref
Jessica N. Nichol, Sarit Assouline & Wilson H. Miller. 2013. Neoplastic Diseases of the Blood. Neoplastic Diseases of the Blood
177
198
.
Young Rock Chung, Emma Schatoff & Omar Abdel-Wahab. (2012) Epigenetic alterations in hematopoietic malignancies. International Journal of Hematology 96:4, pages 413-427.
Crossref
Crossref
Yue Zhang, Aili Chen, Xiao-Mei Yan & Gang Huang. (2012) Disordered epigenetic regulation in MLL-related leukemia. International Journal of Hematology 96:4, pages 428-437.
Crossref
Crossref
Qiang ZhouTiandao LiDavid H. Price. (2012) RNA Polymerase II Elongation Control. Annual Review of Biochemistry 81:1, pages 119-143.
Crossref
Crossref
M Leiva, S Moretti, H Soilihi, I Pallavicini, L Peres, C Mercurio, R Dal Zuffo, S Minucci & H de Thé. (2012) Valproic acid induces differentiation and transient tumor regression, but spares leukemia-initiating activity in mouse models of APL. Leukemia 26:7, pages 1630-1637.
Crossref
Crossref
Zejuan LiHao HuangYuanyuan LiXi JiangPing ChenStephen ArnovitzMichael D. RadmacherKati MaharryAbdel ElkahlounXinan YangChunjiang HeMiao HeZhiyu ZhangKonstanze Dohner, Mary Beth NeillyColles PriceYves A. LussierYanming ZhangRichard A. LarsonMichelle M. Le BeauMichael A. CaligiuriLars Bullinger, Peter J. M. Valk, Ruud Delwel, Bob Lowenberg, Paul P. LiuGuido MarcucciClara D. BloomfieldJanet D. RowleyJianjun Chen. (2012) Up-regulation of a HOXA-PBX3 homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis in patients with cytogenetically abnormal AML. Blood 119:10, pages 2314-2324.
Crossref
Crossref
Andrew G. MunteanJay L. Hess. (2012) The Pathogenesis of Mixed-Lineage Leukemia. Annual Review of Pathology: Mechanisms of Disease 7:1, pages 283-301.
Crossref
Crossref
Jiaying Tan, Morgan Jones, Haruhiko Koseki, Manabu Nakayama, Andrew G. Muntean, Ivan Maillard & Jay L. Hess. (2011) CBX8, a Polycomb Group Protein, Is Essential for MLL-AF9-Induced Leukemogenesis. Cancer Cell 20:5, pages 563-575.
Crossref
Crossref
Nanhai HeCaleb K. ChanBijan Sobhian, Seemay ChouYuhua XueMin Liu, Tom AlberMonsef Benkirane & Qiang Zhou. (2011) Human Polymerase-Associated Factor complex (PAFc) connects the Super Elongation Complex (SEC) to RNA polymerase II on chromatin. Proceedings of the National Academy of Sciences 108:36.
Crossref
Crossref
Scott R. Daigle, Edward J. Olhava, Carly A. Therkelsen, Christina R. Majer, Christopher J. Sneeringer, Jeffrey Song, L. Danielle Johnston, Margaret Porter Scott, Jesse J. Smith, Yonghong Xiao, Lei Jin, Kevin W. Kuntz, Richard Chesworth, Mikel P. Moyer, Kathrin M. Bernt, Jen-Chieh Tseng, Andrew L. Kung, Scott A. Armstrong, Robert A. Copeland, Victoria M. Richon & Roy M. Pollock. (2011) Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor. Cancer Cell 20:1, pages 53-65.
Crossref
Crossref
Nanhai He & Qiang Zhou. (2011) New Insights into the Control of HIV-1 Transcription: When Tat Meets the 7SK snRNP and Super Elongation Complex (SEC). Journal of Neuroimmune Pharmacology 6:2, pages 260-268.
Crossref
Crossref
Robert B. Lorsbach. 2011. Diagnostic Pediatric Hematopathology. Diagnostic Pediatric Hematopathology
272
309
.
Zejuan Li & Jianjun Chen. 2011. MicroRNA and Cancer. MicroRNA and Cancer
185
195
.
Cristina N. Alonso, Claus Meyer, Marta S. Gallego, Jorge G. Rossi, Adrián P. Mansini, Patricia L. Rubio, Adriana Medina, Rolf Marschalek & María S. Felice. (2010) BTBD18: A novel MLL partner gene in an infant with acute lymphoblastic leukemia and inv(11)(q13;q23). Leukemia Research 34:11, pages e294-e296.
Crossref
Crossref
Man Mohan, Chengqi Lin, Erin Guest & Ali Shilatifard. (2010) Licensed to elongate: a molecular mechanism for MLL-based leukaemogenesis. Nature Reviews Cancer 10:10, pages 721-728.
Crossref
Crossref
T Gan, C D Jude, K Zaffuto & P Ernst. (2010) Developmentally induced Mll1 loss reveals defects in postnatal haematopoiesis. Leukemia 24:10, pages 1732-1741.
Crossref
Crossref
Michaela Liedtke, Paul M. Ayton, Tim C. P. Somervaille, Kevin S. Smith & Michael L. Cleary. (2010) Self-association mediated by the Ras association 1 domain of AF6 activates the oncogenic potential of MLL-AF6. Blood 116:1, pages 63-70.
Crossref
Crossref
Joost H.A. Martens & Henk G. Stunnenberg. (2010) The molecular signature of oncofusion proteins in acute myeloid leukemia. FEBS Letters 584:12, pages 2662-2669.
Crossref
Crossref
Adelheid BursenKaren SchwabeBrigitte Rüster, Reinhard Henschler, Martin Ruthardt, Theo DingermannRolf Marschalek. (2010) The AF4·MLL fusion protein is capable of inducing ALL in mice without requirement of MLL·AF4. Blood 115:17, pages 3570-3579.
Crossref
Crossref
Christian Bach, Sebastian Buhl, Dorothée Mueller, María-Paz García-Cuéllar, Emanuel Maethner & Robert K. Slany. (2010) Leukemogenic transformation by HOXA cluster genes. Blood 115:14, pages 2910-2918.
Crossref
Crossref
Khairul I. Ansari & Subhrangsu S. Mandal. (2010) Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing. FEBS Journal 277:8, pages 1790-1804.
Crossref
Crossref
Akihiko Yokoyama, Min Lin, Alpana Naresh, Issay Kitabayashi & Michael L. Cleary. (2010) A Higher-Order Complex Containing AF4 and ENL Family Proteins with P-TEFb Facilitates Oncogenic and Physiologic MLL-Dependent Transcription. Cancer Cell 17:2, pages 198-212.
Crossref
Crossref
Mojdeh Naghashpour, Jeffrey Lancet, Lynn Moscinski & Ling Zhang. (2010) Mixed phenotype acute leukemia with t(11;19)(q23;p13.3)/ MLL-MLLT1(ENL), B/T-lymphoid type: A first case report. American Journal of Hematology, pages n/a-n/a.
Crossref
Crossref
Dorothee Mueller, María-Paz García-Cuéllar, Christian Bach, Sebastian Buhl, Emanuel Maethner & Robert K. Slany. (2009) Misguided Transcriptional Elongation Causes Mixed Lineage Leukemia. PLoS Biology 7:11, pages e1000249.
Crossref
Crossref
Hedi Hegyi, László Buday & Peter Tompa. (2009) Intrinsic Structural Disorder Confers Cellular Viability on Oncogenic Fusion Proteins. PLoS Computational Biology 5:10, pages e1000552.
Crossref
Crossref
Christian Bach & Robert K Slany. (2009) Molecular pathology of mixed-lineage leukemia. Future Oncology 5:8, pages 1271-1281.
Crossref
Crossref
Michaela Liedtke & Michael L. Cleary. (2009) Therapeutic targeting of MLL. Blood 113:24, pages 6061-6068.
Crossref
Crossref
C Bach, D Mueller, S Buhl, M P Garcia-Cuellar & R K Slany. (2008) Alterations of the CxxC domain preclude oncogenic activation of mixed-lineage leukemia 2. Oncogene 28:6, pages 815-823.
Crossref
Crossref
Yasuhiro Oki & Jean - Pierre J. Issa. 2010. Acute Myelogenous Leukemia. Acute Myelogenous Leukemia
19
40
.
Andrew G. Muntean, Diane Giannola, Aaron M. Udager & Jay L. Hess. (2008) The PHD fingers of MLL block MLL fusion protein–mediated transformation. Blood 112:12, pages 4690-4693.
Crossref
Crossref
Jing Chen, Donna A. Santillan, Mark Koonce, Wei Wei, Roger Luo, Michael J. Thirman, Nancy J. Zeleznik-Le & Manuel O. Diaz. (2008) Loss of MLL PHD Finger 3 Is Necessary for MLL-ENL–Induced Hematopoietic Stem Cell Immortalization. Cancer Research 68:15, pages 6199-6207.
Crossref
Crossref
Frank E. ErfurthRelja PopovicJolanta Grembecka, Tomasz Cierpicki, Catherine TheislerZhen-Biao XiaTara StuartManuel O. Diaz, John H. Bushweller & Nancy J. Zeleznik-Le. (2008)
MLL protects CpG clusters from methylation within the
Hoxa9
gene, maintaining transcript expression
. Proceedings of the National Academy of Sciences 105:21, pages 7517-7522.
Crossref
Crossref
Yali Dou & Jay L. Hess. (2007) Mechanisms of transcriptional regulation by MLL and its disruption in acute leukemia. International Journal of Hematology 87:1, pages 10-18.
Crossref
Crossref
S. Rodriguez-Perales, F. Cano, M. N. Lobato & T. H. Rabbitts. (2007) MLL gene fusions in human leukaemias: in vivo modelling to recapitulate these primary tumourigenic events. International Journal of Hematology 87:1, pages 3-9.
Crossref
Crossref
Dorothee MuellerChristian BachDeniz ZeisigMaria-Paz Garcia-Cuellar, Sara Monroe, Arun Sreekumar, Rong Zhou, Alexey Nesvizhskii, Arul Chinnaiyan, Jay L. Hess & Robert K. Slany. (2007) A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification. Blood 110:13, pages 4445-4454.
Crossref
Crossref
Andrei V. Krivtsov & Scott A. Armstrong. (2007) MLL translocations, histone modifications and leukaemia stem-cell development. Nature Reviews Cancer 7:11, pages 823-833.
Crossref
Crossref
Han Liu, Emily H.-Y. Cheng & James J.-D. Hsieh. (2007)
Bimodal degradation of MLL by SCF
Skp2
and APC
Cdc20
assures cell cycle execution: a critical regulatory circuit lost in leukemogenic MLL fusions
. Genes & Development 21:19, pages 2385-2398.
Crossref
Crossref
A Lafon, C S Chang, E M Scott, S J Jacobson & L Pillus. (2007) MYST opportunities for growth control: yeast genes illuminate human cancer gene functions. Oncogene 26:37, pages 5373-5384.
Crossref
Crossref
E Kowarz, T Burmeister, L Lo Nigro, M W J C Jansen, E Delabesse, T Klingebiel, Theo Dingermann, C Meyer & R Marschalek. (2007) Complex MLL rearrangements in t(4;11) leukemia patients with absent AF4 · MLL fusion allele. Leukemia 21:6, pages 1232-1238.
Crossref
Crossref
C Meyer, T Burmeister, S Strehl, B Schneider, D Hubert, O Zach, O Haas, T Klingebiel, T Dingermann & R Marschalek. (2007) Spliced MLL fusions: a novel mechanism to generate functional chimeric MLL-MLLT1 transcripts in t(11;19)(q23;p13.3) leukemia. Leukemia 21:3, pages 588-590.
Crossref
Crossref
Alan D. Friedman. 2007. Acute Myelogenous Leukemia. Acute Myelogenous Leukemia
27
42
.
Donna A. Santillan, Catherine M. Theisler, Amanda S. Ryan, Relja Popovic, Tara Stuart, Ming-Ming Zhou, Serhan Alkan & Nancy J. Zeleznik-Le. (2006) Bromodomain and Histone Acetyltransferase Domain Specificities Control Mixed Lineage Leukemia Phenotype. Cancer Research 66:20, pages 10032-10039.
Crossref
Crossref
Claus Meyer, Eric Kowarz, Björn Schneider, Clarissa Oehm, Thomas Klingebiel, Theo Dingermann & Rolf Marschalek. (2006) Genomic DNA of leukemic patients: Target for clinical diagnosis ofMLL rearrangements. Biotechnology Journal 1:6, pages 656-663.
Crossref
Crossref
M Metzler, A Forster, R Pannell, M J Arends, A Daser, M N Lobato & T H Rabbitts. (2006) A conditional model of MLL-AF4 B-cell tumourigenesis using invertor technology. Oncogene 25:22, pages 3093-3103.
Crossref
Crossref
Robert B. Lorsbach & James R. Downing. 2010. Childhood Leukemias. Childhood Leukemias
298
338
.
Colin Kwok, Bernd B. Zeisig, Shuo Dong & Chi Wai Eric So. (2006) Forced homo-oligomerization of RARα leads to transformation of primary hematopoietic cells. Cancer Cell 9:2, pages 95-108.
Crossref
Crossref
Björn Steffen, Carsten Müller-Tidow, Joachim Schwäble, Wolfgang E. Berdel & Hubert Serve. (2005) The molecular pathogenesis of acute myeloid leukemia. Critical Reviews in Oncology/Hematology 56:2, pages 195-221.
Crossref
Crossref
Lesley F Drynan, Richard Pannell, Alan Forster, Nicole M M Chan, Florencia Cano, Angelika Daser & Terence H Rabbitts. (2005) Mll fusions generated by Cre-loxP-mediated de novo translocations can induce lineage reassignment in tumorigenesis. The EMBO Journal 24:17, pages 3136-3146.
Crossref
Crossref
Deniz T Zeisig, Claudia B Bittner, Bernd B Zeisig, Maria-Paz García-Cuéllar, Jay L Hess & Robert K Slany. (2005) The eleven-nineteen-leukemia protein ENL connects nuclear MLL fusion partners with chromatin. Oncogene 24:35, pages 5525-5532.
Crossref
Crossref
Tomohiko Taki, Masaharu Akiyama, Shinobu Saito, Ryoichi Ono, Masafumi Taniwaki, Yoko Kato, Yuki Yuza, Yoshikatsu Eto & Yasuhide Hayashi. (2005) The MYO1F, unconventional myosin type 1F, gene is fused to MLL in infant acute monocytic leukemia with a complex translocation involving chromosomes 7, 11, 19 and 22. Oncogene 24:33, pages 5191-5197.
Crossref
Crossref
Sandrine Hayette, Pascale Cornillet-Lefebvre, Isabelle Tigaud, Stéphanie Struski, Stéphanie Forissier, Adrien Berchet, Diane Doll, Lucile Gillot, Wajih Brahim, Eric Delabesse, Jean-Pierre Magaud & Ruth Rimokh. (2005)
AF4p12
, a Human Homologue to the
furry
Gene of
Drosophila
, as a Novel
MLL
Fusion Partner
. Cancer Research 65:15, pages 6521-6525.
Crossref
Crossref
Mariko Eguchi, Minenori Eguchi-Ishimae & Mel Greaves. (2005) Molecular Pathogenesis of MLL-Associated Leukemias. International Journal of Hematology 82:1, pages 9-20.
Crossref
Crossref
Charles G. Mullighan, Christian Flotho & James R. Downing. (2005) Genomic Assessment of Pediatric Acute Leukemia. The Cancer Journal 11:4, pages 268-282.
Crossref
Crossref
A. Daser & T.H. Rabbitts. (2005) The versatile mixed lineage leukaemia gene MLL and its many associations in leukaemogenesis. Seminars in Cancer Biology 15:3, pages 175-188.
Crossref
Crossref
Relja Popovic & Nancy J. Zeleznik-Le. (2005) MLL: How complex does it get?. Journal of Cellular Biochemistry 95:2, pages 234-242.
Crossref
Crossref
Ryoichi Ono, Tetsuya Nosaka & Yasuhide Hayashi. (2005) Roles of a trithorax Group Gene, MLL, in Hematopoiesis. International Journal of Hematology 81:4, pages 288-293.
Crossref
Crossref
Robert K Slany. (2005) When epigenetics kills: MLL fusion proteins in leukemia. Hematological Oncology 23:1, pages 1-9.
Crossref
Crossref
Z-Y Li, D-P Liu & C-C Liang. (2004) New insight into the molecular mechanisms of MLL-associated leukemia. Leukemia 19:2, pages 183-190.
Crossref
Crossref
Tae Shimoyama, Kohsuke Kato, Mary Miyaji-Yamaguchi & Kyosuke Nagata. (2005) Synergistic action of MLL, a TRX protein with template activating factor-I, a histone chaperone. FEBS Letters 579:3, pages 757-762.
Crossref
Crossref
Inhua Muyrers-Chen, Tatiana Rozovskaia, Nara Lee, John H Kersey, Tatsuya Nakamura, Eli Canaani & Renato Paro. (2004) Expression of leukemic MLL fusion proteins in Drosophila affects cell cycle control and chromosome morphology. Oncogene 23:53, pages 8639-8648.
Crossref
Crossref
Jay L. Hess. (2004) MLL: a histone methyltransferase disrupted in leukemia. Trends in Molecular Medicine 10:10, pages 500-507.
Crossref
Crossref
Adelheid Bursen, Sven Moritz, Anne Gaussmann, Sören Moritz, Theo Dingermann & Rolf Marschalek. (2004) Interaction of AF4 wild-type and AF4·MLL fusion protein with SIAH proteins: indication for t(4;11) pathobiology?. Oncogene 23:37, pages 6237-6249.
Crossref
Crossref
Claudia B. Bittner, Deniz T. Zeisig, Bernd B. Zeisig & Robert K. Slany. (2004) Direct Physical and Functional Interaction of the NuA4 Complex Components Yaf9p and Swc4p. Eukaryotic Cell 3:4, pages 976-983.
Crossref
Crossref
G. Mitterbauer-Hohendanner & C. Mannhalter. (2004) The biological and clinical significance of MLL abnormalities in haematological malignancies. European Journal of Clinical Investigation 34:s2, pages 12-24.
Crossref
Crossref
R S Srinivasan, J B Nesbit, L Marrero, F Erfurth, V F LaRussa & C S Hemenway. (2004) The synthetic peptide PFWT disrupts AF4–AF9 protein complexes and induces apoptosis in t(4;11) leukemia cells. Leukemia 18:8, pages 1364-1372.
Crossref
Crossref
Mariko EguchiMinenori Eguchi-IshimaeMel Greaves. (2004) The small oligomerization domain of gephyrin converts MLL to an oncogene. Blood 103:10, pages 3876-3882.
Crossref
Crossref
Angelika Daser & Terence H. Rabbitts. (2004)
Extending the repertoire of the mixed-lineage leukemia gene
MLL
in leukemogenesis
. Genes & Development 18:9, pages 965-974.
Crossref
Crossref
Masayuki Hirano, Yuji Kikuchi, Sazuku Nisitani, Akiko Yamaguchi, Atsushi Satoh, Taiji Ito, Hideo Iba & Kiyoshi Takatsu. (2004) Bruton’s tyrosine kinase (Btk) enhances transcriptional co‐activation activity of BAM11, a Btk‐associated molecule of a subunit of SWI/SNF complexes. International Immunology 16:5, pages 747-757.
Crossref
Crossref
Han Liu, Bing Chen, Hui Xiong, Qiu-Hua Huang, Qing-Hua Zhang, Zhu-Gang Wang, Bo-Liang Li, Zhu Chen & Sai-Juan Chen. (2004) Functional contribution of EEN to leukemogenic transformation by MLL-EEN fusion protein. Oncogene 23:19, pages 3385-3394.
Crossref
Crossref
Keijiro Suzuki, Takeshi Sugawara, Shugo Kowata, Taiju Utsugizawa, Shigeki Ito, Kazunori Murai & Yoji Ishida. (2004) Uncommon karyotypic abnormality, t(11;19)(q23;p13.3), in a patient with blastic phase of chronic myeloid leukemia. Cancer Genetics and Cytogenetics 150:2, pages 159-163.
Crossref
Crossref
Anne R. M. von Bergh, Pauline M. Wijers, Arjan J. Groot, Shama van Zelderen-Bhola, J. H. Frederik Falkenburg, Philip M. Kluin & Ed Schuuring. (2004) Identification of a novel RAS GTPase-activating protein (RASGAP) gene at 9q34 as anMLL fusion partner in a patient with de novo acute myeloid leukemia. Genes, Chromosomes and Cancer 39:4, pages 324-334.
Crossref
Crossref
Judy Wai Ping YamDong-Yan JinChi Wai SoLi Chong Chan. (2004) Identification and characterization of EBP, a novel EEN binding protein that inhibits Ras signaling and is recruited into the nucleus by the MLL-EEN fusion protein. Blood 103:4, pages 1445-1453.
Crossref
Crossref
Lih-Wen Deng, Isaac Chiu & Jack L. Strominger. (2004) MLL 5 protein forms intranuclear foci, and overexpression inhibits cell cycle progression. Proceedings of the National Academy of Sciences 101:3, pages 757-762.
Crossref
Crossref
F Erfurth, C S Hemenway, A C de Erkenez & P H Domer. (2003) MLL fusion partners AF4 and AF9 interact at subnuclear foci. Leukemia 18:1, pages 92-102.
Crossref
Crossref
Mariko Eguchi, Minenori Eguchi-Ishimae & Mel Greaves. (2003) The Role of theMLL Gene in Infant Leukemia. International Journal of Hematology 78:5, pages 390-401.
Crossref
Crossref
Paul M. Ayton & Michael L. Cleary. (2003)
Transformation of myeloid progenitors by MLL oncoproteins is dependent on
Hoxa7
and
Hoxa9
. Genes & Development 17:18, pages 2298-2307.
Crossref
Crossref
Chi Wai So, Min Lin, Paul M Ayton, Everett H Chen & Michael L Cleary. (2003) Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias. Cancer Cell 4:2, pages 99-110.
Crossref
Crossref
Sophie Dubé, Raouf Fetni, Sawcène Hazourli, Martin Champagne & Nicole Lemieux. (2003) Rearrangement of the MLL gene and a region proximal to the RARα gene in a case of acute myelocytic leukemia M5 with a t(11;17)(q23;q21). Cancer Genetics and Cytogenetics 145:1, pages 54-59.
Crossref
Crossref
Zhen-Biao Xia, Melanie Anderson, Manuel O. Diaz & Nancy J. Zeleznik-Le. (2003) MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein. Proceedings of the National Academy of Sciences 100:14, pages 8342-8347.
Crossref
Crossref
Adolfo A. FerrandoScott A. ArmstrongDonna S. NeubergStephen E. SallanLewis B. SilvermanStanley J. KorsmeyerA. Thomas Look. (2003) Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation. Blood 102:1, pages 262-268.
Crossref
Crossref
C M T Macrini, M S Pombo-de-Oliveira, A M Ford & G Alves. (2003) MLL AT-hook sequence is strongly conserved in infant acute leukemia with or without MLL gene rearrangement. Leukemia 17:7, pages 1432-1433.
Crossref
Crossref
R Sathish Srinivasan, Andrea C de Erkenez & Charles S Hemenway. (2003) The mixed lineage leukemia fusion partner AF9 binds specific isoforms of the BCL-6 corepressor. Oncogene 22:22, pages 3395-3406.
Crossref
Crossref
Alan Forster, Richard Pannell, Lesley F Drynan, Matthew McCormack, Emma C Collins, Angelika Daser & Terence H Rabbitts. (2003) Engineering de novo reciprocal chromosomal translocations associated with Mll to replicate primary events of human cancer. Cancer Cell 3:5, pages 449-458.
Crossref
Crossref
B B Zeisig, M P García-Cuéllar, T H Winkler & R K Slany. (2003) The Oncoprotein MLL–ENL disturbs hematopoietic lineage determination and transforms a biphenotypic lymphoid/myeloid cell. Oncogene 22:11, pages 1629-1637.
Crossref
Crossref
Martin U Kuefer, Vandana Chinwalla, Nancy J Zeleznik-Le, Frederick G Behm, Clayton W Naeve, Karen M Rakestraw, Suraj T Mukatira, Susana C Raimondi & Stephan W Morris. (2003) Characterization of the MLL partner gene AF15q14 involved in t(11;15)(q23;q14). Oncogene 22:9, pages 1418-1424.
Crossref
Crossref
Kenji Deguchi, Paul M Ayton, Melina Carapeti, Jeffery L Kutok, Cynthia S Snyder, Ifor R Williams, Nicholas C.P Cross, Christopher K Glass, Michael L Cleary & D.Gary Gilliland. (2003) MOZ-TIF2-induced acute myeloid leukemia requires the MOZ nucleosome binding motif and TIF2-mediated recruitment of CBP. Cancer Cell 3:3, pages 259-271.
Crossref
Crossref
B B Zeisig, S Schreiner, M-P García-Cuéllar & R K Slany. (2003) Transcriptional activation is a key function encoded by MLL fusion partners. Leukemia 17:2, pages 359-365.
Crossref
Crossref
Chi Wai SoMichael L. Cleary. (2003) Common mechanism for oncogenic activation of MLL by forkhead family proteins. Blood 101:2, pages 633-639.
Crossref
Crossref
Sabine Strehl, Arndt Borkhardt, Robert Slany, Uta E Fuchs, Margit König & Oskar A Haas. (2003) The human LASP1 gene is fused to MLL in an acute myeloid leukemia with t(11;17)(q23;q21). Oncogene 22:1, pages 157-160.
Crossref
Crossref
Daniel S. Wechsler, Lars D. Engstrom, Brian M. Alexander, David G. Motto & Diane Roulston. (2003) A novel chromosomal inversion at 11q23 in infant acute myeloid leukemia fusesMLL toCALM, a gene that encodes a clathrin assembly protein. Genes, Chromosomes and Cancer 36:1, pages 26-36.
Crossref
Crossref
Nadine MayotteDenis-Claude RoyJing YaoEvert KroonGuy Sauvageau. (2002) Oncogenic interaction between BCR-ABL andNUP98-HOXA9 demonstrated by the use of an in vitro purging culture system. Blood 100:12, pages 4177-4184.
Crossref
Crossref
Akihiko YokoyamaIssay KitabayashiPaul M. AytonMichael L. ClearyMisao Ohki. (2002) Leukemia proto-oncoprotein MLL is proteolytically processed into 2 fragments with opposite transcriptional properties. Blood 100:10, pages 3710-3718.
Crossref
Crossref
Emma C Collins & Terence H Rabbitts. (2002) The promiscuous MLL gene links chromosomal translocations to cellular differentiation and tumour tropism. Trends in Molecular Medicine 8:9, pages 436-442.
Crossref
Crossref
Brooke M Emerling, Jeannette Bonifas, Christian P Kratz, Shane Donovan, Brigit R Taylor, Eric D Green, Michelle M Le Beau & Kevin M Shannon. (2002) MLL5, a homolog of Drosophila trithorax located within a segment of chromosome band 7q22 implicated in myeloid leukemia. Oncogene 21:31, pages 4849-4854.
Crossref
Crossref
Shin Kawamata, Changchun Du, Kaijun Li & Catherine Lavau. (2002) Overexpression of the Notch target genes Hes in vivo induces lymphoid and myeloid alterations. Oncogene 21:24, pages 3855-3863.
Crossref
Crossref
Jorge F. DiMartinoPaul M. AytonEverett H. ChenClarissa C. NaftzgerBryan D. YoungMichael L. Cleary. (2002) The AF10 leucine zipper is required for leukemic transformation of myeloid progenitors by MLL-AF10. Blood 99:10, pages 3780-3785.
Crossref
Crossref
Joseph M Scandura, Piernicola Boccuni, Jorg Cammenga & Stephen D Nimer. (2002) Transcription factor fusions in acute leukemia: variations on a theme. Oncogene 21:21, pages 3422-3444.
Crossref
Crossref
Raymond T. Doty, Gary J. Vanasse, Christine M. Disteche & Dennis M. Willerford. (2002) The Leukemia-Associated Gene Mllt1/ENL: Characterization of a Murine Homolog and Demonstration of an Essential Role in Embryonic Development. Blood Cells, Molecules, and Diseases 28:3, pages 407-417.
Crossref
Crossref
Claudia B Zraly, Yun Feng & Andrew K Dingwall. (2002)
Genetic and Molecular Analysis of Region 88E9;88F2 in
Drosophila melanogaster
, Including the
ear
Gene Related to Human Factors Involved in Lineage-Specific Leukemias
. Genetics 160:3, pages 1051-1065.
Crossref
Crossref
Shin Kawamata, Changchun Du, Kaijun Li & Catherine Lavau. (2002) Notch1 Perturbation of Hemopoiesis Involves Non-Cell- Autonomous Modifications. The Journal of Immunology 168:4, pages 1738-1745.
Crossref
Crossref
Silvana DebernardiAlessandra BassiniLouise K. JonesTracy ChaplinBritta LinderDiederik R. H. de BruijnEckart MeeseBryan D. Young. (2002) The MLL fusion partner AF10 binds GAS41, a protein that interacts with the human SWI/SNF complex. Blood 99:1, pages 275-281.
Crossref
Crossref
Mariko Eguchi, Minenori Eguchi-Ishimae, Masao Seto, Kazuhiro Morishita, Katsuyuki Suzuki, Ryuzo Ueda, Kazuhiro Ueda, Nanao Kamada & Mel Greaves. (2001) GPHN, a novel partner gene fused toMLL in a leukemia with t(11;14)(q23;q24). Genes, Chromosomes and Cancer 32:3, pages 212-221.
Crossref
Crossref
Myriam Alcalay, Annette Orleth, Carla Sebastiani, Natalia Meani, Ferdinando Chiaradonna, Cristina Casciari, Maria Teresa Sciurpi, Vania Gelmetti, Daniela Riganelli, Saverio Minucci, Marta Fagioli & Pier Giuseppe Pelicci. (2001) Common themes in the pathogenesis of acute myeloid leukemia. Oncogene 20:40, pages 5680-5694.
Crossref
Crossref
Paul M Ayton & Michael L Cleary. (2001) Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins. Oncogene 20:40, pages 5695-5707.
Crossref
Crossref
Paul Ayton, Sharon F. Sneddon, Donald B. Palmer, Ian R. Rosewell, Michael J. Owen, Bryan Young, Robert Presley & Vasanta Subramanian. (2001) Truncation of theMLL gene in exon 5 by gene targeting leads to early preimplantation lethality of homozygous embryos. genesis 30:4, pages 201-212.
Crossref
Crossref
Uta FuchsGönna RehkampOskar A. HaasRobert SlanyMargit KönigStig BojesenRainer M. BohleChristine Damm-WelkWolf-Dieter LudwigJochen HarbottArndt Borkhardt. (2001)
The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an
MLL
-fusion partner in acute myelogeneous leukemia
. Proceedings of the National Academy of Sciences 98:15, pages 8756-8761.
Crossref
Crossref
Donna Liedman & Nancy Zeleznik-Le. (2001) Retroviral transduction model of mixed lineage leukemia fused to CREB binding protein. Current Opinion in Hematology 8:4, pages 218-223.
Crossref
Crossref
Charles S Hemenway, Andrea C de Erkenez & Grahame C D Gould. (2001) The polycomb protein MPc3 interacts with AF9, an MLL fusion partner in t(9;11)(p22;q23) acute leukemias. Oncogene 20:29, pages 3798-3805.
Crossref
Crossref
D R H de Bruijn, N R dos Santos, J Thijssen, M Balemans, S Debernardi, B Linder, B D Young & A Geurts van Kessel. (2001) The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10. Oncogene 20:25, pages 3281-3289.
Crossref
Crossref
T Rozovskaia, E Feinstein, O Mor, R Foa, J Blechman, T Nakamura, C M Croce, G Cimino & E Canaani. (2001) Upregulation of Meis1 and HoxA9 in acute lymphocytic leukemias with the t(4 : 11) abnormality. Oncogene 20:7, pages 874-878.
Crossref
Crossref
M P García-Cuéllar, O Zilles, S A Schreiner, M Birke, T H Winkler & R K Slany. (2001) The ENL moiety of the childhood leukemia-associated MLL–ENL oncoprotein recruits human Polycomb 3. Oncogene 20:4, pages 411-419.
Crossref
Crossref
N Niitsu, Y Hayashi & Y Honma. (2001) Downregulation of MLL-CBP fusion gene expression is associated with differentiation of SN-1 cells with t(11;16)(q23;p13). Oncogene 20:3, pages 375-384.
Crossref
Crossref
Mario Faretta, Luciano Di Croce & Pier Giuseppe Pelicci. (2001) Effects of the acute myeloid leukemia-associated fusion proteins on nuclear architecture. Seminars in Hematology 38:1, pages 42-53.
Crossref
Crossref
Ivana Gojo & Judith E. Karp. 2001. Myelodysplastic Syndromes & Secondary Acute Myelogenous Leukemia. Myelodysplastic Syndromes & Secondary Acute Myelogenous Leukemia
231
255
.
Jorge F. DiMartinoTrissa MillerPaul M. AytonTheresa LandeweJay L. HessMichael L. ClearyAli Shilatifard. (2000) A carboxy-terminal domain of ELL is required and sufficient for immortalization of myeloid progenitors by MLL-ELL. Blood 96:12, pages 3887-3893.
Crossref
Crossref
Jorge F. DiMartinoTrissa MillerPaul M. AytonTheresa LandeweJay L. HessMichael L. ClearyAli Shilatifard. (2000) A carboxy-terminal domain of ELL is required and sufficient for immortalization of myeloid progenitors by MLL-ELL. Blood 96:12, pages 3887-3893.
Crossref
Crossref
Cecilie Rekdal, Eva Sjøttem & Terje Johansen. (2000) The Nuclear Factor SPBP Contains Different Functional Domains and Stimulates the Activity of Various Transcriptional Activators. Journal of Biological Chemistry 275:51, pages 40288-40300.
Crossref
Crossref
C Caslini, ASerna Alarcòn, JL Hess, R Tanaka, KG Murti & A Biondi. (2000) The amino terminus targets the mixed lineage leukemia (MLL) protein to the nucleolus, nuclear matrix and mitotic chromosomal scaffolds. Leukemia 14:11, pages 1898-1908.
Crossref
Crossref
Yasuhide Hayashi. (2000) The Molecular Genetics of Recurring Chromosome Abnormalities in Acute Myeloid Leukemia. Seminars in Hematology 37:4, pages 368-380.
Crossref
Crossref
Catherine Lavau, Roger T. Luo, Changchun Du & Michael J. Thirman. (2000)
Retrovirus-mediated gene transfer of
MLL-ELL
transforms primary myeloid progenitors and causes acute myeloid leukemias in mice
. Proceedings of the National Academy of Sciences 97:20, pages 10984-10989.
Crossref
Crossref
Andrea BiondiGiuseppe CiminoRob PietersChing-Hon Pui. (2000) Biological and therapeutic aspects of infant leukemia. Blood 96:1, pages 24-33.
Crossref
Crossref
Andrea BiondiGiuseppe CiminoRob PietersChing-Hon Pui. (2000) Biological and therapeutic aspects of infant leukemia. Blood 96:1, pages 24-33.
Crossref
Crossref
Helen Morgan, Martin Smith, Zoe Burke & David Carter. (2003) The transactivation‐competent carboxyl‐terminal domain of AF‐9 is expressed within a sexually dimorphic transcript in rat pituitary. The FASEB Journal 14:9, pages 1109-1116.
Crossref
Crossref
B Linder, R Newman, L.K Jones, S Debernardi, B.D Young, P Freemont, C.P Verrijzer & V Saha. (2000) Biochemical analyses of the AF10 protein: the extended LAP/PHD-finger mediates oligomerisation 1 1Edited by T. Richmond. Journal of Molecular Biology 299:2, pages 369-378.
Crossref
Crossref
CW So, CKC So, N Cheung, SL Chew, MH Sham & LC Chan. (2000) The interaction between EEN and Abi-1, two MLLfusion partners, and synaptojanin and dynamin: implications for leukaemogenesis. Leukemia 14:4, pages 594-601.
Crossref
Crossref
M P García-Cuéllar, S A Schreiner, M Birke, M Hamacher, G H Fey & R K Slany. (2000) ENL, the MLL fusion partner in t(11;19), binds to the c-Abl interactor protein 1 (ABI1) that is fused to MLL in t(10;11)+. Oncogene 19:14, pages 1744-1751.
Crossref
Crossref
Corrado Caslini, Ali Shilatifard, Liping Yang & Jay L. Hess. (2000) The amino terminus of the mixed lineage leukemia protein (MLL) promotes cell cycle arrest and monocytic differentiation. Proceedings of the National Academy of Sciences 97:6, pages 2797-2802.
Crossref
Crossref
Claire L. Dobson, Alan J. Warren, Richard Pannell, Alan Forster & Terence H. Rabbitts. (2000) Tumorigenesis in mice with a fusion of the leukaemia oncogene Mll and the bacterial lacZ gene. The EMBO Journal 19:5, pages 843-851.
Crossref
Crossref
S Shekhter-Levin, SM Gollin, SS Kaplan & RL Redner. (2000) Involvement of the MLL and RARα genes in a patient with acute monocytic leukemia with t(11;17)(q23;q12). Leukemia 14:3, pages 520-522.
Crossref
Crossref
Tomohiko Taki, Hirotsugu Kano, Masafumi Taniwaki, Masahiro Sako, Masayoshi Yanagisawa & Yasuhide Hayashi. (1999)
AF5q31
, a newly identified
AF4
-related gene, is fused to
MLL
in infant acute lymphoblastic leukemia with ins(5;11)(q31;q13q23)
. Proceedings of the National Academy of Sciences 96:25, pages 14535-14540.
Crossref
Crossref
Changchun DuRobert L. RednerMichael P. CookeCatherine Lavau. (1999) Overexpression of Wild-Type Retinoic Acid Receptor (RAR) Recapitulates Retinoic Acid-Sensitive Transformation of Primary Myeloid Progenitors by Acute Promyelocytic Leukemia RAR-Fusion Genes. Blood 94:2, pages 793-802.
Crossref
Crossref
Changchun DuRobert L. RednerMichael P. CookeCatherine Lavau. (1999) Overexpression of Wild-Type Retinoic Acid Receptor (RAR) Recapitulates Retinoic Acid-Sensitive Transformation of Primary Myeloid Progenitors by Acute Promyelocytic Leukemia RAR-Fusion Genes. Blood 94:2, pages 793-802.
Crossref
Crossref
James Powell, Thomas Traweek, Orren Beatty, Mazin B Qumsiyeh & Philip M Rosoff. (1999) A Novel Chromosomal Rearrangement Associated with Therapy-Related Acute Leukemia. Cancer Genetics and Cytogenetics 112:2, pages 173-177.
Crossref
Crossref
Joan Weliky Conaway & Ronald C. Conaway. (1999) Transcription Elongation and Human Disease. Annual Review of Biochemistry 68:1, pages 301-319.
Crossref
Crossref
David G Swan, Kirsten Phillips, Andrew Tait & Brian R Shiels. (1999) Evidence for localisation of a Theileria parasite AT hook DNA-binding protein to the nucleus of immortalised bovine host cells. Molecular and Biochemical Parasitology 101:1-2, pages 117-129.
Crossref
Crossref
Clemente Cillo, Antonio Faiella, Monica Cantile & Edoardo Boncinelli. (1999) Homeobox Genes and Cancer. Experimental Cell Research 248:1, pages 1-9.
Crossref
Crossref
Tomohiko TakiNoriko ShibuyaMasafumi TaniwakiRyoji HanadaKazuhiro MorishitaFumio BesshoMasayoshi YanagisawaYasuhide Hayashi. (1998) ABI-1, a Human Homolog to Mouse Abl-Interactor 1, Fuses theMLL Gene in Acute Myeloid Leukemia With t(10;11)(p11.2;q23). Blood 92:4, pages 1125-1130.
Crossref
Crossref
Tomohiko TakiNoriko ShibuyaMasafumi TaniwakiRyoji HanadaKazuhiro MorishitaFumio BesshoMasayoshi YanagisawaYasuhide Hayashi. (1998) ABI-1, a Human Homolog to Mouse Abl-Interactor 1, Fuses theMLL Gene in Acute Myeloid Leukemia With t(10;11)(p11.2;q23). Blood 92:4, pages 1125-1130.
Crossref
Crossref
Immaculata De Vivo, Xiangmin Cui, Jos Domen & Michael L. Cleary. (1998) Growth stimulation of primary B cell precursors by the anti-phosphatase Sbf1. Proceedings of the National Academy of Sciences 95:16, pages 9471-9476.
Crossref
Crossref
Xiangmin Cui, Immaculata De Vivo, Robert Slany, Alison Miyamoto, Ron Firestein & Michael L. Cleary. (1998) Association of SET domain and myotubularin-related proteins modulates growth control. Nature Genetics 18:4, pages 331-337.
Crossref
Crossref