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Molecular and Cellular Biology Volume 18, 1998 - Issue 11
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DNA Dynamics and Chromosome Structure

Failure of Hairpin-Ended and Nicked DNA To Activate DNA-Dependent Protein Kinase: Implications for V(D)J Recombination

Vaughn Smidera Departments of Medicine and Biochemistry, Stanford University Medical Center, Stanford, California94305
,
W. Kimryn Rathmella Departments of Medicine and Biochemistry, Stanford University Medical Center, Stanford, California94305
,
Greg Brownb Department of Immunology, University of Toronto, and Division of Immunology/Cancer, Hospital for Sick Children, Toronto, Ontario, Canada
,
Susanna Lewisb Department of Immunology, University of Toronto, and Division of Immunology/Cancer, Hospital for Sick Children, Toronto, Ontario, Canada
&
Gilbert Chua Departments of Medicine and Biochemistry, Stanford University Medical Center, Stanford, California94305Correspondence[email protected]
Pages 6853-6858 | Received 01 Apr 1998, Accepted 12 Aug 1998, Published online: 28 Mar 2023

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Emily A. Agard & Susanna M. Lewis. (2000) Postcleavage Sequence Specificity in V(D)J Recombination. Molecular and Cellular Biology 20:14, pages 5032-5040.
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Ward Giffin, Wenrong Gong, Caroline Schild-Poulter & Robert J. G. Haché. (1999) Ku Antigen-DNA Conformation Determines the Activation of DNA-Dependent Protein Kinase and DNA Sequence-Directed Repression of Mouse Mammary Tumor Virus Transcription. Molecular and Cellular Biology 19:6, pages 4065-4078.
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Articles from other publishers (24)

Lan Liu, Xuemin Chen, Jun Li, Huaibin Wang, Christopher J. Buehl, Noah J. Goff, Katheryn Meek, Wei Yang & Martin Gellert. (2022) Autophosphorylation transforms DNA-PK from protecting to processing DNA ends. Molecular Cell 82:1, pages 177-189.e4.
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Katheryn Meek. (2020) Activation of DNA-PK by hairpinned DNA ends reveals a stepwise mechanism of kinase activation. Nucleic Acids Research 48:16, pages 9098-9108.
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Yanhui Li, Jinyu Wang, Gang Zhou, Michael Lajeunesse, Nga Le, Brittany N Stawicki, Yalitza Lopez Corcino, Kathleen L Berkner & Kurt W Runge. (2017) Nonhomologous End-Joining with Minimal Sequence Loss Is Promoted by the Mre11-Rad50-Nbs1-Ctp1 Complex in Schizosaccharomyces pombe . Genetics 206:1, pages 481-496.
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Shaliny Ramachandran & Alberto Martin. 2016. Encyclopedia of Immunobiology. Encyclopedia of Immunobiology 134 143 .
Haihui Lu, Noriko Shimazaki, Prafulla Raval, Jiafeng Gu, Go Watanabe, Klaus Schwarz, Patrick C. Swanson & Michael R. Lieber. (2008) A Biochemically Defined System for Coding Joint Formation in V(D)J Recombination. Molecular Cell 31:4, pages 485-497.
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Katheryn Meek, Van Dang & Susan P. Lees-Miller. 2008. 33 58 .
Errol C. Friedberg, Graham C. Walker, Wolfram Siede, Richard D. Wood, Roger A. Schultz & Tom Ellenberger. 2005. DNA Repair and Mutagenesis. DNA Repair and Mutagenesis 711 750 .
Eric Hendrickson, Joy Huffman & John Tainer. 2005. DNA Damage Recognition. DNA Damage Recognition.
Dewey Kim, Yoon Rhee, Denise Rhodes, Vikram Sharma, Olav Sorenson, Alan Greener & Vaughn Smider. (2005) Directed Evolution and Identification of Control Regions of ColE1 Plasmid Replication Origins Using Only Nucleotide Deletions. Journal of Molecular Biology 351:4, pages 763-775.
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Ramiro Dip & Hanspeter Naegeli. (2005) More than just strand breaks: the recognition of structural DNA discontinuities by DNA‐dependent protein kinase catalytic subunit. The FASEB Journal 19:7, pages 704-715.
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Klaus Schwarz, Yunmei Ma, Ulrich Pannicke & Michael R. Lieber. (2003) Human severe combined immune deficiency and DNA repair. BioEssays 25:11, pages 1061-1070.
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Susanne Mårtensson, Jonas Nygren, Neil Osheroff & Ola Hammarsten. (2003) Activation of the DNA-Dependent Protein Kinase by Drug-Induced and Radiation-Induced DNA Strand Breaks. Radiation Research 160:3, pages 291-301.
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Caroline Schild-PoulterDiamanto Matheos, Olivia Novac, Bo Cui, Ward Giffin, Marcia T. Ruiz, Gerald B. Price, Maria Zannis-Hadjopoulos & Robert J.G. Haché. (2003) Differential DNA Binding of Ku Antigen Determines Its Involvement in DNA Replication. DNA and Cell Biology 22:2, pages 65-78.
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Yunmei Ma & Michael R. Lieber. (2002) Binding of Inositol Hexakisphosphate (IP6) to Ku but Not to DNA-PKcs. Journal of Biological Chemistry 277:13, pages 10756-10759.
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Susanne Mårtensson & Ola Hammarsten. (2002) DNA-dependent Protein Kinase Catalytic Subunit. Journal of Biological Chemistry 277:4, pages 3020-3029.
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ALEXANDER TAGHVA, YUNMEI MA & MICHAEL R. LIEBER. (2002) Analysis of the Kinetic and Equilibrium Binding of Ku Protein to DNA. Journal of Theoretical Biology 214:1, pages 85-97.
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Sébastien Soubeyrand, Heather Torrance, Ward Giffin, Wenrong Gong, Caroline Schild-Poulter & Robert J. G. Haché. (2001) Activation and autoregulation of DNA-PK from structured single-stranded DNA and coding end hairpins. Proceedings of the National Academy of Sciences 98:17, pages 9605-9610.
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Sebastian D. FugmannAlfred Ian LeePenny E. ShockettIsabelle J. VilleyDavid G. Schatz. (2000) The RAG Proteins and V(D)J Recombination: Complexes, Ends, and Transposition. Annual Review of Immunology 18:1, pages 495-527.
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Ola Hammarsten, Lisa G. DeFazio & Gilbert Chu. (2000) Activation of DNA-dependent Protein Kinase by Single-stranded DNA Ends. Journal of Biological Chemistry 275:3, pages 1541-1550.
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J.M Lin, M.A Landree & D.B Roth. (1999) V(D)J recombination catalyzed by mutant RAG proteins lacking consensus DNA-PK phosphorylation sites. Molecular Immunology 36:18, pages 1263-1269.
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Rudaina H. Alrefai, E.Jeffrey Beecham, Vilhelm A. Bohr & Patricia J. Gearhart. (1999) Less Repair of Pyrimidine Dimers and Single-Strand Breaks in Genes by Scid Cells. Biochemical and Biophysical Research Communications 264:3, pages 878-882.
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Kurt W. Kohn. (1999) Molecular Interaction Map of the Mammalian Cell Cycle Control and DNA Repair Systems. Molecular Biology of the Cell 10:8, pages 2703-2734.
Crossref
Patrick Calsou, Philippe Frit, Odile Humbert, Catherine Muller, David J. Chen & Bernard Salles. (1999) The DNA-dependent Protein Kinase Catalytic Activity Regulates DNA End Processing by Means of Ku Entry into DNA. Journal of Biological Chemistry 274:12, pages 7848-7856.
Crossref
L.E. HUYE, J.-O. HAN & D.B. ROTH. (1999) What Prevents Intermolecular V(D)J Recombination?. Cold Spring Harbor Symposia on Quantitative Biology 64:0, pages 191-196.
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