23
Views
26
CrossRef citations to date
0
Altmetric
DNA Dynamics and Chromosome Structure

Failure of Hairpin-Ended and Nicked DNA To Activate DNA-Dependent Protein Kinase: Implications for V(D)J Recombination

, , , &
Pages 6853-6858 | Received 01 Apr 1998, Accepted 12 Aug 1998, Published online: 28 Mar 2023

REFERENCES

  • Agrawal, A., and D. Schatz 1997. RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination. Cell 89: 43–53.
  • Biedermann, K., J. Sun, A. Giaccia, L. Tosto, and J. M. Brown 1991. Scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair. Proc. Natl. Acad. Sci. USA 88: 1394–1397.
  • Blier, P., A. Griffith, J. Craft, and J. Hardin 1993. Binding of Ku protein to DNA. Measurement of affinity for ends and demonstration of binding to nicks. J. Biol. Chem. 268: 7594–7601.
  • Blunt, T., N. Finnie, G. Taccioli, G. Smith, J. Demengeot, T. Gottlieb, R. Mizuta, A. Varghese, F. Alt, P. Jeggo, and S. Jackson 1995. Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation. Cell 80: 813–823.
  • Blunt, T., D. Gell, M. Fox, G. Taccioli, S. Jackson, A. Lehman, and P. Jeggo 1996. Identification of a nonsense mutation in the carboxy-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse. Proc. Natl. Acad. Sci. USA 93: 10285–10290.
  • Chu, G. 1997. Double-strand break repair. J. Biol. Chem. 272: 24097–24100.
  • Danska, J., D. Holland, S. Mariathasan, K. Williams, and C. Guidos 1996. Biochemical and genetic defects in the DNA-dependent protein kinase in murine scid lymphocytes. Mol. Cell. Biol. 16: 5507–5517.
  • Errami, A., V. Smider, W. K. Rathmell, D. He, E. A. Hendrickson, M. Zdzienicka, and G. Chu 1996. Ku86 defines the genetic defect and restores X-ray resistance and V(D)J recombination to complementation group 5 hamster cells. Mol. Cell. Biol. 16: 1519–1526.
  • Falzon, M., J. W. Fewell, and E. L. Kuff 1993. EBP-80, a transcription factor closely resembling the human autoantigen Ku, recognizes single- to double-strand transitions in DNA. J. Biol. Chem. 268: 10546–10552.
  • Fulop, G., and R. Phillips 1990. The scid mutation in mice causes a general defect in DNA repair. Nature 347: 479–482.
  • Gottlieb, T., and S. Jackson 1993. The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen. Cell 72: 131–142.
  • Hammarsten, O., and G. Chu 1998. DNA-dependent protein kinase: DNA binding and activation in the absence of Ku. Proc. Natl. Acad. Sci. USA 95: 525–530.
  • Hendrickson, E., X. Q. Qin, E. Bump, D. Schatz, M. Oettinger, and D. Weaver 1991. A link between double-strand break related repair and V(D)J recombination: the scid mutation. Proc. Natl. Acad. Sci. USA 88: 4061–4065.
  • Kirchgessner, C., C. Patil, J. Evans, C. Cuomo, L. Fried, T. Carter, M. Oettinger, and J. M. Brown 1995. DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect. Science 267: 1178–1185.
  • Lees-Miller, S., K. Sakaguchi, S. Ullrich, E. Appela, and C. Anderson 1992. Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53. Mol. Cell. Biol. 12: 5041–5049.
  • Leu, T., Q. Eastman, and D. Schatz 1997. Coding joint formation in a cell-free V(D)J recombination system. Immunity 7: 303–314.
  • Lewis, S. M. 1994. P nucleotide insertions, and the resolution of hairpin DNA structures in mammalian cells. Proc. Natl. Acad. Sci. USA 91: 1332–1336.
  • Lieber, M. R., J. E. Hesse, S. Lewis, G. C. Bosma, N. Rosenberg, K. Mizuuchi, M. J. Bosma, and M. Gellert 1988. The defect in murine severe combined immune deficiency: joining of signal sequences but not coding segments in V(D)J recombination. Cell 55: 7–16.
  • McBlane, F., D. van Gent, D. Ramsden, C. Romeo, C. Cuomo, M. Gellert, and M. Oettinger 1995. Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps. Cell 83: 387–395.
  • Meier, J., and S. Lewis 1993. P nucleotides in V(D)J recombination: a fine-structure analysis. Mol. Cell. Biol. 13: 1078–1092.
  • Morozov, V., M. Falzon, C. Anderson, and E. Kuff 1994. DNA-dependent protein kinase is activated by nicks and larger single-stranded gaps. J. Biol. Chem. 269: 16684–16688.
  • Paillard, S., and F. Strauss 1991. Analysis of the mechanism of interaction of simian Ku protein with DNA. Nucleic Acids Res. 19: 5619–5624.
  • Pergola, F., M. Z. Zdzienicka, and M. R. Lieber 1993. V(D)J recombination in mammalian cell mutants defective in DNA double-strand break repair. Mol. Cell. Biol. 13: 3464–3471.
  • Ramsden, D., T. Paull, and M. Gellert 1997. Cell-free V(D)J recombination. Nature 388: 488–491.
  • Roth, D., J. Menetski, P. Nakajima, M. Bosma, and M. Gellert 1992. V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes. Cell 70: 983–991.
  • Shore, D., J. Langowski, and R. Baldwin 1981. DNA flexibility studied by covalent closure of short DNA fragments into circles. Proc. Natl. Acad. Sci. USA 78: 4833–4837.
  • Smider, V., and G. Chu 1997. The end-joining reaction in V(D)J recombination. Semin. Immun. 9: 189–197.
  • Smider, V., W. K. Rathmell, M. Lieber, and G. Chu 1994. Restoration of X-ray resistance and V(D)J recombination in mutant cells by Ku cDNA. Science 266: 288–291.
  • Taccioli, G., T. Gottlieb, T. Blunt, A. Priestly, J. Demengeot, R. Mizuta, A. Lehmann, F. Alt, S. Jackson, and P. Jeggo 1994. Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination. Science 265: 1442–1445.
  • van Gent, D., J. F. McBlane, D. Ramsden, M. Sadofsky, J. Hesse, and M. Gellert 1995. Initiation of V(D)J recombination in a cell-free system. Cell 81: 925–934.
  • van Gent, D., D. Ramsden, and M. Gellert 1996. The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination. Cell 85: 107–113.
  • Weinfeld, M., M. Chaudhry, D. D’Amours, J. Pelletier, G. Poirer, L. Povirk, and S. Lees-Miller 1998. Interaction of DNA-dependent protein kinase and poly(ADP-ribose) polymerase with radiation-induced DNA strand breaks. Radiat. Res. 148: 22–28.
  • Yaneva, M., T. Kowalewski, and M. Lieber 1997. Interaction of DNA-dependent protein kinase with DNA and with Ku: biochemical and atomic-force microscopy studies. EMBO J. 16: 5098–5112.
  • Zhu, C., M. Bogue, D. S. Lim, P. Hasty, and D. Roth 1996. Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates. Cell 86: 379–389.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.