30
Views
47
CrossRef citations to date
0
Altmetric
Cell Growth and Development

N Terminus of Sos1 Ras Exchange Factor: Critical Roles for the Dbl and Pleckstrin Homology Domains

, , , &
Pages 771-778 | Received 13 Aug 1997, Accepted 04 Nov 1997, Published online: 28 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (8)

Jesse E. Jun, Ming Yang, Hang Chen, Arup K. Chakraborty & Jeroen P. Roose. (2013) Activation of Extracellular Signal-Regulated Kinase but Not of p38 Mitogen-Activated Protein Kinase Pathways in Lymphocytes Requires Allosteric Activation of SOS. Molecular and Cellular Biology 33:12, pages 2470-2484.
Read now
Katarzyna Modzelewska, Marc G. Elgort, Jingyu Huang, Gregg Jongeward, Amara Lauritzen, Charles H. Yoon, Paul W. Sternberg & Nadeem Moghal. (2007) An Activating Mutation in sos-1 Identifies Its Dbl Domain as a Critical Inhibitor of the Epidermal Growth Factor Receptor Pathway during Caenorhabditis elegans Vulval Development. Molecular and Cellular Biology 27:10, pages 3695-3707.
Read now
Paul Shapiro. (2002) Ras-MAP Kinase Signaling Pathways and Control of Cell Proliferation: Relevance to Cancer Therapy. Critical Reviews in Clinical Laboratory Sciences 39:4-5, pages 285-330.
Read now
Feng Bi, Balazs Debreceni, Kejin Zhu, Barbara Salani, Alessandra Eva & Yi Zheng. (2001) Autoinhibition Mechanism of Proto-Dbl. Molecular and Cellular Biology 21:5, pages 1463-1474.
Read now
Kejin Zhu, Balazs Debreceni, Feng Bi & Yi Zheng. (2001) Oligomerization of DH Domain Is Essential for Dbl-Induced Transformation. Molecular and Cellular Biology 21:2, pages 425-437.
Read now
Gerard A. Rodrigues, Marco Falasca, Zhongtao Zhang, Siew Hwa Ong & Joseph Schlessinger. (2000) A Novel Positive Feedback Loop Mediated by the Docking Protein Gab1 and Phosphatidylinositol 3-Kinase in Epidermal Growth Factor Receptor Signaling. Molecular and Cellular Biology 20:4, pages 1448-1459.
Read now
Pieter H. Anborgh, Xiaolan Qian, Alex G. Papageorge, William C. Vass, Jeffrey E. DeClue & Douglas R. Lowy. (1999) Ras-Specific Exchange Factor GRF: Oligomerization through Its Dbl Homology Domain and Calcium-Dependent Activation of Raf. Molecular and Cellular Biology 19:7, pages 4611-4622.
Read now
Cristina E. Tognon, Heather E. Kirk, Lori A. Passmore, Ian P. Whitehead, Channing J. Der & Robert J. Kay. (1998) Regulation of RasGRP via a Phorbol Ester-Responsive C1 Domain. Molecular and Cellular Biology 18:12, pages 6995-7008.
Read now

Articles from other publishers (39)

Diana Cai, Peter S. Choi, Maya Gelbard & Matthew Meyerson. (2019) Identification and Characterization of Oncogenic SOS1 Mutations in Lung Adenocarcinoma . Molecular Cancer Research 17:4, pages 1002-1012.
Crossref
Young Kwang Lee, Shalini T. Low-Nam, Jean K. Chung, Scott D. Hansen, Hiu Yue Monatrice Lam, Steven Alvarez & Jay T. Groves. (2017) Mechanism of SOS PR-domain autoinhibition revealed by single-molecule assays on native protein from lysate. Nature Communications 8:1.
Crossref
Hsiao-Wen Su, Nathan J. Lanning, David L. Morris, Lawrence S. Argetsinger, Carey N. Lumeng & Christin Carter-Su. (2013) Phosphorylation of the adaptor protein SH2B1βregulates its ability to enhance growth hormone (GH)-dependent macrophage motility. Journal of Cell Science.
Crossref
Elena Sacco, Marcello Farina, Claudio Greco, Stefano Lamperti, Stefano Busti, Luca DeGioia, Lilia Alberghina, Diego Liberati & Marco Vanoni. (2012) Regulation of hSos1 activity is a system-level property generated by its multi-domain structure. Biotechnology Advances 30:1, pages 154-168.
Crossref
Hyun Sub Hwang, Sang Gil Hwang, Jun-Ho Cho, Ji Soo Chae, Kyoung Wan Yoon, Ssang-Goo Cho & Eui-Ju Choi. (2011) CIIA functions as a molecular switch for the Rac1-specific GEF activity of SOS1. Journal of Cell Biology 195:3, pages 377-386.
Crossref
Yueqiang Zhang & Guangwei Du. (2009) Phosphatidic acid signaling regulation of Ras superfamily of small guanosine triphosphatases. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1791:9, pages 850-855.
Crossref
László Buday & Julian Downward. (2008) Many faces of Ras activation. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1786:2, pages 178-187.
Crossref
Masanao Murakami, Patricio I. Meneses, Jason S. Knight, Ke Lan, Rajeev Kaul, Subhash C. Verma & Erle S. Robertson. (2008) Nm23-H1 modulates the activity of the guanine exchange factor Dbl-1. International Journal of Cancer 123:3, pages 500-510.
Crossref
Chen Zhao, Guangwei Du, Karl Skowronek, Michael A. Frohman & Dafna Bar-Sagi. (2007) Phospholipase D2-generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos. Nature Cell Biology 9:6, pages 707-712.
Crossref
Lunhua Liu, Yili Xie & Liguang Lou. (2006) PI3K is required for insulin-stimulated but not EGF-stimulated ERK1/2 activation. European Journal of Cell Biology 85:5, pages 367-374.
Crossref
Jose M. Rojas & Eugenio Santos. 2006. RAS Family GTPases. RAS Family GTPases 15 43 .
Holger Sondermann, Bhushan Nagar, Dafna Bar-Sagi & John Kuriyan. (2005) Computational docking and solution x-ray scattering predict a membrane-interacting role for the histone domain of the Ras activator son of sevenless. Proceedings of the National Academy of Sciences 102:46, pages 16632-16637.
Crossref
Holger Sondermann, Stephen M. Soisson, Sean Boykevisch, Shao-Song Yang, Dafna Bar-Sagi & John Kuriyan. (2004) Structural Analysis of Autoinhibition in the Ras Activator Son of Sevenless. Cell 119:3, pages 393-405.
Crossref
Laura Patrussi & Cosima T. Baldari. (2004) Positive and negative regulators of Ras in T cells. Signal Transduction 4:1-2, pages 9-16.
Crossref
Holger Sondermann, Stephen M Soisson, Dafna Bar-Sagi & John Kuriyan. (2003) Tandem Histone Folds in the Structure of the N-Terminal Segment of the Ras Activator Son of Sevenless. Structure 11:12, pages 1583-1593.
Crossref
Nathaly Marcoux & Kristiina Vuori. (2003) EGF receptor mediates adhesion-dependent activation of the Rac GTPase: a role for phosphatidylinositol 3-kinase and Vav2. Oncogene 22:38, pages 6100-6106.
Crossref
Ernesto J. Fuentes, Antoine E. Karnoub, Michelle A. Booden, Channing J. Der & Sharon L. Campbell. (2003) Critical Role of the Pleckstrin Homology Domain in Dbs Signaling and Growth Regulation. Journal of Biological Chemistry 278:23, pages 21188-21196.
Crossref
Rocı́o Jorge, Natasha Zarich, José Luis Oliva, Marta Azañedo, Natalia Martı́nez, Xavier de la Cruz & José M. Rojas. (2002) hSos1 Contains a New Amino-terminal Regulatory Motif with Specific Binding Affinity for Its Pleckstrin Homology Domain. Journal of Biological Chemistry 277:46, pages 44171-44179.
Crossref
Shuichi Furuta, Koichi Miura, Terry Copeland, Wei Hao Shang, Aki Oshima & Tohru Kamata. (2002) Light Chain 3 associates with a Sos1 guanine nucleotide exchange factor: its significance in the Sos1-mediated Rac1 signaling leading to membrane ruffling. Oncogene 21:46, pages 7060-7066.
Crossref
Lawrence A Quilliam, John F Rebhun & Ariel F Castro. 2002. 391 444 .
Koichi Miura, Shoko Miyazawa, Shuichi Furuta, Junji Mitsushita, Keiju Kamijo, Hiroshi Ishida, Toru Miki, Kazumi Suzukawa, James Resau, Terry D. Copeland & Tohru Kamata. (2001) The Sos1-Rac1 Signaling. Journal of Biological Chemistry 276:49, pages 46276-46283.
Crossref
Brian E. Hall, Shao Song Yang, P. Ann Boriack-Sjodin, John Kuriyan & Dafna Bar-Sagi. (2001) Structure-based Mutagenesis Reveals Distinct Functions for Ras Switch 1 and Switch 2 in Sos-catalyzed Guanine Nucleotide Exchange. Journal of Biological Chemistry 276:29, pages 27629-27637.
Crossref
Chiara Russo, Yuan Gao, Patrizia Mancini, Cristina Vanni, Matteo Porotto, Marco Falasca, Maria Rosaria Torrisi, Yi Zheng & Alessandra Eva. (2001) Modulation of Oncogenic DBL Activity by Phosphoinositol Phosphate Binding to Pleckstrin Homology Domain. Journal of Biological Chemistry 276:22, pages 19524-19531.
Crossref
Giovanna Benvenuto, Shaowei Li, Samantha J Brown, Richard Braverman, William C Vass, Jeremy P Cheadle, Dicky JJ Halley, Julian R Sampson, Ralf Wienecke & Jeffrey E DeClue. (2000) The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination. Oncogene 19:54, pages 6306-6316.
Crossref
Jodi Clyde-Smith, Gint Silins, Michael Gartside, Sean Grimmond, Maria Etheridge, Ann Apolloni, Nick Hayward & John F. Hancock. (2000) Characterization of RasGRP2, a Plasma Membrane-targeted, Dual Specificity Ras/Rap Exchange Factor. Journal of Biological Chemistry 275:41, pages 32260-32267.
Crossref
Kejin Zhu, Balazs Debreceni, Rong Li & Yi Zheng. (2000) Identification of Rho GTPase-dependent Sites in the Dbl Homology Domain of Oncogenic Dbl That Are Required for Transformation. Journal of Biological Chemistry 275:34, pages 25993-26001.
Crossref
Imanol Arozarena, David S. Aaronson, David Matallanas, Victoria Sanz, Nuria Ajenjo, Stephan P. Tenbaum, Hidemi Teramoto, Tadashi Ighishi, Juan C. Zabala, J. Silvio Gutkind & Piero Crespo. (2000) The Rho Family GTPase Cdc42 Regulates the Activation of Ras/MAP Kinase by the Exchange Factor Ras-GRF. Journal of Biological Chemistry 275:34, pages 26441-26448.
Crossref
Reneé A Chen, Tamer Michaeli, Linda Van Aelst & Roymarie Ballester. (2000) A Role for the Noncatalytic N Terminus in the Function of Cdc25, a Saccharomyces cerevisiae Ras-Guanine Nucleotide Exchange Factor. Genetics 154:4, pages 1473-1484.
Crossref
Xiaolan Qian, Luis Esteban, William C. Vass, Cheerag Upadhyaya, Alex G. Papageorge, Kate Yienger, Jerrold M. Ward, Douglas R. Lowy & Eugenio Santos. (2000) The Sos1 and Sos2 Ras-specific exchange factors: differences in placental expression and signaling properties. The EMBO Journal 19:4, pages 642-654.
Crossref
Angelita RebolloCarlos Martı́nez-A. (1999) Ras Proteins: Recent Advances and New Functions. Blood 94:9, pages 2971-2980.
Crossref
Angelita RebolloCarlos Martı́nez-A. (1999) Ras Proteins: Recent Advances and New Functions. Blood 94:9, pages 2971-2980.
Crossref
Vincent C. Dodelet, Claudia Pazzagli, Andreas H. Zisch, Craig A. Hauser & Elena B. Pasquale. (1999) A Novel Signaling Intermediate, SHEP1, Directly Couples Eph Receptors to R-Ras and Rap1A. Journal of Biological Chemistry 274:45, pages 31941-31946.
Crossref
Niklas Blomberg, Elena Baraldi, Michael Nilges & Matti Saraste. (1999) The PH superfold: a structural scaffold for multiple functions. Trends in Biochemical Sciences 24:11, pages 441-445.
Crossref
Mousumi Majumdar, Tammy M. Seasholtz, Carolan Buckmaster, Deniz Toksoz & Joan Heller Brown. (1999) A Rho Exchange Factor Mediates Thrombin and Gα12-induced Cytoskeletal Responses. Journal of Biological Chemistry 274:38, pages 26815-26821.
Crossref
Yoav Arava, Rony Seger & Michael D. Walker. (1999) GRFβ, a Novel Regulator of Calcium Signaling, Is Expressed in Pancreatic Beta Cells and Brain. Journal of Biological Chemistry 274:35, pages 24449-24452.
Crossref
Raymond V. Fucini, Shuichi Okada & Jeffrey E. Pessin. (1999) Insulin-induced Desensitization of Extracellular Signal-regulated Kinase Activation Results from an Inhibition of Raf Activity Independent of Ras Activation and Dissociation of the Grb2-SOS Complex. Journal of Biological Chemistry 274:26, pages 18651-18658.
Crossref
Tamotsu Ichiba, Yuko Hashimoto, Mie Nakaya, Yasunobu Kuraishi, Shinya Tanaka, Takeshi Kurata, Naoki Mochizuki & Michiyuki Matsuda. (1999) Activation of C3G Guanine Nucleotide Exchange Factor for Rap1 by Phosphorylation of Tyrosine 504. Journal of Biological Chemistry 274:20, pages 14376-14381.
Crossref
Xiaohong Liu, Hong Wang, Matthias Eberstadt, Arndt Schnuchel, Edward T Olejniczak, Robert P Meadows, Jeff M Schkeryantz, David A Janowick, John E Harlan, Edith A.S Harris, Donald E Staunton & Stephen W Fesik. (1998) NMR Structure and Mutagenesis of the N-Terminal Dbl Homology Domain of the Nucleotide Exchange Factor Trio. Cell 95:2, pages 269-277.
Crossref
Stephen M. Soisson, Anjaruwee S. Nimnual, Marc Uy, Dafna Bar-Sagi & John Kuriyan. (1998) Crystal Structure of the Dbl and Pleckstrin Homology Domains from the Human Son of Sevenless Protein. Cell 95:2, pages 259-268.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.