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Molecular and Cellular Biology Volume 18, 1998 - Issue 2
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Cell and Organelle Structure and Assembly

GTP Hydrolysis Is Not Important for Ypt1 GTPase Function in Vesicular Transport

Celeste J. Richardsona Departments of Biochemistry and Molecular Biology
,
Sara Jonesb Pharmacological and Physiological Sciences
,
Robert J. Littc Molecular Genetics and Cell Biology, The University of Chicago, Chicago, Illinois
&
Nava Segevb Pharmacological and Physiological Sciences;c Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IllinoisCorrespondence[email protected]
Pages 827-838 | Received 15 Sep 1997, Accepted 05 Nov 1997, Published online: 28 Mar 2023

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Anne Lisa Mitter, Petra Schlotterhose & Roswitha Krick. (2019) Gyp1 has a dual function as Ypt1 GAP and interaction partner of Atg8 in selective autophagy. Autophagy 15:6, pages 1031-1050.
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Zhanna Lipatova, Adelaide U. Hain, Volodymyr Y. Nazarko & Nava Segev. (2015) Ypt/Rab GTPases: Principles learned from yeast. Critical Reviews in Biochemistry and Molecular Biology 50:3, pages 203-211.
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Céline Lafourcade, Jean-Marc Galan, Yvonne Gloor, Rosine Haguenauer-Tsapis & Matthias Peter. (2004) The GTPase-Activating Enzyme Gyp1p Is Required for Recycling of Internalized Membrane Material by Inactivation of the Rab/Ypt GTPase Ypt1p. Molecular and Cellular Biology 24:9, pages 3815-3826.
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Gwo-Jen Day, Raymond D. Mosteller & Daniel Broek. (1998) Distinct Subclasses of Small GTPases Interact with Guanine Nucleotide Exchange Factors in a Similar Manner. Molecular and Cellular Biology 18:12, pages 7444-7454.
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Articles from other publishers (31)

Jane J. Kim, Zanna Lipatova & Nava Segev. 2021. Rab GTPases. Rab GTPases 189 199 .
Chang Ho Kang, Joung Hun Park, Eun Seon Lee, Seol Ki Paeng, Ho Byoung Chae, Yong Hun Chi & Sang Yeol Lee. (2019) Exploring Novel Functions of the Small GTPase Ypt1p under Heat-Shock by Characterizing a Temperature-Sensitive Mutant Yeast Strain, ypt1-G80D. International Journal of Molecular Sciences 20:1, pages 132.
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Chang Ho Kang, Sun Yong Lee, Joung Hun Park, Yuno Lee, Hyun Suk Jung, Yong Hun Chi, Young Jun Jung, Ho Byoung Chae, Mi Rim Shin, Woe Yeon Kim, Dae‐Jin Yun & Sang Yeol Lee. (2015) Stress‐driven structural and functional switching of Ypt1p from a GTPase to a molecular chaperone mediates thermo tolerance in Saccharomyces cerevisiae . The FASEB Journal 29:11, pages 4424-4434.
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MinJung Kim, Yee Sun Tan, Wen-Chih Cheng, Tami J. Kingsbury, Shelly Heimfeld & Curt I. Civin. (2015) MIR144 and MIR451 regulate human erythropoiesis via RAB14 . British Journal of Haematology 168:4, pages 583-597.
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Diego Huet, Thierry Blisnick, Sylvie Perrot & Philippe Bastin. (2014) The GTPase IFT27 is involved in both anterograde and retrograde intraflagellar transport. eLife 3.
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Lars Langemeyer, Ricardo Nunes Bastos, Yiying Cai, Aymelt Itzen, Karin M Reinisch & Francis A Barr. (2014) Diversity and plasticity in Rab GTPase nucleotide release mechanism has consequences for Rab activation and inactivation. eLife 3.
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Francis A. Barr. (2013) Rab GTPases and membrane identity: Causal or inconsequential?. Journal of Cell Biology 202:2, pages 191-199.
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Agnieszka Lewandowska, Jane Macfarlane & Janet M. Shaw. (2013) Mitochondrial association, protein phosphorylation, and degradation regulate the availability of the active Rab GTPase Ypt11 for mitochondrial inheritance. Molecular Biology of the Cell 24:8, pages 1185-1195.
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Nikoleta G. Tsvetanova, Daniel P. Riordan & Patrick O. Brown. (2012) The Yeast Rab GTPase Ypt1 Modulates Unfolded Protein Response Dynamics by Regulating the Stability of HAC1 RNA. PLoS Genetics 8:7, pages e1002862.
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Francesca Bottanelli, David C. Gershlick & Jürgen Denecke. (2012) Evidence for Sequential Action of Rab5 and Rab7 GTPases in Prevacuolar Organelle Partitioning. Traffic 13:2, pages 338-354.
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Francesca Bottanelli, Ombretta Foresti, Sally Hanton & Jürgen Denecke. (2011) Vacuolar Transport in Tobacco Leaf Epidermis Cells Involves a Single Route for Soluble Cargo and Multiple Routes for Membrane Cargo. The Plant Cell 23:8, pages 3007-3025.
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Hazel Pinheiro, Marketa Samalova, Niko Geldner, Joanne Chory, Alberto Martinez & Ian Moore. (2009) Genetic evidence that the higher plant Rab-D1 and Rab-D2 GTPases exhibit distinct but overlapping interactions in the early secretory pathway. Journal of Cell Science 122:20, pages 3749-3758.
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Kimberly Romero Rosales, Eigen R. Peralta, Garret G. Guenther, Susan Y. Wong & Aimee L. Edinger. (2009) Rab7 Activation by Growth Factor Withdrawal Contributes to the Induction of Apoptosis. Molecular Biology of the Cell 20:12, pages 2831-2840.
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Michael Sacher, Yeon-Gil Kim, Arnon Lavie, Byung-Ha Oh & Nava Segev. (2008) The TRAPP Complex: Insights into its Architecture and Function. Traffic 9:12, pages 2032-2042.
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Hao Wu, Guendalina Rossi & Patrick Brennwald. (2008) The ghost in the machine: small GTPases as spatial regulators of exocytosis. Trends in Cell Biology 18:9, pages 397-404.
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Enrique RojoJurgen Denecke. (2008) What Is Moving in the Secretory Pathway of Plants?. Plant Physiology 147:4, pages 1493-1503.
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Alexander K. Haas, Shin-ichiro Yoshimura, David J. Stephens, Christian Preisinger, Evelyn Fuchs & Francis A. Barr. (2007) Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells. Journal of Cell Science 120:17, pages 2997-3010.
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Alexander K. Haas, Evelyn Fuchs, Robert Kopajtich & Francis A. Barr. (2005) A GTPase-activating protein controls Rab5 function in endocytic trafficking. Nature Cell Biology 7:9, pages 887-893.
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André Bernards. (2003) GAPs galore! A survey of putative Ras superfamily GTPase activating proteins in man and Drosophila. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1603:2, pages 47-82.
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Anna De Antoni, Jana Schmitzová, Hans-Heinrich Trepte, Dieter Gallwitz & Štefan Albert. (2002) Significance of GTP Hydrolysis in Ypt1p-regulated Endoplasmic Reticulum to Golgi Transport Revealed by the Analysis of Two Novel Ypt1-GAPs. Journal of Biological Chemistry 277:43, pages 41023-41031.
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Martin Götte, Thomas Lazar, Jin-San Yoo, Dietrich Scheglmann & Dieter Gallwitz. 2002. Fusion of Biological Membranes and Related Problems. Fusion of Biological Membranes and Related Problems 133 173 .
Nava Segev. (2001) Ypt/Rab GTPases: Regulators of Protein Trafficking. Science's STKE 2001:100.
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Orson L. MoritzBeatrice M. TamLarry L. HurdJohan Peränen, Dusanka Deretic & David S. Papermaster. (2001) Mutant rab8 Impairs Docking and Fusion of Rhodopsin-bearing Post-Golgi Membranes and Causes Cell Death of Transgenic Xenopus Rods . Molecular Biology of the Cell 12:8, pages 2341-2351.
Crossref
Nava Segev. (2001) Ypt and Rab GTPases: insight into functions through novel interactions. Current Opinion in Cell Biology 13:4, pages 500-511.
Crossref
Li-Lin Du & Peter Novick. (2001) Yeast Rab GTPase-activating Protein Gyp1p Localizes to the Golgi Apparatus and Is a Negative Regulator of Ypt1p. Molecular Biology of the Cell 12:5, pages 1215-1226.
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Yoshimi Takai, Takuya Sasaki & Takashi Matozaki. (2001) Small GTP-Binding Proteins. Physiological Reviews 81:1, pages 153-208.
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Lisya Gerez, Karin Mohrmann, Marcel van Raak, Mandy Jongeneelen, Xiao Zhen Zhou, Kun Ping Lu & Peter van der Sluijs. (2000) Accumulation of rab4GTP in the Cytoplasm and Association with the Peptidyl-Prolyl Isomerase Pin1 during Mitosis. Molecular Biology of the Cell 11:7, pages 2201-2211.
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Martin Hetzer, Daniel Bilbao-Cortés, Tobias C Walther, Oliver J Gruss & Iain W Mattaj. (2000) GTP Hydrolysis by Ran Is Required for Nuclear Envelope Assembly. Molecular Cell 5:6, pages 1013-1024.
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Philippe Chavrier & Bruno Goud. (1999) The role of ARF and Rab GTPases in membrane transport. Current Opinion in Cell Biology 11:4, pages 466-475.
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Petra Vollmer, Elke Will, Dietrich Scheglmann, Molly Strom & Dieter Gallwitz. (1999) Primary structure and biochemical characterization of yeast GTPase-activating proteins with substrate preference for the transport GTPase Ypt7p. European Journal of Biochemistry 260:1, pages 284-290.
Crossref
Sara JonesCeleste J. Richardson, Robert J. Litt & Nava Segev. (1998) Identification of Regulators for Ypt1 GTPase Nucleotide Cycling. Molecular Biology of the Cell 9:10, pages 2819-2837.
Crossref

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