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Cell Growth and Development

The Mdm2 Oncoprotein Interacts with the Cell Fate Regulator Numb

Tamar Juven-GershonDepartment of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot76100, Israel
,
Ohad ShifmanDepartment of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot76100, Israel
,
Tamar UngerDepartment of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot76100, Israel
,
Adi ElkelesDepartment of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot76100, Israel
,
Ygal HauptDepartment of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot76100, Israel
&
Moshe OrenDepartment of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot76100, IsraelCorrespondence[email protected]
Pages 3974-3982 | Received 17 Dec 1997, Accepted 21 Apr 1998, Published online: 28 Mar 2023

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Jiabin Liang, Bingbing Han, Yunhe Zhang & Qingfen Yue. (2019) Numb inhibits cell proliferation, invasion, and epithelial–mesenchymal transition through PAK1/β-catenin signaling pathway in ovarian cancer. OncoTargets and Therapy 12, pages 3223-3233.
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Khue Vu Nguyen. (2010) Human p53 and Hdm2: Cloning and Construction of Expression Plasmid. Analytical Letters 43:2, pages 323-334.
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Haiyan Tang, Santiago B. Rompani, Joshua B. Atkins, Yan Zhou, Thomas Osterwalder & Weimin Zhong. (2005) Numb Proteins Specify Asymmetric Cell Fates via an Endocytosis- and Proteasome-Independent Pathway. Molecular and Cellular Biology 25:8, pages 2899-2909.
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Alyssa M. Klein, Rafaela Muniz de Queiroz, Divya Venkatesh & Carol Prives. (2021) The roles and regulation of MDM2 and MDMX: it is not just about p53. Genes & Development 35:9-10, pages 575-601.
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Jie Xian, Yu Cheng, Xue Qin, Yijia Cao, Yetao Luo & Youde Cao. (2020) Progress in the research of p53 tumour suppressor activity controlled by Numb in triple‐negative breast cancer. Journal of Cellular and Molecular Medicine 24:13, pages 7451-7459.
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Stefano Confalonieri, Ivan Nicola Colaluca, Andrea Basile, Salvatore Pece & Pier Paolo Di Fiore. (2019) Exon 3 of the NUMB Gene Emerged in the Chordate Lineage Coopting the NUMB Protein to the Regulation of MDM2 . G3 Genes|Genomes|Genetics 9:10, pages 3359-3367.
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Erik W. J. Mollen, Jonathan Ient, Vivianne C. G. Tjan-Heijnen, Liesbeth J. Boersma, Lucio Miele, Marjolein L. Smidt & Marc A. G. G. Vooijs. (2018) Moving Breast Cancer Therapy up a Notch. Frontiers in Oncology 8.
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Ran Wei, Tomonori Kaneko, Xuguang Liu, Huadong Liu, Lei Li, Courtney Voss, Eric Liu, Ningning He & Shawn S.-C. Li. (2018) Interactome Mapping Uncovers a General Role for Numb in Protein Kinase Regulation. Molecular & Cellular Proteomics 17:11, pages 2216-2228.
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José Manuel García-Heredia & Amancio Carnero. (2018) NUMB and NUMBL differences in gene regulation. Oncotarget 9:10, pages 9219-9234.
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C Shao, S-J Chien, E Farah, Z Li, N Ahmad & X Liu. (2017) Plk1 phosphorylation of Numb leads to impaired DNA damage response. Oncogene 37:6, pages 810-820.
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Ahmed El-HashashAhmed El-Hashash. 2018. Lung Stem Cell Behavior. Lung Stem Cell Behavior 35 55 .
José M. García-Heredia, Eva M. Verdugo Sivianes, Antonio Lucena-Cacace, Sonia Molina-Pinelo & Amancio Carnero. (2016) Numb-like (NumbL) downregulation increases tumorigenicity, cancer stem cell-like properties and resistance to chemotherapy. Oncotarget 7:39, pages 63611-63628.
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Vasanth Ramamurthy, Christine Jolicoeur, Demetra Koutroumbas, Johanna Mühlhans, Yun-Zheng Le, William W. Hauswirth, Andreas Giessl & Michel Cayouette. (2014) Numb Regulates the Polarized Delivery of Cyclic Nucleotide-Gated Ion Channels in Rod Photoreceptor Cilia. The Journal of Neuroscience 34:42, pages 13976-13987.
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Mohamed Berika, Marwa E. Elgayyar & Ahmed H. K. El-Hashash. (2014) Asymmetric cell division of stem cells in the lung and other systems. Frontiers in Cell and Developmental Biology 2.
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