Advanced search
Publication Cover
Molecular and Cellular Biology Volume 18, 1998 - Issue 7
Submit an article Journal homepage
20
Views
61
CrossRef citations to date
0
Altmetric
Transcriptional Regulation

Cytoplasmic Sequestration of the Polyomavirus Enhancer Binding Protein 2 (PEBP2)/Core Binding Factor α (CBFα) Subunit by the Leukemia-Related PEBP2/CBFβ-SMMHC Fusion Protein Inhibits PEBP2/CBF-Mediated Transactivation

Yuka KannoDepartment of Viral Oncology, Institute for Virus Research, Kyoto University, Kyoto606, Japan
,
Tomohiko KannoDepartment of Viral Oncology, Institute for Virus Research, Kyoto University, Kyoto606, Japan
,
Chohei SakakuraDepartment of Viral Oncology, Institute for Virus Research, Kyoto University, Kyoto606, Japan
,
Suk-Chul BaeDepartment of Viral Oncology, Institute for Virus Research, Kyoto University, Kyoto606, Japan
&
Yoshiaki ItoDepartment of Viral Oncology, Institute for Virus Research, Kyoto University, Kyoto606, JapanCorrespondence[email protected]
Pages 4252-4261 | Received 04 Mar 1998, Accepted 21 Apr 1998, Published online: 28 Mar 2023

Citations (61)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (3)

Genyan Yang, Waleed Khalaf, Louis van de Locht, Joop H. Jansen, Meihua Gao, Mary Ann Thompson, Bert A. van der Reijden, David H. Gutmann, Ruud Delwel, D. Wade Clapp & Scott W. Hiebert. (2005) Transcriptional Repression of the Neurofibromatosis-1 Tumor Suppressor by the t(8;21) Fusion Protein. Molecular and Cellular Biology 25:14, pages 5869-5879.
Read now
Kristie L. Durst, Bart Lutterbach, Tanawan Kummalue, Alan D. Friedman & Scott W. Hiebert. (2003) The inv(16) Fusion Protein Associates with Corepressors via a Smooth Muscle Myosin Heavy-Chain Domain. Molecular and Cellular Biology 23:2, pages 607-619.
Read now
Tanawan Kummalue, Jianrong Lou & Alan D. Friedman. (2002) Multimerization via Its Myosin Domain Facilitates Nuclear Localization and Inhibition of Core Binding Factor (CBF) Activities by the CBFβ-Smooth Muscle Myosin Heavy Chain Myeloid Leukemia Oncoprotein. Molecular and Cellular Biology 22:23, pages 8278-8291.
Read now

Articles from other publishers (58)

Tatsushi Yoshida, Kenta Yamasaki, Kenjiro Tadagaki, Yasumichi Kuwahara, Akifumi Matsumoto, Adèm Sofovic, Noriko Kondo, Toshiyuki Sakai & Tsukasa Okuda. (2021) Tumor necrosis factor‑related apoptosis‑inducing ligand is a novel transcriptional target of runt‑related transcription factor 1. International Journal of Oncology 60:1.
Crossref
Peng Liu, Jin-Pin Liu, Si-Jia Sun, Yun Gao, Yingjie Ai, Xiufei Chen, Yiping Sun, Mengyu Zhou, Yun Liu, Yue Xiong & Hai-Xin Yuan. (2021) CBFB-MYH11 Fusion Sequesters RUNX1 in Cytoplasm to Prevent DNMT3A Recruitment to Target Genes in AML. Frontiers in Cell and Developmental Biology 9.
Crossref
. (2020) Insights into Acute Myeloid Leukemia: Critical Analysis on its Wide Aspects. Abasyn Journal Life Sciences, pages 1-9.
Crossref
Gaëlle Cordonnier, Amit Mandoli, Nicolas Cagnard, Guillaume Hypolite, Ludovic Lhermitte, Els Verhoeyen, Vahid Asnafi, Niall Dillon, Elizabeth Macintyre, Joost H.A. Martens & Jonathan Bond. (2020) CBFβ-SMMHC Affects Genome-wide Polycomb Repressive Complex 1 Activity in Acute Myeloid Leukemia. Cell Reports 30:2, pages 299-307.e3.
Crossref
Ya-Huei Kuo, Jing Qi & Guerry J. Cook. (2016) Regain control of p53: Targeting leukemia stem cells by isoform-specific HDAC inhibition. Experimental Hematology 44:5, pages 315-321.
Crossref
Jing Qi, Sandeep Singh, Wei-Kai Hua, Qi Cai, Shi-Wei Chao, Ling Li, Hongjun Liu, Yinwei Ho, Tinisha McDonald, Allen Lin, Guido Marcucci, Ravi Bhatia, Wei-Jan Huang, Chung-I Chang & Ya-Huei Kuo. (2015) HDAC8 Inhibition Specifically Targets Inv(16) Acute Myeloid Leukemic Stem Cells by Restoring p53 Acetylation. Cell Stem Cell 17:5, pages 597-610.
Crossref
Chandrima Sinha, Lea C. Cunningham & Paul P. Liu. (2015) Core Binding Factor Acute Myeloid Leukemia: New Prognostic Categories and Therapeutic Opportunities. Seminars in Hematology 52:3, pages 215-222.
Crossref
Cesar Lopez-Camacho, Andre J. van Wijnen, Jane B. Lian, Janet L. Stein & Gary S. Stein. (2014) CBFβ and the Leukemogenic Fusion Protein CBFβ-SMMHC Associate With Mitotic Chromosomes to Epigenetically Regulate Ribosomal Genes. Journal of Cellular Biochemistry 115:12, pages 2155-2164.
Crossref
Cesar Lopez-Camacho, Andre J. van Wijnen, Jane B. Lian, Janet L. Stein & Gary S. Stein. (2014) Core Binding Factor β (CBFβ) Is Retained in the Midbody During Cytokinesis. Journal of Cellular Physiology 229:10, pages 1466-1474.
Crossref
A Mandoli, A A Singh, P W T C Jansen, A T J Wierenga, H Riahi, G Franci, K Prange, S Saeed, E Vellenga, M Vermeulen, H G Stunnenberg & J H A Martens. (2013) CBFB–MYH11/RUNX1 together with a compendium of hematopoietic regulators, chromatin modifiers and basal transcription factors occupies self-renewal genes in inv(16) acute myeloid leukemia. Leukemia 28:4, pages 770-778.
Crossref
Tanja A. Gruber & James R. Downing. 2013. Childhood Leukemias. Childhood Leukemias 204 238 .
Robert B. Lorsbach. 2011. Diagnostic Pediatric Hematopathology. Diagnostic Pediatric Hematopathology 272 309 .
Mickey Liao & Gary J. Schiller. 2010. Allogeneic Stem Cell Transplantation. Allogeneic Stem Cell Transplantation 177 192 .
Kevin A. Link, Fu-Sheng Chou & James C. Mulloy. (2010) Core binding factor at the crossroads: Determining the fate of the HSC. Journal of Cellular Physiology 222:1, pages 50-56.
Crossref
Hee-Jun WeeDominic Chih-Cheng VoonSuk-Chul Bae & Yoshiaki Ito. (2008) PEBP2-β/CBF-β–dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesis. Blood 112:9, pages 3777-3787.
Crossref
A M S Müller, J Duque, J A Shizuru & M Lübbert. (2008) Complementing mutations in core binding factor leukemias: from mouse models to clinical applications. Oncogene 27:44, pages 5759-5773.
Crossref
Masahiro Ono, Hiroko Yaguchi, Naganari Ohkura, Issay Kitabayashi, Yuko Nagamura, Takashi Nomura, Yoshiki Miyachi, Toshihiko Tsukada & Shimon Sakaguchi. (2007) Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1. Nature 446:7136, pages 685-689.
Crossref
Jan Markus, Matthew T. Garin, Juraj Bies, Naomi Galili, Azra Raza, Michael J. Thirman, Michelle M. Le Beau, Janet D. Rowley, P. Paul Liu & Linda Wolff. (2007) Methylation-Independent Silencing of the Tumor Suppressor INK4b (p15) by CBFβ-SMMHC in Acute Myelogenous Leukemia with inv(16) . Cancer Research 67:3, pages 992-1000.
Crossref
Weiqiang Zhao, David F. Claxton, L. Jeffrey Medeiros, Di Lu, Saroj Vadhan-Raj, Hagop M. Kantarjian, Martin H. Nguyen & Carlos E. Bueso-Ramos. (2006) Immunohistochemical Analysis of CBFβ-SMMHC Protein Reveals a Unique Nuclear Localization in Acute Myeloid Leukemia With inv(16)(p13q22). American Journal of Surgical Pathology 30:11, pages 1436-1444.
Crossref
Mireia Camós & Dolors Colomer. (2006) Molecular biology in acute leukemia. Clinical and Translational Oncology 8:8, pages 550-559.
Crossref
Robert B. Lorsbach & James R. Downing. 2010. Childhood Leukemias. Childhood Leukemias 298 338 .
Suk-Chul Bae & Yong Hee Lee. (2006) Phosphorylation, acetylation and ubiquitination: The molecular basis of RUNX regulation. Gene 366:1, pages 58-66.
Crossref
Björn Steffen, Carsten Müller-Tidow, Joachim Schwäble, Wolfgang E. Berdel & Hubert Serve. (2005) The molecular pathogenesis of acute myeloid leukemia. Critical Reviews in Oncology/Hematology 56:2, pages 195-221.
Crossref
Stefan Fröhling, Claudia Scholl, D. Gary Gilliland & Ross L. Levine. (2005) Genetics of Myeloid Malignancies: Pathogenetic and Clinical Implications. Journal of Clinical Oncology 23:26, pages 6285-6295.
Crossref
Chouhei Sakakura, Akeo Hagiwara, Koji Miyagawa, Susumu Nakashima, Tetsuji Yoshikawa, Shuichi Kin, Yuenn Nakase, Kosei Ito, Hisakazu Yamagishi, Shujiro Yazumi, Tsutomu Chiba & Yoshiaki Ito. (2005) Frequent downregulation of the runt domain transcription factorsRUNX1,RUNX3 and their cofactorCBFB in gastric cancer. International Journal of Cancer 113:2, pages 221-228.
Crossref
Katsuya Shigesada, Bart van de Sluis & P Paul Liu. (2004) Mechanism of leukemogenesis by the inv(16) chimeric gene CBFB/PEBP2B-MHY11. Oncogene 23:24, pages 4297-4307.
Crossref
Ewan R Cameron & James C Neil. (2004) The Runx genes: lineage-specific oncogenes and tumor suppressors. Oncogene 23:24, pages 4308-4314.
Crossref
Gang HuangKatsuya ShigesadaHee-Jun WeeP. Paul LiuMotomi OsatoYoshiaki Ito. (2004) Molecular basis for a dominant inactivation of RUNX1/AML1 by the leukemogenic inversion 16 chimera. Blood 103:8, pages 3200-3207.
Crossref
Hironori HaradaYuka HaradaHiromasa NiimiTaiichi KyoAkiro KimuraToshiya Inaba. (2004) High incidence of somatic mutations in the AML1/RUNX1 gene in myelodysplastic syndrome and low blast percentage myeloid leukemia with myelodysplasia. Blood 103:6, pages 2316-2324.
Crossref
Takakazu HIGUCHI & Mitsuhiro OMINE. (2004) Role of Histone Acetylation in Hematological Malignancies. The Showa University Journal of Medical Sciences 16:1, pages 1-16.
Crossref
Wolfgang Hiddemann, Heinz Huber & Claus R. BartramW. Kern, T. Haferlach & W. Hiddemann. 2004. Die Onkologie. Die Onkologie 1847 1915 .
Lina Zhang, Stephen M Lukasik, Nancy A Speck & John H Bushweller. (2003) Structural and functional characterization of Runx1, CBFβ, and CBFβ-SMMHC. Blood Cells, Molecules, and Diseases 30:2, pages 147-156.
Crossref
Norio Asou. (2003) The role of a Runt domain transcription factor AML1/RUNX1 in leukemogenesis and its clinical implications. Critical Reviews in Oncology/Hematology 45:2, pages 129-150.
Crossref
S. W. Hiebert, B. Lutterbach, J. Amann, K. Durst & B. Linggi. 2003. Acute Leukemias IX. Acute Leukemias IX 21 24 .
Mondira KunduAmy ChenStacie AndersonMartha KirbyLiPing XuLucio H. CastillaDavid BodinePu Paul Liu. (2002) Role of Cbfb in hematopoiesis and perturbations resulting from expression of the leukemogenic fusion gene Cbfb-MYH11. Blood 100:7, pages 2449-2456.
Crossref
Taketoshi Yoshida, Hirokazu Kanegane, Motomi Osato, Masatoshi Yanagida, Toshio Miyawaki, Yoshiaki Ito & Katsuya Shigesada. (2002) Functional Analysis of RUNX2 Mutations in Japanese Patients with Cleidocranial Dysplasia Demonstrates Novel Genotype-Phenotype Correlations. The American Journal of Human Genetics 71:4, pages 724-738.
Crossref
Jae Kyun Rho, Jae Hyun Kim, Jiyeon Yu & Soo Young Choe. (2002) Correlation between cellular localization of TEL/AML1 fusion protein and repression of AML1-mediated transactivation of CR1 gene. Biochemical and Biophysical Research Communications 297:1, pages 91-95.
Crossref
R Nishimura, K Hata, S.E Harris, F Ikeda & T Yoneda. (2002) Core-binding factor α1 (Cbfa1) induces osteoblastic differentiation of C2C12 cells without interactions with Smad1 and Smad5. Bone 31:2, pages 303-312.
Crossref
Nancy A. Speck & D. Gary Gilliland. (2002) Core-binding factors in haematopoiesis and leukaemia. Nature Reviews Cancer 2:7, pages 502-513.
Crossref
Joseph M Scandura, Piernicola Boccuni, Jorg Cammenga & Stephen D Nimer. (2002) Transcription factor fusions in acute leukemia: variations on a theme. Oncogene 21:21, pages 3422-3444.
Crossref
Myriam Alcalay, Annette Orleth, Carla Sebastiani, Natalia Meani, Ferdinando Chiaradonna, Cristina Casciari, Maria Teresa Sciurpi, Vania Gelmetti, Daniela Riganelli, Saverio Minucci, Marta Fagioli & Pier Giuseppe Pelicci. (2001) Common themes in the pathogenesis of acute myeloid leukemia. Oncogene 20:40, pages 5680-5694.
Crossref
Jonathan D Licht. (2001) AML1 and the AML1-ETO fusion protein in the pathogenesis of t(8;21) AML. Oncogene 20:40, pages 5660-5679.
Crossref
Joshua S. KaminkerRajan SinghTim LebestkyHuajun YanUtpal Banerjee. (2001) Redundant function of Runt Domain binding partners, Big brother and Brother, during Drosophila development . Development 128:14, pages 2639-2648.
Crossref
Mondira Kundu & Pu Paul Liu. (2001) Function of the inv(16) fusion gene CBFB-MYH11. Current Opinion in Hematology 8:4, pages 201-205.
Crossref
Janelle D. MillerTerryl StacyP. Paul LiuNancy A. Speck. (2001) Core-binding factor β (CBFβ), but not CBFβ–smooth muscle myosin heavy chain, rescues definitive hematopoiesis in CBFβ-deficient embryonic stem cells. Blood 97:8, pages 2248-2256.
Crossref
Peter B. Langmuir, Richard Aplenc & Beverly J. Lange. (2001) Acute myeloid leukaemia in children. Best Practice & Research Clinical Haematology 14:1, pages 77-93.
Crossref
N Adya, L.H Castilla & P.P Liu. (2000) Function of CBFβ/Bro proteins. Seminars in Cell & Developmental Biology 11:5, pages 361-368.
Crossref
S Kanto, N Chiba, Y Tanaka, S Fujita, M Endo, N Kamada, K Yoshikawa, A Fukuzaki, S Orikasa, T Watanabe & M Satake. (2000) The PEBP2β/CBFβ-SMMHC chimeric protein is localized both in the cell membrane and nuclear subfractions of leukemic cells carrying chromosomal inversion 16. Leukemia 14:7, pages 1253-1259.
Crossref
B Lutterbach & S.W Hiebert. (2000) Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation. Gene 245:2, pages 223-235.
Crossref
David K. Strom, John Nip, Jennifer J. Westendorf, Bryan Linggi, Bart Lutterbach, James R. Downing, Noel Lenny & Scott W. Hiebert. (2000) Expression of the AML-1 Oncogene Shortens the G1Phase of the Cell Cycle. Journal of Biological Chemistry 275:5, pages 3438-3445.
Crossref
Yoshiaki Ito. (1999) Molecular basis of tissue-specific gene expression mediated by the Runt domain transcription factor PEBP2/CBF. Genes to Cells 4:12, pages 685-696.
Crossref
Bart Lutterbach, Yue Hou, Kristie L. Durst & Scott W. Hiebert. (1999) The inv(16) encodes an acute myeloid leukemia 1 transcriptional corepressor. Proceedings of the National Academy of Sciences 96:22, pages 12822-12827.
Crossref
Bob Lowenberg, James R. Downing & Alan Burnett. (1999) Acute Myeloid Leukemia. New England Journal of Medicine 341:14, pages 1051-1062.
Crossref
Ling-Hui Li & J. Peter Gergen. (1999) Differential interactions between Brother proteins and Runt domain proteins in the Drosophila embryo and eye . Development 126:15, pages 3313-3322.
Crossref
James R. Downing. (1999) THE AML1-ETO CHIMAERIC TRANSCRIPTION FACTOR IN ACUTE MYELOID LEUKAEMIA: BIOLOGY AND CLINICAL SIGNIFICANCE. British Journal of Haematology 106:2, pages 296-308.
Crossref
Hidetsugu Kohzaki, Kosei Ito, Gang Huang, Hee-Jun Wee, Yota Murakami & Yoshiaki Ito. (1999) Block of granulocytic differentiation of 32Dcl3 cells by AML1/ETO(MTG8) but not by highly expressed Bcl-2. Oncogene 18:28, pages 4055-4062.
Crossref
Motomi OsatoNorio AsouEssam AbdallaKoyu HoshinoHiroshi YamasakiToshiya OkuboHitoshi SuzushimaKiyoshi TakatsukiTomohiko KannoKatsuya ShigesadaYoshiaki Ito. (1999) Biallelic and Heterozygous Point Mutations in the Runt Domain of theAML1/PEBP2B Gene Associated With Myeloblastic Leukemias. Blood 93:6, pages 1817-1824.
Crossref
Scott C. KoganEric LagasseSusan AtwaterSuk-chul BaeIrving WeissmanYoshiaki ItoJ. Michael Bishop. (1998) The PEBP2 β MYH11 fusion created by Inv(16)(p13;q22) in myeloid leukemia impairs neutrophil maturation and contributes to granulocytic dysplasia . Proceedings of the National Academy of Sciences 95:20, pages 11863-11868.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.