2
Views
70
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Involvement of Prolonged Ras Activation in Thrombopoietin-Induced Megakaryocytic Differentiation of a Human Factor-Dependent Hematopoietic Cell Line

, , , , , , , , & show all
Pages 4282-4290 | Received 17 Feb 1998, Accepted 25 Apr 1998, Published online: 28 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Joel R. Sevinsky, Anne M. Whalen & Natalie G. Ahn. (2004) Extracellular Signal-Regulated Kinase Induces the Megakaryocyte GPIIb/CD41 Gene through MafB/Kreisler. Molecular and Cellular Biology 24:10, pages 4534-4545.
Read now
Sophie Magné, Sandrine Caron, Martine Charon, Marie-Christine Rouyez & Isabelle Dusanter-Fourt. (2003) STAT5 and Oct-1 Form a Stable Complex That Modulates Cyclin D1 Expression. Molecular and Cellular Biology 23:24, pages 8934-8945.
Read now
Caroline Bourgin, Roland P. Bourette, Sylvie Arnaud, Yan Liu, Larry R. Rohrschneider & Guy Mouchiroud. (2002) Induced Expression and Association of the Mona/Gads Adapter and Gab3 Scaffolding Protein during Monocyte/Macrophage Differentiation. Molecular and Cellular Biology 22:11, pages 3744-3756.
Read now
Josefina Garcia, Jean de Gunzburg, Alain Eychène, Sylvie Gisselbrecht & Françoise Porteu. (2001) Thrombopoietin-Mediated Sustained Activation of Extracellular Signal-Regulated Kinase in UT7-Mpl Cells Requires Both Ras–Raf-1- and Rap1–B-Raf-Dependent Pathways. Molecular and Cellular Biology 21:8, pages 2659-2670.
Read now
Warren S. Alexander. (1999) Thrombopoietin. Growth Factors 17:1, pages 13-24.
Read now

Articles from other publishers (65)

Charlotte Nicole Hill, Maria Paz Hernández-Cáceres, Catalina Asencio, Begoña Torres, Benjamin Solis & Gareth I. Owen. (2020) Deciphering the Role of the Coagulation Cascade and Autophagy in Cancer-Related Thrombosis and Metastasis. Frontiers in Oncology 10.
Crossref
Armando Vega-López, Nataraj S. Pagadala, Brenda P. López-Tapia, Ruth L. Madera-Sandoval, Erika Rosales-Cruz, Minerva Nájera-Martínez & Elba Reyes-Maldonado. (2019) Is related the hematopoietic stem cells differentiation in the Nile tilapia with GABA exposure?. Fish & Shellfish Immunology 93, pages 801-814.
Crossref
Lucia Stefanini, Robert H. Lee & Wolfgang Bergmeier. 2017. Platelets in Thrombotic and Non-Thrombotic Disorders. Platelets in Thrombotic and Non-Thrombotic Disorders 263 284 .
Philip A. Beer. 2016. The Genetic Basis of Haematological Cancers. The Genetic Basis of Haematological Cancers 80 132 .
Wolfgang Bergmeier & Ellen C. O’Shaughnessy. 2016. Molecular and Cellular Biology of Platelet Formation. Molecular and Cellular Biology of Platelet Formation 175 191 .
Nan Hu, Yaling Qiu & Fan Dong. (2015) Role of Erk1/2 Signaling in the Regulation of Neutrophil Versus Monocyte Development in Response to G-CSF and M-CSF. Journal of Biological Chemistry 290:40, pages 24561-24573.
Crossref
Veena Sangkhae, Sebastian Jonas Saur, Alexis Kaushansky, Kenneth Kaushansky & Ian Stuart Hitchcock. (2014) Phosphorylated c-Mpl tyrosine 591 regulates thrombopoietin-induced signaling. Experimental Hematology 42:6, pages 477-486.e4.
Crossref
Sebastian DüttingTimo VögtleMartina MorowskiSarah SchiesslCarmen M. SchäferStephanie K. WatsonCraig E. HughesJochen A. AckermannDaniel RadtkeHeike M. HermannsSteve P. WatsonLars NitschkeBernhard Nieswandt. (2014) Growth Factor Receptor–Bound Protein 2 Contributes to (Hem)Immunoreceptor Tyrosine-Based Activation Motif–Mediated Signaling in Platelets. Circulation Research 114:3, pages 444-453.
Crossref
Masahiro Kawahara, Jianhong Chen, Takahiro Sogo, Jinying Teng, Makoto Otsu, Masafumi Onodera, Hiromitsu Nakauchi, Hiroshi Ueda & Teruyuki Nagamune. (2011) Growth promotion of genetically modified hematopoietic progenitors using an antibody/c-Mpl chimera. Cytokine 55:3, pages 402-408.
Crossref
Rodolphe Besancenot, Ronan Chaligné, Carole Tonetti, Florence Pasquier, Caroline Marty, Yann Lécluse, William Vainchenker, Stefan N. Constantinescu & Stéphane Giraudier. (2010) A Senescence-Like Cell-Cycle Arrest Occurs During Megakaryocytic Maturation: Implications for Physiological and Pathological Megakaryocytic Proliferation. PLoS Biology 8:9, pages e1000476.
Crossref
Michael GirardotChristian PecquetSiham Boukour, Laurent Knoops, Augustin Ferrant, William Vainchenker, Stéphane Giraudier & Stefan N. Constantinescu. (2010) miR-28 is a thrombopoietin receptor targeting microRNA detected in a fraction of myeloproliferative neoplasm patient platelets. Blood 116:3, pages 437-445.
Crossref
S. SÉVERIN, C. GHEVAERT & A. MAZHARIAN. (2010) The mitogen‐activated protein kinase signaling pathways: role in megakaryocyte differentiation. Journal of Thrombosis and Haemostasis 8:1, pages 17-26.
Crossref
Sergej Konoplev & Carlos Bueso-Ramos. 2010. Molecular Pathology of Hematolymphoid Diseases. Molecular Pathology of Hematolymphoid Diseases 449 462 .
E. Ricky Chan, Heather Lavender, Geqiang Li, Peter Haviernik, Kevin D. Bunting & Mark D. Adams. (2009) An ENU-induced recessive mutation in Mpl leads to thrombocytopenia with overdominance. Experimental Hematology 37:2, pages 276-284.
Crossref
David J. Kuter. (2008) New drugs for familiar therapeutic targets: thrombopoietin receptor agonists and immune thrombocytopenic purpura. European Journal of Haematology 80, pages 9-18.
Crossref
C Bourgin-Hierle, S Gobert-Gosse, J Thérier, M-F Grasset & G Mouchiroud. (2007) Src-family kinases play an essential role in differentiation signaling downstream of macrophage colony-stimulating factor receptors mediating persistent phosphorylation of phospholipase C-γ2 and MAP kinases ERK1 and ERK2. Leukemia 22:1, pages 161-169.
Crossref
D. A. Gilbert & K. D. Hammond. 2008. Ultradian Rhythms from Molecules to Mind. Ultradian Rhythms from Molecules to Mind 105 128 .
Virginie HamelinClaire LetourneuxPaul-Henri RomeoFrançoise PorteuMurielle Gaudry. (2006) Thrombopoietin regulates IEX-1 gene expression through ERK-induced AML1 phosphorylation. Blood 107:8, pages 3106-3113.
Crossref
Hana RaslovaVéronique BacciniLamya LoussaiefBéatrice CombaJérôme LargheroNajet DebiliWilliam Vainchenker. (2006) Mammalian target of rapamycin (mTOR) regulates both proliferation of megakaryocyte progenitors and late stages of megakaryocyte differentiation. Blood 107:6, pages 2303-2310.
Crossref
Mingjian Shi, John C. Cooper & Chao-Lan Yu. (2006) A Constitutively Active Lck Kinase Promotes Cell Proliferation and Resistance to Apoptosis through Signal Transducer and Activator of Transcription 5b Activation. Molecular Cancer Research 4:1, pages 39-45.
Crossref
Björn Steffen, Carsten Müller-Tidow, Joachim Schwäble, Wolfgang E. Berdel & Hubert Serve. (2005) The molecular pathogenesis of acute myeloid leukemia. Critical Reviews in Oncology/Hematology 56:2, pages 195-221.
Crossref
Stéphanie Gobert Gosse, Caroline Bourgin, Wang Qing Liu, Christiane Garbay & Guy Mouchiroud. (2005) M-CSF stimulated differentiation requires persistent MEK activity and MAPK phosphorylation independent of Grb2–Sos association and phosphatidylinositol 3-kinase activity. Cellular Signalling 17:11, pages 1352-1362.
Crossref
Marie-Christine Rouyez, Marta Lestingi, Martine Charon, Serge Fichelson, Agnès Buzyn & Isabelle Dusanter-Fourt. (2005) IFN Regulatory Factor-2 Cooperates with STAT1 to Regulate Transporter Associated with Antigen Processing-1 Promoter Activity. The Journal of Immunology 174:7, pages 3948-3958.
Crossref
Sachiko Ezoe, Itaru Matsumura, Karin Gale, Yusuke Satoh, Jun Ishikawa, Masao Mizuki, Satoru Takahashi, Naoko Minegishi, Koichi Nakajima, Masayuki Yamamoto, Tariq Enver & Yuzuru Kanakura. (2005) GATA Transcription Factors Inhibit Cytokine-dependent Growth and Survival of a Hematopoietic Cell Line through the Inhibition of STAT3 Activity. Journal of Biological Chemistry 280:13, pages 13163-13170.
Crossref
Soichi Nakata, Itaru Matsumura, Hirokazu Tanaka, Sachiko Ezoe, Yusuke Satoh, Jun Ishikawa, Takumi Era & Yuzuru Kanakura. (2004) NF-κB Family Proteins Participate in Multiple Steps of Hematopoiesis through Elimination of Reactive Oxygen Species. Journal of Biological Chemistry 279:53, pages 55578-55586.
Crossref
Jean-Michel PaulusNajet DebiliFrédéric LarbretJack LevinWilliam Vainchenker. (2004) Thrombopoietin responsiveness reflects the number of doublings undergone by megakaryocyte progenitors. Blood 104:8, pages 2291-2298.
Crossref
Ken'ichiro Hayashi, Katsushi Shibata, Tsuyoshi Morita, Kazuhiro Iwasaki, Masahiro Watanabe & Kenji Sobue. (2004) Insulin Receptor Substrate-1/SHP-2 Interaction, a Phenotype-dependent Switching Machinery of Insulin-like Growth Factor-I Signaling in Vascular Smooth Muscle Cells. Journal of Biological Chemistry 279:39, pages 40807-40818.
Crossref
Michael D. Feese, Taro Tamada, Yoichi Kato, Yoshitake Maeda, Masako Hirose, Yasuko Matsukura, Hideki Shigematsu, Takanori Muto, Atsushi Matsumoto, Hiroshi Watarai, Kinya Ogami, Tomoyuki Tahara, Takashi Kato, Hiroshi Miyazaki & Ryota Kuroki. (2004) Structure of the receptor-binding domain of human thrombopoietin determined by complexation with a neutralizing antibody fragment. Proceedings of the National Academy of Sciences 101:7, pages 1816-1821.
Crossref
Yoshihisa Kataoka, Itaru Matsumura, Sachiko Ezoe, Soichi Nakata, Eri Takigawa, Yusuke Sato, Akira Kawasaki, Takashi Yokota, Koichi Nakajima, Armando Felsani & Yuzuru Kanakura. (2003) Reciprocal Inhibition between MyoD and STAT3 in the Regulation of Growth and Differentiation of Myoblasts. Journal of Biological Chemistry 278:45, pages 44178-44187.
Crossref
Louise C Alldridge & Clare E Bryant. (2003) Annexin 1 regulates cell proliferation by disruption of cell morphology and inhibition of cyclin D1 expression through sustained activation of the ERK1/2 MAPK signal. Experimental Cell Research 290:1, pages 93-107.
Crossref
Arjen-Kars Boer, A.Lyndsay Drayer & Edo Vellenga. (2003) Stem cell factor enhances erythropoietin-mediated transactivation of signal transducer and activator of transcription 5 (STAT5) via the PKA/CREB pathway. Experimental Hematology 31:6, pages 512-520.
Crossref
Akira KawasakiItaru MatsumuraYoshihisa KataokaEri TakigawaKoichi NakajimaYuzuru Kanakura. (2003) Opposing effects of PML and PML/RARα on STAT3 activity. Blood 101:9, pages 3668-3673.
Crossref
Lorrie L. DelehantyMichael MogassSara L. GoniasFrederick K. RackeBrian JohnstoneAdam N. Goldfarb. (2003) Stromal inhibition of megakaryocytic differentiation is associated with blockade of sustained Rap1 activation. Blood 101:5, pages 1744-1751.
Crossref
Koji HashimotoItaru MatsumuraTohru TsujimuraDae-Ki KimHideki OgiharaHirokazu IkedaShuji UedaMasao MizukiHiroyuki SugaharaHirohiko ShibayamaYukihiko KitamuraYuzuru Kanakura. (2003) Necessity of tyrosine 719 and phosphatidylinositol 3′-kinase–mediated signal pathway in constitutive activation and oncogenic potential of c-kit receptor tyrosine kinase with the Asp814Val mutation. Blood 101:3, pages 1094-1102.
Crossref
Annette Ehrhardt, Götz R.A Ehrhardt, Xuecui Guo & John W Schrader. (2002) Ras and relatives—job sharing and networking keep an old family together. Experimental Hematology 30:10, pages 1089-1106.
Crossref
Arjen-Kars BoerA. Lyndsay DrayerHallgeir RuiEdo Vellenga. (2002) Prostaglandin-E2 enhances EPO-mediated STAT5 transcriptional activity by serine phosphorylation of CREB. Blood 100:2, pages 467-473.
Crossref
Gaël A. Millot, William Vainchenker, Dominique Duménil & Fédor Svinarchuk. (2002) Distinct effects of thrombopoietin depending on a threshold level of activated Mpl in BaF-3 cells. Journal of Cell Science 115:11, pages 2329-2337.
Crossref
Itaru Matsumura & Yuzuru Kanakura. (2002) Molecular Control of Megakaryopoiesis and Thrombopoiesis. International Journal of Hematology 75:5, pages 473-483.
Crossref
Junko Sonoyama, Itaru Matsumura, Sachiko Ezoe, Yusuke Satoh, Xian Zhang, Yoshihisa Kataoka, Emi Takai, Masao Mizuki, Takashi Machii, Hiroshi Wakao & Yuzuru Kanakura. (2002) Functional Cooperation among Ras, STAT5, and Phosphatidylinositol 3-Kinase Is Required for Full Oncogenic Activities of BCR/ABL in K562 Cells. Journal of Biological Chemistry 277:10, pages 8076-8082.
Crossref
Marie-Dominique FilippiFrançoise PorteuFrançoise Le PesteurValérie SchiavonGaël A. MillotWilliam VainchenkerFrédéric J. de SauvageAnne Dubart KupperschmittFrancoise Sainteny. (2002) Requirement for mitogen-activated protein kinase activation in the response of embryonic stem cell–derived hematopoietic cells to thrombopoietin in vitro. Blood 99:4, pages 1174-1182.
Crossref
Amy E Geddis, Hannah M Linden & Kenneth Kaushansky. (2002) Thrombopoietin: a pan-hematopoietic cytokine. Cytokine & Growth Factor Reviews 13:1, pages 61-73.
Crossref
Fabrice Gouilleux. 2002. Hormone Signaling. Hormone Signaling 145 178 .
Ying Zhang, Shishinn Sun, Zhengyu Wang, Alexander Thompson, Yulia Kaluzhny, Jeffrey Zimmet & Katya Ravid. (2002) Signaling by the Mpl receptor involves IKK and NF-?B. Journal of Cellular Biochemistry 85:3, pages 523-535.
Crossref
Catherine E. Carow, Norma E. Fox & Kenneth Kaushansky. (2001) Kinetics of endomitosis in primary murine megakaryocytes. Journal of Cellular Physiology 188:3, pages 291-303.
Crossref
Adam N. Goldfarb, Loretta L. Delehanty, Dongyan Wang, Frederick K. Racke & Isa M. Hussaini. (2001) Stromal Inhibition of Megakaryocytic Differentiation Correlates with Blockade of Signaling by Protein Kinase C-ε and ERK/MAPK. Journal of Biological Chemistry 276:31, pages 29526-29530.
Crossref
Didier Bouscary, Carinne Lecoq-Lafon, Stany Chrétien, Simona Zompi, Serge Fichelson, Odile Muller, Françoise Porteu, Isabelle Dusanter-Fourt, Sylvie Gisselbrecht, Patrick Mayeux & Catherine Lacombe. (2001) Role of Gab proteins in phosphatidylinositol 3-kinase activation by thrombopoietin (Tpo). Oncogene 20:18, pages 2197-2204.
Crossref
Tohru Sugimoto, Hiroshi Kuroda, Yoshihiro Horii, Hiroshi Moritake, Takeo Tanaka & Seisuke Hattori. (2001) Signal Transduction Pathways through TRK-A and TRK-B Receptors in Human Neuroblastoma Cells. Japanese Journal of Cancer Research 92:2, pages 152-160.
Crossref
Akira Kawasaki, Itaru Matsumura, Jun-ichiro Miyagawa, Sachiko Ezoe, Hirokazu Tanaka, Yasuhiko Terada, Masaaki Tatsuka, Takashi Machii, Hiroshi Miyazaki, Yusuke Furukawa & Yuzuru Kanakura. (2001) Downregulation of an Aim-1 Kinase Couples with Megakaryocytic Polyploidization of Human Hematopoietic Cells. Journal of Cell Biology 152:2, pages 275-288.
Crossref
Itaru MatsumuraAkira KawasakiHirokazu TanakaJunko SonoyamaSachiko EzoeNaoko MinegishiKoichi NakajimaMasayuki YamamotoYuzuru Kanakura. (2000) Biologic significance of GATA-1 activities in Ras-mediated megakaryocytic differentiation of hematopoietic cell lines. Blood 96:7, pages 2440-2450.
Crossref
Itaru MatsumuraAkira KawasakiHirokazu TanakaJunko SonoyamaSachiko EzoeNaoko MinegishiKoichi NakajimaMasayuki YamamotoYuzuru Kanakura. (2000) Biologic significance of GATA-1 activities in Ras-mediated megakaryocytic differentiation of hematopoietic cell lines. Blood 96:7, pages 2440-2450.
Crossref
Caroline Bourgin, Roland Bourette, Guy Mouchiroud & Sylvie Arnaud. (2000) Expression of Mona (monocytic adapter) in myeloid progenitor cells results in increased and prolonged MAP kinase activation upon macrophage colony-stimulating factor stimulation. FEBS Letters 480:2-3, pages 113-117.
Crossref
Junko Odajima, Itaru Matsumura, Junko Sonoyama, Hanako Daino, Akira Kawasaki, Hirokazu Tanaka, Naohiro Inohara, Toshio Kitamura, Julian Downward, Koichi Nakajima, Toshio Hirano & Yuzuru Kanakura. (2000) Full Oncogenic Activities of v-Src Are Mediated by Multiple Signaling Pathways. Journal of Biological Chemistry 275:31, pages 24096-24105.
Crossref
Hanako DainoItaru MatsumuraKoji TakadaJunko OdajimaHirokazu TanakaShuji UedaHirohiko ShibayamaHirokazu IkedaMasahiko HibiTakashi MachiiToshio HiranoYuzuru Kanakura. (2000) Induction of apoptosis by extracellular ubiquitin in human hematopoietic cells: possible involvement of STAT3 degradation by proteasome pathway in interleukin 6-dependent hematopoietic cells. Blood 95:8, pages 2577-2585.
Crossref
Hanako DainoItaru MatsumuraKoji TakadaJunko OdajimaHirokazu TanakaShuji UedaHirohiko ShibayamaHirokazu IkedaMasahiko HibiTakashi MachiiToshio HiranoYuzuru Kanakura. (2000) Induction of apoptosis by extracellular ubiquitin in human hematopoietic cells: possible involvement of STAT3 degradation by proteasome pathway in interleukin 6-dependent hematopoietic cells. Blood 95:8, pages 2577-2585.
Crossref
C Challier, L Cocault, M Flon, M Pauchard, F Porteu, S Gisselbrecht & M Souyri. (2000) A new feature of Mpl receptor: ligand-induced transforming activity in FRE rat fibroblasts. Oncogene 19:16, pages 2033-2042.
Crossref
Hirokazu TanakaItaru MatsumuraKoichi NakajimaHanako DainoJunko SonoyamaHitoshi YoshidaKenji OritaniTakashi MachiiMasayuki YamamotoToshio HiranoYuzuru Kanakura. (2000) GATA-1 blocks IL-6-induced macrophage differentiation and apoptosis through the sustained expression of cyclin D1 and Bcl-2 in a murine myeloid cell line M1. Blood 95:4, pages 1264-1273.
Crossref
Itaru Matsumura, Hirokazu Tanaka, Akira Kawasaki, Junko Odajima, Hanako Daino, Koji Hashimoto, Hiroshi Wakao, Koichi Nakajima, Takashi Kato, Hiroshi Miyazaki & Yuzuru Kanakura. (2000) Increased D-type Cyclin Expression Together with Decreased cdc2 Activity Confers Megakaryocytic Differentiation of a Human Thrombopoietin-dependent Hematopoietic Cell Line. Journal of Biological Chemistry 275:8, pages 5553-5559.
Crossref
Chris P. MillerZi Y. LiuConstance T. NoguchiDon M. Wojchowski. (1999) A Minimal Cytoplasmic Subdomain of the Erythropoietin Receptor Mediates Erythroid and Megakaryocytic Cell Development. Blood 94:10, pages 3381-3387.
Crossref
Marion DorschNika N. DanialPaul B. RothmanStephen P. Goff. (1999) A Thrombopoietin Receptor Mutant Deficient in Jak-STAT Activation Mediates Proliferation But Not Differentiation in UT-7 Cells. Blood 94:8, pages 2676-2685.
Crossref
Yurika Nosaka, Ayako Arai, Nobuyuki Miyasaka & Osamu Miura. (1999) CrkL Mediates Ras-dependent Activation of the Raf/ERK Pathway through the Guanine Nucleotide Exchange Factor C3G in Hematopoietic Cells Stimulated with Erythropoietin or Interleukin-3. Journal of Biological Chemistry 274:42, pages 30154-30162.
Crossref
Serge FichelsonJean-Marc FreyssinierFrançoise PicardMichaela Fontenay-RoupieMartine GuesnuMustapha CheraiSylvie GisselbrechtFrançoise Porteu. (1999) Megakaryocyte Growth and Development Factor-Induced Proliferation and Differentiation Are Regulated by the Mitogen-Activated Protein Kinase Pathway in Primitive Cord Blood Hematopoietic Progenitors. Blood 94:5, pages 1601-1613.
Crossref
Serge FichelsonJean-Marc FreyssinierFrançoise PicardMichaela Fontenay-RoupieMartine GuesnuMustapha CheraiSylvie GisselbrechtFrançoise Porteu. (1999) Megakaryocyte Growth and Development Factor-Induced Proliferation and Differentiation Are Regulated by the Mitogen-Activated Protein Kinase Pathway in Primitive Cord Blood Hematopoietic Progenitors. Blood 94:5, pages 1601-1613.
Crossref
Karine Cohen-SolalNatacha VitratMonique TiteuxWilliam VainchenkerFrançoise Wendling. (1999) High-Level Expression of Mpl in Platelets and Megakaryocytes Is Independent of Thrombopoietin. Blood 93:9, pages 2859-2866.
Crossref
Karine Cohen-SolalNatacha VitratMonique TiteuxWilliam VainchenkerFrançoise Wendling. (1999) High-Level Expression of Mpl in Platelets and Megakaryocytes Is Independent of Thrombopoietin. Blood 93:9, pages 2859-2866.
Crossref
Chun-fai Lai, Juergen Ripperger, Yanping Wang, Hongkyun Kim, Robert B. Hawley & Heinz Baumann. (1999) The STAT3-independent Signaling Pathway by Glycoprotein 130 in Hepatic Cells. Journal of Biological Chemistry 274:12, pages 7793-7802.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.