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Molecular and Cellular Biology Volume 18, 1998 - Issue 9
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Transcriptional Regulation

Requirement for a Functional Interaction between Mediator Components Med6 and Srb4 in RNA Polymerase II Transcription

Young Chul LeeLaboratory of Molecular Genetics, Center for Molecular Medicine, Samsung Biomedical Research Institute, Kangnam-ku, Seoul 135-230, Korea
&
Young-Joon KimLaboratory of Molecular Genetics, Center for Molecular Medicine, Samsung Biomedical Research Institute, Kangnam-ku, Seoul 135-230, KoreaCorrespondence[email protected]
Pages 5364-5370 | Received 03 Apr 1998, Accepted 09 Jun 1998, Published online: 28 Mar 2023

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Naveen Malik, Pinky Agarwal & Akhilesh Tyagi. (2017) Emerging functions of multi-protein complex Mediator with special emphasis on plants. Critical Reviews in Biochemistry and Molecular Biology 52:5, pages 475-502.
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Dae-Hwan Kim, Gwang Sik Kim, Chul Ho Yun & Young Chul Lee. (2008) Functional Conservation of the Glutamine-Rich Domains of Yeast Gal11 and Human SRC-1 in the Transactivation of Glucocorticoid Receptor Tau 1 in Saccharomyces cerevisiae. Molecular and Cellular Biology 28:3, pages 913-925.
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Christophe Leroy, Laëtitia Cormier & Laurent Kuras. (2006) Independent Recruitment of Mediator and SAGA by the Activator Met4. Molecular and Cellular Biology 26:8, pages 3149-3163.
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Fan Zhang, Laarni Sumibcay, Alan G. Hinnebusch & Mark J. Swanson. (2004) A Triad of Subunits from the Gal11/Tail Domain of Srb Mediator Is an In Vivo Target of Transcriptional Activator Gcn4p. Molecular and Cellular Biology 24:15, pages 6871-6886.
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Young-Hwa Goo, Young Chang Sohn, Dae-Hwan Kim, Seung-Whan Kim, Min-Jung Kang, Dong-Ju Jung, Eunyee Kwak, Nickolai A. Barlev, Shelley L. Berger, Vincent T. Chow, Robert G. Roeder, David O. Azorsa, Paul S. Meltzer, Pan-Gil Suh, Eun Joo Song, Kong-Joo Lee, Young Chul Lee & Jae Woon Lee. (2003) Activating Signal Cointegrator 2 Belongs to a Novel Steady-State Complex That Contains a Subset of Trithorax Group Proteins. Molecular and Cellular Biology 23:1, pages 140-149.
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Dong-Ju Jung, Hee-Sook Sung, Young-Wha Goo, Hyun Mi Lee, Ok Ku Park, Sung-Yun Jung, Janghoo Lim, Han-Jong Kim, Soo-Kyung Lee, Tae Sung Kim, Jae Woon Lee & Young Chul Lee. (2002) Novel Transcription Coactivator Complex Containing Activating Signal Cointegrator 1. Molecular and Cellular Biology 22:14, pages 5203-5211.
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Byung Soo Gim, Jin Mo Park, Jeong Ho Yoon, Changwon Kang & Young-Joon Kim. (2001) Drosophila Med6 Is Required for Elevated Expression of a Large but Distinct Set of Developmentally Regulated Genes. Molecular and Cellular Biology 21:15, pages 5242-5255.
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Jin Mo Park, Byung Soo Gim, Jung Mo Kim, Jeong Ho Yoon, Hye-Suk Kim, Ju-Gyeong Kang & Young-Joon Kim. (2001) Drosophila Mediator Complex Is Broadly Utilized by Diverse Gene-Specific Transcription Factors at Different Types of Core Promoters. Molecular and Cellular Biology 21:7, pages 2312-2323.
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Jin Mo Park, Hye-Suk Kim, Sang Jun Han, Moon-Sun Hwang, Young Chul Lee & Young-Joon Kim. (2000) In Vivo Requirement of Activator-Specific Binding Targets of Mediator. Molecular and Cellular Biology 20:23, pages 8709-8719.
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Sungjoon Kim, Kettly Cabane, Michael Hampsey & Danny Reinberg. (2000) Genetic Analysis of the Ydr1-Bur6 Repressor Complex Reveals an Intricate Balance among Transcriptional Regulatory Proteins in Yeast. Molecular and Cellular Biology 20:7, pages 2455-2465.
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Young Chul Lee, Jin Mo Park, Soyoung Min, Sang Jun Han & Young-Joon Kim. (1999) An Activator Binding Module of Yeast RNA Polymerase II Holoenzyme. Molecular and Cellular Biology 19:4, pages 2967-2976.
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Sang Jun Han, Young Chul Lee, Byung Soo Gim, Gi-Hyuck Ryu, Soon Jung Park, William S. Lane & Young-Joon Kim. (1999) Activator-Specific Requirement of Yeast Mediator Proteins for RNA Polymerase II Transcriptional Activation. Molecular and Cellular Biology 19:2, pages 979-988.
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Michael J. Trnka, Riccardo Pellarin & Philip J. Robinson. (2019) Role of integrative structural biology in understanding transcriptional initiation. Methods 159-160, pages 4-22.
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Alexis Verger, Didier Monté & Vincent Villeret. (2019) Twenty years of Mediator complex structural studies. Biochemical Society Transactions 47:1, pages 399-410.
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Gwang Sik Kim & Young Chul Lee. (2018) Postrecruitment Function of Yeast Med6 Protein during the Transcriptional Activation by Mediator Complex. Biochemistry Research International 2018, pages 1-9.
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Kayo Nozawa, Thomas R. Schneider & Patrick Cramer. (2017) Core Mediator structure at 3.4 Å extends model of transcription initiation complex. Nature 545:7653, pages 248-251.
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Monika Fuxreiter, Ágnes Tóth-Petróczy, Daniel A. Kraut, Andreas T. Matouschek, Roderick Y. H. Lim, Bin Xue, Lukasz Kurgan & Vladimir N. Uversky. (2014) Disordered Proteinaceous Machines. Chemical Reviews 114:13, pages 6806-6843.
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David Barford, Yuichiro Takagi, Patrick Schultz & Imre Berger. (2013) Baculovirus expression: tackling the complexity challenge. Current Opinion in Structural Biology 23:3, pages 357-364.
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Qingmei Guan, Jianmin Wu, Yanyan Zhang, Changhua Jiang, Renyi Liu, Chenglin Chai & Jianhua Zhu. (2013) A DEAD Box RNA Helicase Is Critical for Pre-mRNA Splicing, Cold-Responsive Gene Regulation, and Cold Tolerance in Arabidopsis     . The Plant Cell 25:1, pages 342-356.
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Laurent Larivière, Clemens Plaschka, Martin Seizl, Larissa Wenzeck, Fabian Kurth & Patrick Cramer. (2012) Structure of the Mediator head module. Nature 492:7429, pages 448-451.
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Luciano Galdieri, Parima Desai & Ales Vancura. (2012) Facilitated Assembly of the Preinitiation Complex by Separated Tail and Head/Middle Modules of the Mediator. Journal of Molecular Biology 415:3, pages 464-474.
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David Adler, Hamidur Rahaman, Pernilla Wittung-Stafshede & Stefan Björklund. (2009) Med8, Med18, and Med20 subunits of the Mediator head domain are interdependent upon each other for folding and complex formation. Proceedings of the National Academy of Sciences 106:49, pages 20728-20733.
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Ching-Ti Liu, Shinsheng Yuan & Ker-Chau Li. (2009) Patterns of co-expression for protein complexes by size in Saccharomyces cerevisiae. Nucleic Acids Research 37:2, pages 526-532.
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E. Drobná, A. Bialková & J. Šubík. (2008) Transcriptional regulators of seven yeast species: Comparative genome analysis — Review. Folia Microbiologica 53:4, pages 275-287.
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Tomas Linder, Nina N. Rasmussen, Camilla O. Samuelsen, Emmanouella Chatzidaki, Vera Baraznenok, Jenny Beve, Peter Henriksen, Claes M. Gustafsson & Steen Holmberg. (2008) Two conserved modules of Schizosaccharomyces pombe Mediator regulate distinct cellular pathways. Nucleic Acids Research 36:8, pages 2489-2504.
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Ji Young Kim, Ok Gu Park, Jae Woon Lee & Young Chul Lee. (2007) One- plus Two-hybrid System, a Novel Yeast Genetic Selection for Specific Missense Mutations Disrupting Protein/Protein Interactions. Molecular & Cellular Proteomics 6:10, pages 1727-1740.
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Lorena Peiró-Chova & Francisco Estruch. (2007) Specific Defects in Different Transcription Complexes Compensate for the Requirement of the Negative Cofactor 2 Repressor in Saccharomyces cerevisiae . Genetics 176:1, pages 125-138.
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Parag Sadhale, Jiyoti Verma & Aruna Naorem. (2007) Basal transcription machinery: role in regulation of stress response in eukaryotes. Journal of Biosciences 32:3, pages 569-578.
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Shamara M. Baidoobonso, Benjamin W. Guidi & Lawrence C. Myers. (2007) Med19(Rox3) Regulates Intermodule Interactions in the Saccharomyces cerevisiae Mediator Complex. Journal of Biological Chemistry 282:8, pages 5551-5559.
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Tomas Linder, Xuefeng Zhu, Vera Baraznenok & Claes M. Gustafsson. (2006) The classical srb4-138 mutant allele causes dissociation of yeast Mediator. Biochemical and Biophysical Research Communications 349:3, pages 948-953.
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Yuichiro Takagi, Guillermo Calero, Hirofumi Komori, Jesse A. Brown, Andreas H. Ehrensberger, Andy Hudmon, Francisco Asturias & Roger D. Kornberg. (2006) Head Module Control of Mediator Interactions. Molecular Cell 23:3, pages 355-364.
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Harpreet Singh, Alexander M Erkine, Selena B Kremer, Harry M Duttweiler, Donnie A Davis, Jabed Iqbal, Rachel R Gross & David S Gross. (2006) A Functional Module of Yeast Mediator That Governs the Dynamic Range of Heat-Shock Gene Expression. Genetics 172:4, pages 2169-2184.
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Kristi L. Penheiter & Judith A. Jaehning. 2006. Gene Expression and Regulation. Gene Expression and Regulation 49 66 .
Lihong Li, Tina Quinton, Shawna Miles & Linda L Breeden. (2005) Genetic Interactions Between Mediator and the Late G1-Specific Transcription Factor Swi6 in Saccharomyces cerevisiae . Genetics 171:2, pages 477-488.
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Dhanalakshmi Nair, Yeejin Kim & Lawrence C. Myers. (2005) Mediator and TFIIH Govern Carboxyl-terminal Domain-dependent Transcription in Yeast Extracts. Journal of Biological Chemistry 280:40, pages 33739-33748.
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Rhiannon Biddick & Elton T. Young. (2005) Yeast Mediator and its role in transcriptional regulation. Comptes Rendus Biologies 328:9, pages 773-782.
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Sonja Baumli, Sabine Hoeppner & Patrick Cramer. (2005) A Conserved Mediator Hinge Revealed in the Structure of the MED7·MED21 (Med7·Srb7) Heterodimer. Journal of Biological Chemistry 280:18, pages 18171-18178.
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Young-Joon Kim & John T. Lis. (2005) Interactions between subunits of Drosophila Mediator and activator proteins. Trends in Biochemical Sciences 30:5, pages 245-249.
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Magnus Hallberg, Gennady V. Polozkov, Guo-Zhen Hu, Jenny Beve, Claes M. Gustafsson, Hans Ronne & Stefan Björklund. (2004) Site-specific Srb10-dependent phosphorylation of the yeast Mediator subunit Med2 regulates gene expression from the 2-μm plasmid. Proceedings of the National Academy of Sciences 101:10, pages 3370-3375.
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Young-Hwa Goo, Soon-Young Na, Hao Zhang, Jianming Xu, SunHwa Hong, JaeHun Cheong, Soo-Kyung Lee & Jae Woon Lee. (2004) Interactions between Activating Signal Cointegrator-2 and the Tumor Suppressor Retinoblastoma in Androgen Receptor Transactivation. Journal of Biological Chemistry 279:8, pages 7131-7135.
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Stefan Björklund & Claes M Gustafsson. 2004. Proteins in Eukaryotic Transcription. Proteins in Eukaryotic Transcription 43 65 .
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Francisco Estruch & Charles N. Cole. (2003) An Early Function during Transcription for the Yeast mRNA Export Factor Dbp5p/Rat8p Suggested by Its Genetic and Physical Interactions with Transcription Factor IIH Components. Molecular Biology of the Cell 14:4, pages 1664-1676.
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Joshua A Davis, Yuichiro Takagi, Roger D Kornberg & Francisco J Asturias. (2002) Structure of the Yeast RNA Polymerase II Holoenzyme. Molecular Cell 10:2, pages 409-415.
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Jae Young Kwon, Jeongsil Kim-Ha, Byeong Jae Lee & Junho Lee. (2001) The MED-7 transcriptional mediator encoded by let-49 is required for gonad and germ cell development in Caenorhabditis elegans . FEBS Letters 508:3, pages 305-308.
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Sang Jun Han, Jung-Soon Lee, Jong Seok Kang & Young-Joon Kim. (2001) Med9/Cse2 and Gal11 Modules Are Required for Transcriptional Repression of Distinct Group of Genes. Journal of Biological Chemistry 276:40, pages 37020-37026.
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M. Sipiczki. (2001) Identification of Schizosaccharomyces pombe genes that encode putative homolgues of Saccharomyces cerevisiae mediator complex subunits . Acta Microbiologica et Immunologica Hungarica 48:3-4, pages 519-531.
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Michaela R. Dotson, Chao Xing Yuan, Robert G. Roeder, Lawrence C. Myers, Claes M. Gustafsson, Yi Wei Jiang, Yang Li, Roger D. Kornberg & Francisco J. Asturias. (2000) Structural organization of yeast and mammalian mediator complexes. Proceedings of the National Academy of Sciences 97:26, pages 14307-14310.
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Muriel Boube, Christian Faucher, Laurent Joulia, David L. Cribbs & Henri-Marc Bourbon. (2000) Drosophila homologs of transcriptional mediator complex subunits are required for adult cell and segment identity specification . Genes & Development 14:22, pages 2906-2917.
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Hiroshi Sakurai & Toshio Fukasawa. (2000) Functional Connections between Mediator Components and General Transcription Factors of Saccharomyces cerevisiae. Journal of Biological Chemistry 275:47, pages 37251-37256.
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Anne Gromöller & Norbert Lehming. (2000) Srb7p is essential for the activation of a subset of genes. FEBS Letters 484:1, pages 48-54.
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David R. Moss & Paul J. Laybourn. (2002) Upstream nucleosomes and Rgr1p are required for nucleosomal repression of transcription. Molecular Microbiology 36:6, pages 1293-1305.
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Krishnamurthy Natarajan, Belinda M Jackson, Heng Zhou, Fred Winston & Alan G Hinnebusch. (1999) Transcriptional Activation by Gcn4p Involves Independent Interactions with the SWI/SNF Complex and the SRB/Mediator. Molecular Cell 4:4, pages 657-664.
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