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Sam Van de Velde, Ezra Wiater, Melissa Tran, Yousang Hwang, Philip A. Cole & Marc Montminy. (2019) CREB Promotes Beta Cell Gene Expression by Targeting Its Coactivators to Tissue-Specific Enhancers. Molecular and Cellular Biology 39:17.
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Dwi Setyowati Karolina, Sugunavathi Sepramaniam, Hui Zhing Tan, Arunmozhiarasi Armugam & Kandiah Jeyaseelan. (2013) miR-25 and miR-92a regulate insulin I biosynthesis in rats. RNA Biology 10:8, pages 1365-1378.
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Anne B. Vojtek, Jennifer Taylor, Stacy L. DeRuiter, Jenn-Yah Yu, Claudia Figueroa, Roland P. S. Kwok & David L. Turner. (2003) Akt Regulates Basic Helix-Loop-Helix Transcription Factor–Coactivator Complex Formation and Activity during Neuronal Differentiation. Molecular and Cellular Biology 23:13, pages 4417-4427.
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Yi Qiu, Min Guo, Suming Huang & Roland Stein. (2002) Insulin Gene Transcription Is Mediated by Interactions between the p300 Coactivator and PDX-1, BETA2, and E47. Molecular and Cellular Biology 22:2, pages 412-420.
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Articles from other publishers (63)
Julia Mührer, Mariarosaria Lang-Muritano, Roger Lehmann, Jean-Louis Blouin & Valerie M. Schwitzgebel. (2023)
Atypical familial diabetes associated with a novel
NEUROD1
nonsense variant
. Journal of Pediatric Endocrinology and Metabolism 36:1, pages 101-104.
Crossref
Crossref
Fabrizio Barbetti, Novella Rapini & Stefano Cianfarani. 2023. Neonatal and Early Onset Diabetes Mellitus. Neonatal and Early Onset Diabetes Mellitus
9
22
.
Di Liu, Kevin Y. Yang, Vicken W. Chan, Wenchu Ye, Charing C.N. Chong, Chi Chiu Wang, Huating Wang, Bin Zhou, Kenneth K.Y. Cheng & Kathy O. Lui. (2022) YY1 Regulates Glucose Homeostasis Through Controlling Insulin Transcription in Pancreatic β-Cells. Diabetes 71:5, pages 961-977.
Crossref
Crossref
John M. Haynes, Shanti M. Sibuea, Alita A. Aguiar, Fangwei Li, Joan K. Ho & Colin W. Pouton. (2021) Inhibition of β-catenin dependent WNT signalling upregulates the transcriptional repressor NR0B1 and downregulates markers of an A9 phenotype in human embryonic stem cell-derived dopaminergic neurons: Implications for Parkinson’s disease. PLOS ONE 16:12, pages e0261730.
Crossref
Crossref
Ana Lilia Torres-Machorro. (2021) Homodimeric and Heterodimeric Interactions among Vertebrate Basic Helix–Loop–Helix Transcription Factors. International Journal of Molecular Sciences 22:23, pages 12855.
Crossref
Crossref
Li Zhang, Huachong Xu, Ning Ding, Xue Li, Xiaoyin Chen & Zhuangfei Chen. (2021) Beneficial Effects on Brain Micro-Environment by Caloric Restriction in Alleviating Neurodegenerative Diseases and Brain Aging. Frontiers in Physiology 12.
Crossref
Crossref
Linlin Zhang, Chunxiang Sheng, Feiye Zhou, Kecheng Zhu, Shushu Wang, Qianqian Liu, Miaomiao Yuan, Zhaoqian Xu, Yun Liu, Jieli Lu, Jianmin Liu, Libin Zhou & Xiao Wang. (2021) CBP/p300 HAT maintains the gene network critical for β cell identity and functional maturity. Cell Death & Disease 12:5.
Crossref
Crossref
Sandeep K. Mishra & Mahendra Hidau. (2020) Intranasal Insulin Enhances Intracerebroventricular Streptozotocin–Induced Decrease in Olfactory Discriminative Learning via Upregulation of Subventricular Zone–Olfactory Bulb Neurogenesis in the Rat Model. Molecular Neurobiology 58:3, pages 1248-1259.
Crossref
Crossref
Maryam Soltani asl, Parviz Azimnasab-sorkhabi, Ali-Akbar Abolfathi & Yashar Hashemi aghdam. (2020) Identification of nucleotide polymorphism within the NeuroD1 candidate gene and its association with type 1 diabetes susceptibility in Iranian people by polymerase chain reaction-restriction fragment length polymorphism. Journal of Pediatric Endocrinology and Metabolism 33:10, pages 1293-1297.
Crossref
Crossref
Lubov Borisovna Mitrofanova, Olga Mikhailovna Vorobeva & Andrey Nikolaevich Gorshkov. (2019) Analysis of pituitary adenoma expression patterns suggests a potential role for the NeuroD1 transcription factor in neuroendocrine tumor-targeting therapies. Oncotarget 10:3, pages 289-312.
Crossref
Crossref
Huseyin Demirbilek, Nihal Hatipoglu, Ulku Gul, Zeynep U Tatli, Sian Ellard, Sarah E Flanagan, Elisa De Franco & Selim Kurtoglu. (2018)
Permanent neonatal diabetes mellitus and neurological abnormalities due to a novel homozygous missense mutation in
NEUROD1
. Pediatric Diabetes 19:5, pages 898-904.
Crossref
Crossref
Sandeep Kumar Mishra, Sonu Singh, Shubha Shukla & Rakesh Shukla. (2018) Intracerebroventricular streptozotocin impairs adult neurogenesis and cognitive functions via regulating neuroinflammation and insulin signaling in adult rats. Neurochemistry International 113, pages 56-68.
Crossref
Crossref
Rehana Parvin, Akiko Saito-Hakoda, Hiroki Shimada, Kyoko Shimizu, Erika Noro, Yasumasa Iwasaki, Ken Fujiwara, Atsushi Yokoyama & Akira Sugawara. (2017) Role of NeuroD1 on the negative regulation of Pomc expression by glucocorticoid. PLOS ONE 12:4, pages e0175435.
Crossref
Crossref
Jaemeun Lee, Kyungchan Kim, Seong-Woon Yu & Eun-Kyoung Kim. (2016) Wnt3a upregulates brain-derived insulin by increasing NeuroD1 via Wnt/β-catenin signaling in the hypothalamus. Molecular Brain 9:1.
Crossref
Crossref
Lan-Hsin Wang & Nicholas E. Baker. (2015) E Proteins and ID Proteins: Helix-Loop-Helix Partners in Development and Disease. Developmental Cell 35:3, pages 269-280.
Crossref
Crossref
Sebastian Brandhorst, In Young Choi, Min Wei, Chia Wei Cheng, Sargis Sedrakyan, Gerardo Navarrete, Louis Dubeau, Li Peng Yap, Ryan Park, Manlio Vinciguerra, Stefano Di Biase, Hamed Mirzaei, Mario G. Mirisola, Patra Childress, Lingyun Ji, Susan Groshen, Fabio Penna, Patrizio Odetti, Laura Perin, Peter S. Conti, Yuji Ikeno, Brian K. Kennedy, Pinchas Cohen, Todd E. Morgan, Tanya B. Dorff & Valter D. Longo. (2015) A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan. Cell Metabolism 22:1, pages 86-99.
Crossref
Crossref
Gary T. ZeRuth, Yukimasa Takeda & Anton M. Jetten. (2013) The Krüppel-Like Protein Gli-Similar 3 (Glis3) Functions as a Key Regulator of Insulin Transcription. Molecular Endocrinology 27:10, pages 1692-1705.
Crossref
Crossref
Ricco Lindner, Radhika Puttagunta & Simone Di Giovanni. (2013) Epigenetic Regulation of Axon Outgrowth and Regeneration in CNS Injury: The First Steps Forward. Neurotherapeutics 10:4, pages 771-781.
Crossref
Crossref
Guanlan Xu, Junqin Chen, Gu Jing & Anath Shalev. (2013) Thioredoxin-interacting protein regulates insulin transcription through microRNA-204. Nature Medicine 19:9, pages 1141-1146.
Crossref
Crossref
Elhadji M. Dioum, Jihan K. Osborne, Sean Goetsch, Jamie Russell, Jay W. Schneider & Melanie H. Cobb. (2011) A small molecule differentiation inducer increases insulin production by pancreatic β cells. Proceedings of the National Academy of Sciences 108:51, pages 20713-20718.
Crossref
Crossref
Geert A. Martens, Lei Jiang, Karine H. Hellemans, Geert Stangé, Harry Heimberg, Finn C. Nielsen, Olivier Sand, Jacques Van Helden, Frans K. Gorus & Daniel G. Pipeleers. (2011) Clusters of Conserved Beta Cell Marker Genes for Assessment of Beta Cell Phenotype. PLoS ONE 6:9, pages e24134.
Crossref
Crossref
Fei Ling, Tao Wang, Liqiong Wei, Xiaoping Zhu, Yaosheng Chen, Jiaqi Li, Zongwu Zhang, Hongli Du, Xiaoning Wang & Jufang Wang. (2010) Cloning and characterization of the 5′-flanking region of the pig AgRP gene. Molecular Biology Reports 38:4, pages 2233-2239.
Crossref
Crossref
Gabriele Wolf, Behnam Hessabi, Anke Karkour, Ulrike Henrion, Meike Dahlhaus, Annett Ostmann, Bernd Giese, Martin Fraunholz, Piotr Grabarczyk, Robert Jack & Reinhard Walther. (2010) The Activation of the Rat Insulin Gene II by BETA2 and PDX-1 in Rat Insulinoma Cells Is Repressed by Pax6. Molecular Endocrinology 24:12, pages 2331-2342.
Crossref
Crossref
Oscar Rubio-CabezasJayne A.L. MintonIren KantorDenise WilliamsSian EllardAndrew T. Hattersley. (2010)
Homozygous Mutations in
NEUROD1
Are Responsible for a Novel Syndrome of Permanent Neonatal Diabetes and Neurological Abnormalities
. Diabetes 59:9, pages 2326-2331.
Crossref
Crossref
Magdalena Ewa Tyburczy, Katarzyna Kotulska, Piotr Pokarowski, Jakub Mieczkowski, Joanna Kucharska, Wieslawa Grajkowska, Maciej Roszkowski, Sergiusz Jozwiak & Bozena Kaminska. (2010) Novel Proteins Regulated by mTOR in Subependymal Giant Cell Astrocytomas of Patients with Tuberous Sclerosis Complex and New Therapeutic Implications. The American Journal of Pathology 176:4, pages 1878-1890.
Crossref
Crossref
Wei-na MaShin-Young ParkJoong-Soo Han. (2010) Role of phospholipase D1 in glucose-induced insulin secretion in pancreatic β cells. Experimental and Molecular Medicine 42:6, pages 456.
Crossref
Crossref
A. Vetere, W.-C. Li, F. Paroni, K. Juhl, L. Guo, W. Nishimura, X. Dai, S. Bonner-Weir & A. Sharma. (2009) OVO homologue-like 1 (Ovol1) transcription factor: a novel target of neurogenin-3 in rodent pancreas. Diabetologia 53:1, pages 115-122.
Crossref
Crossref
Anabel Rojas, Adrian Khoo, Juan R. Tejedo, Francisco J. Bedoya, Bernat Soria & Franz Martín. 2010. The Islets of Langerhans. The Islets of Langerhans
59
75
.
Hideaki Kaneto, Taka-aki Matsuoka, Satoshi Kawashima, Kaoru Yamamoto, Ken Kato, Takeshi Miyatsuka, Naoto Katakami & Munehide Matsuhisa. (2009) Role of MafA in pancreatic β-cells. Advanced Drug Delivery Reviews 61:7-8, pages 489-496.
Crossref
Crossref
Rudolf Pillich, Gianfranco Scarsella & Gianfranco Risuleo. (2008) Overexpression of the Pdx-1 Homeodomain Transcription Factor Impairs Glucose Metabolism in Cultured Rat Hepatocytes. Molecules 13:10, pages 2659-2673.
Crossref
Crossref
Sreenath S. AndraliMegan L. SampleyNathan L. VanderfordSabire Özcan. (2008) Glucose regulation of insulin gene expression in pancreatic β-cells. Biochemical Journal 415:1, pages 1-10.
Crossref
Crossref
Lucie Gonsorčíková, Štěpánka Průhová, Ondrej Cinek, Jakob Ek, Terezie Pelikánová, Torben Jørgensen, Hans Eiberg, Oluf Pedersen, Torben Hansen & Jan Lebl. (2008)
Autosomal inheritance of diabetes in two families characterized by obesity and a novel H241Q mutation in
NEUROD1
. Pediatric Diabetes 9:4pt2, pages 367-372.
Crossref
Crossref
Min Zhao, Stephanie A. Amiel, Sanaz Ajami, Jie Jiang, Mohamed Rela, Nigel Heaton & Guo Cai Huang. (2008) Amelioration of Streptozotocin-Induced Diabetes in Mice with Cells Derived from Human Marrow Stromal Cells. PLoS ONE 3:7, pages e2666.
Crossref
Crossref
Hyo-Sup Kim, Jung-Hyun Noh, Seung-Hyun Hong, You-Cheol Hwang, Tae-Young Yang, Myung-Shik Lee, Kwang-Won Kim & Moon-Kyu Lee. (2008) Rosiglitazone stimulates the release and synthesis of insulin by enhancing GLUT-2, glucokinase and BETA2/NeuroD expression. Biochemical and Biophysical Research Communications 367:3, pages 623-629.
Crossref
Crossref
Emma L. Edghill & Andrew T. Hattersley. 2008. Pancreatic Beta Cell in Health and Disease. Pancreatic Beta Cell in Health and Disease
399
430
.
Limei Liu, Hiroto Furuta, Asako Minami, Taishan Zheng, Weiping Jia, Kishio Nanjo & Kunsan Xiang. (2007) A novel mutation, Ser159Pro in the NeuroD1/BETA2 gene contributes to the development of diabetes in a Chinese potential MODY family. Molecular and Cellular Biochemistry 303:1-2, pages 115-120.
Crossref
Crossref
Colin W. Hay & Kevin Docherty. (2006) Comparative Analysis of Insulin Gene Promoters. Diabetes 55:12, pages 3201-3213.
Crossref
Crossref
Michiyo Amemiya-Kudo, Junko Oka, Tomohiro Ide, Takashi Matsuzaka, Hirohito Sone, Tomohiro Yoshikawa, Naoya Yahagi, Shun Ishibashi, Jun-ichi Osuga, Nobuhiro Yamada, Toshio Murase & Hitoshi Shimano. (2005) Sterol Regulatory Element-binding Proteins Activate Insulin Gene Promoter Directly and Indirectly through Synergy with BETA2/E47. Journal of Biological Chemistry 280:41, pages 34577-34589.
Crossref
Crossref
Randal Hand, Dante Bortone, Pierre Mattar, Laurent Nguyen, Julian Ik-Tsen Heng, Sabrice Guerrier, Elizabeth Boutt, Eldon Peters, Anthony P. Barnes, Carlos Parras, Carol Schuurmans, François Guillemot & Franck Polleux. (2005) Phosphorylation of Neurogenin2 Specifies the Migration Properties and the Dendritic Morphology of Pyramidal Neurons in the Neocortex. Neuron 48:1, pages 45-62.
Crossref
Crossref
Steven G. Gray & Pierre De Meyts. (2005) Role of histone and transcription factor acetylation in diabetes pathogenesis. Diabetes/Metabolism Research and Reviews 21:5, pages 416-433.
Crossref
Crossref
Shinsaku Aramata, Song-iee Han, Kunio Yasuda & Kohsuke Kataoka. (2005) Synergistic activation of the insulin gene promoter by the β-cell enriched transcription factors MafA, Beta2, and Pdx1. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1730:1, pages 41-46.
Crossref
Crossref
Hideaki Kaneto, Taka-aki Matsuoka, Yoshihisa Nakatani, Takeshi Miyatsuka, Munehide Matsuhisa, Masatsugu Hori & Yoshimitsu Yamasaki. (2005) A Crucial Role of MafA as a Novel Therapeutic Target for Diabetes*♦. Journal of Biological Chemistry 280:15, pages 15047-15052.
Crossref
Crossref
Christopher Dufton, Edoardo Marcora, Ji Hyung Chae, James McCullough, Jennifer Eby, Melissa Hausburg, Gretchen H. Stein, Shih Khoo, Melanie H. Cobb & Jacqueline E. Lee. (2005) Context-dependent regulation of NeuroD activity and protein accumulation. Molecular and Cellular Neuroscience 28:4, pages 727-736.
Crossref
Crossref
Joon-Young Kim, Khoi Chu, Han-Jong Kim, Hyun-A Seong, Ki-Cheol Park, Sabyasachi Sanyal, Jun Takeda, Hyunjung Ha, Minho Shong, Ming-Jer Tsai & Hueng-Sik Choi. (2004) Orphan Nuclear Receptor Small Heterodimer Partner, a Novel Corepressor for a Basic Helix-Loop-Helix Transcription Factor BETA2/NeuroD. Molecular Endocrinology 18:4, pages 776-790.
Crossref
Crossref
Yi Qiu, Min Guo, Suming Huang & Roland Stein. (2004) Acetylation of the BETA2 Transcription Factor by p300-associated Factor Is Important in Insulin Gene Expression. Journal of Biological Chemistry 279:11, pages 9796-9802.
Crossref
Crossref
Eric Bellefroid & Jacob Souopgui. 2004. The Vertebrate Organizer. The Vertebrate Organizer
151
172
.
Amber L. Mosley & Sabire Özcan. (2003) Glucose Regulates Insulin Gene Transcription by Hyperacetylation of Histone H4. Journal of Biological Chemistry 278:22, pages 19660-19666.
Crossref
Crossref
Martine Uittenbogaard, Debra L. Martinka & Anne Chiaramello. (2003) The basic helix-loop-helix differentiation factor Nex1/MATH-2 functions as a key activator of the GAP-43 gene. Journal of Neurochemistry 84:4, pages 678-688.
Crossref
Crossref
D. Ross Laybutt, Gordon C. Weir, Hideaki Kaneto, Judith Lebet, Richard D. Palmiter, Arun Sharma & Susan Bonner-Weir. (2002) Overexpression of c-Myc in β-Cells of Transgenic Mice Causes Proliferation and Apoptosis, Downregulation of Insulin Gene Expression, and Diabetes. Diabetes 51:6, pages 1793-1804.
Crossref
Crossref
Ji-Won Kim, Victor Seghers, Jang-Hyeon Cho, Yup Kang, Soyeon Kim, Yoonseok Ryu, Kwanghee Baek, Lydia Aguilar-Bryan, Young-Don Lee, Joseph Bryan & Haeyoung Suh-Kim. (2002) Transactivation of the Mouse Sulfonylurea Receptor I Gene by BETA2/NeuroD. Molecular Endocrinology 16:5, pages 1097-1107.
Crossref
Crossref
Hideaki Kaneto, Arun Sharma, Kiyoshi Suzuma, D. Ross Laybutt, Gang Xu, Susan Bonner-Weir & Gordon C. Weir. (2002) Induction of c-Myc Expression Suppresses Insulin Gene Transcription by Inhibiting NeuroD/BETA2-mediated Transcriptional Activation. Journal of Biological Chemistry 277:15, pages 12998-13006.
Crossref
Crossref
Valérie M. Schwitzgebel. (2001) Programming of the pancreas. Molecular and Cellular Endocrinology 185:1-2, pages 99-108.
Crossref
Crossref
Roland Stein. 2011. Comprehensive Physiology. Comprehensive Physiology
25
47
.
Jaideep Chaudhary & Michael K. Skinner. (2001) Role of the Transcriptional Coactivator CBP/p300 in Linking Basic Helix-Loop-Helix and CREB Responses for Follicle-Stimulating Hormone-Mediated Activation of the Transferrin Promoter in Sertoli Cells. Biology of Reproduction 65:2, pages 568-574.
Crossref
Crossref
Jang-Hyeon Cho, Il-Sun Kwon, Soyeon Kim, Sung-Ho Ghil, Ming-Jer Tsai, Yeon-Soo Kim, Young-Don Lee & Haeyoung Suh-Kim. (2008) Overexpression of BETA2/NeuroD induces neurite outgrowth in F11 neuroblastoma cells. Journal of Neurochemistry 77:1, pages 103-109.
Crossref
Crossref
Setareh Sepehri Chong, Ping Hu & Nouria Hernandez. (2001) Reconstitution of Transcription from the Human U6 Small Nuclear RNA Promoter with Eight Recombinant Polypeptides and a Partially Purified RNA Polymerase III Complex. Journal of Biological Chemistry 276:23, pages 20727-20734.
Crossref
Crossref
Pier Lorenzo Puri & Vittorio Sartorelli. (2000) Regulation of muscle regulatory factors by DNA-binding, interacting proteins, and post-transcriptional modifications. Journal of Cellular Physiology 185:2, pages 155-173.
Crossref
Crossref
Li Cai, Eric M. Morrow & Constance L. Cepko. (2000) Misexpression of basic helix-loop-helix genes in the murine cerebral cortex affects cell fate choices and neuronal survival. Development 127:14, pages 3021-3030.
Crossref
Crossref
Richard H. Goodman & Sarah Smolik. (2000) CBP/p300 in cell growth, transformation, and development. Genes & Development 14:13, pages 1553-1577.
Crossref
Crossref
Run-Tao Yan & Shu-Zhen Wang. (2000) Expression of an array of photoreceptor genes in chick embryonic retinal pigment epithelium cell cultures under the induction of neuroD. Neuroscience Letters 280:2, pages 83-86.
Crossref
Crossref
Eitan Glick, Dena Leshkowitz & Michael D. Walker. (2000) Transcription Factor BETA2 Acts Cooperatively with E2A and PDX1 to Activate the Insulin Gene Promoter. Journal of Biological Chemistry 275:3, pages 2199-2204.
Crossref
Crossref
Maciej T. Malecki, Ulupi S. Jhala, Anthony Antonellis, Liz Fields, Alessandro Doria, Tihamer Orban, Mohammed Saad, James H. Warram, Marc Montminy & Andrzej S. Krolewski. (1999) Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus. Nature Genetics 23:3, pages 323-328.
Crossref
Crossref
M.P. Marron, D.I. Hopkins, Y.S. Park & J.-X. She. (1999) NeuroD/Beta2 Polymorphism is Not Associated with Type 1 Diabetes in Chinese, Korean, or Caucasian Populations. International Journal on Disability and Human Development 1:2.
Crossref
Crossref