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Molecular and Cellular Biology Volume 19, 1999 - Issue 10
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Cell Growth and Development

Mouse Receptor Interacting Protein 3 Does Not Contain a Caspase-Recruiting or a Death Domain but Induces Apoptosis and Activates NF-κB

Nanette J. Pazdernik1 Departments of Biochemistry and Molecular Biology;2 Microbiology and Immunology, Indiana University School of Medicine
,
David B. Donner2 Microbiology and Immunology, Indiana University School of Medicine;3 Walther Cancer Institute, Indianapolis, Indiana46202
,
Mark G. Goebl1 Departments of Biochemistry and Molecular Biology;3 Walther Cancer Institute, Indianapolis, Indiana46202
&
Maureen A. Harrington1 Departments of Biochemistry and Molecular Biology;3 Walther Cancer Institute, Indianapolis, Indiana46202Correspondence[email protected]
Pages 6500-6508 | Received 26 May 1999, Accepted 29 Jun 1999, Published online: 28 Mar 2023

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Kim Newton, Xiaoqing Sun & Vishva M. Dixit. (2004) Kinase RIP3 Is Dispensable for Normal NF-κBs, Signaling by the B-Cell and T-Cell Receptors, Tumor Necrosis Factor Receptor 1, and Toll-Like Receptors 2 and 4. Molecular and Cellular Biology 24:4, pages 1464-1469.
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Barbara Munz, Eberhard Hildt, Matthew L. Springer & Helen M. Blau. (2002) RIP2, a Checkpoint in Myogenic Differentiation. Molecular and Cellular Biology 22:16, pages 5879-5886.
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Articles from other publishers (47)

Zhiyong Liu, Eduardo J. Garcia Reino, Oliver Harschnitz, Hongyan Guo, Yi-Hao Chan, Noopur V. KhobrekarMary L. Hasek, Kerry Dobbs, Darawan Rinchai, Marie Materna, Daniela Matuozzo, Danyel Lee, Paul Bastard, Jie ChenYoon Seung Lee, Seong K. KimShuxiang Zhao, Param AminLazaro Lorenzo, Yoann SeeleuthnerRemi Chevalier, Laure MazzolaClaire GayJean-Louis StephanBaptiste MilisavljevicSoraya Boucherit, Flore RozenbergRebeca Perez de Diego, Richard D. Dix, Nico Marr, Vivien Béziat, Aurelie Cobat, Mélodie Aubart, Laurent Abel, Stephane Chabrier, Gregory A. SmithLuigi D. Notarangelo, Edward S. MocarskiLorenz Studer, Jean-Laurent Casanova & Shen-Ying Zhang. (2023) Encephalitis and poor neuronal death–mediated control of herpes simplex virus in human inherited RIPK3 deficiency. Science Immunology 8:82.
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Kaylee Ermine, Jian Yu & Lin Zhang. (2022) Role of Receptor Interacting Protein (RIP) kinases in cancer. Genes & Diseases 9:6, pages 1579-1593.
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Michael J. Morgan & You-Sun Kim. (2022) Roles of RIPK3 in necroptosis, cell signaling, and disease. Experimental & Molecular Medicine 54:10, pages 1695-1704.
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Marie Oliver Metzig & Alexander Hoffmann. (2022) Controlling Cancer Cell Death Types to Optimize Anti-Tumor Immunity. Biomedicines 10:5, pages 974.
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Andrew M. Lamade, Limin Wu, Haider H. Dar, Heather L. Mentrup, Indira H. Shrivastava, Michael W. Epperly, Claudette M. St Croix, Yulia Y. Tyurina, Tamil S. Anthonymuthu, Qin Yang, Aleksandr A. Kapralov, Zhentai Huang, Gaowei Mao, Andrew A. Amoscato, Zachary E. Hier, Margarita A. Artyukhova, Galina Shurin, Joel C. Rosenbaum, Peter J. Gough, John Bertin, Andrew P. VanDemark, Simon C. Watkins, Kevin P. Mollen, Ivet Bahar, Joel S. Greenberger, Valerian E. Kagan, Michael J. Whalen & Hülya Bayır. (2022) Inactivation of RIP3 kinase sensitizes to 15LOX/PEBP1-mediated ferroptotic death. Redox Biology 50, pages 102232.
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Pengfei Zou, Kaiqing Li, Ying Li, Yingjia Shen, Ziping Zhang & Yilei Wang. (2021) RIP3 Associates with RIP1, TRIF, MAVS, and Also IRF3/7 in Host Innate Immune Signaling in Large Yellow Croaker Larimichthys crocea. Antibiotics 10:10, pages 1199.
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Lin Qi, Yufeng Lu, Zhaolin Wang & Guiyun Zhang. (2021) microRNA‐106b derived from endothelial cell–secreted extracellular vesicles prevents skin wound healing by inhibiting JMJD3 and RIPK3. Journal of Cellular and Molecular Medicine 25:10, pages 4551-4561.
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Ying Shi, Xinming Chen, Chunling Huang & Carol Pollock. (2020) RIPK3: A New Player in Renal Fibrosis. Frontiers in Cell and Developmental Biology 8.
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Haiwei Zhang, Xiaoxia Wu, Xiaoming Li, Ming Li, Fang Li, Lingxia Wang, Xixi Zhang, Yue Zhang, Yan Luo, Hui Wang, Yiguo Jiang & Haibing Zhang. (2020) Crucial Roles of the RIP Homotypic Interaction Motifs of RIPK3 in RIPK1-Dependent Cell Death and Lymphoproliferative Disease. Cell Reports 31:7, pages 107650.
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Shu Zhang, Ruizhao Li, Wei Dong, Huan Yang, Li Zhang, Yuanhan Chen, Weidong Wang, Chunling Li, Yanhua Wu, Zhiming Ye, Xingchen Zhao, Zhilian Li, Mengxi Zhang, Shuangxin Liu & Xinling Liang. (2019) RIPK3 mediates renal tubular epithelial cell apoptosis in endotoxin‑induced acute kidney injury. Molecular Medicine Reports.
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Laura W. Hansen, Asha Jacob, Weng Lang Yang, Alexandra C. Bolognese, Jose Prince, Jeffrey M. Nicastro, Gene F. Coppa & Ping Wang. (2018) Deficiency of receptor-interacting protein kinase 3 (RIPK3) attenuates inflammation and organ injury in neonatal sepsis. Journal of Pediatric Surgery 53:9, pages 1699-1705.
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Muhammad Ayaz Anwar & Sangdun Choi. 2018. Encyclopedia of Signaling Molecules. Encyclopedia of Signaling Molecules 4547 4555 .
Junming Ren, Xian Jia, Yihao Zhao, Wenke Shi, Jiongcong Lu, Yingying Zhang, Jianfeng Wu, Bo Liang, Rui Wu, Guo Fu & Jiahuai Han. (2017) The RIP3-RIP1-NF-κB signaling axis is dispensable for necroptotic cells to elicit cross-priming of CD8+ T cells. Cellular & Molecular Immunology 14:7, pages 639-642.
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Xueyan Hou, Chengli Yang, Lijing Zhang, Tingting Hu, Dan Sun, Hua Cao, Fan Yang, Gang Guo, Changyang Gong, Xiaoning Zhang, Aiping Tong, Rui Li & Yu Zheng. (2017) Killing colon cancer cells through PCD pathways by a novel hyaluronic acid-modified shell-core nanoparticle loaded with RIP3 in combination with chloroquine. Biomaterials 124, pages 195-210.
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Inbar Shlomovitz, Sefi Zargrian & Motti Gerlic. (2017) Mechanisms of RIPK3‐induced inflammation. Immunology & Cell Biology 95:2, pages 166-172.
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Muhammad Ayaz Anwar & Sangdun Choi. 2017. Encyclopedia of Signaling Molecules. Encyclopedia of Signaling Molecules 1 10 .
Kenta Moriwaki & Francis Ka-Ming Chan. (2016) Necroptosis-independent signaling by the RIP kinases in inflammation. Cellular and Molecular Life Sciences 73:11-12, pages 2325-2334.
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Ting Zhang, Yan Zhang, Mingyao Cui, Li Jin, Yimei Wang, Fengxiang Lv, Yuli Liu, Wen Zheng, Haibao Shang, Jun Zhang, Mao Zhang, Hongkun Wu, Jiaojiao Guo, Xiuqin Zhang, Xinli Hu, Chun-Mei Cao & Rui-Ping Xiao. (2016) CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress–induced myocardial necroptosis. Nature Medicine 22:2, pages 175-182.
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Muhammad Ayaz Anwar & Sangdun Choi. 2016. Encyclopedia of Signaling Molecules. Encyclopedia of Signaling Molecules 1 10 .
Andrew Godwin, Archna Sharma, Weng-Lang Yang, Zhimin Wang, Jeffrey Nicastro, Gene F. Coppa & Ping Wang. (2015) Receptor-Interacting Protein Kinase 3 Deficiency Delays Cutaneous Wound Healing. PLOS ONE 10:10, pages e0140514.
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Francis Ka-Ming ChanNivea Farias Luz & Kenta Moriwaki. (2015) Programmed Necrosis in the Cross Talk of Cell Death and Inflammation. Annual Review of Immunology 33:1, pages 79-106.
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Pratyusha Mandal, Scott B. Berger, Sirika Pillay, Kenta Moriwaki, Chunzi Huang, Hongyan Guo, John D. Lich, Joshua Finger, Viera Kasparcova, Bart Votta, Michael Ouellette, Bryan W. King, David Wisnoski, Ami S. Lakdawala, Michael P. DeMartino, Linda N. Casillas, Pamela A. Haile, Clark A. Sehon, Robert W. Marquis, Jason Upton, Lisa P. Daley-Bauer, Linda Roback, Nancy Ramia, Cole M. Dovey, Jan E. Carette, Francis Ka-Ming Chan, John Bertin, Peter J. Gough, Edward S. Mocarski & William J. Kaiser. (2014) RIP3 Induces Apoptosis Independent of Pronecrotic Kinase Activity. Molecular Cell 56:4, pages 481-495.
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W D Cook, D M Moujalled, T J Ralph, P Lock, S N Young, J M Murphy & D L Vaux. (2014) RIPK1- and RIPK3-induced cell death mode is determined by target availability. Cell Death & Differentiation 21:10, pages 1600-1612.
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Can Lu, Li-yan Zhou, Hui-jun Xu, Xing-yu Chen, Zhong-sheng Tong, Xiao-dong Liu, Yong-sheng Jia & Yue Chen. (2014) RIP3 overexpression sensitizes human breast cancer cells to parthenolide in vitro via intracellular ROS accumulation. Acta Pharmacologica Sinica 35:7, pages 929-936.
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Ju-Fang Huang, Lei Shang, Meng-Qi Zhang, Hui Wang, Dan Chen, Jian-Bin Tong, He Huang, Xiao-Xin Yan, Le-Ping Zeng & Kun Xiong. (2013) Differential neuronal expression of receptor interacting protein 3 in rat retina: involvement in ischemic stress response. BMC Neuroscience 14:1.
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Isabelle Coupienne, Grégory Fettweis & Jacques Piette. (2011) RIP3 expression induces a death profile change in U2OS osteosarcoma cells after 5-ALA-PDT. Lasers in Surgery and Medicine 43:7, pages 557-564.
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Duanwu Zhang, Juan Lin & Jiahuai Han. (2010) Receptor-interacting protein (RIP) kinase family. Cellular & Molecular Immunology 7:4, pages 243-249.
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Qian Li, Geng Li, Xiaomei Lan, Ming Zheng, Kuang-Hueih Chen, Chun-Mei Cao & Rui-Ping Xiao. (2010) Receptor Interacting Protein 3 Suppresses Vascular Smooth Muscle Cell Growth by Inhibition of the Phosphoinositide 3-Kinase-Akt Axis. Journal of Biological Chemistry 285:13, pages 9535-9544.
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YoungSik Cho, Sreerupa Challa, David Moquin, Ryan Genga, Tathagat Dutta Ray, Melissa Guildford & Francis Ka-Ming Chan. (2009) Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation. Cell 137:6, pages 1112-1123.
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. 2009. Class 2 Transferases. Class 2 Transferases 441 565 .
Mei Li, Shanshan Feng & Mian Wu. (2008) Multiple roles for nuclear localization signal (NLS, aa 442–472) of receptor interacting protein 3 (RIP3). Biochemical and Biophysical Research Communications 372:4, pages 850-855.
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Jason W. Upton, William J. Kaiser & Edward S. Mocarski. (2008) Cytomegalovirus M45 Cell Death Suppression Requires Receptor-interacting Protein (RIP) Homotypic Interaction Motif (RHIM)-dependent Interaction with RIP1. Journal of Biological Chemistry 283:25, pages 16966-16970.
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Svenja Ehlers, Tobias Mueck, Stephanie Adams, Lorena Landuzzi, Pier-Luigi Lollini & Barbara Munz. (2008) RIP2 regulates growth and differentiation of normal myoblasts and of rhabdomyosarcoma cells. European Journal of Cell Biology 87:3, pages 163-172.
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Shanshan Feng, Yonghui Yang, Yide Mei, Li Ma, De-e Zhu, Naseruddin Hoti, Mark Castanares & Mian Wu. (2007) Cleavage of RIP3 inactivates its caspase-independent apoptosis pathway by removal of kinase domain. Cellular Signalling 19:10, pages 2056-2067.
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Mi Suk Jeong, Jeong Soon Park & Se Bok Jang. (2007) Cloning, overexpression, purification, and characterization of receptor-interacting protein 3 truncation inEscherichia coli. Applied Biochemistry and Biotechnology 141:2-3, pages 175-186.
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Stephanie Adams, Sandra Pankow, Sabine Werner & Barbara Munz. (2007) Regulation of NF-κB Activity and Keratinocyte Differentiation by the RIP4 Protein: Implications for Cutaneous Wound Repair. Journal of Investigative Dermatology 127:3, pages 538-544.
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. 2007. Class 2 Transferases VIII. Class 2 Transferases VIII 637 661 .
Shanshan Feng, Li Ma, Yonghui Yang & Mian Wu. (2006) Truncated RIP3 (tRIP3) acts upstream of FADD to induce apoptosis in the human hepatocellular carcinoma cell line QGY-7703. Biochemical and Biophysical Research Communications 347:3, pages 558-565.
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Yonghui Yang, Weiping Hu, Shanshan Feng, Jun Ma & Mian Wu. (2005) RIP3 β and RIP3 γ, two novel splice variants of receptor-interacting protein 3 (RIP3), downregulate RIP3-induced apoptosis. Biochemical and Biophysical Research Communications 332:1, pages 181-187.
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Etienne Meylan & Jürg Tschopp. (2005) The RIP kinases: crucial integrators of cellular stress. Trends in Biochemical Sciences 30:3, pages 151-159.
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Yonghui Yang, Jun Ma, Youjun Chen & Mian Wu. (2004) Nucleocytoplasmic Shuttling of Receptor-interacting Protein 3 (RIP3). Journal of Biological Chemistry 279:37, pages 38820-38829.
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Akihiro Muto, Jürgen Ruland, Linda M. McAllister-Lucas, Peter C. Lucas, Shoji Yamaoka, Felicia F. Chen, Amy Lin, Tak W. Mak, Gabriel Núñez & Naohiro Inohara. (2002) Protein Kinase C-associated Kinase (PKK) Mediates Bcl10-independent NF-κB Activation Induced by Phorbol Ester. Journal of Biological Chemistry 277:35, pages 31871-31876.
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Xiaoqing Sun, Jianping Yin, Melissa A. Starovasnik, Wayne J. Fairbrother & Vishva M. Dixit. (2002) Identification of a Novel Homotypic Interaction Motif Required for the Phosphorylation of Receptor-interacting Protein (RIP) by RIP3. Journal of Biological Chemistry 277:11, pages 9505-9511.
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Toshiyuki Araki, Rakesh Nagarajan & Jeffrey Milbrandt. (2001) Identification of Genes Induced in Peripheral Nerve after Injury. Journal of Biological Chemistry 276:36, pages 34131-34141.
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Karen Heyninck & Rudi Beyaert. (2001) Crosstalk between NF-κB-Activating and Apoptosis-Inducing Proteins of the TNF-Receptor Complex. Molecular Cell Biology Research Communications 4:5, pages 259-265.
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Bharat B Aggarwal. (2000) Apoptosis and nuclear factor-κb: a tale of association and dissociation. Biochemical Pharmacology 60:8, pages 1033-1039.
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Naohiro Inohara, Takeyoshi Koseki, Jingmei Lin, Luis del Peso, Peter C. Lucas, Felicia F. Chen, Yasunori Ogura & Gabriel Núñez. (2000) An Induced Proximity Model for NF-κB Activation in the Nod1/RICK and RIP Signaling Pathways. Journal of Biological Chemistry 275:36, pages 27823-27831.
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