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Molecular and Cellular Biology Volume 19, 1999 - Issue 10
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Cell Growth and Development

The BH3 Domain of Bcl-xS Is Required for Inhibition of the Antiapoptotic Function of Bcl-xL

Brian S. Chang1 Gwen Knapp Center for Lupus and Immunology Research;2 Department of Medicine
,
Ameeta Kelekar1 Gwen Knapp Center for Lupus and Immunology Research;3 Howard Hughes Medical Institute
,
Marian H. Harris1 Gwen Knapp Center for Lupus and Immunology Research;4 Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, Illinois60637
,
John E. Harlan5 Pharmaceutical Discovery Division, Abbott Laboratories, Abbott Park, Illinois60664
,
Stephen W. Fesik5 Pharmaceutical Discovery Division, Abbott Laboratories, Abbott Park, Illinois60664
&
Craig B. Thompson1 Gwen Knapp Center for Lupus and Immunology Research;2 Department of Medicine;3 Howard Hughes Medical Institute;4 Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, Illinois60637Correspondence[email protected]
Pages 6673-6681 | Received 08 Dec 1998, Accepted 06 Jul 1999, Published online: 28 Mar 2023

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F. Gautier, Y. Guillemin, P. F. Cartron, T. Gallenne, N. Cauquil, T. Le Diguarher, P. Casara, F. M. Vallette, S. Manon, J. A. Hickman, O. Geneste & P. Juin. (2011) Bax Activation by Engagement with, Then Release from, the BH3 Binding Site of Bcl-xL. Molecular and Cellular Biology 31:4, pages 832-844.
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Timothée Revil, Johanne Toutant, Lulzim Shkreta, Daniel Garneau, Philippe Cloutier & Benoit Chabot. (2007) Protein Kinase C-Dependent Control of Bcl-x Alternative Splicing. Molecular and Cellular Biology 27:24, pages 8431-8441.
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Zhihui Dou, Dapeng Zhao, Xiaohua Chen, Caipeng Xu, Xiaodong Jin, Xuetian Zhang, Yupei Wang, Xiaodong Xie, Qiang Li, Cuixia Di & Hong Zhang. (2021) Aberrant Bcl-x splicing in cancer: from molecular mechanism to therapeutic modulation. Journal of Experimental & Clinical Cancer Research 40:1.
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Sehar Afreen, Sheila Bohler, Alexandra Müller, Eva-Maria Demmerath, Julia Miriam Weiss, Jonas Samuel Jutzi, Kristina Schachtrup, Mirjam Kunze & Miriam Erlacher. (2020) BCL-XL expression is essential for human erythropoiesis and engraftment of hematopoietic stem cells. Cell Death & Disease 11:1.
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Viacheslav V. Senichkin, Alena Y. Streletskaia, Boris Zhivotovsky & Gelina S. Kopeina. (2019) Molecular Comprehension of Mcl-1: From Gene Structure to Cancer Therapy. Trends in Cell Biology 29:7, pages 549-562.
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Erinna F. Lee & W. Douglas Fairlie. (2019) The Structural Biology of Bcl-xL. International Journal of Molecular Sciences 20:9, pages 2234.
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Chloe F. A. Warren, Michelle W. Wong-Brown & Nikola A. Bowden. (2019) BCL-2 family isoforms in apoptosis and cancer. Cell Death & Disease 10:3.
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Anna Sobol, Caroline Askonas, Sara Alani, Megan J. Weber, Vijayalakshmi Ananthanarayanan, Clodia Osipo & Maurizio Bocchetta. (2017) Deubiquitinase OTUD6B Isoforms Are Important Regulators of Growth and Proliferation. Molecular Cancer Research 15:2, pages 117-127.
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Han-A ParkPawel LicznerskiKambiz N. AlavianMarya ShanabroughElizabeth A. Jonas. (2015) Bcl-xL Is Necessary for Neurite Outgrowth in Hippocampal Neurons. Antioxidants & Redox Signaling 22:2, pages 93-108.
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Erinna F. Lee, Grant Dewson, Marco Evangelista, Anne Pettikiriarachchi, Grace J. Gold, Haoran Zhu, Peter M. Colman & W. Douglas Fairlie. (2014) The Functional Differences between Pro-survival and Pro-apoptotic B Cell Lymphoma 2 (Bcl-2) Proteins Depend on Structural Differences in Their Bcl-2 Homology 3 (BH3) Domains. Journal of Biological Chemistry 289:52, pages 36001-36017.
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Francesco Abate, Andrea Acquaviva, Elisa Ficarra, Roberto Piva & Enrico Macii. (2013) Gelsius: A Literature-Based Workflow for Determining Quantitative Associations between Genes and Biological Processes. IEEE/ACM Transactions on Computational Biology and Bioinformatics 10:3, pages 619-631.
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Sushma Kalmodia, Bikramjit Basu & Thomas J Webster. (2012) Gene expression in osteoblast cells treated with submicron to nanometer hydroxyapatite-mullite eluate particles. Journal of Biomaterials Applications 27:7, pages 891-908.
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Lulzim Shkreta, Brendan Bell, Timothée Revil, Julian P. Venables, Panagiotis Prinos, Sherif Abou Elela & Benoit Chabot. 2013. RNA and Cancer. RNA and Cancer 41 94 .
Christos K. Kontos & Andreas Scorilas. (2012) Molecular cloning of novel alternatively spliced variants of BCL2L12, a new member of the BCL2 gene family, and their expression analysis in cancer cells. Gene 505:1, pages 153-166.
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Francesca Martorana, Liliana Brambilla, Chiara F. Valori, Chiara Bergamaschi, Chiara Roncoroni, Eleonora Aronica, Andrea Volterra, Paola Bezzi & Daniela Rossi. (2012) The BH4 domain of Bcl-XL rescues astrocyte degeneration in amyotrophic lateral sclerosis by modulating intracellular calcium signals. Human Molecular Genetics 21:4, pages 826-840.
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Supatra KachadrokaAlicia M. HallTracy L. NiedzielkoSukumal ChongthammakunCandace L. Floyd. (2010) Effect of Endogenous Androgens on 17 β -Estradiol-Mediated Protection after Spinal Cord Injury in Male Rats . Journal of Neurotrauma 27:3, pages 611-626.
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Silvia Campello & Luca Scorrano. 2009. Essentials of Apoptosis. Essentials of Apoptosis 151 175 .
William Blum & Guido Marcucci. (2008) New approaches in acute myeloid leukemia. Best Practice & Research Clinical Haematology 21:1, pages 29-41.
Crossref
Guido Kroemer, Lorenzo Galluzzi & Catherine Brenner. (2007) Mitochondrial Membrane Permeabilization in Cell Death. Physiological Reviews 87:1, pages 99-163.
Crossref
L Lindenboim, S Kringel, T Braun, C Borner & R Stein. (2005) Bak but not Bax is essential for Bcl-xS-induced apoptosis. Cell Death & Differentiation 12:7, pages 713-723.
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Georg Dangel, Florian Lang & Albrecht Lepple-Wienhues. (2005) Effect of Sphingosine on Ca<sup>2+</sup> Entry and Mitochondrial Potential of Jurkat T Cells - Interaction with Bcl<sub>2</sub>. Cellular Physiology and Biochemistry 16:1-3, pages 9-14.
Crossref
Liora Lindenboim, Sarah Schlipf, Thomas Kaufmann, Christoph Borner & Reuven Stein. (2004) Bcl-xS induces an NGF-inhibitable cytochrome c release. Experimental Cell Research 297:2, pages 392-403.
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M. A. Morgan, J. N. Poynter, J. Maybaum & T. S. Lawrence. (2004) The Role of Bcl-X S in Radiation Sensitivity . Radiation Research 161:5, pages 535-539.
Crossref
Luca Scorrano & Stanley J. Korsmeyer. (2003) Mechanisms of cytochrome c release by proapoptotic BCL-2 family members. Biochemical and Biophysical Research Communications 304:3, pages 437-444.
Crossref
Zhihong Jiang, Xiao Zheng & Keith M. Rich. (2003) Down-regulation of Bcl-2 and Bcl-xL expression with bispecific antisense treatment in glioblastoma cell lines induce cell death. Journal of Neurochemistry 84:2, pages 273-281.
Crossref
Ameeta Kelekar & Craig B. Thompson. 2002. Wiley Encyclopedia of Molecular Medicine. Wiley Encyclopedia of Molecular Medicine.
Arnaud Zaldumbide, Lidia Sevilla, Philippe Pognonec & Kim E. Boulukos. (2001) Contrôle de l’expression de Bcl-x L par les facteurs de transcription Ets . médecine/sciences 17:12, pages 1356-1357.
Crossref
L Lindenboim, C Borner & R Stein. (2001) Bcl-xS can form homodimers and heterodimers and its apoptotic activity requires localization of Bcl-xS to the mitochondria and its BH3 and loop domains. Cell Death & Differentiation 8:9, pages 933-942.
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Yun-Fu Sun, Li-Ying Yu, Mart Saarma, Tõnis Timmusk & Urmas Arumäe. (2001) Neuron-specific Bcl-2 Homology 3 Domain-only Splice Variant of Bak Is Anti-apoptotic in Neurons, but Pro-apoptotic in Non-neuronal Cells. Journal of Biological Chemistry 276:19, pages 16240-16247.
Crossref
Lidia Sevilla, Arnaud Zaldumbide, Francoise Carlotti, Manal Abdel Dayem, Philippe Pognonec & Kim E. Boulukos. (2001) Bcl-xL Expression Correlates with Primary Macrophage Differentiation, Activation of Functional Competence, and Survival and Results from Synergistic Transcriptional Activation by Ets2 and PU.1. Journal of Biological Chemistry 276:21, pages 17800-17807.
Crossref
David R. Plas, Sunit Talapatra, Aimee L. Edinger, Jeffrey C. Rathmell & Craig B. Thompson. (2001) Akt and Bcl-xL Promote Growth Factor-independent Survival through Distinct Effects on Mitochondrial Physiology. Journal of Biological Chemistry 276:15, pages 12041-12048.
Crossref
Alexei Degterev, Alexey Lugovskoy, Michael Cardone, Bradley Mulley, Gerhard Wagner, Timothy Mitchison & Junying Yuan. (2001) Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL. Nature Cell Biology 3:2, pages 173-182.
Crossref
Raj. S. Mitra, Mary A. Benedict, Dalong Qian, Kimberly E. Foreman, Daryoush Ekhterae, Brian J. Nickoloff & Gabriel Nuñez. (2001) Killing of Sarcoma Cells by Proapoptotic Bcl-XS: Role of the BH3 Domain and Regulation by Bcl-XL. Neoplasia 3:5, pages 437-445.
Crossref
Jeehyeon Bae, Chandra P. Leo, Sheau Yu Hsu & Aaron J.W. Hsueh. (2000) MCL-1S, a Splicing Variant of the Antiapoptotic BCL-2 Family Member MCL-1, Encodes a Proapoptotic Protein Possessing Only the BH3 Domain. Journal of Biological Chemistry 275:33, pages 25255-25261.
Crossref

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