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Molecular and Cellular Biology Volume 19, 1999 - Issue 10
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Transcriptional Regulation

hnRNP U Inhibits Carboxy-Terminal Domain Phosphorylation by TFIIH and Represses RNA Polymerase II Elongation

Myung K. Kim1 Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, and Laboratory of Molecular Hematology, National Heart, Lung, and Blood InstituteCorrespondence[email protected]
&
Vera M. Nikodem2 Mechanisms of Gene Regulation Section, Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland20892
Pages 6833-6844 | Received 01 Jun 1999, Accepted 05 Jul 1999, Published online: 28 Mar 2023

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Crossref
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