24
Views
129
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Cell-Extracellular Matrix Interactions Stimulate the AP-1 Transcription Factor in an Integrin-Linked Kinase- and Glycogen Synthase Kinase 3-Dependent Manner

, , &
Pages 7420-7427 | Received 24 May 1999, Accepted 09 Aug 1999, Published online: 28 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Katerina Tsirtsaki & Vasiliki Gkretsi. (2020) The focal adhesion protein Integrin-Linked Kinase (ILK) as an important player in breast cancer pathogenesis. Cell Adhesion & Migration 14:1, pages 204-213.
Read now
Stephanie Hehlgans, Iris Eke & Nils Cordes. (2007) An essential role of integrin-linked kinase in the cellular radiosensitivity of normal fibroblasts during the process of cell adhesion and spreading. International Journal of Radiation Biology 83:11-12, pages 769-779.
Read now
N. Cordes, M. A. Blaese, L. Plasswilm, H. P. Rodemann & D. Van Beuningen. (2003) Fibronectin and laminin increase resistance to ionizing radiation and the cytotoxic drug Ukrain® in human tumour and normal cells in vitro. International Journal of Radiation Biology 79:9, pages 709-720.
Read now
Raymond Reeves, Dale D. Edberg & Ying Li. (2001) Architectural Transcription Factor HMGI(Y) Promotes Tumor Progression and Mesenchymal Transition of Human Epithelial Cells. Molecular and Cellular Biology 21:2, pages 575-594.
Read now

Articles from other publishers (125)

Manrong Qu, Kehui Yu, Aziz Ur Rehman Aziz, Hangyu Zhang, Zhengyao Zhang, Na Li & Bo Liu. (2022) The role of Actopaxin in tumor metastasis. Progress in Biophysics and Molecular Biology 175, pages 90-102.
Crossref
Agata Górska & Antonina Joanna Mazur. (2022) Integrin-linked kinase (ILK): the known vs. the unknown and perspectives. Cellular and Molecular Life Sciences 79:2.
Crossref
Anna S. Sowa, Taissia G. Popova, Tina Harmuth, Jonasz J. Weber, Priscila Pereira Sena, Jana Schmidt, Jeannette Hübener-Schmid & Thorsten Schmidt. (2021) Neurodegenerative phosphoprotein signaling landscape in models of SCA3. Molecular Brain 14:1.
Crossref
Biraja C. Dash, Kaiti Duan, Themis R. Kyriakides & Henry C. Hsia. (2021) Integrin β3 targeting biomaterial preferentially promotes secretion of bFGF and viability of iPSC-derived vascular smooth muscle cells. Biomaterials Science 9:15, pages 5319-5329.
Crossref
Margherita De Marzio, Ayşe KılıçEnrico Maiorino, Jennifer A. Mitchel, Chimwemwe Mwase, Michael J. O’SullivanMaureen McGillRobert Chase, Jeffrey J. Fredberg, Jin-Ah Park, Kimberly GlassScott T. Weiss. (2021) Genomic signatures of the unjamming transition in compressed human bronchial epithelial cells. Science Advances 7:30.
Crossref
Akinori Yuzuriha, Sou Nakamura, Naoshi Sugimoto, Shunsuke Kihara, Masato Nakagawa, Takuya Yamamoto, Kiyotoshi Sekiguchi & Koji Eto. (2021) Extracellular laminin regulates hematopoietic potential of pluripotent stem cells through integrin β1-ILK-β-catenin-JUN axis. Stem Cell Research 53, pages 102287.
Crossref
Leonie Hoffmeister, Mareike Diekmann, Korbinian Brand & René Huber. (2020) GSK3: A Kinase Balancing Promotion and Resolution of Inflammation. Cells 9:4, pages 820.
Crossref
Nilesh Sudhakar Ambhore, Rama Satyanarayana Raju Kalidhindi, Christina M. Pabelick, John R. Hawse, Y. S. Prakash & Venkatachalem Sathish. (2019) Differential estrogen‐receptor activation regulates extracellular matrix deposition in human airway smooth muscle remodeling via NF‐κB pathway . The FASEB Journal 33:12, pages 13935-13950.
Crossref
Mohammed Alasseiri, Afsar U. Ahmed & Bryan R.G. Williams. (2018) Mechanisms and consequences of constitutive activation of integrin-linked kinase in acute myeloid leukemia. Cytokine & Growth Factor Reviews 43, pages 1-7.
Crossref
Mansi Y. Shinde, Simone Sidoli, Katarzyna Kulej, Michael J. Mallory, Caleb M. Radens, Amanda L. Reicherter, Rebecca L. Myers, Yoseph Barash, Kristen W. Lynch, Benjamin A. Garcia & Peter S. Klein. (2017) Phosphoproteomics reveals that glycogen synthase kinase-3 phosphorylates multiple splicing factors and is associated with alternative splicing. Journal of Biological Chemistry 292:44, pages 18240-18255.
Crossref
Monoranjan Boro & Kithiganahalli Narayanaswamy Balaji. (2017) CXCL1 and CXCL2 Regulate NLRP3 Inflammasome Activation via G-Protein–Coupled Receptor CXCR2. The Journal of Immunology 199:5, pages 1660-1671.
Crossref
Marco Hatem-Vaquero, Mercedes Griera, Wieslawa Giermakowska, Alicia Luengo, Laura Calleros, Laura V. Gonzalez Bosc, Diego Rodríguez-Puyol, Manuel Rodríguez-Puyol & Sergio De Frutos. (2017) Integrin linked kinase regulates the transcription of AQP2 by NFATC3. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1860:9, pages 922-935.
Crossref
Qi Ding, Gaoqin Liu, Yuanyuan Zeng, Jianjie Zhu, Zeyi Liu, Junhong Jiang & Jianan Huang. (2017) Glycogen synthase kinase-3β inhibitor reduces LPS-induced acute lung injury in mice. Molecular Medicine Reports 16:5, pages 6715-6721.
Crossref
Qiang Yan, Hao Luo, Baoyao Wang, Weiguo Sui, Guimian Zou, Huaizhou Chen & Hequn Zou. (2017) Correlation between PKB/Akt, GSK-3β expression and tubular epithelial-mesenchymal transition in renal allografts with chronic active antibody-mediated rejection. Experimental and Therapeutic Medicine 13:5, pages 2217-2224.
Crossref
Chih-Feng Yen, Sung Hoon Kim, Shuen-Kuei Liao, Cem Atabekoglu, Serpil Uckac, Aydin Arici, Sefa Arlier, Chyi-Long Lee, Hsin-Shih Wang & Umit A. Kayisli. (2017) Increased expression of integrin-linked kinase during decidualization regulates the morphological transformation of endometrial stromal cells. Fertility and Sterility 107:3, pages 803-812.
Crossref
P. S. Sushma, P. UdayKumar & Aliya Sheik. 2017. Role of Transcription Factors in Gastrointestinal Malignancies. Role of Transcription Factors in Gastrointestinal Malignancies 19 32 .
Silke Kuphal & Nikolas K. Haass. 2017. Melanoma Development. Melanoma Development 227 269 .
Esmat Amiri, Rasoul Ghasemi & Maryam Moosavi. (2015) Agmatine Protects Against 6-OHDA-Induced Apoptosis, and ERK and Akt/GSK Disruption in SH-SY5Y Cells. Cellular and Molecular Neurobiology 36:6, pages 829-838.
Crossref
JIA WANG, XIANYAO WAN, YIFAN GAO, MINTAO ZHONG, LI SHA, BEN LIU, WEI ZHANG, LI TIAN, WENJING RUAN, SHUYUN CAO & MIN HUANG. (2016) Latcripin-13 domain induces apoptosis and cell cycle arrest at the G1 phase in human lung carcinoma A549 cells. Oncology Reports 36:1, pages 441-447.
Crossref
Gang Li, Ye-Yang Li, Jing-En Sun, Wei-hua Lin & Ri-xing Zhou. (2016) ILK–PI3K/AKT pathway participates in cutaneous wound contraction by regulating fibroblast migration and differentiation to myofibroblast. Laboratory Investigation 96:7, pages 741-751.
Crossref
Ay-Huey Huang, Szu-Hua Pan, Wen-Hsin Chang, Qi-Sheng Hong, Jeremy J. W. Chen & Sung-Liang Yu. (2015) PARVA Promotes Metastasis by Modulating ILK Signalling Pathway in Lung Adenocarcinoma. PLOS ONE 10:3, pages e0118530.
Crossref
Meenalakshmi M. Mariappan, Sanjay Prasad, Kristin D'Silva, Esteban Cedillo, Kavithalakshmi Sataranatarajan, Jeffrey L. Barnes, Goutam Ghosh Choudhury & Balakuntalam S. Kasinath. (2014) Activation of Glycogen Synthase Kinase 3β Ameliorates Diabetes-induced Kidney Injury. Journal of Biological Chemistry 289:51, pages 35363-35375.
Crossref
Rong Wang & Xing Zhong Wu. (2014) Roles of galactose 3′-O- sulfation in signaling. Glycoconjugate Journal 31:8, pages 549-554.
Crossref
Chih-Feng Yen, Hsin-Shih Wang, Chyi-Long Lee & Shuen-Kuei Liao. (2014) Roles of integrin-linked kinase in cell signaling and its perspectives as a therapeutic target. Gynecology and Minimally Invasive Therapy 3:3, pages 67-72.
Crossref
Maryam Moosavi, Amir Hossein Zarifkar, Yaghoub Farbood, Mahin Dianat, Alireza Sarkaki & Rasoul Ghasemi. (2014) Agmatine protects against intracerebroventricular streptozotocin-induced water maze memory deficit, hippocampal apoptosis and Akt/GSK3β signaling disruption. European Journal of Pharmacology 736, pages 107-114.
Crossref
Feng Shi, Xiaochun Long, Allison Hendershot, Joseph M. Miano & Jane Sottile. (2014) Fibronectin Matrix Polymerization Regulates Smooth Muscle Cell Phenotype through a Rac1 Dependent Mechanism. PLoS ONE 9:4, pages e94988.
Crossref
Jad El-Hoss, Alice Arabian, Shoukat Dedhar & René St-Arnaud. (2014) Inactivation of the Integrin-Linked Kinase (ILK) in osteoblasts increases mineralization. Gene 533:1, pages 246-252.
Crossref
Yoshiyuki Matsui, Kiran Assi, Osamu Ogawa, Peter A. Raven, Shoukat Dedhar, Martin E. Gleave, Baljinder Salh & Alan I. So. (2012) The importance of integrin-linked kinase in the regulation of bladder cancer invasion. International Journal of Cancer 130:3, pages 521-531.
Crossref
Teresa Ponce-Lopez, Gustavo Liy-Salmeron, Enrique Hong & Alfredo Meneses. (2011) Lithium, phenserine, memantine and pioglitazone reverse memory deficit and restore phospho-GSK3β decreased in hippocampus in intracerebroventricular streptozotocin induced memory deficit model. Brain Research 1426, pages 73-85.
Crossref
Isela García, Yagamare Fall, Xerardo García-Mera & Francisco Prado-Prado. (2011) Theoretical study of GSK−3α: neural networks QSAR studies for the design of new inhibitors using 2D descriptors. Molecular Diversity 15:4, pages 947-955.
Crossref
Gil-Yong Jung, Yoon-Jeong Park & Jung-Suk Han. (2011) Mediation of Rac1 activation by kindlin-2: An essential function in osteoblast adhesion, spreading, and proliferation. Journal of Cellular Biochemistry 112:9, pages 2541-2548.
Crossref
Solange Landreville, François Vigneault, Marjorie-Allison Bergeron, Steeve Leclerc, Manon Gaudreault, Mohib Morcos, Frédéric Mouriaux, Christian Salesse & Sylvain L. Guérin. (2011) Suppression of α5 gene expression is closely related to the tumorigenic properties of uveal melanoma cell lines. Pigment Cell & Melanoma Research 24:4, pages 643-655.
Crossref
Youhei Yamaguchi, Tatsuya Ishigaki, Koushi Sano, Kei-Ichi Miyamoto, Shinsuke Nomura & Takashi Horiuchi. (2011) Three-Dimensional Invasion of Epithelial–Mesenchymal Transition–Positive Human Peritoneal Mesothelial Cells into Collagen Gel is Promoted by the Concentration Gradient of Fibronectin. Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 31:4, pages 477-485.
Crossref
A A Wani, S M Jafarnejad, J Zhou & G Li. (2011) Integrin-linked kinase regulates melanoma angiogenesis by activating NF-κB/interleukin-6 signaling pathway. Oncogene 30:24, pages 2778-2788.
Crossref
Danny Guo, Gayatri Thiyam, Sreedhar Bodiga, Zamaneh Kassiri & Gavin Y. Oudit. (2011) Uncoupling between enhanced excitation–contraction coupling and the response to heart disease: Lessons from the PI3Kγ knockout murine model. Journal of Molecular and Cellular Cardiology 50:4, pages 606-612.
Crossref
Vinicio A. de Jesus Perez, Ziad Ali, Tero-Pekka Alastalo, Fumiaki Ikeno, Hirofumi Sawada, Ying-Ju Lai, Thomas Kleisli, Edda Spiekerkoetter, Xiumei Qu, Laura H. Rubinos, Euan Ashley, Manuel Amieva, Shoukat Dedhar & Marlene Rabinovitch. (2011) BMP promotes motility and represses growth of smooth muscle cells by activation of tandem Wnt pathways. Journal of Cell Biology 192:1, pages 171-188.
Crossref
Silke Kuphal & Nikolas K. Haass. 2011. Melanoma Development. Melanoma Development 181 215 .
J Kalra, B W Sutherland, A L Stratford, W Dragowska, K A Gelmon, S Dedhar, S E Dunn & M B Bally. (2010) Suppression of Her2/neu expression through ILK inhibition is regulated by a pathway involving TWIST and YB-1. Oncogene 29:48, pages 6343-6356.
Crossref
Mykola Maydan, Paul C. McDonald, Jasbinder Sanghera, Jun Yan, Charalampos Rallis, Sheena Pinchin, Gregory E. Hannigan, Leonard J. Foster, David Ish-Horowicz, Michael P. Walsh & Shoukat Dedhar. (2010) Integrin-Linked Kinase Is a Functional Mn2+-Dependent Protein Kinase that Regulates Glycogen Synthase Kinase-3β (GSK-3β) Phosphorylation. PLoS ONE 5:8, pages e12356.
Crossref
Rudolfs Zalups & James KoropatnickAlan Parrish & Walter Prozialeck. 2010. Cellular and Molecular Biology of Metals. Cellular and Molecular Biology of Metals 327 350 .
Danny Guo, Zamaneh Kassiri & Gavin Y. Oudit. 2011. Mechanosensitivity and Mechanotransduction. Mechanosensitivity and Mechanotransduction 141 166 .
Jun Li, Heng Zhang, Jueheng Wu, Hongyu Guan, Jie Yuan, Zhengsong Huang & Mengfeng Li. (2010) Prognostic significance of integrin-linked kinase1 overexpression in astrocytoma. International Journal of Cancer, pages NA-NA.
Crossref
Mallikarjuna Gu, Srirupa Roy, Komal Raina, Chapla Agarwal & Rajesh Agarwal. (2009) Inositol Hexaphosphate Suppresses Growth and Induces Apoptosis in Prostate Carcinoma Cells in Culture and Nude Mouse Xenograft: PI3K-Akt Pathway as Potential Target. Cancer Research 69:24, pages 9465-9472.
Crossref
Hany A. Omar, Aaron M. Sargeant, Jing-Ru Weng, Dasheng Wang, Samuel K. Kulp, Tushar Patel & Ching-Shih Chen. (2009) Targeting of the Akt-Nuclear Factor-κB Signaling Network by [1-(4-Chloro-3-nitrobenzenesulfonyl)-1 H -indol-3-yl]-methanol (OSU-A9), a Novel Indole-3-Carbinol Derivative, in a Mouse Model of Hepatocellular Carcinoma . Molecular Pharmacology 76:5, pages 957-968.
Crossref
Lihua Ying, Agatha Lau, Cristina M. Alvira, Robert West, Gordon M. Cann, Bin Zhou, Caroline Kinnear, Eric Jan, Peter Sarnow, Matt Van de Rijn & Marlene Rabinovitch. (2009) LC3-mediated fibronectin mRNA translation induces fibrosarcoma growth by increasing connective tissue growth factor. Journal of Cell Science 122:9, pages 1441-1451.
Crossref
Sonyo Shin, Takayuki Asano, Yixin Yao, Ronghua Zhang, Francois-Xavier Claret, Murray Korc, Kanaga Sabapathy, David G. Menter, James L. Abbruzzese & Shrikanth A.G. Reddy. (2009) Activator Protein-1 Has an Essential Role in Pancreatic Cancer Cells and Is Regulated by a Novel Akt-Mediated Mechanism. Molecular Cancer Research 7:5, pages 745-754.
Crossref
Joel Cerna Cortés, Eliud Alfredo Garcia Montalvo, Jesús Muñiz, Dominique Mornet, Efrain Garrido, Federico Centeno & Bulmaro Cisneros. (2008) Dp71f Modulates GSK3-β Recruitment to the β1-Integrin Adhesion Complex. Neurochemical Research 34:3, pages 438-444.
Crossref
P.S. Hodkinson & Tariq Sethi. 2009. Drug Resistance in Cancer Cells. Drug Resistance in Cancer Cells 115 135 .
Timothy R. McPhee, Paul C. McDonald, Arusha Oloumi & Shoukat Dedhar. (2008) Integrin-linked kinase regulates E-cadherin expression through PARP-1. Developmental Dynamics 237:10, pages 2737-2747.
Crossref
Claudie Hooper, Richard Killick & Simon Lovestone. (2008) The GSK3 hypothesis of Alzheimer’s disease. Journal of Neurochemistry 104:6, pages 1433-1439.
Crossref
Stephanie Hehlgans, Iris Eke, Yvonne Deuse & Nils Cordes. (2008) Integrin-linked kinase: Dispensable for radiation survival of three-dimensionally cultured fibroblasts. Radiotherapy and Oncology 86:3, pages 329-335.
Crossref
Klaus Unfried, Ulrich Sydlik, Katrin Bierhals, Alexander Weissenberg & Josef Abel. (2008) Carbon nanoparticle-induced lung epithelial cell proliferation is mediated by receptor-dependent Akt activation. American Journal of Physiology-Lung Cellular and Molecular Physiology 294:2, pages L358-L367.
Crossref
T. Arendt. 2008. Handbook of Neurochemistry and Molecular Neurobiology. Handbook of Neurochemistry and Molecular Neurobiology 157 213 .
Frederique M.D. TholozanChristopher Gribbon, Zheng LiMartin W. GoldbergAlan R. Prescott, Norman McKieRoy A. Quinlan. (2007) FGF-2 Release from the Lens Capsule by MMP-2 Maintains Lens Epithelial Cell Viability. Molecular Biology of the Cell 18:11, pages 4222-4231.
Crossref
Manjunath B. Joshi, Danila Ivanov, Maria Philippova, Paul Erne & Thérèse J. Resink. (2007) Integrin‐linked kinase is an essential mediator for T‐cadherin‐dependent signaling via Akt and GSK3β in endothelial cells . The FASEB Journal 21:12, pages 3083-3095.
Crossref
Cuiling Ma, Jian Wang, Ying Gao, Tian-Wen Gao, Gang Chen, Kimberly A. Bower, Mohammed Odetallah, Min Ding, Zunji Ke & Jia Luo. (2007) The Role of Glycogen Synthase Kinase 3β in the Transformation of Epidermal Cells. Cancer Research 67:16, pages 7756-7764.
Crossref
Mark L Johnson & Mohamed A Kamel. (2007) The Wnt signaling pathway and bone metabolism. Current Opinion in Rheumatology 19:4, pages 376-382.
Crossref
Ronald P.C. Wong, Philip Ng, Shoukat Dedhar & Gang Li. (2007) The role of integrin-linked kinase in melanoma cell migration, invasion, and tumor growth. Molecular Cancer Therapeutics 6:6, pages 1692-1700.
Crossref
Walter C. Prozialeck & Joshua R. Edwards. (2007) Cell adhesion molecules in chemically-induced renal injury. Pharmacology & Therapeutics 114:1, pages 74-93.
Crossref
M.P. Ruiz-Torres, G. Perez-Rivero, M.L. Diez-Marques, M. Griera, R. Ortega, M. Rodriguez-Puyol & D. Rodríguez-Puyol. (2007) Role of activator protein-1 on the effect of arginine-glycine-aspartic acid containing peptides on transforming growth factor-β1 promoter activity. The International Journal of Biochemistry & Cell Biology 39:1, pages 133-145.
Crossref
Stephanie Hehlgans, Michael Haase & Nils Cordes. (2007) Signalling via integrins: Implications for cell survival and anticancer strategies. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1775:1, pages 163-180.
Crossref
A Oloumi, S Syam & S Dedhar. (2006) Modulation of Wnt3a-mediated nuclear β-catenin accumulation and activation by integrin-linked kinase in mammalian cells. Oncogene 25:59, pages 7747-7757.
Crossref
Ayodeji A. Asuni, Claudie Hooper, C. Hugh Reynolds, Simon Lovestone, Brian H. Anderton & Richard Killick. (2006) GSK3α exhibits β-catenin and tau directed kinase activities that are modulated by Wnt. European Journal of Neuroscience 24:12, pages 3387-3392.
Crossref
Hideaki Yamabi, Huanzhang Lu, Xiaojing Dai, Yanruo Lu, Gregory Hannigan & John G. Coles. (2006) Overexpression of integrin-linked kinase induces cardiac stem cell expansion. The Journal of Thoracic and Cardiovascular Surgery 132:6, pages 1272-1279.
Crossref
Huanzhang LuPaul W. M. FedakXiaojing DaiChangqing DuYu-Qing ZhouMark HenkelmanPerry S. MongrooArthur LauHideaki YamabiAleksander HinekMansoor HusainGregory HanniganJohn G. Coles. (2006) Integrin-Linked Kinase Expression Is Elevated in Human Cardiac Hypertrophy and Induces Hypertrophy in Transgenic Mice. Circulation 114:21, pages 2271-2279.
Crossref
P S Hodkinson, T Elliott, W S Wong, R C Rintoul, A C Mackinnon, C Haslett & T Sethi. (2006) ECM overrides DNA damage-induced cell cycle arrest and apoptosis in small-cell lung cancer cells through β1 integrin-dependent activation of PI3-kinase. Cell Death & Differentiation 13:10, pages 1776-1788.
Crossref
Yining Zhang, Tadashi Ikegami, Akira Honda, Teruo Miyazaki, Bernard Bouscarel, Marcos Rojkind, Ichinosuke Hyodo & Yasushi Matsuzaki. (2006) Involvement of integrin-linked kinase in carbon tetrachloride–induced hepatic fibrosis in rats. Hepatology 44:3, pages 612-622.
Crossref
Shinri Tamura, Shinnosuke Toriumi, Jun-ichi Saito, Kenjiro Awano, Tada-aki Kudo & Takayasu Kobayashi. (2006) PP2C family members play key roles in regulation of cell survival and apoptosis. Cancer Science 97:7, pages 563-567.
Crossref
Miriam Wittmann, Claudia Killig, Manuela Bruder, Ralf Gutzmer & Thomas Werfel. (2006) Critical involvement of IL-12 in IFN-γ induction by calcineurin antagonists in activated human lymphocytes. Journal of Leukocyte Biology 80:1, pages 75-86.
Crossref
Etienne Boulter & Ellen Van Obberghen-Schilling. (2006) Integrin-linked kinase and its partners: A modular platform regulating cell–matrix adhesion dynamics and cytoskeletal organization. European Journal of Cell Biology 85:3-4, pages 255-263.
Crossref
Yong-Jun Yang, Yu-Jing Cao, Shu-Min Bo, Sha Peng, Wei-Min Liu & En-Kui Duan. (2006) Leptin-directed embryo implantation: Leptin regulates adhesion and outgrowth of mouse blastocysts and receptivity of endometrial epithelial cells. Animal Reproduction Science 92:1-2, pages 155-167.
Crossref
Kyle R. Legate, Eloi Montañez, Oliver Kudlacek & Reinhard Füssler. (2005) ILK, PINCH and parvin: the tIPP of integrin signalling. Nature Reviews Molecular Cell Biology 7:1, pages 20-31.
Crossref
X. Xin, Z. A. Khan, S. Chen & S. Chakrabarti. (2005) Glucose-induced Akt1 activation mediates fibronectin synthesis in endothelial cells. Diabetologia 48:11, pages 2428-2436.
Crossref
Mariarita Bianchi, Stefania De Lucchini, Oriano Marin, David L. TurnerSteven K. HanksEmma Villa-Moruzzi. (2005) Regulation of FAK Ser-722 phosphorylation and kinase activity by GSK3 and PP1 during cell spreading and migration. Biochemical Journal 391:2, pages 359-370.
Crossref
Hyun-Jai ChoSeock-Won YounSoo-In CheonTae-Youn KimJin HurShu-Ying ZhangSeung Pyo LeeKyung-Woo ParkMyoung-Mook LeeYun-Shik ChoiYoung-Bae ParkHyo-Soo Kim. (2005) Regulation of Endothelial Cell and Endothelial Progenitor Cell Survival and Vasculogenesis by Integrin-Linked Kinase. Arteriosclerosis, Thrombosis, and Vascular Biology 25:6, pages 1154-1160.
Crossref
Silke Kuphal, Richard Bauer & Anja-Katrin Bosserhoff. (2005) Integrin signaling in malignant melanoma. Cancer and Metastasis Reviews 24:2, pages 195-222.
Crossref
Mark S. Duxbury, Hiromichi Ito, Eric Benoit, Talat Waseem, Stanley W. Ashley & Edward E. Whang. (2005) RNA Interference Demonstrates a Novel Role for Integrin-Linked Kinase as a Determinant of Pancreatic Adenocarcinoma Cell Gemcitabine Chemoresistance. Clinical Cancer Research 11:9, pages 3433-3438.
Crossref
Gregory Hannigan, Armelle A. Troussard & Shoukat Dedhar. (2005) Integrin-linked kinase: a cancer therapeutic target unique among its ILK. Nature Reviews Cancer 5:1, pages 51-63.
Crossref
Wara A.K.M. Khyrul, David P. LaLonde, Michael C. Brown, Howard Levinson & Christopher E. Turner. (2004) The Integrin-linked Kinase Regulates Cell Morphology and Motility in a Rho-associated Kinase-dependent Manner. Journal of Biological Chemistry 279:52, pages 54131-54139.
Crossref
Isabelle Quélo, Claude Gauthier, Gregory E. Hannigan, Shoukat Dedhar & René St-Arnaud. (2004) Integrin-linked Kinase Regulates the Nuclear Entry of the c-Jun Coactivator α-NAC and Its Coactivation Potency. Journal of Biological Chemistry 279:42, pages 43893-43899.
Crossref
Carsten Grashoff, Ingo Thievessen, Katrin Lorenz, Siegfried Ussar & Reinhard Fässler. (2004) Integrin-linked kinase: integrin’s mysterious partner. Current Opinion in Cell Biology 16:5, pages 565-571.
Crossref
Arusha Oloumi, Timothy McPhee & Shoukat Dedhar. (2004) Regulation of E-cadherin expression and β-catenin/Tcf transcriptional activity by the integrin-linked kinase. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1691:1, pages 1-15.
Crossref
Nils Cordes & Dirk van Beuningen. (2004) Arrest of human lung fibroblasts in G2 phase after irradiation is regulated by converging phosphatidylinositol-3 kinase and β1-integrin signaling in vitro. International Journal of Radiation Oncology*Biology*Physics 58:2, pages 453-462.
Crossref
Lincoln A Edwards, Jennifer A Shabbits, Marcel Bally & Shoukat Dedhar. 2004. Molecular Targeting and Signal Transduction. Molecular Targeting and Signal Transduction 59 75 .
R. Ortega-Velázquez, M. L. Dí Ez-Marqués, M. P. Ruiz-Torres, M. González-Rubio, M. Rodrí Guez-Puyol & D. Rodrí Guez Puyol. (2003) Arg‐Gly‐Asp‐Ser peptide stimulates transforming growth factor‐β1 transcription and secretion through integrin activation. The FASEB Journal 17:11, pages 1-17.
Crossref
Leonieke Terpstra, Josée Prud'homme, Alice Arabian, Shu Takeda, Gérard Karsenty, Shoukat Dedhar & René St-Arnaud. (2003) Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes. Journal of Cell Biology 162:1, pages 139-148.
Crossref
Toshiaki Ishii, Hidefumi Furuoka, Yoshikage Muroi & Masakazu Nishimura. (2003) Inactivation of Integrin-linked Kinase Induces Aberrant Tau Phosphorylation via Sustained Activation of Glycogen Synthase Kinase 3β in N1E-115 Neuroblastoma Cells. Journal of Biological Chemistry 278:29, pages 26970-26975.
Crossref
N Cordes & D van Beuningen. (2003) Cell adhesion to the extracellular matrix protein fibronectin modulates radiation-dependent G2 phase arrest involving integrin-linked kinase (ILK) and glycogen synthase kinase-3β (GSK-3β) in vitro. British Journal of Cancer 88:9, pages 1470-1479.
Crossref
Séverine Cruet-Hennequart, Sylvie Maubant, José Luis, Pascal Gauduchon, Cathy Staedel & Shoukat Dedhar. (2003) αv integrins regulate cell proliferation through integrin-linked kinase (ILK) in ovarian cancer cells. Oncogene 22:11, pages 1688-1702.
Crossref
Julia Mills, Murat Digicaylioglu, Arthur T. Legg, Clint E. Young, Sean S. Young, Alasdair M. Barr, Lauren Fletcher, Timothy P. O'Connor & Shoukat Dedhar. (2003) Role of Integrin-Linked Kinase in Nerve Growth Factor-Stimulated Neurite Outgrowth. The Journal of Neuroscience 23:5, pages 1638-1648.
Crossref
Bina Mittal, Mohammad M. Doroudchi, Suh Young Jeong, Bharatkumar N. Patel & Samuel David. (2003) Expression of a membrane-bound form of the ferroxidase ceruloplasmin by leptomeningeal cells. Glia 41:4, pages 337-346.
Crossref
Sandrine Etienne-Manneville & Alan Hall. (2003) Cdc42 regulates GSK-3β and adenomatous polyposis coli to control cell polarity. Nature 421:6924, pages 753-756.
Crossref
Christèle Desbois-Mouthon, Marie-José Blivet-Van Eggelpoë, Eléonore Beurel, Mathieu Boissan, Roland Delélo, Axelle Cadoret & Jacqueline Capeau. (2002) Dysregulation of glycogen synthase kinase-3β signaling in hepatocellular carcinoma cells. Hepatology 36:6, pages 1528-1536.
Crossref
Hyo-Soo Kim, Carsten Skurk, Shane R. Thomas, Ann Bialik, Toshimitsu Suhara, Yasuko Kureishi, Morris Birnbaum, John F. KeaneyJr.Jr. & Kenneth Walsh. (2002) Regulation of Angiogenesis by Glycogen Synthase Kinase-3β. Journal of Biological Chemistry 277:44, pages 41888-41896.
Crossref
Koji Sayama, Kenshi Yamasaki, Yasushi Hanakawa, Yuji Shirakata, Sho Tokumaru, Takeshi Ijuin, Tadaomi Takenawa & Koji Hashimoto. (2002) Phosphatidylinositol 3-Kinase Is a Key Regulator of Early Phase Differentiation in Keratinocytes. Journal of Biological Chemistry 277:43, pages 40390-40396.
Crossref
Leslie Fischer, Genevieve Boland & Rocky S. Tuan. (2002) Wnt-3A Enhances Bone Morphogenetic Protein-2-mediated Chondrogenesis of Murine C3H10T1/2 Mesenchymal Cells. Journal of Biological Chemistry 277:34, pages 30870-30878.
Crossref
Elisheva Smith, Gerhard A. Coetzee & Baruch Frenkel. (2002) Glucocorticoids Inhibit Cell Cycle Progression in Differentiating Osteoblasts via Glycogen Synthase Kinase-3β. Journal of Biological Chemistry 277:20, pages 18191-18197.
Crossref
Xiaohua Li, Gautam N Bijur & Richard S Jope. (2002) Glycogen synthase kinase-3β, mood stabilizers, and neuroprotection. Bipolar Disorders 4:2, pages 137-144.
Crossref
L. González-SantiagoS. López-OngilM. Rodríguez-PuyolD. Rodríguez-Puyol. (2002) Decreased Nitric Oxide Synthesis in Human Endothelial Cells Cultured on Type I Collagen. Circulation Research 90:5, pages 539-545.
Crossref
Cornel Badorff, Hartmut Ruetten, Sven Mueller, Meike Stahmer, Doris Gehring, Frank Jung, Christian Ihling, Andreas M. Zeiher & Stefanie Dimmeler. (2002) Fas receptor signaling inhibits glycogen synthase kinase 3β and induces cardiac hypertrophy following pressure overload. Journal of Clinical Investigation 109:3, pages 373-381.
Crossref
Cornel Badorff, Hartmut Ruetten, Sven Mueller, Meike Stahmer, Doris Gehring, Frank Jung, Christian Ihling, Andreas M. Zeiher & Stefanie Dimmeler. (2002) Fas receptor signaling inhibits glycogen synthase kinase 3β and induces cardiac hypertrophy following pressure overload. Journal of Clinical Investigation 109:3, pages 373-381.
Crossref
Clara Tan, Alice Mui & Shoukat Dedhar. (2002) Integrin-linked Kinase Regulates Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Expression in an NF-κB-dependent Manner. Journal of Biological Chemistry 277:5, pages 3109-3116.
Crossref
N. Yoganathan, A. Yee, Z. Zhang, D. Leung, J. Yan, L. Fazli, D.L. Kojic, P.C. Costello, M. Jabali, S. Dedhar & J. Sanghera. (2002) Integrin-linked kinase, a promising cancer therapeutic target: biochemical and biological properties. Pharmacology & Therapeutics 93:2-3, pages 233-242.
Crossref
VIJAYALAKSHMI THAMILSELVAN, WEI LI, BAUER E. SUMPIO & MARC D. BASSON. (2002) SPHINGOSINE-1-PHOSPHATE STIMULATES HUMAN CACO-2 INTESTINAL EPITHELIAL PROLIFERATION VIA p38 ACTIVATION AND ACTIVATES ERK BY AN INDEPENDENT MECHANISM. In Vitro Cellular & Developmental Biology - Animal 38:4, pages 246.
Crossref
Dirk W. Sommerfeldt, Jizu Zhi, Clinton T. Rubin & Michael Hadjiargyrou. (2002) Proline-rich transcript of the brain (prtb) is a serum-responsive gene in osteoblasts and upregulated during adhesion. Journal of Cellular Biochemistry 84:2, pages 301-308.
Crossref
Carol A Grimes & Richard S Jope. (2001) The multifaceted roles of glycogen synthase kinase 3β in cellular signaling. Progress in Neurobiology 65:4, pages 391-426.
Crossref
Donald E White, Robert D Cardiff, Shoukat Dedhar & William J Muller. (2001) Mammary epithelial-specific expression of the integrin linked kinase (ILK) results in the induction of mammary gland hyperplasias and tumors in transgenic mice. Oncogene 20:48, pages 7064-7072.
Crossref
Sujata Persad, Sarah Attwell, Virginia Gray, Nasrin Mawji, Jing Ti Deng, Dan Leung, Jun Yan, Jasbinder Sanghera, Michael P. Walsh & Shoukat Dedhar. (2001) Regulation of Protein Kinase B/Akt-Serine 473 Phosphorylation by Integrin-linked Kinase. Journal of Biological Chemistry 276:29, pages 27462-27469.
Crossref
Sujata Persad, Armelle A.Troussard, Timothy R. McPhee, David J. Mulholland & Shoukat Dedhar. (2001) Tumor Suppressor Pten Inhibits Nuclear Accumulation of β-Catenin and T Cell/Lymphoid Enhancer Factor 1–Mediated Transcriptional Activation. Journal of Cell Biology 153:6, pages 1161-1174.
Crossref
Barbara Adler, Samy Ashkar, Harvey Cantor & Georg F. Weber. (2001) Costimulation by Extracellular Matrix Proteins Determines the Response to TCR Ligation. Cellular Immunology 210:1, pages 30-40.
Crossref
A. Somasiri, A. Howarth, D. Goswami, S. Dedhar & C.D. Roskelley. (2001) Overexpression of the integrin-linked kinase mesenchymally transforms mammary epithelial cells. Journal of Cell Science 114:6, pages 1125-1136.
Crossref
Clara Tan, Penny Costello, Jasbinder Sanghera, David Dominguez, Josep Baulida, Antonio Garcia de Herreros & Shoukat Dedhar. (2001) Inhibition of integrin linked kinase (ILK) suppresses β-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC−/− human colon carcinoma cells. Oncogene 20:1, pages 133-140.
Crossref
Berit B. Tysnes, H. Rainer Maurert, Torsten Porwol, Beatrice Probst, Rolf Bjerkvig & Frank Hoover. (2001) Bromelain Reversibly Inhibits Invasive Properties of Glioma Cells. Neoplasia 3:6, pages 469-479.
Crossref
Armelle A Troussard, Penny Costello, T Nathan Yoganathan, Shigehiro Kumagai, Calvin D Roskelley & Shoukat Dedhar. (2000) The integrin linked kinase (ILK) induces an invasive phenotype via AP-1 transcription factor-dependent upregulation of matrix metalloproteinase 9 (MMP-9). Oncogene 19:48, pages 5444-5452.
Crossref
Imogen MP Johnston, Heather J Spence, Joseph N Winnie, Lynn McGarry, J Keith Vass, Liam Meagher, Genevieve Stapleton & Bradford W Ozanne. (2000) Regulation of a multigenic invasion programme by the transcription factor, AP-1: re-expression of a down-regulated gene, TSC-36, inhibits invasion. Oncogene 19:47, pages 5348-5358.
Crossref
Leonard H. Augenlicht, Roger Davis, Michael P. Lisanti, Jacob Zhurinsky, Armelle A. Troussard, Mark D'Amico, Lawrence A. Donehower, Ken-Ichi Takemaru, Randall T. Moon, Avri Ben-Ze'ev, Shoukat Dedhar, Richard G. Pestell, James Hulit, Derek F. Amanatullah, Brian T. Zafonte, Chris Albanese, Boumediene Bouzahzah, Maofu Fu & Michael Shtutman. (2000) The Integrin-linked Kinase Regulates the Cyclin D1 Gene through Glycogen Synthase Kinase 3β and cAMP-responsive Element-binding Protein-dependent Pathways. Journal of Biological Chemistry 275:42, pages 32649-32657.
Crossref
Matthew P Coghlan, Ainsley A Culbert, Darren AE Cross, Stacey L Corcoran, John W Yates, Nigel J Pearce, Oliver L Rausch, Gregory J Murphy, Paul S Carter, Lynne Roxbee Cox, David Mills, Murray J Brown, David Haigh, Robert W Ward, David G Smith, Kenneth J Murray, Alastair D Reith & Julie C Holder. (2000) Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription. Chemistry & Biology 7:10, pages 793-803.
Crossref
T.Nathan Yoganathan, Penny Costello, Xiaoyi Chen, Mojgan Jabali, Jun Yan, Dan Leung, Zaihui Zhang, Arthur Yee, Shoukat Dedhar & Jasbinder Sanghera. (2000) Integrin-linked kinase (ILK): a “hot” therapeutic target. Biochemical Pharmacology 60:8, pages 1115-1119.
Crossref
Baljinder S Salh, Jason Martens, Rajinder S Hundal, Nathan Yoganathan, David Charest, Alice Mui & Antonio Gómez-Muñoz. (2000) PD98059 Attenuates Hydrogen Peroxide-Induced Cell Death through Inhibition of Jun N-Terminal Kinase in HT29 Cells. Molecular Cell Biology Research Communications 4:3, pages 158-165.
Crossref
Yao Huang, Ji Li, Yongjun Zhang & Chuanyue Wu. (2000) The Roles of Integrin-Linked Kinase in the Regulation of Myogenic Differentiation. Journal of Cell Biology 150:4, pages 861-872.
Crossref
Sarah Attwell, Calvin Roskelley & Shoukat Dedhar. (2000) The integrin-linked kinase (ILK) suppresses anoikis. Oncogene 19:33, pages 3811-3815.
Crossref
Faquan Liang, Amha Atakilit & David G. Gardner. (2000) Integrin Dependence of Brain Natriuretic Peptide Gene Promoter Activation by Mechanical Strain. Journal of Biological Chemistry 275:27, pages 20355-20360.
Crossref
Shoukat Dedhar. (2000) Cell–substrate interactions and signaling through ILK. Current Opinion in Cell Biology 12:2, pages 250-256.
Crossref
Sujata Persad, Sarah Attwell, Virginia Gray, Marc Delcommenne, Armelle Troussard, Jasbinder Sanghera & Shoukat Dedhar. (2000) Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells. Proceedings of the National Academy of Sciences 97:7, pages 3207-3212.
Crossref
C. Wu. (1999) Integrin-linked kinase and PINCH: partners in regulation of cell-extracellular matrix interaction and signal transduction. Journal of Cell Science 112:24, pages 4485-4489.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.