2
Views
111
CrossRef citations to date
0
Altmetric
Transcriptional Regulation

Multiple Cbfa/AML Sites in the Rat Osteocalcin Promoter Are Required for Basal and Vitamin D-Responsive Transcription and Contribute to Chromatin Organization

, , , , , & show all
Pages 7491-7500 | Received 25 Mar 1999, Accepted 05 Aug 1999, Published online: 28 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Mohammad Q. Hassan, Rahul Tare, Suk Hee Lee, Matthew Mandeville, Brian Weiner, Martin Montecino, Andre J. van Wijnen, Janet L. Stein, Gary S. Stein & Jane B. Lian. (2007) HOXA10 Controls Osteoblastogenesis by Directly Activating Bone Regulatory and Phenotypic Genes. Molecular and Cellular Biology 27:9, pages 3337-3352.
Read now
Jitesh Pratap, Amjad Javed, Lucia R. Languino, Andre J. van Wijnen, Janet L. Stein, Gary S. Stein & Jane B. Lian. (2005) The Runx2 Osteogenic Transcription Factor Regulates Matrix Metalloproteinase 9 in Bone Metastatic Cancer Cells and Controls Cell Invasion. Molecular and Cellular Biology 25:19, pages 8581-8591.
Read now
Mohammad Q. Hassan, Amjad Javed, Maria I. Morasso, Jeremy Karlin, Martin Montecino, Andre J. van Wijnen, Gary S. Stein, Janet L. Stein & Jane B. Lian. (2004) Dlx3 Transcriptional Regulation of Osteoblast Differentiation: Temporal Recruitment of Msx2, Dlx3, and Dlx5 Homeodomain Proteins to Chromatin of the Osteocalcin Gene. Molecular and Cellular Biology 24:20, pages 9248-9261.
Read now
Roberto Paredes, Gloria Arriagada, Fernando Cruzat, Alejandro Villagra, Juan Olate, Kaleem Zaidi, Andre van Wijnen, Jane B. Lian, Gary S. Stein, Janet L. Stein & Martin Montecino. (2004) Bone-Specific Transcription Factor Runx2 Interacts with the 1α,25-Dihydroxyvitamin D3 Receptor To Up-Regulate Rat Osteocalcin Gene Expression in Osteoblastic Cells. Molecular and Cellular Biology 24:20, pages 8847-8861.
Read now
Jose Sierra, Alejandro Villagra, Roberto Paredes, Fernando Cruzat, Soraya Gutierrez, Amjad Javed, Gloria Arriagada, Juan Olate, Maria Imschenetzky, Andre J. van Wijnen, Jane B. Lian, Gary S. Stein, Janet L. Stein & Martin Montecino. (2003) Regulation of the Bone-Specific Osteocalcin Gene by p300 Requires Runx2/Cbfa1 and the Vitamin D3 Receptor but Not p300 Intrinsic Histone Acetyltransferase Activity. Molecular and Cellular Biology 23:9, pages 3339-3351.
Read now
Jane B. Lian, Janet L. Stein, Gary S. Stein, André J. van Wijnen, Martin Montecino, Amjad Javed, Soraya Gutierrez, Jiali Shen, S. Kaleem Zaidi & Hicham Drissi. (2003) Runx2/Cbfa1 Functions: Diverse Regulation of Gene Transcription by Chromatin Remodeling and Co-Regulatory Protein Interactions. Connective Tissue Research 44:1, pages 141-148.
Read now
Amjad Javed, George L. Barnes, B. O. Jasanya, Janet L. Stein, Louis Gerstenfeld, Jane B. Lian & Gary S. Stein. (2001) runt Homology Domain Transcription Factors (Runx, Cbfa, and AML) Mediate Repression of the Bone Sialoprotein Promoter: Evidence for Promoter Context-Dependent Activity of Cbfa Proteins. Molecular and Cellular Biology 21:8, pages 2891-2905.
Read now

Articles from other publishers (104)

Guokai Zhang, Zhenying Liu, Zihan Li, Bing Zhang, Pengyu Yao & Yun Qiao. (2023) Therapeutic approach of natural products that treat osteoporosis by targeting epigenetic modulation. Frontiers in Genetics 14.
Crossref
Daniel Moena, Esther Vargas & Martin Montecino. 2023. Hormones and Epigenetics. Hormones and Epigenetics 51 74 .
Kanchan Phadwal, Eve Koo, Ross A. Jones, Rachael O. Forsythe, Keyi Tang, Qiyu Tang, Brendan M. Corcoran, Andrea Caporali & Vicky E. MacRae. (2022) Metformin protects against vascular calcification through the selective degradation of Runx2 by the p62 autophagy receptor. Journal of Cellular Physiology 237:11, pages 4303-4316.
Crossref
Andrew J. Fritz, Mohammed El Dika, Rabail H. Toor, Princess D. Rodriguez, Stephen J. Foley, Rahim Ullah, Daijing Nie, Bodhisattwa Banerjee, Dorcas Lohese, Kirsten M. Tracy, Karen C. Glass, Seth Frietze, Prachi N. Ghule, Jessica L. Heath, Anthony N. Imbalzano, Andre van Wijnen, Jonathan Gordon, Jane B. Lian, Janet L. Stein & Gary S. Stein. 2022. Nuclear, Chromosomal, and Genomic Architecture in Biology and Medicine. Nuclear, Chromosomal, and Genomic Architecture in Biology and Medicine 339 373 .
Andrew M. Cobb, Syabira YusoffRobert HaywardSadia AhmadMengxi SunAnja Verhulst, Patrick C. D’HaeseCatherine M. Shanahan. (2021) Runx2 (Runt-Related Transcription Factor 2) Links the DNA Damage Response to Osteogenic Reprogramming and Apoptosis of Vascular Smooth Muscle Cells. Arteriosclerosis, Thrombosis, and Vascular Biology 41:4, pages 1339-1357.
Crossref
Amel Dudakovic, Rebekah M. Samsonraj, Christopher R. Paradise, Catalina Galeano-Garces, Merel O. Mol, Daniela Galeano-Garces, Pengfei Zan, M. Lizeth Galvan, Mario Hevesi, Oksana Pichurin, Roman Thaler, Dana L. Begun, Peter Kloen, Marcel Karperien, A. Noelle Larson, Jennifer J. Westendorf, Simon M. Cool & Andre J. van Wijnen. (2020) Inhibition of the epigenetic suppressor EZH2 primes osteogenic differentiation mediated by BMP2. Journal of Biological Chemistry 295:23, pages 7877-7893.
Crossref
Anthony J. PettyIIII, Rebecca L. Keate, Bin Jiang, Guillermo A. Ameer & Jonathan Rivnay. (2020) Conducting Polymers for Tissue Regeneration in Vivo . Chemistry of Materials 32:10, pages 4095-4115.
Crossref
Anja Wessely, Anna Waltera, Torsten E. Reichert, Sabine Stöckl, Susanne Grässel & Richard J. Bauer. (2019) Induction of ALP and MMP9 activity facilitates invasive behavior in heterogeneous human BMSC and HNSCC 3D spheroids. The FASEB Journal 33:11, pages 11884-11893.
Crossref
Ye Xiao, Qi Guo, Tie‑Jian Jiang, Ying Yuan, Li Yang, Guang‑Wei Wang & Wen‑Feng Xiao. (2019) miR‑483‑3p regulates osteogenic differentiation of bone marrow mesenchymal stem cells by targeting STAT1. Molecular Medicine Reports.
Crossref
Li Zeng, Jiahui Wei, Na Zhao, Shichen Sun, Yixiang Wang & Hailan Feng. (2018) A novel 18-bp in-frame deletion mutation in RUNX2 causes cleidocranial dysplasia. Archives of Oral Biology 96, pages 243-248.
Crossref
Phillip W. L. Tai, Hai Wu, André J. van Wijnen, Gary S. Stein, Janet L. Stein & Jane B. Lian. (2017) Genome-wide DNase hypersensitivity, and occupancy of RUNX2 and CTCF reveal a highly dynamic gene regulome during MC3T3 pre-osteoblast differentiation. PLOS ONE 12:11, pages e0188056.
Crossref
Milka Martinez, Marcela Hinojosa, Daniel Trombly, Violeta Morin, Janet Stein, Gary Stein, Amjad Javed & Soraya E. Gutierrez. (2016) Transcriptional Auto-Regulation of RUNX1 P1 Promoter. PLOS ONE 11:2, pages e0149119.
Crossref
Laura J. Lambert, Anil K. Challa, Aidi Niu, Lihua Zhou, Janusz Tucholski, Maria S. Johnson, Tim R. Nagy, Alan W. Eberhardt, Patrick N. Estep, Robert A. Kesterson & Jayleen M. Grams. (2016) Increased trabecular bone and improved biomechanics in an osteocalcin null rat model created by CRISPR/Cas9 technology. Disease Models & Mechanisms.
Crossref
Yong-Xing Zhang, Hai-Lang Sun, He Liang, Kai Li, Qi-Ming Fan & Qing-Hua Zhao. (2015) Dynamic and distinct histone modifications of osteogenic genes during osteogenic differentiation. Journal of Biochemistry, pages mvv059.
Crossref
Yu Fei Lee, Keisuke Nimura, Wan Ning Lo, Kotaro Saga & Yasufumi Kaneda. (2014) Histone H3 Lysine 36 Methyltransferase Whsc1 Promotes the Association of Runx2 and p300 in the Activation of Bone-Related Genes. PLoS ONE 9:9, pages e106661.
Crossref
Anna Neve, Addolorata Corrado & Francesco Paolo Cantatore. (2013) Osteocalcin: Skeletal and extra-skeletal effects. Journal of Cellular Physiology 228:6, pages 1149-1153.
Crossref
Peng Xue, Xuelun Wu, Lixin Zhou, Huan Ma, Yan Wang, Yan Liu, Jianxia Ma & Yukun Li. (2013) IGF1 promotes osteogenic differentiation of mesenchymal stem cells derived from rat bone marrow by increasing TAZ expression. Biochemical and Biophysical Research Communications 433:2, pages 226-231.
Crossref
Hayk Hovhannisyan, Ying Zhang, Mohammad Q. Hassan, Hai Wu, Carlotta Glackin, Jane B. Lian, Janet L. Stein, Martin Montecino, Gary S. Stein & Andre J. van Wijnen. (2013) Genomic occupancy of HLH, AP1 and Runx2 motifs within a nuclease sensitive site of the Runx2 gene. Journal of Cellular Physiology 228:2, pages 313-321.
Crossref
Johannes P.T.M. van Leeuwen, B.C.J. van der Eerden, J. van de Peppel, Gary S. Stein & J.B. Lian. 2013. Osteoporosis. Osteoporosis 161 207 .
Shin-Jen Lin, Hsin-Chiu Ho, Yi-Fen Lee, Ning-Chun Liu, Su Liu, Gonghui Li, Chih-Rong Shyr & Chawnshang Chang. (2012) Reduced osteoblast activity in the mice lacking TR4 nuclear receptor leads to osteoporosis. Reproductive Biology and Endocrinology 10:1.
Crossref
Gillian H. Little, Houtan Noushmehr, Sanjeev K. Baniwal, Benjamin P. Berman, Gerhard A. Coetzee & Baruch Frenkel. (2012) Genome-wide Runx2 occupancy in prostate cancer cells suggests a role in regulating secretion. Nucleic Acids Research 40:8, pages 3538-3547.
Crossref
Lídia Agueda, Rafael Velázquez-Cruz, Roser Urreizti, Guy Yoskovitz, Patricia Sarrión, Susana Jurado, Roberto Güerri, Natàlia Garcia-Giralt, Xavier Nogués, Leonardo Mellibovsky, Adolfo Díez-Pérez, Pierre J Marie, Susana Balcells & Daniel Grinberg. (2011) Functional relevance of the BMD-associated polymorphism rs312009: Novel Involvement of RUNX2 in LRP5 transcriptional regulation. Journal of Bone and Mineral Research 26:5, pages 1133-1144.
Crossref
Gerald J. Atkins, David M. Findlay, Paul H. Anderson & Howard A. Morris. 2011. Vitamin D. Vitamin D 411 424 .
Jane B. Lian, Gary S. Stein, Martin Montecino, Janet L. Stein & Andre J. van Wijnen. 2011. Vitamin D. Vitamin D 301 319 .
Jane B. Lian, Ellen M. Gravallese & Gary S. Stein. 2011. Osteoimmunology. Osteoimmunology 101 140 .
Gauthami JalagadugulaGuangfen MaoGurpreet KaurLawrence E. GoldfingerDanny N. Dhanasekaran & A. Koneti Rao. (2010) Regulation of platelet myosin light chain (MYL9) by RUNX1: implications for thrombocytopenia and platelet dysfunction in RUNX1 haplodeficiency. Blood 116:26, pages 6037-6045.
Crossref
Amjad Javed, Haiyan Chen & Farah Y. Ghori. (2010) Genetic and Transcriptional Control of Bone Formation. Oral and Maxillofacial Surgery Clinics of North America 22:3, pages 283-293.
Crossref
Jane B. Lian & Gary S. Stein. 2010. Fundamentals of Osteoporosis. Fundamentals of Osteoporosis 55 112 .
Mary J. MacDougall & Amjad Javed. 2010. Bone and Development. Bone and Development 183 200 .
Martin A. Montecino, Jane B. Lian, Janet L. Stein, Gary S. Stein, André J. van Wijnen & Fernando Cruzat. 2010. Vitamin D. Vitamin D 189 209 .
Min-Kyung Choo, Hyeonju Yeo & Majd Zayzafoon. (2009) NFATc1 mediates HDAC-dependent transcriptional repression of osteocalcin expression during osteoblast differentiation. Bone 45:3, pages 579-589.
Crossref
Changhui Deng, Eric Ueda, KuanHui E. Chen, Craig Bula, Anthony W. Norman, Richard A. Luben & Ameae M. Walker. (2009) Prolactin Blocks Nuclear Translocation of VDR by Regulating Its Interaction with BRCA1 in Osteosarcoma Cells. Molecular Endocrinology 23:2, pages 226-236.
Crossref
Gary S. SteinSayyed K. ZaidiJanet L. SteinJane B. LianAndre J. van WijnenMartin MontecinoDaniel W. YoungAmjad JavedJitesh PratapJe-Yong ChoiSyed A. AliSandhya PandeMohammad Q. Hassan. (2009) Transcription-factor-mediated epigenetic control of cell fate and lineage commitmentThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB’s 51st Annual Meeting – Epigenetics and Chromatin Dynamics, and has undergone the Journal’s usual peer review process.. Biochemistry and Cell Biology 87:1, pages 1-6.
Crossref
Gary S. Stein, Sayyed K. Zaidi, Janet L. Stein, Jane B. Lian, Andre J. Van Wijnen, Martin Montecino, Daniel W. Young, Amjad Javed, Jitesh Pratap, Je-Yong Choi, Syed A. Ali, Sandhya Pande & Mohammad Q. Hassan. (2009) Organization, Integration, and Assembly of Genetic and Epigenetic Regulatory Machinery in Nuclear Microenvironments. Annals of the New York Academy of Sciences 1155:1, pages 4-14.
Crossref
Dafna Benayahu, Gabi Shefer & Irena Shur. (2009) Insights into the transcriptional and chromatin regulation of mesenchymal stem cells in musculo-skeletal tissues. Annals of Anatomy - Anatomischer Anzeiger 191:1, pages 2-12.
Crossref
Elisabetta Cenni, Francesca Perut, Gabriela Ciapetti, Lucia Savarino, Dante Dallari, Annarita Cenacchi, Cesare Stagni, Armando Giunti, Pier Maria Fornasari & Nicola Baldini. (2008) In vitro evaluation of freeze-dried bone allografts combined with platelet rich plasma and human bone marrow stromal cells for tissue engineering. Journal of Materials Science: Materials in Medicine 20:1, pages 45-50.
Crossref
Gary S. Stein, Sayyed K. Zaidi, Janet L. Stein, Jane B. Lian, Andre J. van Wijnen, Martin Montecino, Daniel W. Young, Amjad Javed, Jitesh Pratap, Je-Yong Choi, Syed A. Ali, Sandhya Pande & Mohammad Q. Hassan. (2008) Genetic and epigenetic regulation in nuclear microenvironments for biological control in cancer. Journal of Cellular Biochemistry 104:6, pages 2016-2026.
Crossref
Rami I. Aqeilan, Mohammad Q. Hassan, Alain de Bruin, John P. Hagan, Stefano Volinia, Titziana Palumbo, Sadiq Hussain, Suk-Hee Lee, Tripti Gaur, Gary S. Stein, Jane B. Lian & Carlo M. Croce. (2008) The WWOX Tumor Suppressor Is Essential for Postnatal Survival and Normal Bone Metabolism. Journal of Biological Chemistry 283:31, pages 21629-21639.
Crossref
Marthe Rousseau, Hélène Boulzaguet, Julie Biagianti, Denis Duplat, Christian Milet, Evelyne Lopez & Laurent Bédouet. (2008) Low molecular weight molecules of oyster nacre induce mineralization of the MC3T3-E1 cells. Journal of Biomedical Materials Research Part A 85A:2, pages 487-497.
Crossref
Naoyuki Makita, Mitsuhiro Suzuki, Shiori Asami, Rintaroh Takahata, Daika Kohzaki, Sho Kobayashi, Takashi Hakamazuka & Nobumichi Hozumi. (2008) Two of four alternatively spliced isoforms of RUNX2 control osteocalcin gene expression in human osteoblast cells. Gene 413:1-2, pages 8-17.
Crossref
Eric D Jensen, Tania M Schroeder, Jaclyn Bailey, Rajaram Gopalakrishnan & Jennifer J Westendorf. (2007) Histone Deacetylase 7 Associates With Runx2 and Represses Its Activity During Osteoblast Maturation in a Deacetylation-Independent Manner. Journal of Bone and Mineral Research 23:3, pages 361-372.
Crossref
Loreto Carvallo, Berta Henríquez, Roberto Paredes, Juan Olate, Sergio Onate, Andre J. van Wijnen, Jane B. Lian, Gary S. Stein, Janet L. Stein & Martin Montecino. (2008) 1α,25-dihydroxy vitamin D3-enhanced expression of the osteocalcin gene involves increased promoter occupancy of basal transcription regulators and gradual recruitment of the 1α,25-dihydroxy vitamin D3 receptor-SRC-1 coactivator complex. Journal of Cellular Physiology 214:3, pages 740-749.
Crossref
Robert F. Klees, Roman M. Salasznyk, Donald F. Ward, Donna E. Crone, William A. Williams, Mark P. Harris, Adele Boskey, Vito Quaranta & George E. Plopper. (2008) Dissection of the osteogenic effects of laminin-332 utilizing specific LG domains: LG3 induces osteogenic differentiation, but not mineralization. Experimental Cell Research 314:4, pages 763-773.
Crossref
JANE B. LIAN & GARY S. STEIN. 2008. Osteoporosis. Osteoporosis 93 150 .
Sylvia Christakos. 2008. Principles of Bone Biology. Principles of Bone Biology 779 794 .
Gary S. Stein, Jane B. Lian, Martin Montecino, J. van Wijnen, Janet L. Stein, Amjad Javed, Daniel W. Young, Mohammad Q. Hassan & Sayyed K. Zaidi. 2008. Principles of Bone Biology. Principles of Bone Biology 263 283 .
Martin MontecinoJanet L. SteinGary S. SteinJane B. LianAndre J. van WijnenFernando CruzatSoraya GutiérrezJuan OlateSylvain MarcelliniJosé L. Gutiérrez. (2007) Nucleosome organization and targeting of SWI/SNF chromatin-remodeling complexes: contributions of the DNA sequenceThis paper is one of a selection of papers published in this Special Issue, entitled 28th International West Coast Chromatin and Chromosomes Conference, and has undergone the Journal's usual peer review process.. Biochemistry and Cell Biology 85:4, pages 419-425.
Crossref
Zenjiro Maruyama, Carolina A. Yoshida, Tatsuya Furuichi, Norio Amizuka, Masako Ito, Ryo Fukuyama, Toshihiro Miyazaki, Hideki Kitaura, Kouhei Nakamura, Takashi Fujita, Naoko Kanatani, Takeshi Moriishi, Kei Yamana, Wenguang Liu, Hiroshi Kawaguchi, Kozo Nakamura & Toshihisa Komori. (2007) Runx2 determines bone maturity and turnover rate in postnatal bone development and is involved in bone loss in estrogen deficiency. Developmental Dynamics 236:7, pages 1876-1890.
Crossref
Martin Montecino, Gary S. Stein, Fernando Cruzat, Sylvain Marcellini, Janet L. Stein, Jane B. Lian, Andre J. van Wijnen & Gloria Arriagada. (2007) An architectural perspective of vitamin D responsiveness. Archives of Biochemistry and Biophysics 460:2, pages 293-299.
Crossref
Loreto Carvallo, Berta Henriquez, Juan Olate, Andre J. van Wijnen, Jane B. Lian, Gary S. Stein, Sergio Onate, Janet L. Stein & Martin Montecino. (2007) The 1α,25-dihydroxy Vitamin D3 receptor preferentially recruits the coactivator SRC-1 during up-regulation of the osteocalcin gene. The Journal of Steroid Biochemistry and Molecular Biology 103:3-5, pages 420-424.
Crossref
Jong-Sup Bae, Soraya Gutierrez, Radhika Narla, Jitesh Pratap, Rajitha Devados, Andre J. van Wijnen, Janet L. Stein, Gary S. Stein, Jane B. Lian & Amjad Javed. (2007) Reconstitution of Runx2/Cbfa1-null cells identifies a requirement for BMP2 signaling through a Runx2 functional domain during osteoblast differentiation. Journal of Cellular Biochemistry 100:2, pages 434-449.
Crossref
Gary S. Stein, Jane B. Lian, Andre J. van Wijnen, Janet L. Stein, Amjad Javed, Martin Montecino, Je-Yong Choi, Diana Vradii, Sayyed K. Zaidi, Jitesh Pratap & Daniel Young. (2007) Organization of transcriptional regulatory machinery in nuclear microenvironments: Implications for biological control and cancer. Advances in Enzyme Regulation 47:1, pages 242-250.
Crossref
Sayyed K. Zaidi, Amjad Javed, Jitesh Pratap, Tania M. Schroeder, Jennifer J. Westendorf, Jane B. Lian, Andre J. van Wijnen, Gary S. Stein & Janet L. Stein. (2006) Alterations in intranuclear localization of Runx2 affect biological activity. Journal of Cellular Physiology 209:3, pages 935-942.
Crossref
Alejandro Villagra, Fernando Cruzat, Loreto Carvallo, Roberto Paredes, Juan Olate, Andre J. van Wijnen, Gary S. Stein, Jane B. Lian, Janet L. Stein, Anthony N. Imbalzano & Martin Montecino. (2006) Chromatin Remodeling and Transcriptional Activity of the Bone-specific Osteocalcin Gene Require CCAAT/Enhancer-binding Protein β-dependent Recruitment of SWI/SNF Activity. Journal of Biological Chemistry 281:32, pages 22695-22706.
Crossref
Naoko Kanatani, Takashi Fujita, Ryo Fukuyama, Wenguang Liu, Carolina A. Yoshida, Takeshi Moriishi, Kei Yamana, Toshihiro Miyazaki, Satoru Toyosawa & Toshihisa Komori. (2006) Cbfβ regulates Runx2 function isoform-dependently in postnatal bone development. Developmental Biology 296:1, pages 48-61.
Crossref
Jane B. Lian, Gary S. Stein, Amjad Javed, Andre J. van Wijnen, Janet L. Stein, Martin Montecino, Mohammad Q. Hassan, Tripti Gaur, Christopher J. Lengner & Daniel W. Young. (2006) Networks and hubs for the transcriptional control of osteoblastogenesis. Reviews in Endocrine and Metabolic Disorders 7:1-2, pages 1-16.
Crossref
Toru Nishiwaki, Toru Yamaguchi, Chen Zhao, Hitoshi Amano, Kurt D Hankenson, Paul Bornstein, Yoshiaki Toyama & Koichi Matsuo. (2005) Reduced Expression of Thrombospondins and Craniofacial Dysmorphism in Mice Overexpressing Fra1. Journal of Bone and Mineral Research 21:4, pages 596-604.
Crossref
GEERT CARMELIET, ANNEMIEKE VERSTUYF, CHRISTA MAES, GUY EELEN & ROGER BOUILLON. 2006. Dynamics of Bone and Cartilage Metabolism. Dynamics of Bone and Cartilage Metabolism 307 325 .
Qi Shen & Sylvia Christakos. (2005) The Vitamin D Receptor, Runx2, and the Notch Signaling Pathway Cooperate in the Transcriptional Regulation of Osteopontin. Journal of Biological Chemistry 280:49, pages 40589-40598.
Crossref
Faiza Afzal, Jitesh Pratap, Kosei Ito, Yoshiaki Ito, Janet L. Stein, Andre J. van Wijnen, Gary S. Stein, Jane B. Lian & Amjad Javed. (2005) Smad function and intranuclear targeting share a Runx2 motif required for osteogenic lineage induction and BMP2 responsive transcription. Journal of Cellular Physiology 204:1, pages 63-72.
Crossref
Mario Galindo, Jitesh Pratap, Daniel W. Young, Hayk Hovhannisyan, Hee-Jeong Im, Je-Yong Choi, Jane B. Lian, Janet L. Stein, Gary S. Stein & Andre J. van Wijnen. (2005) The Bone-specific Expression of Runx2 Oscillates during the Cell Cycle to Support a G1-related Antiproliferative Function in Osteoblasts. Journal of Biological Chemistry 280:21, pages 20274-20285.
Crossref
Evangelos Terpos, Marianna Politou & Amin Rahemtulla. (2005) The role of markers of bone remodeling in multiple myeloma. Blood Reviews 19:3, pages 125-142.
Crossref
Nathan Smith, Yufeng Dong, Jane B. Lian, Jitesh Pratap, Paul D. Kingsley, Andre J. van Wijnen, Janet L. Stein, Edward M. Schwarz, Regis J. O'Keefe, Gary S. Stein & M. Hicham Drissi. (2005) Overlapping expression of Runx1(Cbfa2) and Runx2(Cbfa1) transcription factors supports cooperative induction of skeletal development. Journal of Cellular Physiology 203:1, pages 133-143.
Crossref
Daniel W. Young, Jitesh Pratap, Amjad Javed, Brian Weiner, Yasuyuki Ohkawa, Andre van Wijnen, Martin Montecino, Gary S. Stein, Janet L. Stein, Anthony N. Imbalzano & Jane B. Lian. (2005) SWI/SNF chromatin remodeling complex is obligatory for BMP2-induced, Runx2-dependent skeletal gene expression that controls osteoblast differentiation. Journal of Cellular Biochemistry 94:4, pages 720-730.
Crossref
Amjad Javed, George L. Barnes, Jitesh Pratap, Tomasz Antkowiak, Louis C. Gerstenfeld, Andre J. van Wijnen, Janet L. Stein, Jane B. Lian & Gary S. Stein. (2005) Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis in vivo . Proceedings of the National Academy of Sciences 102:5, pages 1454-1459.
Crossref
GERALD J. ATKINS, DAVID M. FINDLAY, PAUL H. ANDERSON & HOWARD A. MORRIS. 2005. Vitamin D. Vitamin D 711 720 .
GARY S. STEIN, JANE B. LIAN, JANET L. STEIN, ANDRE J. VAN WIJNEN, AMJAD JAVED, S. KALEEM ZAIDI, JIALI SHEN, SHIRWIN POCKWINSE, DANIEL YOUNG, MARTIN MONTECINO, SORAYA GUTIERREZ & JE-YONG CHOI. 2005. Vitamin D. Vitamin D 327 340 .
Michael Centrella, Sylvia Christakos & Thomas L. McCarthy. (2004) Skeletal hormones and the C/EBP and Runx transcription factors: interactions that integrate and redefine gene expression. Gene 342:1, pages 13-24.
Crossref
Michitaka Notoya, Eri Otsuka, Akira Yamaguchi & Hiromi Hagiwara. (2004) Runx-2 is not essential for the vitamin D-regulated expression of RANKL and osteoprotegerin in osteoblastic cells. Biochemical and Biophysical Research Communications 324:2, pages 655-660.
Crossref
Soraya Gutierrez, Jilin Liu, Amjad Javed, Martin Montecino, Gary S. Stein, Jane B. Lian & Janet L. Stein. (2004) The Vitamin D Response Element in the Distal Osteocalcin Promoter Contributes to Chromatin Organization of the Proximal Regulatory Domain. Journal of Biological Chemistry 279:42, pages 43581-43588.
Crossref
Gary S Stein, Jane B Lian, Andre J van Wijnen, Janet L Stein, Martin Montecino, Amjad Javed, Sayyed K Zaidi, Daniel W Young, Je-Yong Choi & Shirwin M Pockwinse. (2004) Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression. Oncogene 23:24, pages 4315-4329.
Crossref
Roberto Paredes, Gloria Arriagada, Fernando Cruzat, Juan Olate, Andre van Wijnen, Jane Lian, Gary Stein, Janet Stein & Martin Montecino. (2004) The Runx2 transcription factor plays a key role in the 1α,25-dihydroxy Vitamin D3-dependent upregulation of the rat osteocalcin (OC) gene expression in osteoblastic cells. The Journal of Steroid Biochemistry and Molecular Biology 89-90, pages 269-271.
Crossref
Brad Sevetson, Scott Taylor & Yang Pan. (2004) Cbfa1/RUNX2 Directs Specific Expression of the Sclerosteosis Gene (SOST). Journal of Biological Chemistry 279:14, pages 13849-13858.
Crossref
Felix Bronner & Mary C. Farach-CarsonMarja M. Hurley & Joseph A. Lorenzo. 2004. Bone Formation. Bone Formation 44 70 .
Sayyed K. Zaidi, Daniel W. Young, Shirwin M. Pockwinse, Amjad Javed, Jane B. Lian, Janet L. Stein, Andre J. van Wijnen & Gary S. Stein. (2003) Mitotic partitioning and selective reorganization of tissue-specific transcription factors in progeny cells. Proceedings of the National Academy of Sciences 100:25, pages 14852-14857.
Crossref
Sunhwa Kim, Takako Koga, Miho Isobe, Britt E. Kern, Taeko Yokochi, Y. Eugene Chin, Gerard Karsenty, Tadatsugu Taniguchi & Hiroshi Takayanagi. (2003) Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiation. Genes & Development 17:16, pages 1979-1991.
Crossref
Jiali Shen, Hayk Hovhannisyan, Jane B. Lian, Martin A. Montecino, Gary S. Stein, Janet L. Stein & Andre J. van Wijnen. (2003) Transcriptional Induction of the Osteocalcin Gene During Osteoblast Differentiation Involves Acetylation of Histones H3 and H4. Molecular Endocrinology 17:4, pages 743-756.
Crossref
Jude Canon & Utpal Banerjee. (2003) In vivo analysis of a developmental circuit for direct transcriptional activation and repression in the same cell by a Runx protein. Genes & Development 17:7, pages 838-843.
Crossref
Gary S Stein, Jane B Lian, Janet L Stein, André J van Wijnen, Martin Montecino, Jitesh Pratap, J.e Choi, S.Kaleem Zaidi, Amjad Javed, Soraya Gutierrez, Kimberly Harrington, Jiali Shen & Daniel Young. (2003) Intranuclear organization of RUNX transcriptional regulatory machinery in biological control of skeletogenesis and cancer. Blood Cells, Molecules, and Diseases 30:2, pages 170-176.
Crossref
Gary S. Stein, Jane B. Lian, Janet L. Stein, André J. van Wijnen, Martin Montecino, Amjad Javed, Jitesh Pratap, Je Choi, S. Kaleem Zaidi, Soraya Gutierrez, Kimberly Harrington, Jiali Shen & Daniel Young. (2003) Intranuclear trafficking of transcription factors: Requirements for vitamin D-mediated biological control of gene expression. Journal of Cellular Biochemistry 88:2, pages 340-355.
Crossref
M. ZhaoJ.E. BerryM.J. Somerman. (2003) Bone Morphogenetic Protein-2 Inhibits Differentiation and Mineralization of Cementoblasts in vitro . Journal of Dental Research 82:1, pages 23-27.
Crossref
Z Kalajzic, P Liu, I Kalajzic, Z Du, A Braut, M Mina, E Canalis & D.W Rowe. (2002) Directing the expression of a green fluorescent protein transgene in differentiated osteoblasts: comparison between rat type I collagen and rat osteocalcin promoters. Bone 31:6, pages 654-660.
Crossref
Cristina Hernández-Munain & Michael S. Krangel. (2002) Distinct Roles for c-Myb and Core Binding Factor/Polyoma Enhancer-Binding Protein 2 in the Assembly and Function of a Multiprotein Complex on the TCR δ Enhancer In Vivo. The Journal of Immunology 169:8, pages 4362-4369.
Crossref
Jian Q. Feng, Jianghong Zhang, Sarah L. Dallas, Yongbo Lu, Shuo Chen, Xiaoyu Tan, Michael Owen, Stephen E. Harris & Mary Macdougall. (2002) Dentin Matrix Protein 1, a Target Molecule for Cbfa1 in Bone, Is a Unique Bone Marker Gene. Journal of Bone and Mineral Research 17:10, pages 1822-1831.
Crossref
Taketoshi Yoshida, Hirokazu Kanegane, Motomi Osato, Masatoshi Yanagida, Toshio Miyawaki, Yoshiaki Ito & Katsuya Shigesada. (2002) Functional Analysis of RUNX2 Mutations in Japanese Patients with Cleidocranial Dysplasia Demonstrates Novel Genotype-Phenotype Correlations. The American Journal of Human Genetics 71:4, pages 724-738.
Crossref
Tamotsu Kiyoshima, Masato Yamauchi, Cherrie Wong, Andrew Jheon, Bernhard Ganss & Jaro Sodek. (2002) An L1 element disrupts human bone sialoprotein promoter: lack of tissue-specific regulation by distalless5 (Dlx5) and runt homeodomain protein2 (Runx2)/core binding factor a1 (Cbfa1) elements. Gene 299:1-2, pages 205-217.
Crossref
Kanaklata Roy, Ivana L. de la Serna & Anthony N. Imbalzano. (2002) The Myogenic Basic Helix-Loop-Helix Family of Transcription Factors Shows Similar Requirements for SWI/SNF Chromatin Remodeling Enzymes during Muscle Differentiation in Culture. Journal of Biological Chemistry 277:37, pages 33818-33824.
Crossref
Sayyed K. Zaidi, Andrew J. Sullivan, Andre J. van Wijnen, Janet L. Stein, Gary S. Stein & Jane B. Lian. (2002) Integration of Runx and Smad regulatory signals at transcriptionally active subnuclear sites. Proceedings of the National Academy of Sciences 99:12, pages 8048-8053.
Crossref
Jiali Shen, Martin Montecino, Jane B. Lian, Gary S. Stein, Andre J. van Wijnen & Janet L. Stein. (2002) Histone Acetylation in Vivo at the Osteocalcin Locus Is Functionally Linked to Vitamin D-dependent, Bone Tissue-specific Transcription. Journal of Biological Chemistry 277:23, pages 20284-20292.
Crossref
Soraya Gutierrez, Amjad Javed, Daniel K. Tennant, Monique van Rees, Martin Montecino, Gary S. Stein, Janet L. Stein & Jane B. Lian. (2002) CCAAT/Enhancer-binding Proteins (C/EBP) β and δ Activate Osteocalcin Gene Transcription and Synergize with Runx2 at the C/EBP Element to Regulate Bone-specific Expression. Journal of Biological Chemistry 277:2, pages 1316-1323.
Crossref
Vincent Laudet & Hinrich Gronemeyer. 2002. The Nuclear Receptor FactsBook. The Nuclear Receptor FactsBook 204 219 .
Sylvia Christakos. 2002. Principles of Bone Biology. Principles of Bone Biology 573 586 .
Gary S. Stein, Jane B. Lian, Martin Montecino, André J. van Wijnen, Janet L. Stein, Amjad Javed & Kaleem Zaidi. 2002. Principles of Bone Biology. Principles of Bone Biology 169 XVII .
Alejandro Villagra, José Gutiérrez, Roberto Paredes, José Sierra, Marcia Puchi, Maria Imschenetzky, Andre van Wijnen, Jane Lian, Gary Stein, Janet Stein & Martin Montecino. (2002) Reduced CpG methylation is associated with transcriptional activation of the bone-specific rat osteocalcin gene in osteoblasts*. Journal of Cellular Biochemistry 85:1, pages 112-122.
Crossref
Wenguang Liu, Satoru Toyosawa, Tatsuya Furuichi, Naoko Kanatani, Carolina Yoshida, Yang Liu, Miki Himeno, Satoru Narai, Akira Yamaguchi & Toshihisa Komori. (2001) Overexpression of Cbfa1 in osteoblasts inhibits osteoblast maturation and causes osteopenia with multiple fractures. Journal of Cell Biology 155:1, pages 157-166.
Crossref
S. Kaleem Zaidi, Amjad Javed, Je-Yong Choi, André J. van Wijnen, Janet L. Stein, Jane B. Lian & Gary S. Stein. (2001) A specific targeting signal directs Runx2/Cbfa1 to subnuclear domains and contributes to transactivation of the osteocalcin gene. Journal of Cell Science 114:17, pages 3093-3102.
Crossref
Joshua S. KaminkerRajan SinghTim LebestkyHuajun YanUtpal Banerjee. (2001) Redundant function of Runt Domain binding partners, Big brother and Brother, during Drosophila development . Development 128:14, pages 2639-2648.
Crossref
Jane B. Lian, Janet L. Stein, Gary S. Stein, Martin Montecino, André J. van Wijnen, Amjad Javed & Soraya Gutierrez. (2001) Contributions of nuclear architecture and chromatin to vitamin D-dependent transcriptional control of the rat osteocalcin gene. Steroids 66:3-5, pages 159-170.
Crossref
Ivana L. de la Serna, Kerri A. Carlson & Anthony N. Imbalzano. (2001) Mammalian SWI/SNF complexes promote MyoD-mediated muscle differentiation. Nature Genetics 27:2, pages 187-190.
Crossref
Jane B. Lian & Gary S. Stein. 2001. Osteoporosis. Osteoporosis 21 71 .
Yu-Wen Zhang, Natsuo Yasui, Kosei Ito, Gang Huang, Makiko Fujii, Jun-ichi Hanai, Hiroshi Nogami, Takahiro Ochi, Kohei Miyazono & Yoshiaki Ito. (2000) A RUNX2/PEBP2 αA/ CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia . Proceedings of the National Academy of Sciences 97:19, pages 10549-10554.
Crossref
Hicham Drissi, Quyen Luc, Rauf Shakoori, Susana Chuva De Sousa Lopes, Je-Yong Choi, Anne Terry, Ming Hu, Stephen Jones, James C. Neil, Jane B. Lian, Janet L. Stein, Andr� J. Van Wijnen & Gary S. Stein. (2000) Transcriptional autoregulation of the bone related CBFA1/RUNX2 gene. Journal of Cellular Physiology 184:3, pages 341-350.
Crossref
A. JavedB. GuoS. HiebertJ.Y. ChoiJ. GreenS.C. ZhaoM.A. OsborneS. StifaniJ.L. SteinJ.B. LianA.J. van WijnenG.S. Stein. (2000) Groucho/TLE/R-esp proteins associate with the nuclear matrix and repress RUNX (CBF(alpha)/AML/PEBP2(alpha)) dependent activation of tissue-specific gene transcription. Journal of Cell Science 113:12, pages 2221-2231.
Crossref
Gary S. Stein, Andr� J. van Wijnen, Janet L. Stein, Jane B. Lian, Martin Montecino, Kaleem Zaidi & Amjad Javed. (2000) Subnuclear organization and trafficking of regulatory proteins: Implications for biological control and cancer. Journal of Cellular Biochemistry 79:S35, pages 84-92.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.