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Molecular and Cellular Biology Volume 19, 1999 - Issue 11
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DNA Dynamics and Chromosome Structure

Separation-of-Function Mutations in Saccharomyces cerevisiae MSH2 That Confer Mismatch Repair Defects but Do Not Affect Nonhomologous-Tail Removal during Recombination

Barbara Studamire1 Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York14853-2703
,
Gavrielle Price1 Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York14853-2703
,
Neal Sugawara2 Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts02254-9110
,
James E. Haber2 Rosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts02254-9110
&
Eric Alani1 Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York14853-2703Correspondence[email protected]
Pages 7558-7567 | Received 13 Apr 1999, Accepted 29 Jul 1999, Published online: 28 Mar 2023

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Elaine Ayres Sia, Margaret Dominska, Lela Stefanovic & Thomas D. Petes. (2001) Isolation and Characterization of Point Mutations in Mismatch Repair Genes That Destabilize Microsatellites in Yeast. Molecular and Cellular Biology 21:23, pages 8157-8167.
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Yali Xie, Yuan Liu, Juan Lucas Argueso, Leigh A. Henricksen, Hui-I Kao, Robert A. Bambara & Eric Alani. (2001) Identification of rad27 Mutations That Confer Differential Defects in Mutation Avoidance, Repeat Tract Instability, and Flap Cleavage. Molecular and Cellular Biology 21:15, pages 4889-4899.
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Elizabeth Evans & Eric Alani. (2000) Roles for Mismatch Repair Factors in Regulating Genetic Recombination. Molecular and Cellular Biology 20:21, pages 7839-7844.
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James E. Haber. (2021) Learning Yeast Genetics from Miro Radman. Cells 10:4, pages 945.
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Qian Liu, Xuefeng Zhu, Michelle Lindström, Yonghong Shi, Ju Zheng, Xinxin Hao, Claes M. Gustafsson & Beidong Liu. (2020) Yeast mismatch repair components are required for stable inheritance of gene silencing. PLOS Genetics 16:5, pages e1008798.
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Elena Rakosy-Tican, Enikö Lörincz-Besenyei, Imola Molnár, Ramona Thieme, Frank Hartung, Thorben Sprink, Olga Antonova, Ivan Famelaer, Geert Angenon & Adriana Aurori. (2019) New Phenotypes of Potato Co-induced by Mismatch Repair Deficiency and Somatic Hybridization. Frontiers in Plant Science 10.
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Robin Eichmiller, Melisa Medina-Rivera, Rachel DeSanto, Eugen Minca, Christopher Kim, Cory Holland, Ja-Hwan Seol, Megan Schmit, Diane Oramus, Jessica Smith, Ignacio F Gallardo, Ilya J Finkelstein, Sang Eun Lee & Jennifer A Surtees. (2018) Coordination of Rad1–Rad10 interactions with Msh2–Msh3, Saw1 and RPA is essential for functional 3′ non-homologous tail removal. Nucleic Acids Research 46:10, pages 5075-5096.
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Ranjith P. Anand, Olga Tsaponina, Patricia W. Greenwell, Cheng-Sheng Lee, Wei Du, Thomas D. Petes & James E. Haber. (2014) Chromosome rearrangements via template switching between diverged repeated sequences. Genes & Development 28:21, pages 2394-2406.
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Charanya Kumar, Robin Eichmiller, Bangchen Wang, Gregory M. Williams, Piero R. Bianco & Jennifer A. Surtees. (2014) ATP binding and hydrolysis by Saccharomyces cerevisiae Msh2–Msh3 are differentially modulated by mismatch and double-strand break repair DNA substrates. DNA Repair 18, pages 18-30.
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Lyudmila Y. Kadyrova, Tony M. Mertz, Yu Zhang, Matthew R. Northam, Ziwei Sheng, Kirill S. Lobachev, Polina V. Shcherbakova & Farid A. Kadyrov. (2013) A Reversible Histone H3 Acetylation Cooperates with Mismatch Repair and Replicative Polymerases in Maintaining Genome Stability. PLoS Genetics 9:10, pages e1003899.
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Charanya Kumar, Gregory M. Williams, Brett Havens, Michelle K. Dinicola & Jennifer A. Surtees. (2013) Distinct Requirements within the Msh3 Nucleotide Binding Pocket for Mismatch and Double-Strand Break Repair. Journal of Molecular Biology 425:11, pages 1881-1898.
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Serge Boiteux & Sue Jinks-Robertson. (2013) DNA Repair Mechanisms and the Bypass of DNA Damage in Saccharomyces cerevisiae . Genetics 193:4, pages 1025-1064.
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Yevgeniy Raynes, Matthew R Gazzara & Paul D Sniegowski. (2011) Mutator dynamics in sexual and asexual experimental populations of yeast. BMC Evolutionary Biology 11:1.
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Charanya Kumar, Sarah C. Piacente, Justin Sibert, Andrew R. Bukata, Jaime O'Connor, Eric Alani & Jennifer A. Surtees. (2011) Multiple Factors Insulate Msh2–Msh6 Mismatch Repair Activity from Defects in Msh2 Domain I. Journal of Molecular Biology 411:4, pages 765-780.
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Glenn M. Manthey, Nilan Naik & Adam M. Bailis. (2009) Msh2 Blocks an Alternative Mechanism for Non-Homologous Tail Removal during Single-Strand Annealing in Saccharomyces cerevisiae. PLoS ONE 4:10, pages e7488.
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Leah Pogorzala, Shona Mookerjee & Elaine A Sia. (2009) Evidence That Msh1p Plays Multiple Roles in Mitochondrial Base Excision Repair. Genetics 182:3, pages 699-709.
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Amy M. Lyndaker & Eric Alani. (2009) A tale of tails: insights into the coordination of 3′ end processing during homologous recombination. BioEssays 31:3, pages 315-321.
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Nicholas R. Pannunzio, Glenn M. Manthey & Adam M. Bailis. (2008) RAD59 is required for efficient repair of simultaneous double-strand breaks resulting in translocations in Saccharomyces cerevisiae. DNA Repair 7:5, pages 788-800.
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Susan D. Lee, Jennifer A. Surtees & Eric Alani. (2007) Saccharomyces cerevisiae MSH2–MSH3 and MSH2–MSH6 Complexes Display Distinct Requirements for DNA Binding Domain I in Mismatch Recognition. Journal of Molecular Biology 366:1, pages 53-66.
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James E. Haber. 2007. Molecular Genetics of Recombination. Molecular Genetics of Recombination 285 316 .
Saara Ollila, Laura Sarantaus, Reetta Kariola, Philip Chan, Heather Hampel, Elke Holinski–Feder, Finlay Macrae, Maija Kohonen–Corish, Anne–Marie Gerdes, Päivi Peltomäki, Elisabeth Mangold, Albert de la Chapelle, Marc Greenblatt & Minna Nyström. (2006) Pathogenicity of MSH2 Missense Mutations Is Typically Associated With Impaired Repair Capability of the Mutated Protein. Gastroenterology 131:5, pages 1408-1417.
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Jennifer A. Surtees & Eric Alani. (2006) Mismatch Repair Factor MSH2-MSH3 Binds and Alters the Conformation of Branched DNA Structures Predicted to form During Genetic Recombination. Journal of Molecular Biology 360:3, pages 523-536.
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Ainsley Nicholson, Rebecca M Fabbri, Jason W Reeves & Gray F Crouse. (2006) The Effects of Mismatch Repair and RAD1 Genes on Interchromosomal Crossover Recombination in Saccharomyces cerevisiae . Genetics 173:2, pages 647-659.
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Shona A. Mookerjee & Elaine A. Sia. (2006) Overlapping contributions of Msh1p and putative recombination proteins Cce1p, Din7p, and Mhr1p in large-scale recombination and genome sorting events in the mitochondrial genome of Saccharomyces cerevisiae. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 595:1-2, pages 91-106.
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Errol C. Friedberg, Graham C. Walker, Wolfram Siede, Richard D. Wood, Roger A. Schultz & Tom Ellenberger. 2005. DNA Repair and Mutagenesis. DNA Repair and Mutagenesis 389 447 .
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Tamara Goldfarb & Eric Alani. (2005) Distinct Roles for the Saccharomyces cerevisiae Mismatch Repair Proteins in Heteroduplex Rejection, Mismatch Repair and Nonhomologous Tail Removal. Genetics 169:2, pages 563-574.
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I.V. Kovtun, A.R. Thornhill & C.T. McMurray. (2004) Somatic deletion events occur during early embryonic development and modify the extent of CAG expansion in subsequent generations. Human Molecular Genetics 13:24, pages 3057-3068.
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