Advanced search
Publication Cover
Molecular and Cellular Biology Volume 19, 1999 - Issue 11
Submit an article Journal homepage
18
Views
56
CrossRef citations to date
0
Altmetric
Transcriptional Regulation

RelB Modulation of IκBα Stability as a Mechanism of Transcription Suppression of Interleukin-1α (IL-1α), IL-1β, and Tumor Necrosis Factor Alpha in Fibroblasts

Yiyang Xia1 Department of Immunology, The Scripps Research Institute, La Jolla, California92037
,
Shizhong Chen1 Department of Immunology, The Scripps Research Institute, La Jolla, California92037
,
Yibin Wang2 Department of Medicine, University of California, San Diego, La Jolla, California92093
,
Nigel Mackman1 Department of Immunology, The Scripps Research Institute, La Jolla, California92037
,
George Ku3 Vertex Pharmaceuticals Inc., Cambridge, Massachusetts02139
,
David Lo1 Department of Immunology, The Scripps Research Institute, La Jolla, California92037
&
Lili Feng1 Department of Immunology, The Scripps Research Institute, La Jolla, California92037Correspondence[email protected]
 show all
Pages 7688-7696 | Received 03 Mar 1999, Accepted 10 Aug 1999, Published online: 28 Mar 2023

Citations (56)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Marina M. Bellet, Loredana Zocchi & Paolo Sassone-Corsi. (2012) The RelB subunit of NFκB acts as a negative regulator of circadian gene expression. Cell Cycle 11:17, pages 3304-3311.
Read now
Xiaobo Wang, Karine Belguise, Christine F. O'Neill, Nuria Sánchez-Morgan, Mathilde Romagnoli, Sean F. Eddy, Nora D. Mineva, Ziyang Yu, Chengyin Min, Vickery Trinkaus-Randall, Dany Chalbos & Gail E. Sonenshein. (2009) RelB NF-κB Represses Estrogen Receptor α Expression via Induction of the Zinc Finger Protein Blimp1. Molecular and Cellular Biology 29:14, pages 3832-3844.
Read now

Articles from other publishers (54)

Colleen S. Curran & Jeffrey B. Kopp. (2022) Aryl Hydrocarbon Receptor Mechanisms Affecting Chronic Kidney Disease. Frontiers in Pharmacology 13.
Crossref
Xuewu Liang, YiChun Cao, Chunpu Li, Haolan Yu, Chenghua Yang & Hong Liu. (2021) MALT1 as a promising target to treat lymphoma and other diseases related to MALT1 anomalies. Medicinal Research Reviews 41:4, pages 2388-2422.
Crossref
Anne Bertelsen, Stuart J. Elborn & Bettina C. Schock. (2020) Toll like Receptor signalling by Prevotella histicola activates alternative NF-κB signalling in Cystic Fibrosis bronchial epithelial cells compared to P. aeruginosa. PLOS ONE 15:10, pages e0235803.
Crossref
Karol G. Makowczenko, Jan P. Jastrzebski, Karol Szeszko, Nina Smolinska, Lukasz Paukszto, Kamil Dobrzyn, Marta Kiezun, Edyta Rytelewska, Barbara Kaminska & Tadeusz Kaminski. (2020) Transcription Analysis of the Chemerin Impact on Gene Expression Profile in the Luteal Cells of Gilts. Genes 11:6, pages 651.
Crossref
Anil K. Singh, Sabrina Fechtner, Mukesh Chourasia, Jerry Sicalo & Salahuddin Ahmed. (2018) Critical role of IL‐1α in IL‐1β‐induced inflammatory responses: cooperation with NF‐κBp65 in transcriptional regulation. The FASEB Journal 33:2, pages 2526-2536.
Crossref
Matthew Tegowski & Albert Baldwin. (2018) Noncanonical NF-κB in Cancer. Biomedicines 6:2, pages 66.
Crossref
Prema M. Nair, Malcolm R. Starkey, Tatt Jhong Haw, Roland Ruscher, Gang Liu, Muralidhara R. Maradana, Ranjeny Thomas, Brendan J. O’Sullivan & Philip M. Hansbro. (2018) RelB-Deficient Dendritic Cells Promote the Development of Spontaneous Allergic Airway Inflammation. American Journal of Respiratory Cell and Molecular Biology 58:3, pages 352-365.
Crossref
Yin Luo, Xiaoyan Xie, Di Luo, Yuan Wang & Yijun Gao. (2017) The role of halofuginone in fibrosis: more to be explored?. Journal of Leukocyte Biology 102:6, pages 1333-1345.
Crossref
Véronique Baud & Davi Collares. (2016) Post-Translational Modifications of RelB NF-κB Subunit and Associated Functions. Cells 5:2, pages 22.
Crossref
Rana Al-Sadi, Shuhong Guo, Dongmei Ye, Manmeet Rawat & Thomas Y. Ma. (2016) TNF-α Modulation of Intestinal Tight Junction Permeability Is Mediated by NIK/IKK-α Axis Activation of the Canonical NF-κB Pathway. The American Journal of Pathology 186:5, pages 1151-1165.
Crossref
Subash Chand Verma, Pooja Agarwal & Manju Y. Krishnan. (2016) Primary mouse lung fibroblasts help macrophages to tackle Mycobacterium tuberculosis more efficiently and differentiate into myofibroblasts up on bacterial stimulation. Tuberculosis 97, pages 172-180.
Crossref
Myrthe A. M. van Delft, Leonie F. A. Huitema & Sander W. Tas. (2015) The contribution of NF-κB signalling to immune regulation and tolerance. European Journal of Clinical Investigation 45:5, pages 529-539.
Crossref
Wei Zhu, Naishuo Zhu, Dou Bai, Jinfeng Miao & Sixiang Zou. (2014) The crosstalk between Dectin1 and TLR4 via NF-κB subunits p65/RelB in mammary epithelial cells. International Immunopharmacology 23:2, pages 417-425.
Crossref
Craig M. BerchtoldAdam CoughlinZachary KasperSusan L. Thibeault. (2013) Paracrine potential of fibroblasts exposed to cigarette smoke extract with vascular growth factor induction. The Laryngoscope 123:9, pages 2228-2236.
Crossref
Chiara Gasparini, Brian M. Foxwell & Marc Feldmann. (2013) RelB/p50 regulates TNF production in LPS-stimulated dendritic cells and macrophages. Cytokine 61:3, pages 736-740.
Crossref
Eliseo F. Castillo, Alexander Dekonenko, John Arko-Mensah, Michael A. Mandell, Nicolas Dupont, Shanya Jiang, Monica Delgado-Vargas, Graham S. TimminsDhruva Bhattacharya, Hongliang Yang, Julie Hutt, C. Rick Lyons, Karen M. Dobos & Vojo Deretic. (2012) Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation. Proceedings of the National Academy of Sciences 109:46.
Crossref
Ching-Shuang Wu, Cheng-Che E. Lan, Hsuan-Yu Kuo, Chee-Yin Chai, Wan-Tzu Chen & Gwo-Shing Chen. (2012) Differential regulation of nuclear factor-kappa B subunits on epidermal keratinocytes by ultraviolet B and tacrolimus. The Kaohsiung Journal of Medical Sciences 28:11, pages 577-585.
Crossref
Jiro Yamana, Eric F. Morand, Tsuno Manabu, Katsue Sunahori, Kouji Takasugi, Hirofumi Makino & Masahiro Yamamura. (2012) Inhibition of TNF-induced IL-6 by the TWEAK-Fn14 interaction in rheumatoid arthritis fibroblast like synoviocytes. Cellular Immunology 272:2, pages 293-298.
Crossref
Bodo Brand, Anja Hartmann, Dirk Repsilber, Bettina Griesbeck-Zilch, Olga Wellnitz, Christa Kühn, Siriluck Ponsuksili, Heinrich HD Meyer & Manfred Schwerin. (2011) Comparative expression profiling of E. coli and S. aureus inoculated primary mammary gland cells sampled from cows with different genetic predispositions for somatic cell score. Genetics Selection Evolution 43:1.
Crossref
Stephan HailfingerHendrik Nogai, Christiane PelzerMaike JaworskiKatrin CabalzarJean-Enno ChartonMontserrat GuzzardiChantal DécailletMichael Grau, Bernd Dörken, Peter Lenz, Georg Lenz & Margot Thome. (2011) Malt1-dependent RelB cleavage promotes canonical NF-κB activation in lymphocytes and lymphoma cell lines. Proceedings of the National Academy of Sciences 108:35, pages 14596-14601.
Crossref
Lisa A. Madge & Michael J. May. (2010) Classical NF-κB Activation Negatively Regulates Noncanonical NF-κB-dependent CXCL12 Expression. Journal of Biological Chemistry 285:49, pages 38069-38077.
Crossref
Michelle Kiebala, Oksana Polesskaya, Zhenqiang Yao, Seth W. Perry & Sanjay B. Maggirwar. (2010) Nuclear Factor-Kappa B Family Member RelB Inhibits Human Immunodeficiency Virus-1 Tat-Induced Tumor Necrosis Factor-Alpha Production. PLoS ONE 5:7, pages e11875.
Crossref
Mingzhao Zhu & Yangxin Fu. (2010) The complicated role of NF-κB in T-cell selection. Cellular & Molecular Immunology 7:2, pages 89-93.
Crossref
Xiaoping Chen, Mohamed El Gazzar, Barbara K. Yoza & Charles E. McCall. (2009) The NF-κB Factor RelB and Histone H3 Lysine Methyltransferase G9a Directly Interact to Generate Epigenetic Silencing in Endotoxin Tolerance. Journal of Biological Chemistry 284:41, pages 27857-27865.
Crossref
Pablo Muriel. (2009) NF- κ B in liver diseases: a target for drug therapy . Journal of Applied Toxicology 29:2, pages 91-100.
Crossref
Se-Ran Yang, Hongwei Yao, Saravanan Rajendrasozhan, Sangwoon Chung, Indika Edirisinghe, Samantha Valvo, George Fromm, Michael J. McCabeJr.Jr., Patricia J. Sime, Richard P. Phipps, Jian-Dong Li, Michael Bulger & Irfan Rahman. (2009) RelB Is Differentially Regulated by IκB Kinase-α in B Cells and Mouse Lung by Cigarette Smoke. American Journal of Respiratory Cell and Molecular Biology 40:2, pages 147-158.
Crossref
Casey W. WrightColin S. Duckett. (2009) The Aryl Hydrocarbon Nuclear Translocator Alters CD30-Mediated NF-κB–Dependent Transcription. Science 323:5911, pages 251-255.
Crossref
Carolyn J. Baglole, Sanjay B. Maggirwar, Thomas A. Gasiewicz, Thomas H. Thatcher, Richard P. Phipps & Patricia J. Sime. (2008) The Aryl Hydrocarbon Receptor Attenuates Tobacco Smoke-induced Cyclooxygenase-2 and Prostaglandin Production in Lung Fibroblasts through Regulation of the NF-κB Family Member RelB. Journal of Biological Chemistry 283:43, pages 28944-28957.
Crossref
Mohamed El Gazzar, Barbara K. Yoza, Jean Y.-Q. Hu, Sue L. Cousart & Charles E. McCall. (2007) Epigenetic Silencing of Tumor Necrosis Factor α during Endotoxin Tolerance. Journal of Biological Chemistry 282:37, pages 26857-26864.
Crossref
Xiaoren Zhang, Hongshan Wang, Estefania Claudio, Keith Brown & Ulrich Siebenlist. (2007) A Role for the IκB Family Member Bcl-3 in the Control of Central Immunologic Tolerance. Immunity 27:3, pages 438-452.
Crossref
Claudia Wietek & Luke A.J. O’Neill. (2007) Diversity and regulation in the NF-κB system. Trends in Biochemical Sciences 32:7, pages 311-319.
Crossref
T. LawrenceM. Bebien. (2007) IKKα in the regulation of inflammation and adaptive immunity. Biochemical Society Transactions 35:2, pages 270-272.
Crossref
J. Witowski, K. Ksiązek, C. Warnecke, M. Kuźlan, K. Korybalska, H. Tayama, J. Wiśniewska-Elnur, K. Pawlaczyk, J. Trómińska, A. Bręborowicz & A. Jörres. (2007) Role of mesothelial cell-derived granulocyte colony-stimulating factor in interleukin-17-induced neutrophil accumulation in the peritoneum. Kidney International 71:6, pages 514-525.
Crossref
Almut Jörgl, Barbara Platzer, Sabine Taschner, Leonhard X. Heinz, Bernhard Höcher, Peter M. Reisner, Florian Göbel & Herbert Strobl. (2006) Human Langerhans-cell activation triggered in vitro by conditionally expressed MKK6 is counterregulated by the downstream effector RelB. Blood 109:1, pages 185-193.
Crossref
Barbara K. Yoza, Jean Y.-Q. Hu, Sue L. Cousart, Lolita M. Forrest & Charles E. McCall. (2006) Induction of RelB Participates in Endotoxin Tolerance. The Journal of Immunology 177:6, pages 4080-4085.
Crossref
Jonathan M. Starkey, Sigmund J. Haidacher, Wanda S. LeJeune, Xiaoquan Zhang, Brian C. Tieu, Sanjeev Choudhary, Allan R. Brasier, Larry A. Denner & Ronald G. Tilton. (2006) Diabetes-Induced Activation of Canonical and Noncanonical Nuclear Factor-κB Pathways in Renal Cortex. Diabetes 55:5, pages 1252-1259.
Crossref
Emilie Jacque, Thierry Tchenio, Guillaume Piton, Paul-Henri Romeo & Véronique Baud. (2005) RelA repression of RelB activity induces selective gene activation downstream of TNF receptors. Proceedings of the National Academy of Sciences 102:41, pages 14635-14640.
Crossref
Fiona Oakley, Jelena Mann, Sarah Nailard, David E. Smart, Narendra Mungalsingh, Christothea Constandinou, Shakir Ali, Susan J. Wilson, Harry Millward-Sadler, John P. Iredale & Derek A. Mann. (2005) Nuclear Factor-κB1 (p50) Limits the Inflammatory and Fibrogenic Responses to Chronic Injury. The American Journal of Pathology 166:3, pages 695-708.
Crossref
Quan-Zhen LiPing LiGabriela E. GarciaRichard J. JohnsonLili Feng. (2005) Genomic Profiling of Neutrophil Transcripts in Asian Qigong Practitioners: A Pilot Study in Gene Regulation by Mind–Body Interaction . The Journal of Alternative and Complementary Medicine 11:1, pages 29-39.
Crossref
Giuseppina Bonizzi, Magali Bebien, Dennis C Otero, Kirsten E Johnson-Vroom, Yixue Cao, Don Vu, Anil G Jegga, Bruce J Aronow, Gourisankar Ghosh, Robert C Rickert & Michael Karin. (2004) Activation of IKKα target genes depends on recognition of specific κB binding sites by RelB:p52 dimers. The EMBO Journal 23:21, pages 4202-4210.
Crossref
Xinkang Wang, Xiang Li, Lin Xu, Yutian Zhan, Shoshanit Yaish-Ohad, Joseph A. Erhardt, Frank C. Barone & Giora Z. Feuerstein. (2003) Up-Regulation of Secretory Leukocyte Protease Inhibitor (SLPI) in the Brain after Ischemic Stroke: Adenoviral Expression of SLPI Protects Brain from Ischemic Injury. Molecular Pharmacology 64:4, pages 833-840.
Crossref
Dirk Elewaut, Raziya B. Shaikh, Kirsten J. L. Hammond, Hilde De Winter, Andrew J. Leishman, Stephane Sidobre, Olga Turovskaya, Theodore I. Prigozy, Lisa Ma, Theresa A. Banks, David Lo, Carl F. Ware, Hilde Cheroutre & Mitchell Kronenberg. (2003) NIK-dependent RelB Activation Defines a Unique Signaling Pathway for the Development of Vα14i NKT Cells. Journal of Experimental Medicine 197:12, pages 1623-1633.
Crossref
Emmanuel Derudder, Emmanuel Dejardin, Linda L. Pritchard, Douglas R. Green, Marie Körner & Véronique Baud. (2003) RelB/p50 Dimers Are Differentially Regulated by Tumor Necrosis Factor-α and Lymphotoxin-β Receptor Activation. Journal of Biological Chemistry 278:26, pages 23278-23284.
Crossref
Ralf Marienfeld, Michael J. May, Ingolf Berberich, Edgar Serfling, Sankar Ghosh & Manfred Neumann. (2003) RelB Forms Transcriptionally Inactive Complexes with RelA/p65. Journal of Biological Chemistry 278:22, pages 19852-19860.
Crossref
Lin Xu, Yutian Zhan, Yibin Wang, Giora Z Feuerstein & Xinkang Wang. (2002) Recombinant adenoviral expression of dominant negative IκBα protects brain from cerebral ischemic injury. Biochemical and Biophysical Research Communications 299:1, pages 14-17.
Crossref
H Nakamura, M Aoki, K Tamai, M Oishi, T Ogihara, Y Kaneda & R Morishita. (2002) Prevention and regression of atopic dermatitis by ointment containing NF-kB decoy oligodeoxynucleotides in NC/Nga atopic mouse model. Gene Therapy 9:18, pages 1221-1229.
Crossref
Manabu Kitazawa, Takashi Nakano, Hiromi Chuujou, Eiji Shiojiri, Keiji Iwasaki & Kazutami Sakamoto. (2002) Intracellular redox regulation by a cystine derivative suppresses UV-induced NF-κB activation. FEBS Letters 526:1-3, pages 106-110.
Crossref
Ulrich Bolder, Andrea Schmidt, Lukas Landmann, Verena Kidder, Stefan Tange & Karl–Walter Jauch. (2002) Heat stress prevents impairment of bile acid transport in endotoxemic rats by a posttranscriptional mechanism. Gastroenterology 122:4, pages 963-973.
Crossref
Ralf Marienfeld, Friederike Berberich-Siebelt, Ingolf Berberich, Andrea Denk, Edgar Serfling & Manfred Neumann. (2001) Signal-specific and phosphorylation-dependent RelB degradation: a potential mechanism of NF-κB control. Oncogene 20:56, pages 8142-8147.
Crossref
Donald J. WeaverJr.Jr., Brian Poligone, Thi Bui, Ussama M. Abdel-Motal, Albert S. BaldwinJr.Jr. & Roland Tisch. (2001) Dendritic Cells from Nonobese Diabetic Mice Exhibit a Defect in NF-κB Regulation Due to a Hyperactive IκB Kinase. The Journal of Immunology 167:3, pages 1461-1468.
Crossref
Dietlind Zohlnhöfer, Thomas Richter, Franz-Josef Neumann, Thomas Nührenberg, Rainer Wessely, Richard Brandl, Alexander Murr, Christoph A. Klein & Patrick A. Baeuerle. (2001) Transcriptome Analysis Reveals a Role of Interferon-γ in Human Neointima Formation. Molecular Cell 7:5, pages 1059-1069.
Crossref
Sergei S Makarov. (2000) NF-κB as a therapeutic target in chronic inflammation: recent advances. Molecular Medicine Today 6:11, pages 441-448.
Crossref
. (2000) Cloning LiteratureWatch. Cloning 2:2, pages 101-113.
Crossref
Chul-Gyu Yoo, Seunghee Lee, Choon-Taek Lee, Young Whan Kim, Sung Koo Han & Young-Soo Shim. (2000) Anti-Inflammatory Effect of Heat Shock Protein Induction Is Related to Stabilization of IκBα Through Preventing IκB Kinase Activation in Respiratory Epithelial Cells. The Journal of Immunology 164:10, pages 5416-5423.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.