21
Views
79
CrossRef citations to date
0
Altmetric
DNA Dynamics and Chromosome Structure

Saccharomyces cerevisiae pol30 (Proliferating Cell Nuclear Antigen) Mutations Impair Replication Fidelity and Mismatch Repair

, , , &
Pages 7801-7815 | Received 26 May 1999, Accepted 30 Jul 1999, Published online: 28 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (8)

Sapna Das-Bradoo, Robin M. Ricke & Anja-Katrin Bielinsky. (2006) Interaction between PCNA and Diubiquitinated Mcm10 Is Essential for Cell Growth in Budding Yeast. Molecular and Cellular Biology 26:13, pages 4806-4817.
Read now
Atsuko Niimi, Siripan Limsirichaikul, Shonen Yoshida, Shigenori Iwai, Chikahide Masutani, Fumio Hanaoka, Eric T. Kool, Yukihiro Nishiyama & Motoshi Suzuki. (2004) Palm Mutants in DNA Polymerases α and η Alter DNA Replication Fidelity and Translesion Activity. Molecular and Cellular Biology 24:7, pages 2734-2746.
Read now
Patrick J. Lau, Hernan Flores-Rozas & Richard D. Kolodner. (2002) Isolation and Characterization of New Proliferating Cell Nuclear Antigen (POL30) Mutator Mutants That Are Defective in DNA Mismatch Repair. Molecular and Cellular Biology 22:19, pages 6669-6680.
Read now
Cecilia Ramilo, Liya Gu, Shuangli Guo, Xiping Zhang, Steve M. Patrick, John J. Turchi & Guo-Min Li. (2002) Partial Reconstitution of Human DNA Mismatch Repair In Vitro: Characterization of the Role of Human Replication Protein A. Molecular and Cellular Biology 22:7, pages 2037-2046.
Read now
Neelam S. Amin, My-Nga Nguyen, Scott Oh & Richard D. Kolodner. (2001) exo1-Dependent Mutator Mutations: Model System for Studying Functional Interactions in Mismatch Repair. Molecular and Cellular Biology 21:15, pages 5142-5155.
Read now
Elizabeth Evans & Eric Alani. (2000) Roles for Mismatch Repair Factors in Regulating Genetic Recombination. Molecular and Cellular Biology 20:21, pages 7839-7844.
Read now
Robert J. Kokoska, Lela Stefanovic, Jeremy DeMai & Thomas D. Petes. (2000) Increased Rates of Genomic Deletions Generated by Mutations in the Yeast Gene Encoding DNA Polymerase δ or by Decreases in the Cellular Levels of DNA Polymerase δ. Molecular and Cellular Biology 20:20, pages 7490-7504.
Read now
Phuoc T. Tran & R. Michael Liskay. (2000) Functional Studies on the Candidate ATPase Domains of Saccharomyces cerevisiae MutLα. Molecular and Cellular Biology 20:17, pages 6390-6398.
Read now

Articles from other publishers (71)

Christopher D. Putnam. (2021) Strand discrimination in DNA mismatch repair. DNA Repair 105, pages 103161.
Crossref
Lynne Dieckman. (2021) Something’s gotta give: How PCNA alters its structure in response to mutations and the implications on cellular processes. Progress in Biophysics and Molecular Biology 163, pages 46-59.
Crossref
Denis A Kiktev, Margaret Dominska, Tony Zhang, Joseph Dahl, Elena I Stepchenkova, Piotr Mieczkowski, Peter M Burgers, Scott Lujan, Adam Burkholder, Thomas A Kunkel & Thomas D Petes. (2021) The fidelity of DNA replication, particularly on GC-rich templates, is reduced by defects of the Fe–S cluster in DNA polymerase δ. Nucleic Acids Research 49:10, pages 5623-5636.
Crossref
Erika Shor & David S. Perlin. (2021) DNA damage response of major fungal pathogen Candida glabrata offers clues to explain its genetic diversity. Current Genetics 67:3, pages 439-445.
Crossref
Erika Shor, Rocio Garcia-Rubio, Lucius DeGregorio & David S. Perlin. (2020) A Noncanonical DNA Damage Checkpoint Response in a Major Fungal Pathogen. mBio 11:6.
Crossref
Qingwen Jiang, Weimin Zhang, Chenghao Liu, Yicong Lin, Qingyu Wu & Junbiao Dai. (2019) Dissecting PCNA function with a systematically designed mutant library in yeast. Journal of Genetics and Genomics 46:6, pages 301-313.
Crossref
Joanna Luczkowiak, Mar Álvarez, Alba Sebastián-Martín & Luis Menéndez-Arias. 2019. Viral Polymerases. Viral Polymerases 95 134 .
Nikki BowenRichard D. Kolodner. (2017) Reconstitution of Saccharomyces cerevisiae DNA polymerase ε-dependent mismatch repair with purified proteins . Proceedings of the National Academy of Sciences 114:14, pages 3607-3612.
Crossref
Rosemary H.C. Wilson, Antonio J. Biasutto, Lihao Wang, Roman Fischer, Emma L. Baple, Andrew H. Crosby, Erika J. Mancini & Catherine M. Green. (2017) PCNA dependent cellular activities tolerate dramatic perturbations in PCNA client interactions. DNA Repair 50, pages 22-35.
Crossref
Yoshitaka Kawasoe, Toshiki Tsurimoto, Takuro Nakagawa, Hisao Masukata & Tatsuro S Takahashi. (2016) MutSα maintains the mismatch repair capability by inhibiting PCNA unloading. eLife 5.
Crossref
Guo-Min Li. (2016) A Personal Tribute to 2015 Nobel Laureate Paul Modrich. DNA Repair 37, pages A14-A21.
Crossref
Richard Fishel & Jong-Bong Lee. 2016. DNA Replication, Recombination, and Repair. DNA Replication, Recombination, and Repair 305 339 .
Y-W Chang, R-T Mai, W-H Fang, C-C Lin, C-C Chiu & Y-H Wu Lee. (2013) YB-1 disrupts mismatch repair complex formation, interferes with MutSα recruitment on mismatch and inhibits mismatch repair through interacting with PCNA. Oncogene 33:43, pages 5065-5077.
Crossref
Eva M. Goellner, Catherine E. Smith, Christopher S. Campbell, Hans Hombauer, Arshad Desai, Christopher D. Putnam & Richard D. Kolodner. (2014) PCNA and Msh2-Msh6 Activate an Mlh1-Pms1 Endonuclease Pathway Required for Exo1-Independent Mismatch Repair. Molecular Cell 55:2, pages 291-304.
Crossref
Jonathan Gómez-Raja & German Larriba. (2013) Reprint of Comparison of two approaches for identification of haplotypes and point mutations in Candida albicans and Saccharomyces cerevisiae. Journal of Microbiological Methods 95:3, pages 448-454.
Crossref
Nina V. Romanova & Gray F. Crouse. (2013) Different Roles of Eukaryotic MutS and MutL Complexes in Repair of Small Insertion and Deletion Loops in Yeast. PLoS Genetics 9:10, pages e1003920.
Crossref
Lynne M. Dieckman, Elizabeth M. Boehm, Manju M. Hingorani & M. Todd Washington. (2013) Distinct Structural Alterations in Proliferating Cell Nuclear Antigen Block DNA Mismatch Repair. Biochemistry 52:33, pages 5611-5619.
Crossref
Jonathan Gómez-Raja & German Larriba. (2013) Comparison of two approaches for identification of haplotypes and point mutations in Candida albicans and Saccharomyces cerevisiae. Journal of Microbiological Methods 94:1, pages 47-53.
Crossref
Hai Dang Nguyen, Jordan Becker, Yee Mon Thu, Michael Costanzo, Elizabeth N. Koch, Stephanie Smith, Kyungjae Myung, Chad L. Myers, Charles Boone & Anja-Katrin Bielinsky. (2013) Unligated Okazaki Fragments Induce PCNA Ubiquitination and a Requirement for Rad59-Dependent Replication Fork Progression. PLoS ONE 8:6, pages e66379.
Crossref
Natalie Saini, Yu Zhang, Yuri Nishida, Ziwei Sheng, Shilpa Choudhury, Piotr Mieczkowski & Kirill S. Lobachev. (2013) Fragile DNA Motifs Trigger Mutagenesis at Distant Chromosomal Loci in Saccharomyces cerevisiae. PLoS Genetics 9:6, pages e1003551.
Crossref
Rodrigo Gómez & Claudia P. Spampinato. (2013) Mismatch recognition function of Arabidopsis thaliana MutSγ. DNA Repair 12:4, pages 257-264.
Crossref
Motoshi Suzuki & Takashi Takahashi. (2013) Aberrant DNA replication in cancer. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 743-744, pages 111-117.
Crossref
Hans HombauerAnjana SrivatsanChristopher D. PutnamRichard D. Kolodner. (2011) Mismatch Repair, But Not Heteroduplex Rejection, Is Temporally Coupled to DNA Replication. Science 334:6063, pages 1713-1716.
Crossref
S. Abbà, M. Vallino, S. Daghino, L. Di Vietro, R. Borriello & S. Perotto. (2011) A PLAC8-containing protein from an endomycorrhizal fungus confers cadmium resistance to yeast cells by interacting with Mlh3p. Nucleic Acids Research 39:17, pages 7548-7563.
Crossref
D. Kumar, A. L. Abdulovic, J. Viberg, A. K. Nilsson, T. A. Kunkel & A. Chabes. (2010) Mechanisms of mutagenesis in vivo due to imbalanced dNTP pools. Nucleic Acids Research 39:4, pages 1360-1371.
Crossref
Claudia P. Spampinato, Rodrigo L. Gomez, Celina Galles & Luciana D. Lario. (2009) From bacteria to plants: A compendium of mismatch repair assays. Mutation Research/Reviews in Mutation Research 682:2-3, pages 110-128.
Crossref
Changying Jiang, Gloria Komazin-Meredith, Wang Tian, Donald M. Coen & Charles B. C. Hwang. (2009) Mutations That Increase DNA Binding by the Processivity Factor of Herpes Simplex Virus Affect Virus Production and DNA Replication Fidelity. Journal of Virology 83:15, pages 7573-7580.
Crossref
Phuoc T. Tran, Julien P. Fey, Naz Erdeniz, Lionel Gellon, Serge Boiteux & R. Michael Liskay. (2007) A mutation in EXO1 defines separable roles in DNA mismatch repair and post-replication repair. DNA Repair 6:11, pages 1572-1583.
Crossref
Scarlet S. Shell, Christopher D. Putnam & Richard D. Kolodner. (2007) The N Terminus of Saccharomyces cerevisiae Msh6 Is an Unstructured Tether to PCNA. Molecular Cell 26:4, pages 565-578.
Crossref
Suzanne M. Deschênes, Guy Tomer, Megan Nguyen, Naz Erdeniz, Nicole C. Juba, Natalia Sepúlveda, Jenna E. Pisani & R. Michael Liskay. (2007) The E705K mutation in hPMS2 exerts recessive, not dominant, effects on mismatch repair. Cancer Letters 249:2, pages 148-156.
Crossref
Changying Jiang, Ying T. Hwang, John C. W. Randell, Donald M. Coen & Charles B. C. Hwang. (2007) Mutations That Decrease DNA Binding of the Processivity Factor of the Herpes Simplex Virus DNA Polymerase Reduce Viral Yield, Alter the Kinetics of Viral DNA Replication, and Decrease the Fidelity of DNA Replication. Journal of Virology 81:7, pages 3495-3502.
Crossref
Clark C. Chen, Akira Motegi, Yuko Hasegawa, Kyungjae Myung, Richard Kolodner & Alan D’Andrea. (2006) Genetic analysis of ionizing radiation-induced mutagenesis in Saccharomyces cerevisiae reveals TransLesion Synthesis (TLS) independent of PCNA K164 SUMOylation and ubiquitination. DNA Repair 5:12, pages 1475-1488.
Crossref
Matthew R Northam, Parie Garg, Dmitri M Baitin, Peter M J Burgers & Polina V Shcherbakova. (2006) A novel function of DNA polymerase ζ regulated by PCNA. The EMBO Journal 25:18, pages 4316-4325.
Crossref
John M. Fortune, Carrie M. Stith, Grace E. Kissling, Peter M. J. Burgers & Thomas A. Kunkel. (2006) RPA and PCNA suppress formation of large deletion errors by yeast DNA polymerase δ. Nucleic Acids Research 34:16, pages 4335-4341.
Crossref
Ainsley Nicholson, Rebecca M Fabbri, Jason W Reeves & Gray F Crouse. (2006) The Effects of Mismatch Repair and RAD1 Genes on Interchromosomal Crossover Recombination in Saccharomyces cerevisiae . Genetics 173:2, pages 647-659.
Crossref
Francisco J. López de Saro, Martin G. Marinus, Paul Modrich & Mike O'Donnell. (2006) The β Sliding Clamp Binds to Multiple Sites within MutL and MutS. Journal of Biological Chemistry 281:20, pages 14340-14349.
Crossref
Changying Jiang, Ying T. Hwang & Charles Bih-Chen Hwang. (2006) Herpes simplex virus type 1 recombinants without the oriL sequence replicate DNA with increased fidelity. Virology 347:2, pages 277-285.
Crossref
Ravi R. Iyer, Anna Pluciennik, Vickers Burdett & Paul L. Modrich. (2005) DNA Mismatch Repair:  Functions and Mechanisms. Chemical Reviews 106:2, pages 302-323.
Crossref
Christophe Redon, Duane R Pilch & William M Bonner. (2006) Genetic Analysis of Saccharomyces cerevisiae H2A Serine 129 Mutant Suggests a Functional Relationship Between H2A and the Sister-Chromatid Cohesion Partners Csm3–Tof1 for the Repair of Topoisomerase I-Induced DNA Damage . Genetics 172:1, pages 67-76.
Crossref
Youri I. Pavlov, Polina V. Shcherbakova & Igor B. Rogozin. 2006. A Survey of Cell Biology. A Survey of Cell Biology 41 132 .
Errol C. Friedberg, Graham C. Walker, Wolfram Siede, Richard D. Wood, Roger A. Schultz & Tom Ellenberger. 2005. DNA Repair and Mutagenesis. DNA Repair and Mutagenesis 389 447 .
Anna Bebenek, Geraldine T Carver, Farid A Kadyrov, Grace E Kissling & John W Drake. (2005) Processivity Clamp gp45 and ssDNA-Binding-Protein gp32 Modulate the Fidelity of Bacteriophage RB69 DNA Polymerase in a Sequence-Specific Manner, Sometimes Enhancing and Sometimes Compromising Accuracy. Genetics 169:4, pages 1815-1824.
Crossref
Arturo López, Noel Xamena, Ricard Marcos & Antonia Velázquez. (2005) Germline genomic instability in PCNA mutants of Drosophila: DNA fingerprinting and microsatellite analysis. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 570:2, pages 253-265.
Crossref
Giancarlo Marra & Josef Jiricny. 2005. Genome Instability in Cancer Development. Genome Instability in Cancer Development 85 123 .
Gaku Ohnishi, Kingo Endo, Akiko Doi, Atsushige Fujita, Yasukazu Daigaku, Tatsuo Nunoshiba & Kazuo Yamamoto. (2004) Spontaneous mutagenesis in haploid and diploid Saccharomyces cerevisiae. Biochemical and Biophysical Research Communications 325:3, pages 928-933.
Crossref
Mark J. SchofieldPeggy Hsieh. (2003) DNA Mismatch Repair: Molecular Mechanisms and Biological Function. Annual Review of Microbiology 57:1, pages 579-608.
Crossref
A Baida, A López, R Marcos & A Velázquez. (2003) Germline mutations at microsatellite loci in homozygous and heterozygous mutants for mismatch repair and PCNA genes in Drosophila. DNA Repair 2:7, pages 827-833.
Crossref
Phuoc T Tran, Naz Erdeniz, Sandra Dudley & R.Michael Liskay. (2002) Characterization of nuclease-dependent functions of Exo1p in Saccharomyces cerevisiae. DNA Repair 1:11, pages 895-912.
Crossref
Lionel Gellon, Michel Werner & Serge Boiteux. (2002) Ntg2p, a Saccharomyces cerevisiae DNAN-Glycosylase/Apurinic or Apyrimidinic Lyase Involved in Base Excision Repair of Oxidative DNA Damage, Interacts with the DNA Mismatch Repair Protein Mlh1p. Journal of Biological Chemistry 277:33, pages 29963-29972.
Crossref
Ting-Fang Wang & Wen-Mei Kung. (2002) Supercomplex formation between Mlh1–Mlh3 and Sgs1–Top3 heterocomplexes in meiotic yeast cells. Biochemical and Biophysical Research Communications 296:4, pages 949-953.
Crossref
Lani F. Wu, Timothy R. Hughes, Armaity P. Davierwala, Mark D. Robinson, Roland Stoughton & Steven J. Altschuler. (2002) Large-scale prediction of Saccharomyces cerevisiae gene function using overlapping transcriptional clusters. Nature Genetics 31:3, pages 255-265.
Crossref
Meng-Er Huang, Anne-Gaëlle Rio, Marie-Dominique Galibert & Francis Galibert. (2002) Pol32, a Subunit of Saccharomyces cerevisiae DNA Polymerase δ, Suppresses Genomic Deletions and Is Involved in the Mutagenic Bypass Pathway . Genetics 160:4, pages 1409-1422.
Crossref
Thomas M. Marti, Christophe Kunz & Oliver Fleck. (2002) DNA mismatch repair and mutation avoidance pathways. Journal of Cellular Physiology 191:1, pages 28-41.
Crossref
Juan Lucas Argueso, Daniel Smith, James Yi, Marc Waase, Sumeet Sarin & Eric Alani. (2002) Analysis of Conditional Mutations in the Saccharomyces cerevisiae MLH1 Gene in Mismatch Repair and in Meiotic Crossing Over . Genetics 160:3, pages 909-921.
Crossref
Marta Szadkowski & Josef Jiricny. (2002) Identification and functional characterization of the promoter region of the humanMSH6 gene. Genes, Chromosomes and Cancer 33:1, pages 36-46.
Crossref
Youri I Pavlov, Polina V Shcherbakova & Thomas A Kunkel. (2001) In Vivo Consequences of Putative Active Site Mutations in Yeast DNA Polymerases α, ε, δ, and ζ . Genetics 159:1, pages 47-64.
Crossref
Geoffrey Frank, Junzhuan Qiu, Li Zheng & Binghui Shen. (2001) Stimulation of Eukaryotic Flap Endonuclease-1 Activities by Proliferating Cell Nuclear Antigen (PCNA) Is Independent of Its in Vitro Interaction via a Consensus PCNA Binding Region. Journal of Biological Chemistry 276:39, pages 36295-36302.
Crossref
Phuoc T. Tran, Jeffrey A. Simon & R. Michael Liskay. (2001) Interactions of Exo1p with components of MutLα in Saccharomyces cerevisiae . Proceedings of the National Academy of Sciences 98:17, pages 9760-9765.
Crossref
Michael Lisby, Rodney Rothstein & Uffe H. Mortensen. (2001) Rad52 forms DNA repair and recombination centers during S phase. Proceedings of the National Academy of Sciences 98:15, pages 8276-8282.
Crossref
Peggy Hsieh. (2001) Molecular mechanisms of DNA mismatch repair. Mutation Research/DNA Repair 486:2, pages 71-87.
Crossref
Youri I Pavlov, Dinh Nguyen & Thomas A Kunkel. (2001) Mutator effects of overproducing DNA polymerase η (Rad30) and its catalytically inactive variant in yeast. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 478:1-2, pages 129-139.
Crossref
Jayson Bowers, Phuoc T Tran, Amita Joshi, R.Michael Liskay & Eric Alani. (2001) MSH-MLH complexes formed at a DNA mismatch are disrupted by the PCNA sliding clamp. Journal of Molecular Biology 306:5, pages 957-968.
Crossref
Kyungjae Myung, Abhijit Datta & Richard D Kolodner. (2001) Suppression of Spontaneous Chromosomal Rearrangements by S Phase Checkpoint Functions in Saccharomyces cerevisiae. Cell 104:3, pages 397-408.
Crossref
Uwe Sauer. 2001. Metabolic Engineering. Metabolic Engineering 129 169 .
Brian D HarfeSue Jinks-Robertson. (2000) DNA MISMATCH REPAIR AND GENETIC INSTABILITY. Annual Review of Genetics 34:1, pages 359-399.
Crossref
Alan B. Clark, Frank Valle, Karin Drotschmann, Ronald K. Gary & Thomas A. Kunkel. (2000) Functional Interaction of Proliferating Cell Nuclear Antigen with MSH2-MSH6 and MSH2-MSH3 Complexes. Journal of Biological Chemistry 275:47, pages 36498-36501.
Crossref
Hernan Flores-Rozas, Delbert Clark & Richard D. Kolodner. (2000) Proliferating cell nuclear antigen and Msh2p-Msh6p interact to form an active mispair recognition complex. Nature Genetics 26:3, pages 375-378.
Crossref
Abhijit Datta, James L. Schmeits, Neelam S. Amin, Patrick J. Lau, Kyungjae Myung & Richard D. Kolodner. (2000) Checkpoint-Dependent Activation of Mutagenic Repair in Saccharomyces cerevisiae pol3-01 Mutants. Molecular Cell 6:3, pages 593-603.
Crossref
Andr�s Aguilera, Sebasti�n Ch�vez & Francisco Malag�n. (2000) Mitotic recombination in yeast: elements controlling its incidence. Yeast 16:8, pages 731-754.
Crossref
Thomas A. KunkelKatarzyna Bebenek. (2000) DNA Replication Fidelity. Annual Review of Biochemistry 69:1, pages 497-529.
Crossref
Tanya Sokolsky & Eric Alani. (2000) EXO1 and MSH6 Are High-Copy Suppressors of Conditional Mutations in the MSH2 Mismatch Repair Gene of Saccharomyces cerevisiae . Genetics 155:2, pages 589-599.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.