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Molecular and Cellular Biology Volume 19, 1999 - Issue 3
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DNA Dynamics and Chromosome Structure

The Saccharomyces cerevisiae ETH1 Gene, an Inducible Homolog of Exonuclease III That Provides Resistance to DNA-Damaging Agents and Limits Spontaneous Mutagenesis

Richard A. O. BennettDepartment of Cancer Cell Biology, Harvard School of Public Health, Boston, Massachusetts02115Correspondence[email protected]
Pages 1800-1809 | Received 22 Sep 1998, Accepted 16 Nov 1998, Published online: 27 Mar 2023

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Wenjian Ma, Vijayalakshmi Panduri, Joan F. Sterling, Bennett Van Houten, Dmitry A. Gordenin & Michael A. Resnick. (2009) The Transition of Closely Opposed Lesions to Double-Strand Breaks during Long-Patch Base Excision Repair Is Prevented by the Coordinated Action of DNA Polymerase δ and Rad27/Fen1. Molecular and Cellular Biology 29:5, pages 1212-1221.
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Alexander A. Ishchenko, Xiaoming Yang, Dindial Ramotar & Murat Saparbaev. (2005) The 3′→5′ Exonuclease of Apn1 Provides an Alternative Pathway To Repair 7,8-Dihydro-8-Oxodeoxyguanosine in Saccharomyces cerevisiae. Molecular and Cellular Biology 25:15, pages 6380-6390.
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Marie Guillet & Serge Boiteux. (2003) Origin of Endogenous DNA Abasic Sites in Saccharomyces cerevisiae. Molecular and Cellular Biology 23:22, pages 8386-8394.
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John R. Vance & Thomas E. Wilson. (2001) Repair of DNA Strand Breaks by the Overlapping Functions of Lesion-Specific and Non-Lesion-Specific DNA 3′ Phosphatases. Molecular and Cellular Biology 21:21, pages 7191-7198.
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Carlos A. Torres-Ramos, Robert E. Johnson, Louise Prakash & Satya Prakash. (2000) Evidence for the Involvement of Nucleotide Excision Repair in the Removal of Abasic Sites in Yeast. Molecular and Cellular Biology 20:10, pages 3522-3528.
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Jinchao Li, Cong Wang, Wenjie Liang, Jun Zhang, Chen-Kun Jiang, Yi Liu, Zhitong Ren, Dong Ci, Jinjie Chang, Shangling Han, Xing Wang Deng, Yingxiang Wang & Weiqiang Qian. (2023) Functional importance and divergence of plant apurinic/apyrimidinic endonucleases in somatic and meiotic DNA repair. The Plant Cell.
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Anne McMahon, Jianjun Zhao & Shan Yan. (2023) APE2: catalytic function and synthetic lethality draw attention as a cancer therapy target. NAR Cancer 5:1.
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Sima Chaudhari, Akshay P. Ware, Pradyumna Jayaram, Sankar Prasad Gorthi, Sherif F. El-Khamisy & Kapaettu Satyamoorthy. (2021) Apurinic/Apyrimidinic Endonuclease 2 (APE2): An ancillary enzyme for contextual base excision repair mechanisms to preserve genome stability. Biochimie 190, pages 70-90.
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Kasey Stokdyk, Alexandra Berroyer, Zacharia A. Grami & Nayun Kim. (2021) The activity of yeast Apn2 AP endonuclease at uracil-derived AP sites is dependent on the major carbon source. Current Genetics 67:2, pages 283-294.
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Rayssa Karla de Medeiros Oliveira, Fabián Andrés Hurtado, Pedro Henrique Gomes, Luiza Lassi Puglia, Fernanda Fonsêca Ferreira, Kunal Ranjan, Patrícia Albuquerque, Márcio José Poças-Fonseca, Ildinete Silva-Pereira & Larissa Fernandes. (2021) Base Excision Repair AP-Endonucleases-Like Genes Modulate DNA Damage Response and Virulence of the Human Pathogen Cryptococcus neoformans. Journal of Fungi 7:2, pages 133.
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Alison K Thurston, Catherine A Radebaugh, Adam R Almeida, Juan Lucas Argueso & Laurie A Stargell. (2018) Genome Instability Is Promoted by the Chromatin-Binding Protein Spn1 in Saccharomyces cerevisiae . Genetics 210:4, pages 1227-1237.
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Lydia P. Morris, Andrew B. Conley, Natalya Degtyareva, I. King Jordan & Paul W. Doetsch. (2017) Genome-wide map of Apn1 binding sites under oxidative stress in Saccharomyces cerevisiae . Yeast 34:11, pages 447-458.
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Sabrina Wemhoff, Roland Klassen, Anja Beetz & Friedhelm Meinhardt. (2016) DNA Damage Responses Are Induced by tRNA Anticodon Nucleases and Hygromycin B. PLOS ONE 11:7, pages e0157611.
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Nicholas C. Bauer, Anita H. Corbett & Paul W. Doetsch. (2015) The current state of eukaryotic DNA base damage and repair. Nucleic Acids Research, pages gkv1136.
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Serge Boiteux & Sue Jinks-Robertson. (2013) DNA Repair Mechanisms and the Bypass of DNA Damage in Saccharomyces cerevisiae . Genetics 193:4, pages 1025-1064.
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Dindial Ramotar & Mustapha Aouida. 2013. Advances in DNA Repair in Cancer Therapy. Advances in DNA Repair in Cancer Therapy 187 209 .
Monika Aggarwal & Robert M. BroshJr.Jr.. (2012) Functional analyses of human DNA repair proteins important for aging and genomic stability using yeast genetics. DNA Repair 11:4, pages 335-348.
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Daniel B. Swartzlander, Nicholas C. Bauer, Anita H. Corbett & Paul W. Doetsch. 2012. Mechanisms of DNA Repair. Mechanisms of DNA Repair 93 121 .
James M. Daley, Chadi Zakaria & Dindial Ramotar. (2010) The endonuclease IV family of apurinic/apyrimidinic endonucleases. Mutation Research/Reviews in Mutation Research 705:3, pages 217-227.
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James M. Daley, Thomas E. Wilson & Dindial Ramotar. (2010) Genetic interactions between HNT3/Aprataxin and RAD27/FEN1 suggest parallel pathways for 5′ end processing during base excision repair. DNA Repair 9:6, pages 690-699.
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Matthew R Northam, Heather A Robinson, Olga V Kochenova & Polina V Shcherbakova. (2010) Participation of DNA Polymerase ζ in Replication of Undamaged DNA in Saccharomyces cerevisiae . Genetics 184:1, pages 27-42.
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Leah Pogorzala, Shona Mookerjee & Elaine A Sia. (2009) Evidence That Msh1p Plays Multiple Roles in Mitochondrial Base Excision Repair. Genetics 182:3, pages 699-709.
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Sean Fortier, Xiaojie Yang, Yi Wang, Richard A. O. Bennett & Phyllis R. Strauss. (2009) Base Excision Repair in Early Zebrafish Development: Evidence for DNA Polymerase Switching and Standby AP Endonuclease Activity. Biochemistry 48:23, pages 5396-5404.
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Yu Fu, Landon Pastushok & Wei Xiao. (2008) DNA damage-induced gene expression in Saccharomyces cerevisiae . FEMS Microbiology Reviews 32:6, pages 908-926.
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Wenjian Ma, Michael A. Resnick & Dmitry A. Gordenin. (2008) Apn1 and Apn2 endonucleases prevent accumulation of repair-associated DNA breaks in budding yeast as revealed by direct chromosomal analysis. Nucleic Acids Research 36:6, pages 1836-1846.
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Sophie Couvé-Privat, Alexander A. Ishchenko, Jacques Laval & Murat Saparbaev. 2007. Oxidative Damage to Nucleic Acids. Oxidative Damage to Nucleic Acids 54 66 .
Haruna Tanihigashi, Ayako Yamada, Emi Igawa & Shogo Ikeda. (2006) The role of Schizosaccharomyces pombe DNA repair enzymes Apn1p and Uve1p in the base excision repair of apurinic/apyrimidinic sites. Biochemical and Biophysical Research Communications 347:4, pages 889-894.
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Srinivasa R. Peddi, Ranajoy Chattopadhyay, C.V. Naidu & Tadahide Izumi. (2006) The human apurinic/apyrimidinic endonuclease-1 suppresses activation of poly(adp-ribose) polymerase-1 induced by DNA single strand breaks. Toxicology 224:1-2, pages 44-55.
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Ana Kitanovic & Stefan Wölfl. (2006) Fructose-1,6-bisphosphatase mediates cellular responses to DNA damage and aging in Saccharomyces cerevisiae. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 594:1-2, pages 135-147.
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Paul Auerbach, Richard A. O. Bennett, Elisabeth A. Bailey, Hans E. Krokan & Bruce Demple. (2005) Mutagenic specificity of endogenously generated abasic sites in Saccharomyces cerevisiae chromosomal DNA . Proceedings of the National Academy of Sciences 102:49, pages 17711-17716.
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Bruce Demple & Jung-Suk Sung. (2005) Molecular and biological roles of Ape1 protein in mammalian base excision repair. DNA Repair 4:12, pages 1442-1449.
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Errol C. Friedberg, Graham C. Walker, Wolfram Siede, Richard D. Wood, Roger A. Schultz & Tom Ellenberger. 2005. DNA Repair and Mutagenesis. DNA Repair and Mutagenesis 169 226 .
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Andrea Shatilla, Anick Leduc, Xiaoming Yang & Dindial Ramotar. (2005) Identification of two apurinic/apyrimidinic endonucleases from Caenorhabditis elegans by cross-species complementation. DNA Repair 4:6, pages 655-670.
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Carmen Michán, Fernando Monje-Casas & Carmen Pueyo. (2005) Transcript copy number of genes for DNA repair and translesion synthesis in yeast: contribution of transcription rate and mRNA stability to the steady-state level of each mRNA along with growth in glucose-fermentative medium. DNA Repair 4:4, pages 469-478.
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Sven Pfeifer & Thomas Greiner-Stöffele. (2005) A recombinant exonuclease III homologue of the thermophilic archaeon Methanothermobacter thermautotrophicus. DNA Repair 4:4, pages 433-444.
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Andrei Maksimenko, Alexander A Ishchenko, Guenhaël Sanz, Jacques Laval, Rhoderick H Elder & Murat K Saparbaev. (2004) A molecular beacon assay for measuring base excision repair activities. Biochemical and Biophysical Research Communications 319:1, pages 240-246.
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K Anke Schürer, Christian Rudolph, Helle D Ulrich & Wilfried Kramer. (2004) Yeast MPH1 Gene Functions in an Error-Free DNA Damage Bypass Pathway That Requires Genes From Homologous Recombination, but Not From Postreplicative Repair . Genetics 166:4, pages 1673-1686.
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Serge Boiteux & Marie Guillet. (2004) Abasic sites in DNA: repair and biological consequences in Saccharomyces cerevisiae. DNA Repair 3:1, pages 1-12.
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J.Lee A Fraser, Erin Neill & Scott Davey. (2003) Fission yeast Uve1 and Apn2 function in distinct oxidative damage repair pathways in vivo. DNA Repair 2:11, pages 1253-1267.
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Natalie J Morey, Paul W Doetsch & Sue Jinks-Robertson. (2003) Delineating the Requirements for Spontaneous DNA Damage Resistance Pathways in Genome Maintenance and Viability in Saccharomyces cerevisiae . Genetics 164:2, pages 443-455.
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A. Leduc, C. H. He & D. Ramotar. (2003) Disruption of the Saccharomyces cerevisiae cell-wall pathway gene SLG1 causes hypersensitivity to the antitumor drug bleomycin. Molecular Genetics and Genomics 269:1, pages 78-89.
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Bruce Demple & Michael S DeMott. (2002) Dynamics and diversions in base excision DNA repair of oxidized abasic lesions. Oncogene 21:58, pages 8926-8934.
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Laurent Gros, Murat K Saparbaev & Jacques Laval. (2002) Enzymology of the repair of free radicals-induced DNA damage. Oncogene 21:58, pages 8905-8925.
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Chunyan Liu, Jeffrey J. Pouliot & Howard A. Nash. (2002) Repair of topoisomerase I covalent complexes in the absence of the tyrosyl-DNA phosphodiesterase Tdp1. Proceedings of the National Academy of Sciences 99:23, pages 14970-14975.
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Masood Z Hadi, Krzysztof Ginalski, Lam H Nguyen & David M WilsonIIIIII. (2002) Determinants in nuclease specificity of ape1 and ape2, human homologues of Escherichia coli exonuclease III. Journal of Molecular Biology 316:3, pages 853-866.
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Anne Britt. (2002) Repair of Damaged Bases. The Arabidopsis Book 1, pages e0005.
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Lucymara F. Agnez-Lima, Sílvia R. Batistuzzo de Medeiros, Bruno S. Maggi & Giovanna A.S. Quaresma. (2001) Base excision repair in sugarcane. Genetics and Molecular Biology 24:1-4, pages 123-129.
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Wei Xiao, Barbara L Chow, Michelle Hanna & Paul W Doetsch. (2001) Deletion of the MAG1 DNA glycosylase gene suppresses alkylation-induced killing and mutagenesis in yeast cells lacking AP endonucleases. Mutation Research/DNA Repair 487:3-4, pages 137-147.
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David M WilsonIIIIII & Daniel Barsky. (2001) The major human abasic endonuclease: formation, consequences and repair of abasic lesions in DNA. Mutation Research/DNA Repair 485:4, pages 283-307.
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Ildiko Unk, Lajos Haracska, Robert E. Johnson, Satya Prakash & Louise Prakash. (2000) Apurinic Endonuclease Activity of Yeast Apn2 Protein. Journal of Biological Chemistry 275:29, pages 22427-22434.
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Asli Memisoglu & Leona Samson. (2000) Base excision repair in yeast and mammals. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 451:1-2, pages 39-51.
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Asli Memisoglu & Leona Samson. (2000) Contribution of Base Excision Repair, Nucleotide Excision Repair, and DNA Recombination to Alkylation Resistance of the Fission Yeast Schizosaccharomyces pombe . Journal of Bacteriology 182:8, pages 2104-2112.
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Rodrigo S. Galhardo, Carlos E. B. Almeida, Alvaro C. Leitão & Januário B. Cabral-Neto. (2000) Repair of DNA Lesions Induced by Hydrogen Peroxide in the Presence of Iron Chelators in Escherichia coli : Participation of Endonuclease IV and Fpg . Journal of Bacteriology 182:7, pages 1964-1968.
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Natalie J Morey, Christopher N Greene & Sue Jinks-Robertson. (2000) Genetic Analysis of Transcription-Associated Mutation in Saccharomyces cerevisiae. Genetics 154:1, pages 109-120.
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Masood Z. Hadi & David M. Wilson. (2000) Second human protein with homology to theEscherichia coli abasic endonuclease exonuclease III. Environmental and Molecular Mutagenesis 36:4, pages 312-324.
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