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DNA Dynamics and Chromosome Structure

Requirement for the Kinase Activity of Human DNA-Dependent Protein Kinase Catalytic Subunit in DNA Strand Break Rejoining

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Pages 3877-3884 | Received 05 Oct 1998, Accepted 16 Feb 1999, Published online: 28 Mar 2023

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Byeong Kim, Yunkyung Hong, Seunghoon Lee, Pengda Liu, Ji Lim, Yong Lee, Tae Lee, Kyu Chang & Yonggeun Hong. (2015) Therapeutic Implications for Overcoming Radiation Resistance in Cancer Therapy. International Journal of Molecular Sciences 16:11, pages 26880-26913.
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Lisa A. MiosgeMatthew A. FieldYovina SontaniVicky ChoSimon JohnsonAnna PalkovaBhavani BalakishnanRong LiangYafei ZhangStephen LyonBruce BeutlerBelinda WhittleEdward M. BertramAnselm EndersChristopher C. Goodnow & T. Daniel Andrews. (2015) Comparison of predicted and actual consequences of missense mutations. Proceedings of the National Academy of Sciences 112:37.
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Jonathan F. Goodwin, Vishal Kothari, Justin M. Drake, Shuang Zhao, Emanuela Dylgjeri, Jeffry L. Dean, Matthew J. Schiewer, Christopher McNair, Jennifer K. Jones, Alvaro Aytes, Michael S. Magee, Adam E. Snook, Ziqi Zhu, Robert B. Den, Ruth C. Birbe, Leonard G. Gomella, Nicholas A. Graham, Ajay A. Vashisht, James A. Wohlschlegel, Thomas G. Graeber, R. Jeffrey Karnes, Mandeep Takhar, Elai Davicioni, Scott A. Tomlins, Cory Abate-Shen, Nima Sharifi, Owen N. Witte, Felix Y. Feng & Karen E. Knudsen. (2015) DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis. Cancer Cell 28:1, pages 97-113.
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Crossref
Jessica S. Brown & Stephen P. Jackson. (2015) Ubiquitylation, neddylation and the DNA damage response. Open Biology 5:4, pages 150018.
Crossref
Nicholas Jette & Susan P. Lees-Miller. (2015) The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosis. Progress in Biophysics and Molecular Biology 117:2-3, pages 194-205.
Crossref
Lan Yu, Zeng-Fu Shang, Feng-Ming Hsu, Zhang Zhang, Vasu Tumati, Yu-Fen Lin, Benjamin P.C. Chen & Debabrata Saha. (2015) NSCLC cells demonstrate differential mode of cell death in response to the combined treatment of radiation and a DNA-PKcs inhibitor. Oncotarget 6:6, pages 3848-3860.
Crossref
Jonathan F. Goodwin & Karen E. Knudsen. (2014) Beyond DNA Repair: DNA-PK Function in Cancer. Cancer Discovery 4:10, pages 1126-1139.
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Elzbieta Pastwa, Tomasz Poplawski, Urszula Lewandowska, Stella B. Somiari, Janusz Blasiak & Richard I. Somiari. (2014) Wortmannin potentiates the combined effect of etoposide and cisplatin in human glioma cells. The International Journal of Biochemistry & Cell Biology 53, pages 423-431.
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Hollie Chandler, Harshil Patel, Richard Palermo, Sharon Brookes, Nik Matthews & Gordon Peters. (2014) Role of Polycomb Group Proteins in the DNA Damage Response – A Reassessment. PLoS ONE 9:7, pages e102968.
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Pauline Douglas, Ruiqiong Ye, Laura Trinkle-Mulcahy, Jessica A. NealVeerle De Wever, Nick A. MorriceKatheryn MeekSusan P. Lees-Miller. (2014) Polo-like kinase 1 (PLK1) and protein phosphatase 6 (PP6) regulate DNA-dependent protein kinase catalytic subunit (DNA-PKcs) phosphorylation in mitosis. Bioscience Reports 34:3.
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Anthony J. Davis, Benjamin P.C. Chen & David J. Chen. (2014) DNA-PK: A dynamic enzyme in a versatile DSB repair pathway. DNA Repair 17, pages 21-29.
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Gabrielle J. Grundy, Hayley A. Moulding, Keith W. Caldecott & Stuart L. Rulten. (2014) One ring to bring them all—The role of Ku in mammalian non-homologous end joining. DNA Repair 17, pages 30-38.
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Sarvan Kumar Radhakrishnan, Nicholas Jette & Susan P. Lees-Miller. (2014) Non-homologous end joining: Emerging themes and unanswered questions. DNA Repair 17, pages 2-8.
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Catherine J. Pears & Nicholas D. Lakin. (2014) Emerging models for DNA repair: Dictyostelium discoideum as a model for nonhomologous end-joining. DNA Repair 17, pages 121-131.
Crossref
Yu-Fen Lin, Hatsumi Nagasawa, John B. Little, Takamitsu A. Kato, Hung-Ying Shih, Xian-Jin Xie, Paul F. Wilson Jr.John R. Brogan, Akihiro Kurimasa, David J. Chen, Joel S. Bedford & Benjamin P. C. Chen. (2014) Differential Radiosensitivity Phenotypes of DNA-PKcs Mutations Affecting NHEJ and HRR Systems following Irradiation with Gamma-Rays or Very Low Fluences of Alpha Particles. PLoS ONE 9:4, pages e93579.
Crossref
Salim Abdisalaam, Anthony J. Davis, David J. Chen & George Alexandrakis. (2014) Scanning fluorescence correlation spectroscopy techniques to quantify the kinetics of DNA double strand break repair proteins after γ-irradiation and bleomycin treatment. Nucleic Acids Research 42:1, pages e5-e5.
Crossref
Stephany Veuger & Nicola J. Curtin. 2014. Cancer Drug Design and Discovery. Cancer Drug Design and Discovery 193 237 .
Candelaria Bracalente, Irene L. Ibañez, Beatriz Molinari, Mónica Palmieri, Andrés Kreiner, Alejandro Valda, Jorge Davidson & Hebe Durán. (2013) Induction and Persistence of Large γH2AX Foci by High Linear Energy Transfer Radiation in DNA-Dependent protein kinase–Deficient Cells. International Journal of Radiation Oncology*Biology*Physics 87:4, pages 785-794.
Crossref
N J Curtin. (2013) Inhibiting the DNA damage response as a therapeutic manoeuvre in cancer. British Journal of Pharmacology 169:8, pages 1745-1765.
Crossref
Ting Zhou, Paul Hasty, Christi A. Walter, Alexander J.R. Bishop, Linda M. Scott & Vivienne I. Rebel. (2013) Myelodysplastic syndrome: An inability to appropriately respond to damaged DNA?. Experimental Hematology 41:8, pages 665-674.
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F. Javier Molina-Estevez, M. Luz Lozano, Susana Navarro, Yaima Torres, Ivana Grabundzija, Zoltan Ivics, Enrique Samper, Juan A. Bueren & Guillermo Guenechea. (2013) Brief Report: Impaired Cell Reprogramming in Nonhomologous End Joining Deficient Cells. Stem Cells 31:8, pages 1726-1730.
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ULRIKE FISCHER, STEFANIE RHEINHEIMER, ANDREA KREMPLER, MARKUS LÖBRICH & ECKART MEESE. (2013) Glioma-amplified sequence KUB3 influences double-strand break repair after ionizing radiation. International Journal of Oncology 43:1, pages 50-56.
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Chen Wang & Susan P. Lees-Miller. (2013) Detection and Repair of Ionizing Radiation-Induced DNA Double Strand Breaks: New Developments in Nonhomologous End Joining. International Journal of Radiation Oncology*Biology*Physics 86:3, pages 440-449.
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Hongpeng He, Mei-Chin Lee, Li-Ling Zheng, Lei ZhengYan Luo. (2013) Integration of the metabolic/redox state, histone gene switching, DNA replication and S-phase progression by moonlighting metabolic enzymes. Bioscience Reports 33:2.
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Anthony J. Davis, Kyung-Jong Lee & David J. Chen. (2013) The N-terminal Region of the DNA-dependent Protein Kinase Catalytic Subunit Is Required for Its DNA Double-stranded Break-mediated Activation. Journal of Biological Chemistry 288:10, pages 7037-7046.
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Nicola J. Curtin. (2012) DNA repair dysregulation from cancer driver to therapeutic target. Nature Reviews Cancer 12:12, pages 801-817.
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E. Aaron Runkle, Hongtao Zhang, Zheng Cai, Zhiqiang Zhu, Barry L. Karger, Shiaw-Lin Wu, Donald M. O'Rourke, Zhaocai Zhou, Qiang Wang & Mark I. Greene. (2012) Reversion of the ErbB malignant phenotype and the DNA damage response. Experimental and Molecular Pathology 93:3, pages 324-333.
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Shruti Malu, Vidyasagar Malshetty, Dailia Francis & Patricia Cortes. (2012) Role of non-homologous end joining in V(D)J recombination. Immunologic Research 54:1-3, pages 233-246.
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Michael Story, Liang-hao Ding, William A. Brock, K. Kian Ang, Ghazi Alsbeih, John Minna, Seongmi Park & Amit Das. (2012) Defining Molecular and Cellular Responses after Low and High Linear Energy Transfer Radiations to Develop Biomarkers of Carcinogenic Risk or Therapeutic Outcome. Health Physics 103:5, pages 596-606.
Crossref
Petra Groth, Manuel Luís Orta, Ingegerd Elvers, Muntasir Mamun Majumder, Anne Lagerqvist & Thomas Helleday. (2012) Homologous recombination repairs secondary replication induced DNA double-strand breaks after ionizing radiation. Nucleic Acids Research 40:14, pages 6585-6594.
Crossref
Chi-Hui Tang, Wei Wei & Limin Liu. (2012) Regulation of DNA repair by S-nitrosylation. Biochimica et Biophysica Acta (BBA) - General Subjects 1820:6, pages 730-735.
Crossref
K. Meek, S. P. Lees-Miller & M. Modesti. (2011) N-terminal constraint activates the catalytic subunit of the DNA-dependent protein kinase in the absence of DNA or Ku. Nucleic Acids Research 40:7, pages 2964-2973.
Crossref
Tibor Pankotai, Céline Bonhomme, David Chen & Evi Soutoglou. (2012) DNAPKcs-dependent arrest of RNA polymerase II transcription in the presence of DNA breaks. Nature Structural & Molecular Biology 19:3, pages 276-282.
Crossref
Bipasha Mukherjee, Nozomi Tomimatsu, Kaushik Amancherla, Cristel V. Camacho, Nandini Pichamoorthy & Sandeep Burma. (2012) The Dual PI3K/mTOR Inhibitor NVP-BEZ235 Is a Potent Inhibitor of ATM- and DNA-PKCs-Mediated DNA Damage Responses. Neoplasia 14:1, pages 34-IN8.
Crossref
Kate M. Clapham, Tommy Rennison, Gavin Jones, Faye Craven, Julia Bardos, Bernard T. Golding, Roger J. Griffin, Karen Haggerty, Ian R. Hardcastle, Pia Thommes, Attilla Ting & Céline Cano. (2012) Potent enantioselective inhibition of DNA-dependent protein kinase (DNA-PK) by atropisomeric chromenone derivatives. Organic & Biomolecular Chemistry 10:33, pages 6747.
Crossref
Cristian Boboila, Frederick W. Alt & Bjoern Schwer. 2012. Advances in Immunology Volume 116. Advances in Immunology Volume 116 1 49 .
Michael Weinfeld & Susan P. Lees-Miller. 2012. DNA Repair in Cancer Therapy. DNA Repair in Cancer Therapy 161 189 .
Angela E. Zolner, Ismail Abdou, Ruiqiong Ye, Rajam S. Mani, Mesfin Fanta, Yaping Yu, Pauline Douglas, Nasser Tahbaz, Shujuan Fang, Tracey Dobbs, Chen Wang, Nick Morrice, Michael J. Hendzel, Michael Weinfeld & Susan P. Lees-Miller. (2011) Phosphorylation of polynucleotide kinase/ phosphatase by DNA-dependent protein kinase and ataxia-telangiectasia mutated regulates its association with sites of DNA damage. Nucleic Acids Research 39:21, pages 9224-9237.
Crossref
Katherine S PawelczakSara M BennettJohn J Turchi. (2011) Coordination of DNA–PK Activation and Nuclease Processing of DNA Termini in NHEJ. Antioxidants & Redox Signaling 14:12, pages 2531-2543.
Crossref
Jessica A. Neal & Katheryn Meek. (2011) Choosing the right path: Does DNA-PK help make the decision?. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 711:1-2, pages 73-86.
Crossref
Kyung-Jong Lee, Yu-Fen Lin, Han-Yi Chou, Hirohiko Yajima, Kazi R. Fattah, Sheng-Chung Lee & Benjamin P.C. Chen. (2011) Involvement of DNA-dependent Protein Kinase in Normal Cell Cycle Progression through Mitosis. Journal of Biological Chemistry 286:14, pages 12796-12802.
Crossref
Takashi HisatomiNaoko Sueoka-AraganeAkemi SatoRika TomimasuMasaru IdeAkihiro KurimasaKazuya Okamoto, Shinya KimuraEisaburo Sueoka. (2011) NK314 potentiates antitumor activity with adult T-cell leukemia-lymphoma cells by inhibition of dual targets on topoisomerase IIα and DNA-dependent protein kinase. Blood 117:13, pages 3575-3584.
Crossref
Kate M. Clapham, Julia Bardos, M. Raymond V. Finlay, Bernard T. Golding, Edward J. Griffen, Roger J. Griffin, Ian R. Hardcastle, Keith A. Menear, Attilla Ting, Paul Turner, Gail L. Young & Céline Cano. (2011) DNA-dependent protein kinase (DNA-PK) inhibitors: Structure–activity relationships for O-alkoxyphenylchromen-4-one probes of the ATP-binding domain. Bioorganic & Medicinal Chemistry Letters 21:3, pages 966-970.
Crossref
Bennie B. L. G. Lemmens & Marcel Tijsterman. (2010) DNA double-strand break repair in Caenorhabditis elegans. Chromosoma 120:1, pages 1-21.
Crossref
Hatsumi Nagasawa, John B. Little, Yu-Fen Lin, Sairei So, Akihiro Kurimasa, Yuanlin Peng, John R. Brogan, David J. Chen, Joel S. Bedford & Benjamin P. C. Chen. (2011) Differential Role of DNA-PKcs Phosphorylations and Kinase Activity in Radiosensitivity and Chromosomal Instability. Radiation Research 175:1, pages 83-89.
Crossref
Céline Cano, Olivier R. Barbeau, Christine Bailey, Xiao-Ling Cockcroft, Nicola J. Curtin, Heather Duggan, Mark Frigerio, Bernard T. Golding, Ian R. Hardcastle, Marc G. Hummersone, Charlotte Knights, Keith A. Menear, David R. Newell, Caroline J. Richardson, Graeme C. M. Smith, Ben Spittle & Roger J. Griffin. (2010) DNA-Dependent Protein Kinase (DNA-PK) Inhibitors. Synthesis and Biological Activity of Quinolin-4-one and Pyridopyrimidin-4-one Surrogates for the Chromen-4-one Chemotype. Journal of Medicinal Chemistry 53:24, pages 8498-8507.
Crossref
Tracey A. Dobbs, John A. Tainer & Susan P. Lees-Miller. (2010) A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation. DNA Repair 9:12, pages 1307-1314.
Crossref
Bipasha Mukherjee, Hak Choy, Chaitanya Nirodi & Sandeep Burma. (2010) Targeting Nonhomologous End-Joining Through Epidermal Growth Factor Receptor Inhibition: Rationale and Strategies for Radiosensitization. Seminars in Radiation Oncology 20:4, pages 250-257.
Crossref
Resham Lal Gurung, Shi Ni Lim, Aik Kia Khaw, Jasmine Fen Fen Soon, Kirthan Shenoy, Safiyya Mohamed Ali, Manikandan Jayapal, Swaminathan Sethu, Rajamanickam Baskar & M. Prakash Hande. (2010) Thymoquinone Induces Telomere Shortening, DNA Damage and Apoptosis in Human Glioblastoma Cells. PLoS ONE 5:8, pages e12124.
Crossref
Sumati RajagopalanMark W. MoyleIrma JoostenEric O. Long. (2010) DNA-PKcs Controls an Endosomal Signaling Pathway for a Proinflammatory Response by Natural Killer Cells. Science Signaling 3:110.
Crossref
Cynthia L. Hendrickson, Shubhadeep Purkayastha, Elzbieta Pastwa, Ronald D. Neumann & Thomas A. Winters. (2010) Coincident In Vitro Analysis of DNA-PK-Dependent and -Independent Nonhomologous End Joining . Journal of Nucleic Acids 2010, pages 1-11.
Crossref
Céline Cano, Bernard T. Golding, Karen Haggerty, Ian R. Hardcastle, Marcus Peacock & Roger J. Griffin. (2010) Atropisomeric 8-arylchromen-4-ones exhibit enantioselective inhibition of the DNA-dependent protein kinase (DNA-PK). Organic & Biomolecular Chemistry 8:8, pages 1922.
Crossref
Graeme C.M. Smith & Stephen P. Jackson. 2010. Handbook of Cell Signaling. Handbook of Cell Signaling 575 580 .
Miho Noguchi, Ryoichi Hirayama, Sergey Druzhinin & Ryuichi Okayasu. (2009) Enhanced radiation-induced cell killing by Herbimycin A pre-treatment. Radiation Physics and Chemistry 78:12, pages 1184-1187.
Crossref
Elsa Callén, Mila Jankovic, Nancy Wong, Shan Zha, Hua-Tang Chen, Simone Difilippantonio, Michela Di Virgilio, Gordon Heidkamp, Frederick W. Alt, André Nussenzweig & Michel Nussenzweig. (2009) Essential Role for DNA-PKcs in DNA Double-Strand Break Repair and Apoptosis in ATM-Deficient Lymphocytes. Molecular Cell 34:3, pages 285-297.
Crossref
Brandi L. Mahaney, Katheryn MeekSusan P. Lees-Miller. (2009) Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining. Biochemical Journal 417:3, pages 639-650.
Crossref
Laura M. Williamson, Chris T. Williamson & Susan P. Lees-Miller. 2009. The DNA Damage Response: Implications on Cancer Formation and Treatment. The DNA Damage Response: Implications on Cancer Formation and Treatment 157 177 .
Haiyang Li, Adayabalam S. Balajee, Tao Su, Bo Cen, Tom K. Hei & I. Bernard Weinstein. (2008) The HINT1 tumor suppressor regulates both γ-H2AX and ATM in response to DNA damage. The Journal of Cell Biology 183:2, pages 253-265.
Crossref
Javier F. Torres-RocaCraig W. Stevens. (2008) Predicting Response to Clinical Radiotherapy: Past, Present, and Future Directions. Cancer Control 15:2, pages 151-156.
Crossref
Ken‐ichi Yano, Keiko Morotomi‐Yano, Shih‐Ya Wang, Naoya Uematsu, Kyung‐Jong Lee, Aroumougame Asaithamby, Eric Weterings & David J Chen. (2007) Ku recruits XLF to DNA double‐strand breaks. EMBO reports 9:1, pages 91-96.
Crossref
Eric Weterings & David J Chen. (2008) The endless tale of non-homologous end-joining. Cell Research 18:1, pages 114-124.
Crossref
Meena Shrivastav, Leyma P De Haro & Jac A Nickoloff. (2007) Regulation of DNA double-strand break repair pathway choice. Cell Research 18:1, pages 134-147.
Crossref
Katheryn Meek, Van Dang & Susan P. Lees-Miller. 2008. 33 58 .
Sarah A. Maas, Lura Brianna Caddle & Kevin D. Mills. 2008. Mouse Models of Human Blood Cancers. Mouse Models of Human Blood Cancers 81 120 .
D C van Gent & M van der Burg. (2007) Non-homologous end-joining, a sticky affair. Oncogene 26:56, pages 7731-7740.
Crossref
Eric Weterings & David J. Chen. (2007) DNA-dependent protein kinase in nonhomologous end joining: a lock with multiple keys?. Journal of Cell Biology 179:2, pages 183-186.
Crossref
Satoko Iwahori, Noriko Shirata, Yasushi Kawaguchi, Sandra K. Weller, Yoshitaka Sato, Ayumi Kudoh, Sanae Nakayama, Hiroki Isomura & Tatsuya Tsurumi. (2007) Enhanced Phosphorylation of Transcription Factor Sp1 in Response to Herpes Simplex Virus Type 1 Infection Is Dependent on the Ataxia Telangiectasia-Mutated Protein. Journal of Virology 81:18, pages 9653-9664.
Crossref
Elisabeth Kodym, Reinhard Kodym, Benjamin P. Chen, David J. Chen, Keiko Morotomi-Yano, Hak Choy & Debabrata Saha. (2007) DNA-PKcs–Dependent Modulation of Cellular Radiosensitivity by a Selective Cyclooxygenase-2 Inhibitor. International Journal of Radiation Oncology*Biology*Physics 69:1, pages 187-193.
Crossref
Dong-Sik Ju, Mi-Ju Kim, Jae-Ho Bae, Hye-Soon Song, Byung-Seon Chung, Min-Ki Lee, Chi-Dug Kang, Hyun-Sun Lee, Dong-Wan Kim & Sun-Hee Kim. (2007) Camptothecin acts synergistically with imatinib and overcomes imatinib resistance through Bcr-Abl independence in human K562 cells. Cancer Letters 252:1, pages 75-85.
Crossref
Silvia Costantini, Lisa Woodbine, Lucia Andreoli, Penny A. Jeggo & Alessandro Vindigni. (2007) Interaction of the Ku heterodimer with the DNA ligase IV/Xrcc4 complex and its regulation by DNA-PK. DNA Repair 6:6, pages 712-722.
Crossref
Naoya Uematsu, Eric Weterings, Ken-ichi Yano, Keiko Morotomi-Yano, Burkhard Jakob, Gisela Taucher-Scholz, Pierre-Olivier Mari, Dik C. van Gent, Benjamin P.C. Chen & David J. Chen. (2007) Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks. The Journal of Cell Biology 177:2, pages 219-229.
Crossref
Joe Budman, Sunny A. Kim & Gilbert Chu. (2007) Processing of DNA for Nonhomologous End-joining Is Controlled by Kinase Activity and XRCC4/Ligase IV. Journal of Biological Chemistry 282:16, pages 11950-11959.
Crossref
Jonathan J. Hollick, Laurent J. M. Rigoreau, Celine Cano-Soumillac, Xiaoling Cockcroft, Nicola J. Curtin, Mark Frigerio, Bernard T. Golding, Sophie Guiard, Ian R. Hardcastle, Ian Hickson, Marc G. Hummersone, Keith A. Menear, Niall M. B. Martin, Ian Matthews, David R. Newell, Rachel Ord, Caroline J. Richardson, Graeme C. M. Smith & Roger J. Griffin. (2007) Pyranone, Thiopyranone, and Pyridone Inhibitors of Phosphatidylinositol 3-Kinase Related Kinases. Structure−Activity Relationships for DNA-Dependent Protein Kinase Inhibition, and Identification of the First Potent and Selective Inhibitor of the Ataxia Telangiectasia Mutated Kinase. Journal of Medicinal Chemistry 50:8, pages 1958-1972.
Crossref
Benjamin P.C. Chen, Naoya Uematsu, Junya Kobayashi, Yaniv Lerenthal, Andrea Krempler, Hirohiko Yajima, Markus Löbrich, Yosef Shiloh & David J. Chen. (2007) Ataxia Telangiectasia Mutated (ATM) Is Essential for DNA-PKcs Phosphorylations at the Thr-2609 Cluster upon DNA Double Strand Break. Journal of Biological Chemistry 282:9, pages 6582-6587.
Crossref
Kerstin Kiefer, Jennifer Oshinsky, Jiyoon Kim, Pamela B. Nakajima, Gayle C. Bosma & Melvin J. Bosma. (2007) The catalytic subunit of DNA–protein kinase (DNA-PKcs) is not required for Ig class-switch recombination. Proceedings of the National Academy of Sciences 104:8, pages 2843-2848.
Crossref
Longhou Fang, YiGuo Wang, Dan Du, Guang Yang, Tim Tak Kwok, Siu Kai Kong, Benjamin Chen, David J Chen & Zhengjun Chen. (2007) Cell polarity protein Par3 complexes with DNA-PK via Ku70 and regulates DNA double-strand break repair. Cell Research 17:2, pages 100-116.
Crossref
Andrea Krempler & Markus Löbrich. 2007. Genome Integrity. Genome Integrity 399 421 .
B. Salles, P. Calsou, P. Frit & C. Muller. (2006) The DNA repair complex DNA-PK, a pharmacological target in cancer chemotherapy and radiotherapy. Pathologie Biologie 54:4, pages 185-193.
Crossref
Bipasha Mukherjee, Chase Kessinger, Junya Kobayashi, Benjamin P.C. Chen, David J. Chen, Aloke Chatterjee & Sandeep Burma. (2006) DNA-PK phosphorylates histone H2AX during apoptotic DNA fragmentation in mammalian cells. DNA Repair 5:5, pages 575-590.
Crossref
Yang Xu. (2006) DNA damage: a trigger of innate immunity but a requirement for adaptive immune homeostasis. Nature Reviews Immunology 6:4, pages 261-270.
Crossref
Errol C. Friedberg, Graham C. Walker, Wolfram Siede, Richard D. Wood, Roger A. Schultz & Tom Ellenberger. 2005. DNA Repair and Mutagenesis. DNA Repair and Mutagenesis 711 750 .
Eric Hendrickson, Joy Huffman & John Tainer. 2005. DNA Damage Recognition. DNA Damage Recognition.
Pauline Douglas, Shikha Gupta, Nick Morrice, Katheryn Meek & Susan P. Lees-Miller. (2005) DNA-PK-dependent phosphorylation of Ku70/80 is not required for non-homologous end joining. DNA Repair 4:9, pages 1006-1018.
Crossref
Costas G. Hadjipanayis & Neal A. DeLuca. (2005) Inhibition of DNA Repair by a Herpes Simplex Virus Vector Enhances the Radiosensitivity of Human Glioblastoma Cells. Cancer Research 65:12, pages 5310-5316.
Crossref
Jingxuan Pan, Miaorong She, Zhi-Xiang Xu, Lily Sun & Sai-Ching Jim Yeung. (2005) Farnesyltransferase Inhibitors Induce DNA Damage via Reactive Oxygen Species in Human Cancer Cells. Cancer Research 65:9, pages 3671-3681.
Crossref
Benjamin P.C. Chen, Doug W. Chan, Junya Kobayashi, Sandeep Burma, Aroumougame Asaithamby, Keiko Morotomi-Yano, Elliot Botvinick, Jun Qin & David J. Chen. (2005) Cell Cycle Dependence of DNA-dependent Protein Kinase Phosphorylation in Response to DNA Double Strand Breaks. Journal of Biological Chemistry 280:15, pages 14709-14715.
Crossref
Akihiro Otsuki, Candice G.T. Tahimic, Nozomi Tomimatsu, Motonobu Katoh, David J. Chen, Akihiro Kurimasa & Mitsuo Oshimura. (2005) Construction of a novel expression system on a human artificial chromosome. Biochemical and Biophysical Research Communications 329:3, pages 1018-1025.
Crossref
Jia Li & David F. Stern. (2005) Regulation of CHK2 by DNA-dependent Protein Kinase. Journal of Biological Chemistry 280:12, pages 12041-12050.
Crossref
Spencer J Collis, Theodore L DeWeese, Penelope A Jeggo & Antony R Parker. (2004) The life and death of DNA-PK. Oncogene 24:6, pages 949-961.
Crossref
Erin Convery, Euy Kyun Shin, Qi Ding, Wei Wang, Pauline Douglas, Laurie S. Davis, Jac A. Nickoloff, Susan P. Lees-Miller & Katheryn Meek. (2005) Inhibition of homologous recombination by variants of the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs). Proceedings of the National Academy of Sciences 102:5, pages 1345-1350.
Crossref
Roger J. GriffinGabriele FontanaBernard T. GoldingSophie GuiardIan R. HardcastleJustin J. J. LeahyNiall MartinCaroline RichardsonLaurent RigoreauMartin StockleyGraeme C. M. Smith. (2004) Selective Benzopyranone and Pyrimido[2,1- a ]isoquinolin-4-one Inhibitors of DNA-Dependent Protein Kinase:  Synthesis, Structure−Activity Studies, and Radiosensitization of a Human Tumor Cell Line in Vitro . Journal of Medicinal Chemistry 48:2, pages 569-585.
Crossref
Penny A. Jeggo. 2005. Genome Instability in Cancer Development. Genome Instability in Cancer Development 175 197 .
Justin J.J. Leahy, Bernard T. Golding, Roger J. Griffin, Ian R. Hardcastle, Caroline Richardson, Laurent Rigoreau & Graeme C.M. Smith. (2004) Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries. Bioorganic & Medicinal Chemistry Letters 14:24, pages 6083-6087.
Crossref
Eric Weterings & Dik C. van Gent. (2004) The mechanism of non-homologous end-joining: a synopsis of synapsis. DNA Repair 3:11, pages 1425-1435.
Crossref
Catherine Poinsignon, Regina de Chasseval, Sebastien Soubeyrand, Despina Moshous, Alain Fischer, Robert J. G. Haché & Jean-Pierre de Villartay. (2004) Phosphorylation of Artemis following irradiation-induced DNA damage. European Journal of Immunology 34:11, pages 3146-3155.
Crossref
Takashi Nishikawa, Anupama Munshi, Michael D Story, Sheikh Ismail, Craig Stevens, Sunil Chada & Raymond E Meyn. (2004) Adenoviral-mediated mda-7 expression suppresses DNA repair capacity and radiosensitizes non-small-cell lung cancer cells. Oncogene 23:42, pages 7125-7131.
Crossref
Armine Darbinyan, Khwaja M. Siddiqui, Dorota Slonina, Nune Darbinian, Shohreh Amini, Martyn K. White & Kamel Khalili. (2004) Role of JC Virus Agnoprotein in DNA Repair. Journal of Virology 78:16, pages 8593-8600.
Crossref
Sean Rooney, Jayanta Chaudhuri & Frederick W. Alt. (2004) The role of the non-homologous end-joining pathway in lymphocyte development. Immunological Reviews 200:1, pages 115-131.
Crossref
Katheryn Meek, Shikha Gupta, Dale A. Ramsden & Susan P. Lees-Miller. (2004) The DNA-dependent protein kinase: the director at the end. Immunological Reviews 200:1, pages 132-141.
Crossref
Maki Okada, Shiori Saito & Ryuichi Okayasu. (2004) Facilitated detection of chromosome break and repair at low levels of ionizing radiation by addition of wortmannin to G1-type PCC fusion incubation. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 562:1-2, pages 11-17.
Crossref
Sandeep Burma & David J. Chen. (2004) Role of DNA–PK in the cellular response to DNA double-strand breaks. DNA Repair 3:8-9, pages 909-918.
Crossref
Ziming Zhang, Weidong Hu, Leticia Cano, Terry D Lee, David J Chen & Yuan Chen. (2004) Solution Structure of the C-Terminal Domain of Ku80 Suggests Important Sites for Protein-Protein Interactions. Structure 12:3, pages 495-502.
Crossref
Sheikh M. Ismail, Monica Puppi, Sheela Prithivirajsingh, Anupama Munshi, Uma Raju, Raymond E. Meyn, Thomas A. Buchholz, Michael D. Story, William A. Brock, Luka Milas, Howard D. Thames & Craig W. Stevens. (2004) Predicting Radiosensitivity Using DNA End-Binding Complex Analysis. Clinical Cancer Research 10:4, pages 1226-1234.
Crossref
Thomas Wechsler, Benjamin P. C. Chen, Ryan Harper, Keiko Morotomi-Yano, Betty C. B. Huang, Katheryn Meek, James E. Cleaver, David J. Chen & Matthias Wabl. (2004) DNA–PKcs function regulated specifically by protein phosphatase 5. Proceedings of the National Academy of Sciences 101:5, pages 1247-1252.
Crossref
Martin Kühne, Enriqueta Riballo, Nicole Rief, Kai Rothkamm, Penny A. Jeggo & Markus Löbrich. (2004) A Double-Strand Break Repair Defect in ATM-Deficient Cells Contributes to Radiosensitivity. Cancer Research 64:2, pages 500-508.
Crossref
Ana Sandoval & Paul Labhart. (2004) High G/C content of cohesive overhangs renders DNA end joining Ku-independent. DNA Repair 3:1, pages 13-21.
Crossref
Kai Rothkamm. 2004. Life Sciences and Radiation. Life Sciences and Radiation 179 186 .
Yaping Yu, Wei Wang, Qi Ding, Ruiqiong Ye, Dawn Chen, Dennis Merkle, David Schriemer, Katheryn Meek & Susan P Lees-Miller. (2003) DNA-PK phosphorylation sites in XRCC4 are not required for survival after radiation or for V(D)J recombination. DNA Repair 2:11, pages 1239-1252.
Crossref
I. B. Nazarov, A. N. Smirnova, R. I. Krutilina, M. P. Svetlova, L. V. Solovjeva, A. A. Nikiforov, S-L. Oei, I. A. Zalenskaya, P. M. Yau, E. M. Bradbury & N. V. Tomilin. (2003) Dephosphorylation of Histone γ-H2AX during Repair of DNA Double-Strand Breaks in Mammalian Cells and its Inhibition by Calyculin A. Radiation Research 160:3, pages 309-317.
Crossref
Susanne Mårtensson, Jonas Nygren, Neil Osheroff & Ola Hammarsten. (2003) Activation of the DNA-Dependent Protein Kinase by Drug-Induced and Radiation-Induced DNA Strand Breaks. Radiation Research 160:3, pages 291-301.
Crossref
Elzbieta Pastwa, Erin M Lubner, Katherina Mezhevaya, Ronald D Neumann & Thomas A Winters. (2003) DNA uptake and repair enzyme access to transfected DNA is under reported by gene expression. Biochemical and Biophysical Research Communications 306:2, pages 421-429.
Crossref
Patrick Calsou, Christine Delteil, Philippe Frit, Jérôme Drouet & Bernard Salles. (2003) Coordinated Assembly of Ku and p460 Subunits of the DNA-dependent Protein Kinase on DNA Ends is Necessary for XRCC4–ligase IV Recruitment. Journal of Molecular Biology 326:1, pages 93-103.
Crossref
George Martin, Fuki Hisama & Sherman WeissmanDavid Chen & David Gilley. 2003. Chromosomal Instability and Aging. Chromosomal Instability and Aging.
Jane M. Bradbury & Stephen P. Jackson. 2003. Handbook of Cell Signaling. Handbook of Cell Signaling 219 224 .
Graeme C.M. Smith & Stephen P. Jackson. 2003. Handbook of Cell Signaling. Handbook of Cell Signaling 557 561 .
Chung-Hui Kim, Su-Jung Park & Suk-Hee Lee. (2002) A Targeted Inhibition of DNA-Dependent Protein Kinase Sensitizes Breast Cancer Cells Following Ionizing Radiation. Journal of Pharmacology and Experimental Therapeutics 303:2, pages 753-759.
Crossref
Isabelle Ader, Catherine Muller, Jacques Bonnet, Gilles Favre, Elizabeth Cohen-Jonathan, Bernard Salles & Christine Toulas. (2002) The radioprotective effect of the 24 kDa FGF-2 isoform in HeLa cells is related to an increased expression and activity of the DNA dependent protein kinase (DNA-PK) catalytic subunit. Oncogene 21:42, pages 6471-6479.
Crossref
Doug W. Chan, Benjamin Ping-Chi Chen, Sheela Prithivirajsingh, Akihiro Kurimasa, Michael D. Story, Jun Qin & David J. Chen. (2002) Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks. Genes & Development 16:18, pages 2333-2338.
Crossref
Yoshinori Nimura, Sheikh M. Ismail, Akihiro Kurimas, David J. Chen & Craig W. Stevens. (2002) DNA-PK and ATM are Required for Radiation-Enhanced Integration. Radiation Research 157:5, pages 562-567.
Crossref
Parimal Karmakar, Jason Piotrowski, Robert M. BroshJr.Jr., Joshua A. Sommers, Susan P. Lees Miller, Wen-Hsing Cheng, Carey M. Snowden, Dale A. Ramsden & Vilhelm A. Bohr. (2002) Werner Protein Is a Target of DNA-dependent Protein Kinase in Vivo and in Vitro, and Its Catalytic Activities Are Regulated by Phosphorylation. Journal of Biological Chemistry 277:21, pages 18291-18302.
Crossref
Chris Allen, Akihiro Kurimasa, Mark A. Brenneman, David J. Chen & Jac A. Nickoloff. (2002) DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination. Proceedings of the National Academy of Sciences 99:6, pages 3758-3763.
Crossref
Hsin-Ling Hsu, Steven M Yannone & David J Chen. (2002) Defining interactions between DNA-PK and ligase IV/XRCC4. DNA Repair 1:3, pages 225-235.
Crossref
Susanne Mårtensson & Ola Hammarsten. (2002) DNA-dependent Protein Kinase Catalytic Subunit. Journal of Biological Chemistry 277:4, pages 3020-3029.
Crossref
David Gilley, Hiromi Tanaka, M. Prakash Hande, Akihiro Kurimasa, Gloria C. Li, Mitsuo Oshimura & David J. Chen. (2001) DNA-PKcs is critical for telomere capping. Proceedings of the National Academy of Sciences 98:26, pages 15084-15088.
Crossref
Katheryn Meek, Laura Kienker, Clarissa Dallas, Wei Wang, Michael J. Dark, Patrick J. Venta, Maryann L. Huie, Rochelle Hirschhorn & Tom Bell. (2001) SCID in Jack Russell Terriers: A New Animal Model of DNA-PKcs Deficiency. The Journal of Immunology 167:4, pages 2142-2150.
Crossref
Fredrik Bryntesson, Jenny C. Regan, Penny A. Jeggo, Guillermo E. Taccioli & Michael Hubank. (2001) Analysis of Gene Transcription in Cells Lacking DNA-PK Activity. Radiation Research 156:2, pages 167-176.
Crossref
Catherine Muller, Sylvie Monferran, Alexander-Christopher Gamp, Patrick Calsou & Bernard Salles. (2001) Inhibition of Ku heterodimer DNA end binding activity during granulocytic differentiation of human promyelocytic cell lines. Oncogene 20:32, pages 4373-4382.
Crossref
Carl W. Anderson, John J. Dunn, Paul I. Freimuth, Anne M. Galloway & M. Joan Allalunis-Turner. (2001) Frameshift Mutation in PRKDC , the Gene for DNA-PKcs, in the DNA Repair-Defective, Human, Glioma-Derived Cell Line M059J . Radiation Research 156:1, pages 2-9.
Crossref
Jennifer L. Mannino, Wan-Ju Kim, Meredith Wernick, Son V. Nguyen, Ray Braquet, Aaron W. Adamson, Zhining Den, Mark A. Batzer, Colin C. Collins & Kevin D. Brown. (2001) Evidence for alternate splicing within the mRNA transcript encoding the DNA damage response kinase ATR. Gene 272:1-2, pages 35-43.
Crossref
Pauline Douglas, Greg B.G. Moorhead, Ruiqiong Ye & Susan P. Lees-Miller. (2001) Protein Phosphatases Regulate DNA-dependent Protein Kinase Activity. Journal of Biological Chemistry 276:22, pages 18992-18998.
Crossref
Daniel Durocher & Stephen P Jackson. (2001) DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?. Current Opinion in Cell Biology 13:2, pages 225-231.
Crossref
Daiji Endoh, Toyo Okui, Yasuhiro Kon & Masanobu Hayashi. (2001) Hypertonic Treatment Inhibits Radiation-Induced Nuclear Translocation of the Ku Proteins G22p1 (Ku70) and Xrcc5 (Ku80) in Rat Fibroblasts. Radiation Research 155:2, pages 320-327.
Crossref
David G.T. Hesslein & David G. Schatz. 2001. 169 232 .
Philippe Frit, Ruo-Ya Li, Doriane Arzel, Bernard Salles & Patrick Calsou. (2000) Ku Entry into DNA Inhibits Inward DNA Transactions in Vitro. Journal of Biological Chemistry 275:46, pages 35684-35691.
Crossref
Ryutaro Fukumura, Ryoko Araki, Akira Fujimori, Yoko Tsutsumi, Akihiro Kurimasa, Gloria C. Li, David J. Chen, Kouichi Tatsumi & Masumi Abe. (2000) Signal Joint Formation Is Also Impaired in DNA-Dependent Protein Kinase Catalytic Subunit Knockout Cells. The Journal of Immunology 165:7, pages 3883-3889.
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