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Molecular and Cellular Biology Volume 19, 1999 - Issue 6
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Cell Growth and Development

Regulatory Role of the Conserved Stem-Loop Structure at the 5′ End of Collagen α1(I) mRNA

B. StefanovicDepartments of Medicine and Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North CarolinaCorrespondence[email protected]
,
C. HellerbrandDepartments of Medicine and Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
&
D. A. BrennerDepartments of Medicine and Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Pages 4334-4342 | Received 01 Jun 1998, Accepted 17 Mar 1999, Published online: 27 Mar 2023

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Lela Stefanovic, Liam Longo, Yujie Zhang & Branko Stefanovic. (2014) Characterization of binding of LARP6 to the 5’ stem-loop of collagen mRNAs: Implications for synthesis of type I collagen. RNA Biology 11:11, pages 1386-1401.
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Milica Vukmirovic, Zarko Manojlovic & Branko Stefanovic. (2013) Serine-Threonine Kinase Receptor-Associated Protein (STRAP) Regulates Translation of Type I Collagen mRNAs. Molecular and Cellular Biology 33:19, pages 3893-3906.
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Azariyas A. Challa & Branko Stefanovic. (2011) A Novel Role of Vimentin Filaments: Binding and Stabilization of Collagen mRNAs. Molecular and Cellular Biology 31:18, pages 3773-3789.
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Le Cai, Dillon Fritz, Lela Stefanovic & Branko Stefanovic. (2009) Coming together: liver fibrosis, collagen mRNAs and the RNA binding protein. Expert Review of Gastroenterology & Hepatology 3:1, pages 1-3.
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Branko Stefanovic, Lela Stefanovic, Bernd Schnabl, Ramon Bataller & David A. Brenner. (2004) TRAM2 Protein Interacts with Endoplasmic Reticulum Ca2+ Pump Serca2b and Is Necessary for Collagen Type I Synthesis. Molecular and Cellular Biology 24:4, pages 1758-1768.
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Fulton T. Crews. (2001) Summary Report of a Symposium: Genes and Gene Delivery for Diseases of Alcoholism. Alcoholism: Clinical and Experimental Research 25:12, pages 1778-1800.
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