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Transcriptional Regulation

Transcriptional Cofactor CA150 Regulates RNA Polymerase II Elongation in a TATA-Box-Dependent Manner

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Pages 4719-4728 | Received 05 Mar 1999, Accepted 09 Apr 1999, Published online: 28 Mar 2023

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Marta Montes, Alexandre Cloutier, Noemí Sánchez-Hernández, Laetitia Michelle, Bruno Lemieux, Marco Blanchette, Cristina Hernández-Munain, Benoit Chabot & Carlos Suñé. (2012) TCERG1 Regulates Alternative Splicing of the Bcl-x Gene by Modulating the Rate of RNA Polymerase II Transcription. Molecular and Cellular Biology 32:4, pages 751-762.
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Miguel Sánchez-Álvarez, Aaron C. Goldstrohm, Mariano A. Garcia-Blanco & Carlos Suñé. (2006) Human Transcription Elongation Factor CA150 Localizes to Splicing Factor-Rich Nuclear Speckles and Assembles Transcription and Splicing Components into Complexes through Its Amino and Carboxyl Regions. Molecular and Cellular Biology 26:13, pages 4998-5014.
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Matthew J. Smith, Sarang Kulkarni & Tony Pawson. (2004) FF Domains of CA150 Bind Transcription and Splicing Factors through Multiple Weak Interactions. Molecular and Cellular Biology 24:21, pages 9274-9285.
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Kai-Ti Lin, Ruei-Min Lu & Woan-Yuh Tarn. (2004) The WW Domain-Containing Proteins Interact with the Early Spliceosome and Participate in Pre-mRNA Splicing In Vivo. Molecular and Cellular Biology 24:20, pages 9176-9185.
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Aaron C. Goldstrohm, Todd R. Albrecht, Carles Suñé, Mark T. Bedford & Mariano A. Garcia-Blanco. (2001) The Transcription Elongation Factor CA150 Interacts with RNA Polymerase II and the Pre-mRNA Splicing Factor SF1. Molecular and Cellular Biology 21:22, pages 7617-7628.
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Articles from other publishers (43)

Carlos Esteban Hernando, Mariano García Hourquet, María José de Leone, Daniel Careno, Javier Iserte, Santiago Mora Garcia & Marcelo Javier Yanovsky. (2019) A Role for Pre-mRNA-PROCESSING PROTEIN 40C in the Control of Growth, Development, and Stress Tolerance in Arabidopsis thaliana. Frontiers in Plant Science 10.
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Magdalena M Maslon, Ulrich Braunschweig, Stuart Aitken, Abigail R Mann, Fiona Kilanowski, Chris J Hunter, Benjamin J Blencowe, Alberto R Kornblihtt, Ian R Adams & Javier F Cáceres. (2019) A slow transcription rate causes embryonic lethality and perturbs kinetic coupling of neuronal genes. The EMBO Journal 38:9.
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Cristina Moreno-Castro, Silvia Prieto-Sánchez, Noemí Sánchez-Hernández, Cristina Hernández-Munain & Carlos Suñé. (2019) Role for the splicing factor TCERG1 in Cajal body integrity and snRNP assembly. Journal of Cell Science.
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Marine Pons, Silvia Prieto, Laetitia Miguel, Thierry Frebourg, Dominique Campion, Carles Suñé & Magalie Lecourtois. (2018) Identification of TCERG1 as a new genetic modulator of TDP-43 production in Drosophila. Acta Neuropathologica Communications 6:1.
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Juan Pablo Muñoz-Cobo, Noemí Sánchez-Hernández, Sara Gutiérrez, Younes El Yousfi, Marta Montes, Carme Gallego, Cristina Hernández-Munain & Carlos Suñé. (2016) Transcriptional Elongation Regulator 1 Affects Transcription and Splicing of Genes Associated with Cellular Morphology and Cytoskeleton Dynamics and Is Required for Neurite Outgrowth in Neuroblastoma Cells and Primary Neuronal Cultures. Molecular Neurobiology 54:10, pages 7808-7823.
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Noemí Sánchez-Hernández, Silvia Prieto-Sánchez, Cristina Moreno-Castro, Juan Pablo Muñoz-Cobo, Younes El Yousfi, Sofía Boyero-Corral, Marc Suñé-Pou, Cristina Hernández-Munain & Carlos Suñé. (2017) Targeting proteins to RNA transcription and processing sites within the nucleus. The International Journal of Biochemistry & Cell Biology 91, pages 194-202.
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Noemí Sánchez-Hernández, Stéphanie Boireau, Ute Schmidt, Juan Pablo Muñoz-Cobo, Cristina Hernández-Munain, Edouard Bertrand & Carlos Suñé. (2016) The in vivo dynamics of TCERG1, a factor that couples transcriptional elongation with splicing. RNA 22:4, pages 571-582.
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Nicholas J. Miller, Kaitlyn Schick, Nikolai Timchenko, Emmett Harrison & William J. Roesler. (2016) The Glutamine-Alanine Repeat Domain of TCERG1 is Required for the Inhibition of the Growth Arrest Activity of C/EBPα. Journal of Cellular Biochemistry 117:3, pages 612-620.
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Marta Montes, Mayte Coiras, Soraya Becerra, Cristina Moreno-Castro, Elena Mateos, Jara Majuelos, F. Javier Oliver, Cristina Hernández-Munain, José Alcamí & Carlos Suñé. (2015) Functional Consequences for Apoptosis by Transcription Elongation Regulator 1 (TCERG1)-Mediated Bcl-x and Fas/CD95 Alternative Splicing. PLOS ONE 10:10, pages e0139812.
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Soraya Becerra, Marta Montes, Cristina Hernández-Munain & Carlos Suñé. (2015) Prp40 pre-mRNA processing factor 40 homolog B (PRPF40B) associates with SF1 and U2AF 65 and modulates alternative pre-mRNA splicing in vivo . RNA 21:3, pages 438-457.
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Chih-chun Janet Lin & Meng Carla Wang. 2015. Stem Cell Aging: Mechanisms, Consequences, Rejuvenation. Stem Cell Aging: Mechanisms, Consequences, Rejuvenation 51 70 .
Mayte Coiras, Marta Montes, Immaculada Montanuy, María Rosa López-Huertas, Elena Mateos, Caroline Le Sommer, Mariano A Garcia-Blanco, Cristina Hernández-Munain, José Alcamí & Carlos Suñé. (2013) Transcription elongation regulator 1 (TCERG1) regulates competent RNA polymerase II-mediated elongation of HIV-1 transcription and facilitates efficient viral replication. Retrovirology 10:1.
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Jeffry L. Corden. (2013) RNA Polymerase II C-Terminal Domain: Tethering Transcription to Transcript and Template. Chemical Reviews 113:11, pages 8423-8455.
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Adam Antebi. (2013) Regulation of longevity by the reproductive system. Experimental Gerontology 48:7, pages 596-602.
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Arjumand Ghazi. (2013) Transcriptional networks that mediate signals from reproductive tissues to influence lifespan. genesis 51:1, pages 1-15.
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Noemí Sánchez-Hernández, Lidia Ruiz, Miguel Sánchez-Álvarez, Marta Montes, Maria J. Macias, Cristina Hernández-Munain & Carlos Suñé. (2012) The FF4 and FF5 Domains of Transcription Elongation Regulator 1 (TCERG1) Target Proteins to the Periphery of Speckles. Journal of Biological Chemistry 287:21, pages 17789-17800.
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Banafsheh Moazed, Shanna L. Banman, Grey A. Wilkinson & William J. Roesler. (2011) TCERG1 inhibits C/EBPα through a mechanism that does not involve sequestration of C/EBPα at pericentromeric heterochromatin. Journal of Cellular Biochemistry 112:9, pages 2317-2326.
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Jie Zhou, Yang Liu, Wei Zhang, Vladimir M. Popov, Min Wang, Nagarajan Pattabiraman, Carlos Suñé, Ales Cvekl, Kongming Wu, Jie Jiang, Chenguang Wang & Richard G. Pestell. (2010) Transcription Elongation Regulator 1 Is a Co-integrator of the Cell Fate Determination Factor Dachshund Homolog 1. Journal of Biological Chemistry 285:51, pages 40342-40350.
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Miguel Sánchez-Álvarez, Marta Montes, Noemí Sánchez-Hernández, Cristina Hernández-Munain & Carlos Suñé. (2010) Differential Effects of Sumoylation on Transcription and Alternative Splicing by Transcription Elongation Regulator 1 (TCERG1). Journal of Biological Chemistry 285:20, pages 15220-15233.
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Joseph A. Jablonski, Antonio L. Amelio, Mauro Giacca & Massimo Caputi. (2010) The transcriptional transactivator Tat selectively regulates viral splicing. Nucleic Acids Research 38:4, pages 1249-1260.
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Shanna L. Banman, Pamela J. McFie, Heather L. Wilson & William J. Roesler. (2010) Nuclear redistribution of TCERG1 is required for its ability to inhibit the transcriptional and anti-proliferative activities of C/EBPα. Journal of Cellular Biochemistry 109:1, pages 140-151.
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James M. Murphy, D. Flemming Hansen, Silke Wiesner, D. Ranjith Muhandiram, Mikael Borg, Matthew J. Smith, Frank Sicheri, Lewis E. Kay, Julie D. Forman-Kay & Tony Pawson. (2009) Structural Studies of FF Domains of the Transcription Factor CA150 Provide Insights into the Organization of FF Domain Tandem Arrays. Journal of Molecular Biology 393:2, pages 409-424.
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Ming Lu, Jun Yang, Zhiyong Ren, Subir Sabui, Alexsandra Espejo, Mark T. Bedford, Raymond H. Jacobson, David Jeruzalmi, John S. McMurray & Xiaomin Chen. (2009) Crystal Structure of the Three Tandem FF Domains of the Transcription Elongation Regulator CA150. Journal of Molecular Biology 393:2, pages 397-408.
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Arjumand Ghazi, Sivan Henis-Korenblit & Cynthia Kenyon. (2009) A Transcription Elongation Factor That Links Signals from the Reproductive System to Lifespan Extension in Caenorhabditis elegans. PLoS Genetics 5:9, pages e1000639.
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James L. Pearson, Timothy J. Robinson, Manuel J. Muñoz, Alberto R. Kornblihtt & Mariano A. Garcia-Blanco. (2008) Identification of the Cellular Targets of the Transcription Factor TCERG1 Reveals a Prevalent Role in mRNA Processing. Journal of Biological Chemistry 283:12, pages 7949-7961.
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Immaculada Montanuy, Rosana Torremocha, Cristina Hernández-Munain & Carlos Suñé. (2008) Promoter Influences Transcription Elongation. Journal of Biological Chemistry 283:12, pages 7368-7378.
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Donghang Cheng, Jocelyn Côté, Salam Shaaban & Mark T. Bedford. (2007) The Arginine Methyltransferase CARM1 Regulates the Coupling of Transcription and mRNA Processing. Molecular Cell 25:1, pages 71-83.
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Ricardo DeMarco, Katia C. Oliveira, Thiago M. Venancio & Sergio Verjovski-Almeida. (2006) Gender biased differential alternative splicing patterns of the transcriptional cofactor CA150 gene in Schistosoma mansoni. Molecular and Biochemical Parasitology 150:2, pages 123-131.
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Nancy E. Ward, Neal R. Pellis, Semyon A. Risin & Diana Risin. (2006) Gene expression alterations in activated human T-cells induced by modeled microgravity. Journal of Cellular Biochemistry 99:4, pages 1187-1202.
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Pamela J. McFie, Guo-Li Wang, Nicholai A. Timchenko, Heather L. Wilson, Xiaobin Hu & William J. Roesler. (2006) Identification of a Co-repressor That Inhibits the Transcriptional and Growth-Arrest Activities of CCAAT/Enhancer-binding Protein α. Journal of Biological Chemistry 281:26, pages 18069-18080.
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Margarita Arango, Sébastien Holbert, Dania Zala, Emmanuel Brouillet, James Pearson, Etienne Régulier, Ashwani Kumar Thakur, Patrick Aebischer, Ronald Wetzel, Nicole Déglon & Christian Néri. (2006) CA150 Expression Delays Striatal Cell Death in Overexpression and Knock-In Conditions for Mutant Huntingtin Neurotoxicity. The Journal of Neuroscience 26:17, pages 4649-4659.
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Xin Sun, Jian Zhao, Karin Kylberg, Teresa Soop, Kevin Palka, Erik Sonnhammer, Neus Visa, Alla T. Alzhanova-Ericsson & Bertil Daneholt. (2004) Conspicuous accumulation of transcription elongation repressor hrp130/CA150 on the intron-rich Balbiani ring 3 gene. Chromosoma 113:5, pages 244-257.
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Nicole D. Robson-Dixon & Mariano A. Garcia-Blanco. (2004) MAZ Elements Alter Transcription Elongation and Silencing of the Fibroblast Growth Factor Receptor 2 Exon IIIb. Journal of Biological Chemistry 279:28, pages 29075-29084.
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Lars H. Lund, Britta Wahren & Mariano A. Garcia-Blanco. (2003) A functional genetic approach suggests a novel interaction between the human immunodeficiency virus type 1 (HIV-1) Tat protein and HIV-1 TAR RNA in vivo. Journal of General Virology 84:3, pages 603-606.
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Ruisheng Yao, Yian Wang, Ronald A. Lubet & Ming You. (2003) Differential Gene Expression in Chemically Induced Mouse Lung Adenomas. Neoplasia 5:1, pages 41-52.
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Sherry M. Carty & Arno L. Greenleaf. (2002) Hyperphosphorylated C-terminal Repeat Domain-associating Proteins in the Nuclear Proteome Link Transcription to DNA/Chromatin Modification and RNA Processing. Molecular & Cellular Proteomics 1:8, pages 598-610.
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Stefan Hermann, Kurt D. Berndt & Anthony P. Wright. (2001) How Transcriptional Activators Bind Target Proteins. Journal of Biological Chemistry 276:43, pages 40127-40132.
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Aaron C Goldstrohm, Arno L Greenleaf & Mariano A Garcia-Blanco. (2001) Co-transcriptional splicing of pre-messenger RNAs: considerations for the mechanism of alternative splicing. Gene 277:1-2, pages 31-47.
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Sébastien HolbertIsabelle DenghienTamara KiechleAdam RosenblattCheryll WellingtonMichael R. HaydenRussell L. MargolisChristopher A. RossJean DaussetRobert J. FerranteChristian Néri. (2001) The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: Neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis. Proceedings of the National Academy of Sciences 98:4, pages 1811-1816.
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Carlos Suñé, Aaron C. Goldstrohm, Junmin Peng, David H. Price & Mariano A. Garcia-Blanco. (2000) An In Vitro Transcription System that Recapitulates Equine Infectious Anemia Virus Tat-Mediated Inhibition of Human Immunodeficiency Virus Type 1 Tat Activity Demonstrates a Role for Positive Transcription Elongation Factor b and Associated Proteins in the Mechanism of Tat Activation. Virology 274:2, pages 356-366.
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Sherry M. Carty, Aaron C. Goldstrohm, Carles Suñé, Mariano A. Garcia-Blanco & Arno L. Greenleaf. (2000) Protein-interaction modules that organize nuclear function: FF domains of CA150 bind the phosphoCTD of RNA polymerase II. Proceedings of the National Academy of Sciences 97:16, pages 9015-9020.
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Joan W Conaway, Ali Shilatifard, Arik Dvir & Ronald C Conaway. (2000) Control of elongation by RNA polymerase II. Trends in Biochemical Sciences 25:8, pages 375-380.
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Todd R. Albrecht, Lars H. Lund & Mariano A. Garcia-Blanco. (2000) Canine Cyclin T1 Rescues Equine Infectious Anemia Virus Tat Trans-Activation in Human Cells. Virology 268:1, pages 7-11.
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