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Cell Growth and Development

Mechanism of Protein Kinase B Activation by Cyclic AMP-Dependent Protein Kinase

Nathalie Filippa1 Institut National de la Santé et de la Recherche Médicale Faculté de Médecine, 06107Nice Cedex 2, France
,
Carol L. Sable1 Institut National de la Santé et de la Recherche Médicale Faculté de Médecine, 06107Nice Cedex 2, France
,
Chantal Filloux1 Institut National de la Santé et de la Recherche Médicale Faculté de Médecine, 06107Nice Cedex 2, France
,
Brian Hemmings2 Friedrich Miescher Institute, CH 4002Basel, Switzerland
&
Emmanuel Van Obberghen1 Institut National de la Santé et de la Recherche Médicale Faculté de Médecine, 06107Nice Cedex 2, FranceCorrespondence[email protected]
Pages 4989-5000 | Received 06 Nov 1998, Accepted 25 Mar 1999, Published online: 28 Mar 2023

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Maureen O. Ripple, Sahana Kalmadi & Alan Eastman. (2005) Inhibition of Either Phosphatidylinositol 3-kinase/Akt or the Mitogen/Extracellular-regulated Kinase, MEK/ERK, Signaling Pathways Suppress Growth of Breast Cancer Cell Lines, but MEK/ERK Signaling is Critical for Cell Survival. Breast Cancer Research and Treatment 93:2, pages 177-188.
Crossref
Tong Wu. (2005) Cyclooxygenase-2 and prostaglandin signaling in cholangiocarcinoma. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1755:2, pages 135-150.
Crossref
Ana Luisa Kadekaro, Renny Kavanagh, Hiromi Kanto, Silva Terzieva, Jennifer Hauser, Nobuhiko Kobayashi, Sandy Schwemberger, James Cornelius, George Babcock, Howard G. Shertzer, Glynis Scott & Zalfa A. Abdel-Malek. (2005) α-Melanocortin and Endothelin-1 Activate Antiapoptotic Pathways and Reduce DNA Damage in Human Melanocytes. Cancer Research 65:10, pages 4292-4299.
Crossref
Kentaro Machida, Hiromasa Inoue, Koichiro Matsumoto, Miyuki Tsuda, Satoru Fukuyama, Hiroshi Koto, Hisamichi Aizawa, Yasuko Kureishi, Nobuyuki Hara & Yoichi Nakanishi. (2005) Activation of PI3K-Akt pathway mediates antiapoptotic effects of β-adrenergic agonist in airway eosinophils. American Journal of Physiology-Lung Cellular and Molecular Physiology 288:5, pages L860-L867.
Crossref
Daniel S. Cowen, Nadine N. Johnson-Farley & Tatyana Travkina. (2005) 5-HT1A receptors couple to activation of Akt, but not extracellular-regulated kinase (ERK), in cultured hippocampal neurons. Journal of Neurochemistry 93:4, pages 910-917.
Crossref
Michael D. Kaytor, Courtney E. Byam, Susan K. Tousey, Samuel D. Stevens, Huda Y. Zoghbi & Harry T. Orr. (2005) A cell-based screen for modulators of ataxin-1 phosphorylation. Human Molecular Genetics 14:8, pages 1095-1105.
Crossref
Takayuki Hanamoto, Toshinori Ozaki, Kazushige Furuya, Mitsuchika Hosoda, Syunji Hayashi, Mitsuru Nakanishi, Hideki Yamamoto, Hironobu Kikuchi, Satoru Todo & Akira Nakagawara. (2005) Identification of Protein Kinase A Catalytic Subunit β as a Novel Binding Partner of p73 and Regulation of p73 Function. Journal of Biological Chemistry 280:17, pages 16665-16675.
Crossref
Michael J. Chen & Amelia A. Russo-Neustadt. (2005) Exercise activates the phosphatidylinositol 3-kinase pathway. Molecular Brain Research 135:1-2, pages 181-193.
Crossref
Anastasios Chanalaris, Kevin M. Lawrence, Paul A. Townsend, Sean Davidson, Yalda Jashmidi, Anastasis Stephanou, Richard D. Knight, Sheau Y. Hsu, Aaron J.W. Hsueh & David S. Latchman. (2005) Hypertrophic effects of urocortin homologous peptides are mediated via activation of the Akt pathway. Biochemical and Biophysical Research Communications 328:2, pages 442-448.
Crossref
Gang Song, Gaoliang Ouyang & Shideng Bao. (2005) The activation of Akt/PKB signaling pathway and cell survival. Journal of Cellular and Molecular Medicine 9:1, pages 59-71.
Crossref
Nadine N. Johnson-Farley, Sylvia B. Kertesy, George R. Dubyak & Daniel S. Cowen. (2005) Enhanced activation of Akt and extracellular-regulated kinase pathways by simultaneous occupancy of Gq-coupled 5-HT2A receptors and Gs-coupled 5-HT7A receptors in PC12 cells. Journal of Neurochemistry 92:1, pages 72-82.
Crossref
Thomas F. Franke & Daniel C. Berwick. 2005. Signaling Pathways in Liver Diseases. Signaling Pathways in Liver Diseases 239 257 .
Annabel Rose, Pascal Froment, Valérie Perrot, Michael J. Quon, Derek LeRoith & Joëlle Dupont. (2004) The Luteinizing Hormone-releasing Hormone Inhibits the Anti-apoptotic Activity of Insulin-like Growth Factor-1 in Pituitary αT3 Cells by Protein Kinase Cα-mediated Negative Regulation of Akt. Journal of Biological Chemistry 279:50, pages 52500-52516.
Crossref
Tushar B. Deb, Christine M. Coticchia & Robert B. Dickson. (2004) Calmodulin-mediated Activation of Akt Regulates Survival of c-Myc-overexpressing Mouse Mammary Carcinoma Cells. Journal of Biological Chemistry 279:37, pages 38903-38911.
Crossref
Kimberly A. Cullen, John McCool, M. Sawkat Anwer & Cynthia R. L. Webster. (2004) Activation of cAMP-guanine exchange factor confers PKA-independent protection from hepatocyte apoptosis. American Journal of Physiology-Gastrointestinal and Liver Physiology 287:2, pages G334-G343.
Crossref
Alan K Howe. (2004) Regulation of actin-based cell migration by cAMP/PKA. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1692:2-3, pages 159-174.
Crossref
David Raben, Barb Helfrich & Paul A BunnJrJr. (2004) Targeted therapies for non–small-cell lung cancer: biology, rationale, and preclinical results from a radiation oncology perspective. International Journal of Radiation Oncology*Biology*Physics 59:2, pages S27-S38.
Crossref
Kyle L. Hoehn, Susan F. Hudachek, Scott A. Summers & Gregory L. Florant. (2004) Seasonal, tissue-specific regulation of Akt/protein kinase B and glycogen synthase in hibernators. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 286:3, pages R498-R504.
Crossref
Donovan L. Fogt, Shujia Pan, Sukho Lee, Zhenping Ding, Angus Scrimgeour, John C. LawrenceJr.Jr. & John L. Ivy. (2004) Effect of glycogen synthase overexpression on insulin-stimulated muscle glucose uptake and storage. American Journal of Physiology-Endocrinology and Metabolism 286:3, pages E363-E369.
Crossref
Karina Pfeil, Iris E. Eder, Thomas Putz, Reinhold Ramoner, Zoran Culig, Florian Ueberall, Georg Bartsch & Helmut Klocker. (2004) Long-term androgen-ablation causes increased resistance to PI3K/Akt pathway inhibition in prostate cancer cells. The Prostate 58:3, pages 259-268.
Crossref
Thomas F Franke, Christoph P Hornik, Lisa Segev, Grigoriy A Shostak & Chizuru Sugimoto. (2003) PI3K/Akt and apoptosis: size matters. Oncogene 22:56, pages 8983-8998.
Crossref
Marcos Rivas & Pilar Santisteban. (2003) TSH-activated signaling pathways in thyroid tumorigenesis. Molecular and Cellular Endocrinology 213:1, pages 31-45.
Crossref
Claudia Miele, Audrey Riboulet, Maria Alessandra Maitan, Francesco Oriente, Chiara Romano, Pietro Formisano, Jean Giudicelli, Francesco Beguinot & Emmanuel Van Obberghen. (2003) Human Glycated Albumin Affects Glucose Metabolism in L6 Skeletal Muscle Cells by Impairing Insulin-induced Insulin Receptor Substrate (IRS) Signaling through a Protein Kinase Cα-mediated Mechanism. Journal of Biological Chemistry 278:48, pages 47376-47387.
Crossref
Jan A. Ehses, Vanbric R. Casilla, Tim Doty, J. Andrew Pospisilik, Kyle D. Winter, Hans-Ulrich Demuth, Raymond A. Pederson & Christopher H. S. McIntosh. (2003) Glucose-Dependent Insulinotropic Polypeptide Promotes β-(INS-1) Cell Survival via Cyclic Adenosine Monophosphate-Mediated Caspase-3 Inhibition and Regulation of p38 Mitogen-Activated Protein Kinase. Endocrinology 144:10, pages 4433-4445.
Crossref
Michele Andreucci, Ashour Michael, Cornelis Kramers, Kwon Moo Park, Ang Chen, Tilman Matthaeus, Alessandro Alessandrini, Syed Haq, Thomas Force & Joseph V. Bonventre. (2003) Renal ischemia/reperfusion and ATP depletion/repletion in LLC-PK1 cells result in phosphorylation of FKHR and FKHRL1. Kidney International 64:4, pages 1189-1198.
Crossref
Shu-chi Hsiung, Mella Adlersberg, Victoria Arango, J. John Mann, Hadassah Tamir & Kuo-peing Liu. (2003) Attenuated 5-HT1A receptor signaling in brains of suicide victims: involvement of adenylyl cyclase, phosphatidylinositol 3-kinase, Akt and mitogen-activated protein kinase. Journal of Neurochemistry 87:1, pages 182-194.
Crossref
Ana Luisa Kadekaro, Renny J. Kavanagh, Kazumasa Wakamatsu, Shosuke Ito, Michelle A. Pipitone & Zalfa A. Abdel-Malek. (2003) Cutaneous Photobiology. The Melanocyte vs. the Sun: Who Will Win the Final Round?. Pigment Cell Research 16:5, pages 434-447.
Crossref
Naoyoshi Maeda, Yasuo Inoshima, David A. Fruman, Saskia M. Brachmann & Hung Fan. (2003) Transformation of Mouse Fibroblasts by Jaagsiekte Sheep Retrovirus Envelope Does Not Require Phosphatidylinositol 3-Kinase. Journal of Virology 77:18, pages 9951-9959.
Crossref
Bing-Sheng Li, Wu Ma, Howard Jaffe, Yali Zheng, Satoru Takahashi, Lei Zhang, Ashok B. Kulkarni & Harish C. Pant. (2003) Cyclin-dependent Kinase-5 Is Involved in Neuregulin-dependent Activation of Phosphatidylinositol 3-Kinase and Akt Activity Mediating Neuronal Survival. Journal of Biological Chemistry 278:37, pages 35702-35709.
Crossref
Jae Mi Suh, Jung Hun Song, Dong Wook Kim, Ho Kim, Hyo Kyun Chung, Jung Hwan Hwang, Jin Man Kim, Eun Suk Hwang, Jongkyeong Chung, Jeung-Hwan Han, Bo Youn Cho, Heung Kyu Ro & Minho Shong. (2003) Regulation of the Phosphatidylinositol 3-Kinase, Akt/Protein Kinase B, FRAP/Mammalian Target of Rapamycin, and Ribosomal S6 Kinase 1 Signaling Pathways by Thyroid-stimulating Hormone (TSH) and Stimulating type TSH Receptor Antibodies in the Thyroid Gland. Journal of Biological Chemistry 278:24, pages 21960-21971.
Crossref
C. Christian Johansson, Maria K. Dahle, Sandra Rodrigo Blomqvist, Line M. Grønning, Einar M. Aandahl, Sven Enerbäck & Kjetil Taskén. (2003) A Winged Helix Forkhead (FOXD2) Tunes Sensitivity to cAMP in T Lymphocytes through Regulation of cAMP-dependent Protein Kinase RIα. Journal of Biological Chemistry 278:19, pages 17573-17579.
Crossref
Isabelle Briaud, Melissa K. Lingohr, Lorna M. Dickson, Christian E. Wrede & Christopher J. Rhodes. (2003) Differential Activation Mechanisms of Erk-1/2 and p70S6K by Glucose in Pancreatic β-Cells. Diabetes 52:4, pages 974-983.
Crossref
Yang Xia, Hong Y. Wen, Martin E. Young, Patrick H. Guthrie, Heinrich Taegtmeyer & Rodney E. Kellems. (2003) Mammalian Target of Rapamycin and Protein Kinase A Signaling Mediate the Cardiac Transcriptional Response to Glutamine. Journal of Biological Chemistry 278:15, pages 13143-13150.
Crossref
J.E. Kaufmann, M. Iezzi & U.M. Vischer. (2003) Desmopressin (DDAVP) induces NO production in human endothelial cells via V2 receptor- and cAMP-mediated signaling. Journal of Thrombosis and Haemostasis 1:4, pages 821-828.
Crossref
Jinwoong Bok, Xiang-Ming Zha, Yang-Sun Cho & Steven H. Green. (2003) An Extranuclear Locus of cAMP-Dependent Protein Kinase Action Is Necessary and Sufficient for Promotion of Spiral Ganglion Neuronal Survival by cAMP. The Journal of Neuroscience 23:3, pages 777-787.
Crossref
Tatehiro Kagawa, Lyuba Varticovski, Yoshimichi Sai & Irwin M. Arias. (2002) Mechanism by which cAMP activates PI3-kinase and increases bile acid secretion in WIF-B9 cells. American Journal of Physiology-Cell Physiology 283:6, pages C1655-C1666.
Crossref
Albrecht Piiper, Ivan Dikic, Manfred P. Lutz, Jürgen Leser, Bernd Kronenberger, Robert Elez, Henning Cramer, Werner Müller-Esterl & Stefan Zeuzem. (2002) Cyclic AMP Induces Transactivation of the Receptors for Epidermal Growth Factor and Nerve Growth Factor, Thereby Modulating Activation of MAP Kinase, Akt, and Neurite Outgrowth in PC12 Cells. Journal of Biological Chemistry 277:46, pages 43623-43630.
Crossref
R.B Abramovitch, G Yang & J.W Kronstad. (2002) The ukb1 gene encodes a putative protein kinase required for bud site selection and pathogenicity in Ustilago maydis. Fungal Genetics and Biology 37:1, pages 98-108.
Crossref
Eun Joo Kim, Kyoung Ja Kwon, Jee-Young Park, Soo Hwan Lee, Chang-Hyun Moon & Eun Joo Baik. (2002) Neuroprotective effects of prostaglandin E2 or cAMP against microglial and neuronal free radical mediated toxicity associated with inflammation. Journal of Neuroscience Research 70:1, pages 97-107.
Crossref
Cynthia R. L. Webster, Paul Usechak & M. Sawkat Anwer. (2002) cAMP inhibits bile acid-induced apoptosis by blocking caspase activation and cytochrome c release . American Journal of Physiology-Gastrointestinal and Liver Physiology 283:3, pages G727-G738.
Crossref
Mehdi Khaled, Lionel Larribere, Karine Bille, Edith Aberdam, Jean-Paul Ortonne, Robert Ballotti & Corine Bertolotto. (2002) Glycogen Synthase Kinase 3β Is Activated by cAMP and Plays an Active Role in the Regulation of Melanogenesis. Journal of Biological Chemistry 277:37, pages 33690-33697.
Crossref
Liguang Lou, Julie Urbani, Fernando Ribeiro-Neto & Daniel L. Altschuler. (2002) cAMP Inhibition of Akt Is Mediated by Activated and Phosphorylated Rap1b. Journal of Biological Chemistry 277:36, pages 32799-32806.
Crossref
Monica Montagnani, Lingamanaidu V. Ravichandran, Hui Chen, Diana L. Esposito & Michael J. Quon. (2002) Insulin Receptor Substrate-1 and Phosphoinositide-Dependent Kinase-1 Are Required for Insulin-Stimulated Production of Nitric Oxide in Endothelial Cells. Molecular Endocrinology 16:8, pages 1931-1942.
Crossref
Xiao-Ping ZhangHideo TadaZiping WangThomas H. Hintze. (2002) cAMP Signal Transduction, A Potential Compensatory Pathway for Coronary Endothelial NO Production After Heart Failure. Arteriosclerosis, Thrombosis, and Vascular Biology 22:8, pages 1273-1278.
Crossref
Loic Lhuillier & Stuart E. Dryer. (2002) Developmental Regulation of Neuronal K Ca Channels by TGFβ1: An Essential Role for PI3 Kinase Signaling and Membrane Insertion . Journal of Neurophysiology 88:2, pages 954-964.
Crossref
Bernardo Yusta, Jennifer Estall & Daniel J. Drucker. (2002) Glucagon-like Peptide-2 Receptor Activation Engages Bad and Glycogen Synthase Kinase-3 in a Protein Kinase A-dependent Manner and Prevents Apoptosis following Inhibition of Phosphatidylinositol 3-Kinase. Journal of Biological Chemistry 277:28, pages 24896-24906.
Crossref
Pnina Fishman, Lea Madi, Sara Bar-Yehuda, Faina Barer, Luis Del Valle & Kamel Khalili. (2002) Evidence for involvement of Wnt signaling pathway in IB-MECA mediated suppression of melanoma cells. Oncogene 21:25, pages 4060-4064.
Crossref
Yoshihiro Iijima, Martin Laser, Hirokazu Shiraishi, Christopher D. Willey, Balasubramanian Sundaravadivel, Lin Xu, Paul J. McDermott & Dhandapani Kuppuswamy. (2002) c-Raf/MEK/ERK Pathway Controls Protein Kinase C-mediated p70S6K Activation in Adult Cardiac Muscle Cells. Journal of Biological Chemistry 277:25, pages 23065-23075.
Crossref
Maria K. Dahle, Line M. Grønning, Anna Cederberg, Heidi Kiil Blomhoff, Naoyuki Miura, Sven Enerbäck, Kristin A. Taskén & Kjetil Taskén. (2002) Mechanisms of FOXC2- and FOXD1-mediated Regulation of the RIα Subunit of cAMP-dependent Protein Kinase Include Release of Transcriptional Repression and Activation by Protein Kinase Bα and cAMP. Journal of Biological Chemistry 277:25, pages 22902-22908.
Crossref
Philip J.S Stork & John M Schmitt. (2002) Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation. Trends in Cell Biology 12:6, pages 258-266.
Crossref
Candace Shelly & Roman Herrera. (2002) Activation of SGK1 by HGF, Rac1 and integrin-mediated cell adhesion in MDCK cells: PI-3K-dependent and -independent pathways. Journal of Cell Science 115:9, pages 1985-1993.
Crossref
Elisabetta Ciani, Marco Virgili & Antonio Contestabile. (2002) Akt pathway mediates a cGMP-dependent survival role of nitric oxide in cerebellar granule neurones. Journal of Neurochemistry 81:2, pages 218-228.
Crossref
John M Dickenson. (2002) Stimulation of protein kinase B and p70 S6 kinase by the histamine H 1 receptor in DDT 1 MF-2 smooth muscle cells . British Journal of Pharmacology 135:8, pages 1967-1976.
Crossref
Fang C. Mei, Jingbo Qiao, Oxana M. Tsygankova, Judy L. Meinkoth, Lawrence A. Quilliam & Xiaodong Cheng. (2002) Differential Signaling of Cyclic AMP. Journal of Biological Chemistry 277:13, pages 11497-11504.
Crossref
Isabelle Laffont, Motoko Takahashi, Yukinao Shibukawa, Koichi Honke, Vladimir V. Shuvaev, Gérard Siest, Sophie Visvikis & Naoyuki Taniguchi. (2002) Apolipoprotein E Activates Akt Pathway in Neuro-2a in an Isoform-Specific Manner. Biochemical and Biophysical Research Communications 292:1, pages 83-87.
Crossref
B Li, SA Desai, RA MacCorkle-Chosnek, L Fan & DM Spencer. (2002) A novel conditional Akt ‘survival switch’ reversibly protects cells from apoptosis. Gene Therapy 9:4, pages 233-244.
Crossref
Shao Jun Tang, Gerald Reis, Hyejin Kang, Anne-Claude Gingras, Nahum Sonenberg & Erin M. Schuman. (2001) A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus. Proceedings of the National Academy of Sciences 99:1, pages 467-472.
Crossref
Carmine Vecchione, Angelo Maffei, Salvatore Colella, Alessandra Aretini, Roberta Poulet, Giacomo Frati, Maria Teresa Gentile, Luigi Fratta, Valentina Trimarco, Bruno Trimarco & Giuseppe Lembo. (2002) Leptin Effect on Endothelial Nitric Oxide Is Mediated Through Akt–Endothelial Nitric Oxide Synthase Phosphorylation Pathway. Diabetes 51:1, pages 168-173.
Crossref
Hiromichi Fujino, Kimberly A. West & John W. Regan. (2002) Phosphorylation of Glycogen Synthase Kinase-3 and Stimulation of T-cell Factor Signaling following Activation of EP2 and EP4 Prostanoid Receptors by Prostaglandin E2. Journal of Biological Chemistry 277:4, pages 2614-2619.
Crossref
Min Ding, Jingxia Li, Stephen S. Leonard, Xianglin Shi, Max Costa, Vincent Castranova, Val Vallyathan & Chuanshu Huang. 2002. Oxygen/Nitrogen Radicals: Cell Injury and Disease. Oxygen/Nitrogen Radicals: Cell Injury and Disease 81 90 .
Timur O. Yarovinsky & Gary W. Hunninghake. (2001) Lung fibroblasts inhibit activation-induced death of T cells through PGE 2 -dependent mechanisms . American Journal of Physiology-Lung Cellular and Molecular Physiology 281:5, pages L1248-L1256.
Crossref
Sunita Kumari, Xueman Liu, Thuyen Nguyen, Xuebin Zhang & Santosh R D’Mello. (2001) Distinct phosphorylation patterns underlie Akt activation by different survival factors in neurons. Molecular Brain Research 96:1-2, pages 157-162.
Crossref
Chuanshu Huang, Jingxia Li, Min Ding, Stephen S. Leonard, Liying Wang, Vincent Castranova, Val Vallyathan & Xianglin Shi. (2001) UV Induces Phosphorylation of Protein Kinase B (Akt) at Ser-473 and Thr-308 in Mouse Epidermal Cl 41 Cells through Hydrogen Peroxide. Journal of Biological Chemistry 276:43, pages 40234-40240.
Crossref
Carol A. Grimes & Richard S. Jope. (2001) CREB DNA binding activity is inhibited by glycogen synthase kinase-3β and facilitated by lithium. Journal of Neurochemistry 78:6, pages 1219-1232.
Crossref
Yves Gorin, Nam‐Ho Kim, Denis Feliers, Basant Bhandari, Goutam Ghosh Choudhury & Hanna E. Abboud. (2001) Angiotensin II activates Akt/protein kinase B by an arachidonic acid/redox‐dependent pathway and independent of phosphoinositide 3‐kinase. The FASEB Journal 15:11, pages 1909-1920.
Crossref
Chih-Hung Lin, Shiu-Hwa Yeh, Chia-Ho Lin, Kwok-Tung Lu, Tzeng-Horng Leu, Wen-Chang Chang & Po-Wu Gean. (2001) A Role for the PI-3 Kinase Signaling Pathway in Fear Conditioning and Synaptic Plasticity in the Amygdala. Neuron 31:5, pages 841-851.
Crossref
Nick R. LeslieRicardo M. BiondiDario R. Alessi. (2001) Phosphoinositide-Regulated Kinases and Phosphoinositide Phosphatases. Chemical Reviews 101:8, pages 2365-2380.
Crossref
Keith A. Gottlieb & Luis P. Villarreal. (2001) Natural Biology of Polyomavirus Middle T Antigen. Microbiology and Molecular Biology Reviews 65:2, pages 288-318.
Crossref
Federico Colombo, Josette Noël, Phillipe Mayers, Isabelle Mercier & Angelino Calderone. (2001) β -Adrenergic Stimulation of Rat Cardiac Fibroblasts Promotes Protein Synthesis via the Activation of Phosphatidylinositol 3-kinase. Journal of Molecular and Cellular Cardiology 33:6, pages 1091-1106.
Crossref
Hongmiao Sheng, Jinyi Shao, M. Kay Washington & Raymond N. DuBois. (2001) Prostaglandin E2 Increases Growth and Motility of Colorectal Carcinoma Cells. Journal of Biological Chemistry 276:21, pages 18075-18081.
Crossref
JoAnne S. Richards. (2001) New Signaling Pathways for Hormones and Cyclic Adenosine 3′,5′-Monophosphate Action in Endocrine Cells. Molecular Endocrinology 15:2, pages 209-218.
Crossref
Ying Li, Donald Dowbenko & Laurence A. Lasky. (2001) Caenorhabditis elegans PIAK, a Phospholipid-independent Kinase That Activates the AKT/PKB Survival Kinase. Journal of Biological Chemistry 276:23, pages 20323-20329.
Crossref
Costas Demetzos & Konstantinos S. Dimas. 2001. Bioactive Natural Products (Part F). Bioactive Natural Products (Part F) 235 292 .
James F. Powers, Suniti Misra, Kimberly Schelling, Lyuba Varticovski & Arthur S. Tischler. (2001) Mitogenic signaling by cyclic adenosine monophosphate in chromaffin cells involves phosphatidylinositol 3-kinase activation. Journal of Cellular Biochemistry 81:S36, pages 89-98.
Crossref
Soo-Jeong Lim, Gabriel Lopez-Berestein, Mien-Chie Hung, Ruth Lupu & Ana M Tari. (2000) Grb2 downregulation leads to Akt inactivation in heregulin-stimulated and ErbB2-overexpressing breast cancer cells. Oncogene 19:54, pages 6271-6276.
Crossref
KATJA TRÜMPER, ANDREA TRÜMPER, HEIDI TRUSHEIM, RUDOLF ARNOLD, BURKHARD GÖKE & DIETER HÖRSCH. (2006) Integrative Mitogenic Role of Protein Kinase B/Akt in β-Cells. Annals of the New York Academy of Sciences 921:1, pages 242-250.
Crossref
Beáta Törőcsik & József Szeberényi. (2000) Anisomycin Affects Both Pro- and Antiapoptotic Mechanisms in PC12 Cells. Biochemical and Biophysical Research Communications 278:3, pages 550-556.
Crossref
Xianjun Fang, Shuang Xing Yu, Yiling Lu, Robert C. BastJr.Jr., James R. Woodgett & Gordon B. Mills. (2000) Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A. Proceedings of the National Academy of Sciences 97:22, pages 11960-11965.
Crossref
Miles D. Houslay & Walter Kolch. (2000) Cell-Type Specific Integration of Cross-Talk between Extracellular Signal-Regulated Kinase and cAMP Signaling. Molecular Pharmacology 58:4, pages 659-668.
Crossref
Jun-ichi Okano, Irphan Gaslightwala, Morris J. Birnbaum, Anil K. Rustgi & Hiroshi Nakagawa. (2000) Akt/Protein Kinase B Isoforms Are Differentially Regulated by Epidermal Growth Factor Stimulation. Journal of Biological Chemistry 275:40, pages 30934-30942.
Crossref
Jiro Kitaura, Koichi Asai, Mari Maeda-Yamamoto, Yuko Kawakami, Ushio Kikkawa & Toshiaki Kawakami. (2000) Akt-Dependent Cytokine Production in Mast Cells. Journal of Experimental Medicine 192:5, pages 729-740.
Crossref
Cosmas Giallourakis, Masaki Kashiwada, Ping-Ying Pan, Nika Danial, Hong Jiang, John Cambier, K. Mark Coggeshall & Paul Rothman. (2000) Positive Regulation of Interleukin-4-mediated Proliferation by the SH2-containing Inositol-5′-phosphatase. Journal of Biological Chemistry 275:38, pages 29275-29282.
Crossref
C Leloup, D M Michaelson, A Fisher, T Hartmann, K Beyreuther & R Stein. (2000) M1 muscarinic receptors block caspase activation by phosphoinositide 3-kinase- and MAPK/ERK-independent pathways. Cell Death & Differentiation 7:9, pages 825-833.
Crossref
Claudia Miele, Justin J. Rochford, Nathalie Filippa, Sophie Giorgetti-Peraldi & Emmanuel Van Obberghen. (2000) Insulin and Insulin-like Growth Factor-I Induce Vascular Endothelial Growth Factor mRNA Expression via Different Signaling Pathways. Journal of Biological Chemistry 275:28, pages 21695-21702.
Crossref
Renée Germack & John M Dickenson. (2000) Activation of protein kinase B by the A 1 -adenosine receptor in DDT 1 MF-2 cells . British Journal of Pharmacology 130:4, pages 867-874.
Crossref
Carmine Morisco, David Zebrowski, Gianluigi Condorelli, Philip Tsichlis, Stephen F. Vatner & Junichi Sadoshima. (2000) The Akt-Glycogen Synthase Kinase 3β Pathway Regulates Transcription of Atrial Natriuretic Factor Induced by β-Adrenergic Receptor Stimulation in Cardiac Myocytes. Journal of Biological Chemistry 275:19, pages 14466-14475.
Crossref
Wen-Hua Zheng, Satyabrata Kar & Rémi Quirion. (2000) Stimulation of Protein Kinase C Modulates Insulin-like Growth Factor-1-induced Akt Activation in PC12 Cells. Journal of Biological Chemistry 275:18, pages 13377-13385.
Crossref
Jianrong Li, Sufang Yang & Timothy R. Billiar. (2000) Cyclic Nucleotides Suppress Tumor Necrosis Factor α-Mediated Apoptosis by Inhibiting Caspase Activation and Cytochrome cRelease in Primary Hepatocytes via a Mechanism Independent of Akt Activation. Journal of Biological Chemistry 275:17, pages 13026-13034.
Crossref
Elke Butt, Manfred Bernhardt, Albert Smolenski, Peter Kotsonis, Lothar G. Fröhlich, Albert Sickmann, Helmut E. Meyer, Suzanne M. Lohmann & Harald H.H.W. Schmidt. (2000) Endothelial Nitric-oxide Synthase (Type III) Is Activated and Becomes Calcium Independent upon Phosphorylation by Cyclic Nucleotide-dependent Protein Kinases. Journal of Biological Chemistry 275:7, pages 5179-5187.
Crossref
Eugene S. Kandel & Nissim Hay. (1999) The Regulation and Activities of the Multifunctional Serine/Threonine Kinase Akt/PKB. Experimental Cell Research 253:1, pages 210-229.
Crossref

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