Citations (65)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (7)
Sonja I. Gringhuis, Ellen A. M. Papendrecht-van der Voort, Angela Leow, E. W. Nivine Levarht, Ferdinand C. Breedveld & Cornelis L. Verweij. (2002) Effect of Redox Balance Alterations on Cellular Localization of LAT and Downstream T-Cell Receptor Signaling Pathways. Molecular and Cellular Biology 22:2, pages 400-411.
Read now
Read now
John M. Schmitt & Philip J. S. Stork. (2001) Cyclic AMP-Mediated Inhibition of Cell Growth Requires the Small G Protein Rap1. Molecular and Cellular Biology 21:11, pages 3671-3683.
Read now
Read now
Josefina Garcia, Jean de Gunzburg, Alain Eychène, Sylvie Gisselbrecht & Françoise Porteu. (2001) Thrombopoietin-Mediated Sustained Activation of Extracellular Signal-Regulated Kinase in UT7-Mpl Cells Requires Both Ras–Raf-1- and Rap1–B-Raf-Dependent Pathways. Molecular and Cellular Biology 21:8, pages 2659-2670.
Read now
Read now
Kendall D. Carey, Tara J. Dillon, John M. Schmitt, Allison M. Baird, Amy D. Holdorf, David B. Straus, Andrey S. Shaw & Philip J. S. Stork. (2000) CD28 and the Tyrosine Kinase Lck Stimulate Mitogen-Activated Protein Kinase Activity in T Cells via Inhibition of the Small G Protein Rap1. Molecular and Cellular Biology 20:22, pages 8409-8419.
Read now
Read now
Yusuke Ohba, Naoki Mochizuki, Keiko Matsuo, Shigeko Yamashita, Mie Nakaya, Yuko Hashimoto, Michinari Hamaguchi, Takeshi Kurata, Kazuo Nagashima & Michiyuki Matsuda. (2000) Rap2 as a Slowly Responding Molecular Switch in the Rap1 Signaling Cascade. Molecular and Cellular Biology 20:16, pages 6074-6083.
Read now
Read now
Fumi Shima, Tomoyo Okada, Masahiro Kido, Hiroyoshi Sen, Yasuhiro Tanaka, Masako Tamada, Chang-Deng Hu, Yuriko Yamawaki-Kataoka, Ken-ichi Kariya & Tohru Kataoka. (2000) Association of Yeast Adenylyl Cyclase with Cyclase-Associated Protein CAP Forms a Second Ras-Binding Site Which Mediates Its Ras-Dependent Activation. Molecular and Cellular Biology 20:1, pages 26-33.
Read now
Read now
Verónica Ayllón, Angelita Rebollo. (2000) Ras-induced cellular events. Molecular Membrane Biology 17:2, pages 65-73.
Read now
Read now
Articles from other publishers (58)
Rahim Ullah, Qing Yin, Aidan H. Snell & Lixin Wan. (2022) RAF-MEK-ERK pathway in cancer evolution and treatment. Seminars in Cancer Biology 85, pages 123-154.
Crossref
Crossref
Kien Nguyen, Cesar A. López, Chris Neale, Que N. Van, Timothy S. Carpenter, Francesco Di Natale, Timothy Travers, Timothy H. Tran, Albert H. Chan, Harsh Bhatia, Peter H. Frank, Marco Tonelli, Xiaohua Zhang, Gulcin Gulten, Tyler Reddy, Violetta Burns, Tomas Oppelstrup, Nick Hengartner, Dhirendra K. Simanshu, Peer-Timo Bremer, De Chen, James N. Glosli, Rebika Shrestha, Thomas Turbyville, Frederick H. Streitz, Dwight V. Nissley, Helgi I. Ingólfsson, Andrew G. Stephen, Felice C. Lightstone & Sandrasegaram Gnanakaran. (2022) Exploring CRD mobility during RAS/RAF engagement at the membrane. Biophysical Journal 121:19, pages 3630-3650.
Crossref
Crossref
Hongfei Li, Shuangrui Lin, Pengzhi Qi, Jingtian Wang, Meihua Fan, Hongwei Huang, Zhenyu Dong, Kaida Xu & Baoying Guo. (2022) Proteomic analysis of the spineless cuttlefish Sepiella japonica: Exploratory analyses on the phenomenon of death after spawning. Frontiers in Marine Science 9.
Crossref
Crossref
Ruth Nussinov, Mingzhen Zhang, Ryan Maloney, Yonglan Liu, Chung-Jung Tsai & Hyunbum Jang. (2022) Allostery: Allosteric Cancer Drivers and Innovative Allosteric Drugs. Journal of Molecular Biology 434:17, pages 167569.
Crossref
Crossref
Venkatesh P. Mysore, Zhi-Wei Zhou, Chiara Ambrogio, Lianbo Li, Jonas N. Kapp, Chunya Lu, Qi Wang, Maxwell R. Tucker, Jeffrey J. Okoro, Gabriela Nagy-Davidescu, Xiaochen Bai, Andreas Plückthun, Pasi A. Jänne, Kenneth D. Westover, Yibing Shan & David E. Shaw. (2021) A structural model of a Ras–Raf signalosome. Nature Structural & Molecular Biology 28:10, pages 847-857.
Crossref
Crossref
Timothy H. Tran, Albert H. Chan, Lucy C. Young, Lakshman Bindu, Chris Neale, Simon Messing, Srisathiyanarayanan Dharmaiah, Troy Taylor, John-Paul Denson, Dominic Esposito, Dwight V. Nissley, Andrew G. Stephen, Frank McCormick & Dhirendra K. Simanshu. (2021) KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation. Nature Communications 12:1.
Crossref
Crossref
Ruth Nussinov, Hyunbum Jang, Attila Gursoy, Ozlem Keskin & Vadim Gaponenko. (2021) Inhibition of Nonfunctional Ras. Cell Chemical Biology 28:2, pages 121-133.
Crossref
Crossref
Zhenhao FangKi-Young LeeKu-Geng Huo, Geneviève Gasmi-Seabrook, Le ZhengNadeem Moghal, Ming-Sound Tsao, Mitsuhiko Ikura & Christopher B. Marshall. (2020) Multivalent assembly of KRAS with the RAS-binding and cysteine-rich domains of CRAF on the membrane. Proceedings of the National Academy of Sciences 117:22, pages 12101-12108.
Crossref
Crossref
Ruth Nussinov, Hyunbum Jang, Mingzhen Zhang, Chung-Jung Tsai & Anna A. Sablina. (2020) The Mystery of Rap1 Suppression of Oncogenic Ras. Trends in Cancer 6:5, pages 369-379.
Crossref
Crossref
Coralie Dorard, Botond Cseh, Karin Ehrenreiter, Reiner Wimmer, Andrea Varga, Tatjana Hirschmugl, Barbara Maier, Karina Kramer, Sabine Fürlinger, Eszter Doma & Manuela Baccarini. (2019)
RAF
dimers control vascular permeability and cytoskeletal rearrangements at endothelial cell‐cell junctions
. The FEBS Journal 286:12, pages 2277-2294.
Crossref
Crossref
Soheila Rezaei Adariani, Marcel Buchholzer, Mohammad Akbarzadeh, Saeideh Nakhaei-Rad, Radovan Dvorsky & Mohammad Reza Ahmadian. (2018) Structural snapshots of RAF kinase interactions. Biochemical Society Transactions 46:6, pages 1393-1406.
Crossref
Crossref
Nicholas Cope, Christine Candelora, Kenneth Wong, Sujeet Kumar, Haihan Nan, Michael Grasso, Borna Novak, Yana Li, Ronen Marmorstein & Zhihong Wang. (2018) Mechanism of BRAF Activation through Biochemical Characterization of the Recombinant Full-Length Protein. ChemBioChem 19:18, pages 1988-1997.
Crossref
Crossref
Devanand T, Prasanna Venkatraman & Satyavani Vemparala. (2018) Phosphorylation promotes binding affinity of Rap-Raf complex by allosteric modulation of switch loop dynamics. Scientific Reports 8:1.
Crossref
Crossref
Timothy Travers, Cesar A. López, Que N. Van, Chris Neale, Marco Tonelli, Andrew G. Stephen & S. Gnanakaran. (2018) Molecular recognition of RAS/RAF complex at the membrane: Role of RAF cysteine-rich domain. Scientific Reports 8:1.
Crossref
Crossref
William G. RobichauxIIIIII & Xiaodong Cheng. (2018) Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development. Physiological Reviews 98:2, pages 919-1053.
Crossref
Crossref
Chae-Seok Lim, Cheng Wen, Yanghui Sheng, Guangfu Wang, Zhuan Zhou, Shiqiang Wang, Huaye Zhang, Anpei Ye & J. Julius Zhu. (2017) Piconewton-Scale Analysis of Ras-BRaf Signal Transduction with Single-Molecule Force Spectroscopy. Small 13:40, pages 1701972.
Crossref
Crossref
Ryan J. Sullivan. (2016) The role of mitogen-activated protein targeting in melanoma beyond BRAFV600. Current Opinion in Oncology 28:2, pages 185-191.
Crossref
Crossref
Irena Antic, Marco Biancucci, Yueming Zhu, David R. Gius & Karla J. F. Satchell. (2015) Site-specific processing of Ras and Rap1 Switch I by a MARTX toxin effector domain. Nature Communications 6:1.
Crossref
Crossref
Susanne Wolfenstetter, David Chakravorty, Ryan Kula, Daisuke Urano, Yuri Trusov, Michael B. Sheahan, David W. McCurdy, Sarah M. Assmann, Alan M. Jones & José R. Botella. (2014) Evidence for an unusual transmembrane configuration of AGG3, a class C Gγ subunit of Arabidopsis. The Plant Journal 81:3, pages 388-398.
Crossref
Crossref
Reiner Wimmer, Botond Cseh, Barbara Maier, Karina Scherrer & Manuela Baccarini. (2012) Angiogenic Sprouting Requires the Fine Tuning of Endothelial Cell Cohesion by the Raf-1/Rok-α Complex. Developmental Cell 22:1, pages 158-171.
Crossref
Crossref
David Chakravorty, Yuri Trusov, Wei Zhang, Biswa R. Acharya, Michael B. Sheahan, David W. McCurdy, Sarah M. Assmann & José Ramón Botella. (2011) An atypical heterotrimeric G-protein γ-subunit is involved in guard cell K+-channel regulation and morphological development in Arabidopsis thaliana. The Plant Journal 67:5, pages 840-851.
Crossref
Crossref
María Rodríguez-MuñozElena de la Torre-MadridPilar Sánchez-BlázquezJavier Garzón. (2011) NO-released Zinc Supports the Simultaneous Binding of Raf-1 and PKCγ Cysteine-Rich Domains to HINT1 Protein at the Mu-Opioid Receptor. Antioxidants & Redox Signaling 14:12, pages 2413-2425.
Crossref
Crossref
Ki-Wook Chung, Insoo Suh & Orlo H. Clark. 2009. Endocrine Surgery. Endocrine Surgery
97
110
.
Trairak Pisitkun, Vinitha Jacob, Stephen M. Schleicher, Chung-Lin Chou, Ming-Jiun Yu & Mark A. Knepper. (2008) Akt and ERK1/2 pathways are components of the vasopressin signaling network in rat native IMCD. American Journal of Physiology-Renal Physiology 295:4, pages F1030-F1043.
Crossref
Crossref
Lawrence E. Goldfinger. (2008) Choose your own path: specificity in Ras GTPase signaling. Molecular BioSystems 4:4, pages 293.
Crossref
Crossref
Irina A. Potapova, Ira S. Cohen & Sergey V. Doronin. (2007) Voltage-gated ion channel Kv4.3 is associated with Rap guanine nucleotide exchange factors and regulates angiotensin receptor type 1 signaling to small G-protein Rap. FEBS Journal 274:17, pages 4375-4384.
Crossref
Crossref
Yoko Yoshikawa, Takaya Satoh, Takashi Tamura, Ping Wei, Shymaa E. Bilasy, Hironori Edamatsu, Atsu AibaKoko Katagiri, Tatsuo Kinashi, Kazuki Nakao & Tohru Kataoka. (2007) The M-Ras-RA-GEF-2-Rap1 Pathway Mediates Tumor Necrosis Factor-α–dependent Regulation of Integrin Activation in Splenocytes. Molecular Biology of the Cell 18:8, pages 2949-2959.
Crossref
Crossref
Alfonso CatalanoPaola CaprariSimona MorettiMonica FaronatoLuca TamagnoneAntonio Procopio. (2006) Semaphorin-3A is expressed by tumor cells and alters T-cell signal transduction and function. Blood 107:8, pages 3321-3329.
Crossref
Crossref
Deborah K. Morrison & Ira O. Daar. 2006. RAS Family GTPases. RAS Family GTPases
67
93
.
Jean De Gunzburg. 2006. RAS Family GTPases. RAS Family GTPases
295
339
.
Muralidhar Beeram, Amita Patnaik & Eric K. Rowinsky. (2005) Raf: A Strategic Target for Therapeutic Development Against Cancer. Journal of Clinical Oncology 23:27, pages 6771-6790.
Crossref
Crossref
Yongliang Zhu, Xian Zhong, Shu Zheng, Qin Du & Weizhen Xu. (2005) Transformed immortalized gastric epithelial cells by virulence factor CagA of Helicobacter pylori through Erk mitogen-activated protein kinase pathway. Oncogene 24:24, pages 3886-3895.
Crossref
Crossref
Kazuhiro Nomura, Hoshimi Kanemura, Takaya Satoh & Tohru Kataoka. (2004) Identification of a Novel Domain of Ras and Rap1 That Directs Their Differential Subcellular Localizations. Journal of Biological Chemistry 279:21, pages 22664-22673.
Crossref
Crossref
Hicham Lahlou, Nathalie Saint-Laurent, Jean-Pierre Estève, Alain Eychène, Lucien Pradayrol, Stéphane Pyronnet & Christiane Susini. (2003) sst2 Somatostatin Receptor Inhibits Cell Proliferation through Ras-, Rap1-, and B-Raf-dependent ERK2 Activation. Journal of Biological Chemistry 278:41, pages 39356-39371.
Crossref
Crossref
Daisuke Ishida, Hailin Yang, Kyoko Masuda, Kanami Uesugi, Hiroshi Kawamoto, Masakazu Hattori & Nagahiro Minato. (2003) Antigen-driven T cell anergy and defective memory T cell response via deregulated Rap1 activation in SPA-1-deficient mice. Proceedings of the National Academy of Sciences 100:19, pages 10919-10924.
Crossref
Crossref
Kathryn E. Mercer & Catrin A. Pritchard. (2003) Raf proteins and cancer: B-Raf is identified as a mutational target. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1653:1, pages 25-40.
Crossref
Crossref
Tara L. Baker, Hui Zheng, Joy Walker, Jonathan L. Coloff & Janice E. Buss. (2003) Distinct Rates of Palmitate Turnover on Membrane-bound Cellular and Oncogenic H-Ras. Journal of Biological Chemistry 278:21, pages 19292-19300.
Crossref
Crossref
Huira Chong, Haris G Vikis & Kun-Liang Guan. (2003) Mechanisms of regulating the Raf kinase family. Cellular Signalling 15:5, pages 463-469.
Crossref
Crossref
Shinya Mitsuhashi, Hiroshi Shima, Nobuhiro Tanuma, Nobuyasu Matsuura, Mutsuhiro Takekawa, Takeshi Urano, Tohru Kataoka, Makoto Ubukata & Kunimi Kikuchi. (2003) Usage of Tautomycetin, a Novel Inhibitor of Protein Phosphatase 1 (PP1), Reveals That PP1 Is a Positive Regulator of Raf-1 in Vivo. Journal of Biological Chemistry 278:1, pages 82-88.
Crossref
Crossref
Kendall D. Carey, Robert T. Watson, Jeffrey E. Pessin & Philip J.S. Stork. (2003) The Requirement of Specific Membrane Domains for Raf-1 Phosphorylation and Activation. Journal of Biological Chemistry 278:5, pages 3185-3196.
Crossref
Crossref
Kimberly D. Fralix, Shujie Zhao, Kolaparthi Venkatasubbarao & James W. Freeman. (2003) Rap1 reverses transcriptional repression of TGF-? type II receptor by a mechanism involving AP-1 in the human pancreatic cancer cell line, UK Pan-1. Journal of Cellular Physiology 194:1, pages 88-99.
Crossref
Crossref
Albrecht Piiper, Ivan Dikic, Manfred P. Lutz, Jürgen Leser, Bernd Kronenberger, Robert Elez, Henning Cramer, Werner Müller-Esterl & Stefan Zeuzem. (2002) Cyclic AMP Induces Transactivation of the Receptors for Epidermal Growth Factor and Nerve Growth Factor, Thereby Modulating Activation of MAP Kinase, Akt, and Neurite Outgrowth in PC12 Cells. Journal of Biological Chemistry 277:46, pages 43623-43630.
Crossref
Crossref
Takashi Fujita, Toru Meguro, Ryo Fukuyama, Hiromichi Nakamuta & Masao Koida. (2002) New Signaling Pathway for Parathyroid Hormone and Cyclic AMP Action on Extracellular-regulated Kinase and Cell Proliferation in Bone Cells. Journal of Biological Chemistry 277:25, pages 22191-22200.
Crossref
Crossref
Fernando Ribeiro-Neto, Julie Urbani, Nicolas Lemee, Liguang Lou & Daniel L. Altschuler. (2002)
On the mitogenic properties of Rap1b: cAMP-induced G
1
/S entry requires activated and phosphorylated Rap1b
. Proceedings of the National Academy of Sciences 99:8, pages 5418-5423.
Crossref
Crossref
Kendall D. Carey & Philip J.S. Stork. 2002. G Protein Pathways - Part C, Effector Mechanisms. G Protein Pathways - Part C, Effector Mechanisms
383
397
.
Xianlong Gao, Takaya Satoh, Yanhong Liao, Chunhua Song, Chang-Deng Hu, Ken-ichi Kariya & Tohru Kataoka. (2001) Identification and Characterization of RA-GEF-2, a Rap Guanine Nucleotide Exchange Factor That Serves as a Downstream Target of M-Ras. Journal of Biological Chemistry 276:45, pages 42219-42225.
Crossref
Crossref
Tai-Guang Jin, Takaya Satoh, Yanhong Liao, Chunhua Song, Xianlong Gao, Ken-ichi Kariya, Chang-Deng Hu & Tohru Kataoka. (2001) Role of the CDC25 Homology Domain of Phospholipase Cε in Amplification of Rap1-dependent Signaling. Journal of Biological Chemistry 276:32, pages 30301-30307.
Crossref
Crossref
Zhu Chen, Tara Beers Gibson, Fred Robinson, Loraine Silvestro, Gray Pearson, Bing-e Xu, Angelique Wright, Colleen Vanderbilt & Melanie H. Cobb. (2001) MAP Kinases. Chemical Reviews 101:8, pages 2449-2476.
Crossref
Crossref
Sandra König, Bernard Guibert, Cecile Morice, Philippe Vernier & Jean Vianney Barnier. (2001) Phosphorylation by PKA of a site unique to B-Raf kinase. Comptes Rendus de l'Académie des Sciences - Series III - Sciences de la Vie 324:8, pages 673-681.
Crossref
Crossref
Montserrat Jaumot & John F Hancock. (2001) Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions. Oncogene 20:30, pages 3949-3958.
Crossref
Crossref
Yanhong Liao, Takaya Satoh, Xianlong Gao, Tai-Guang Jin, Chang-Deng Hu & Tohru Kataoka. (2001) RA-GEF-1, a Guanine Nucleotide Exchange Factor for Rap1, Is Activated by Translocation Induced by Association with Rap1·GTP and Enhances Rap1-dependent B-Raf Activation. Journal of Biological Chemistry 276:30, pages 28478-28483.
Crossref
Crossref
Shih-chu Kao, Rama K. Jaiswal, Walter Kolch & Gary E. Landreth. (2001) Identification of the Mechanisms Regulating the Differential Activation of the MAPK Cascade by Epidermal Growth Factor and Nerve Growth Factor in PC12 Cells. Journal of Biological Chemistry 276:21, pages 18169-18177.
Crossref
Crossref
Johannes L. Bos, Johan de Rooij & Kris A. Reedquist. (2001) Rap1 signalling: adhering to new models. Nature Reviews Molecular Cell Biology 2:5, pages 369-377.
Crossref
Crossref
Gray Pearson, Fred Robinson, Tara Beers Gibson, Bing-e Xu, Mahesh Karandikar, Kevin Berman & Melanie H. Cobb. (2001) Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*. Endocrine Reviews 22:2, pages 153-183.
Crossref
Crossref
John M. Schmitt & Philip J.S. Stork. (2000) β2-Adrenergic Receptor Activates Extracellular Signal-regulated Kinases (ERKs) via the Small G Protein Rap1 and the Serine/Threonine Kinase B-Raf. Journal of Biological Chemistry 275:33, pages 25342-25350.
Crossref
Crossref
Michelle A. Booden, Donald S. Sakaguchi & Janice E. Buss. (2000) Mutation of Ha-Ras C Terminus Changes Effector Pathway Utilization. Journal of Biological Chemistry 275:31, pages 23559-23568.
Crossref
Crossref
Chad A Ellis & Geoff Clark. (2000) The importance of being K-Ras. Cellular Signalling 12:7, pages 425-434.
Crossref
Crossref
Hiroyoshi Sendoh, Chang-Deng Hu, Dongmei Wu, Chunhua Song, Yuriko Yamawaki-Kataoka, Joji Kotani, Tomoyo Okada, Fumi Shima, Ken-ichi Kariya & Tohru Kataoka. (2000) Role of Raf-1 Conserved Region 2 in Regulation of Ras-Dependent Raf-1 Activation. Biochemical and Biophysical Research Communications 271:3, pages 596-602.
Crossref
Crossref